DE3877811D1 - - Google Patents

Info

Publication number
DE3877811D1
DE3877811D1 DE88304059T DE3877811T DE3877811D1 DE 3877811 D1 DE3877811 D1 DE 3877811D1 DE 88304059 T DE88304059 T DE 88304059T DE 3877811 T DE3877811 T DE 3877811T DE 3877811 D1 DE3877811 D1 DE 3877811D1
Authority
DE
Germany
Prior art keywords
hemosafe
derived
hemoglobin
human
hemosafes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88304059T
Other languages
English (en)
Other versions
DE3877811T2 (de
Inventor
Jen-Chang Concord Ontario Ca Hsia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minister of National Defence of Canada
Original Assignee
Minister of National Defence of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minister of National Defence of Canada filed Critical Minister of National Defence of Canada
Application granted granted Critical
Publication of DE3877811D1 publication Critical patent/DE3877811D1/de
Publication of DE3877811T2 publication Critical patent/DE3877811T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
DE8888304059T 1987-05-05 1988-05-05 Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis. Expired - Lifetime DE3877811T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878710598A GB8710598D0 (en) 1987-05-05 1987-05-05 Hemoglobin based blood substitute

Publications (2)

Publication Number Publication Date
DE3877811D1 true DE3877811D1 (de) 1993-03-11
DE3877811T2 DE3877811T2 (de) 1993-05-27

Family

ID=10616838

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888304059T Expired - Lifetime DE3877811T2 (de) 1987-05-05 1988-05-05 Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis.

Country Status (15)

Country Link
US (2) US4857636A (de)
EP (1) EP0290252B1 (de)
JP (1) JPS63297330A (de)
KR (1) KR910009343B1 (de)
CN (1) CN1032471C (de)
AT (1) ATE84970T1 (de)
AU (1) AU610883B2 (de)
CA (1) CA1306583C (de)
DE (1) DE3877811T2 (de)
DK (1) DK174286B1 (de)
ES (1) ES2053729T3 (de)
GB (1) GB8710598D0 (de)
IL (1) IL86258A (de)
NZ (1) NZ224479A (de)
ZA (1) ZA883171B (de)

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US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
AU622610B2 (en) * 1986-11-10 1992-04-16 Biopure Corporation Extra pure semi-synthetic blood substitute
US5753616A (en) * 1986-11-10 1998-05-19 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5955581A (en) * 1986-11-10 1999-09-21 Biopure Corporation Method for producing a stable polymerized hemoglobin blood-substitute
US5854209A (en) * 1995-03-23 1998-12-29 Biopure Corporation Method for oxygenating tissue having reduced red blood cell flow
US5189146A (en) * 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
ATE136466T1 (de) * 1989-12-29 1996-04-15 Univ Texas Tech Polyhämoglobin durch purinderivate und glutathion stabilisiert
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
JP3021041B2 (ja) * 1990-03-14 2000-03-15 ザ ユニバーシティ オブ トロント イノベーションズ ファンデーション アシルリン酸エステルおよびそれによる蛋白質の改質
US5248766A (en) * 1990-08-17 1993-09-28 Baxter International Inc. Oxirane-modified hemoglobin based composition
AU9067791A (en) * 1990-11-20 1992-06-11 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
DK0559655T3 (da) * 1990-11-29 1995-07-24 Upjohn Co Med imidoester tværbundne hæmoglobinpræparater
DE69130483T2 (de) * 1991-02-12 1999-06-10 Univ Texas Tech Verbesserter blutersatz
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
US5646252A (en) * 1992-02-10 1997-07-08 Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid Hemoglobin composition and preparation thereof
US5399671A (en) * 1992-11-18 1995-03-21 Kluger; Ronald Specifically crosslinked hemoglobin with free functionality
ATE146189T1 (de) * 1993-03-16 1996-12-15 Hemosol Inc Selektive vernetzung von hemoglobin mittels oxidierten, ringgeöffneten sacchariden
EP0804244A1 (de) * 1993-03-26 1997-11-05 Biorelease Technologies, Inc. Häm-proteine enthaltende zusammensetzungen und dazu gehörende methoden
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
CA2135739C (en) * 1994-11-14 1997-10-21 Felice D'agnillo Hemoglobin-enzyme complexes
US5895810A (en) * 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US6288027B1 (en) 1995-03-23 2001-09-11 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
US5691452A (en) * 1995-03-23 1997-11-25 Biopure Corporation Method for preserving a hemoglobin blood substitute
US6271351B1 (en) 1995-03-23 2001-08-07 Biopure Corporation Method for preserving a hemoglobin blood substitute
US5865784A (en) 1995-06-07 1999-02-02 Alliance Pharmaceutical Corp. Method of hemodilution facilitated by monitoring oxygenation status
US5952470A (en) * 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin
US5691453A (en) * 1995-06-07 1997-11-25 Biopure Corporation Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC
EP0862583A1 (de) * 1995-09-11 1998-09-09 STAAT DER NEDERLANDEN, DE MINISTER VAN DEFENSIE, voor deze: HET HOOFD VAN DE AFDELING MILITAIR GENEESKUNDIG BELEID Sprühtrocknung von hämoglobin
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
WO1997033914A1 (en) * 1996-03-15 1997-09-18 Staat Der Nederlanden, De Minister Van Defensie Methods for producing hemoglobin preparations and preparations obtainable thereby
US5917020A (en) * 1997-01-15 1999-06-29 Kluger; Ronald H. Bis-tetrameric hemoglobin and reagents for its production
US6358678B1 (en) 1998-02-11 2002-03-19 The United States Of America As Represented By The Secretary Of The Navy Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes
US6436705B1 (en) 1997-02-18 2002-08-20 The United States Of America As Represented By The Secretary Of The Navy Shape stabilized erythrocytes
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
JP4583510B2 (ja) * 1997-02-28 2010-11-17 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 無細胞系による酸素輸送の最適化のための方法と組成物
CA2233725A1 (en) 1998-03-31 1999-09-30 Hemosol Inc. Hemoglobin-hydroxyethyl starch complexes
DE10031741A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung als Externum zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel
DE10031742A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine
DE10031740A1 (de) * 2000-06-29 2002-02-14 Sanguibio Tech Ag Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung
DE10031744A1 (de) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
CA2319966A1 (en) * 2000-09-19 2002-03-19 Dextro-Sang Corporation Improved dextran-hemoglobin conjugate as potential blood substitute
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US6518010B2 (en) * 2001-02-28 2003-02-11 Biopure Corporation Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier
US6808503B2 (en) * 2001-03-06 2004-10-26 Baxter International Inc. Automated system and method for pre-surgical blood donation and fluid replacement
US6884228B2 (en) * 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
KR20030097834A (ko) * 2001-04-18 2003-12-31 노쓰필드 라보라토리스, 인코포레이티드 안정화된 헤모글로빈 용액을 저장하기 위한 가요성 용기시스템
JP4416356B2 (ja) * 2001-07-10 2010-02-17 克博 山本 食肉・食肉加工品退色防止方法
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
EP1469811A4 (de) * 2002-01-11 2006-01-04 Sangart Inc Verfahren und zusammensetzungen für den sauerstofftransport mit modifiziertem hämoglobin in plasma
US20050119161A1 (en) * 2002-01-11 2005-06-02 Winslow Robert M. Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution
SI1465643T1 (sl) 2002-01-11 2008-06-30 Sangart Inc Postopki in sestavki za transport kisika z visokoafiniteto za kisik
US20050164915A1 (en) * 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
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IL149611A (en) * 2002-05-13 2011-07-31 Safetin Ltd Method for extended storage of viable and pathogen-safe blood and blood components using carbon monoxide
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
ES2347805T3 (es) * 2004-08-31 2010-11-04 Sangart, Inc. Metodos para aumentar la estabilidad hemodinamica usando composiciones que transportan oxigeno.
WO2008021577A2 (en) 2006-01-24 2008-02-21 The Board Of Trustees Of The University Of Illinois Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
US7759306B2 (en) * 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
BRPI1010775A2 (pt) * 2009-06-09 2016-03-22 Prolong Pharmaceuticals Llc composição, método para preparar uma composição, e, uso de uma composição.
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US20110319858A1 (en) * 2010-06-23 2011-12-29 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical compositions and the use thereof
ES2432075T3 (es) * 2011-07-23 2013-11-29 Sastomed Gmbh Espray para heridas
MX358784B (es) 2012-04-03 2018-09-04 Sangart Inc Compuestos de nitroxilo activados con succinimida y metodos para el uso de los mismos para nitroxilacion de proteinas.
WO2014145755A1 (en) 2013-03-15 2014-09-18 Sangart, Inc. Polyalkylene oxide valerate hemoglobin conjugates
CA2910380C (en) 2013-05-03 2020-09-29 Washington University Blood substitute composition and method of use
CN103387613B (zh) * 2013-08-02 2016-12-28 西北大学 一种血红蛋白及血红蛋白氧载体病毒灭活的方法
CN114514034A (zh) * 2019-10-11 2022-05-17 医疗技术协会第二股份有限公司 稳定的血红蛋白组合物及其药物制剂

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US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
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AU622610B2 (en) * 1986-11-10 1992-04-16 Biopure Corporation Extra pure semi-synthetic blood substitute
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Also Published As

Publication number Publication date
NZ224479A (en) 1991-04-26
CN1032471C (zh) 1996-08-07
GB8710598D0 (en) 1987-06-10
AU1563588A (en) 1988-11-10
IL86258A0 (en) 1988-11-15
AU610883B2 (en) 1991-05-30
ES2053729T3 (es) 1994-08-01
US5364932A (en) 1994-11-15
DE3877811T2 (de) 1993-05-27
JPH0532372B2 (de) 1993-05-14
JPS63297330A (ja) 1988-12-05
CN1030425A (zh) 1989-01-18
DK242888D0 (da) 1988-05-04
ATE84970T1 (de) 1993-02-15
EP0290252B1 (de) 1993-01-27
DK242888A (da) 1988-11-06
EP0290252A2 (de) 1988-11-09
EP0290252A3 (en) 1989-01-18
KR910009343B1 (ko) 1991-11-12
US4857636A (en) 1989-08-15
DK174286B1 (da) 2002-11-11
KR880013571A (ko) 1988-12-21
CA1306583C (en) 1992-08-18
ZA883171B (en) 1989-03-29
IL86258A (en) 1994-11-28

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