DE3878239T2 - Kristalle aus menschlichem serumalbumin und verfahren zu deren herstellung. - Google Patents

Kristalle aus menschlichem serumalbumin und verfahren zu deren herstellung.

Info

Publication number
DE3878239T2
DE3878239T2 DE8888402228T DE3878239T DE3878239T2 DE 3878239 T2 DE3878239 T2 DE 3878239T2 DE 8888402228 T DE8888402228 T DE 8888402228T DE 3878239 T DE3878239 T DE 3878239T DE 3878239 T2 DE3878239 T2 DE 3878239T2
Authority
DE
Germany
Prior art keywords
crystals
production
human serum
serum albumine
albumine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888402228T
Other languages
English (en)
Other versions
DE3878239D1 (de
Inventor
Carter, Ph D
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Aeronautics and Space Administration NASA
Original Assignee
National Aeronautics and Space Administration NASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Aeronautics and Space Administration NASA filed Critical National Aeronautics and Space Administration NASA
Publication of DE3878239D1 publication Critical patent/DE3878239D1/de
Application granted granted Critical
Publication of DE3878239T2 publication Critical patent/DE3878239T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/30—Self-sustaining carbon mass or layer with impregnant or other layer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31536—Including interfacial reaction product of adjacent layers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31725—Of polyamide
    • Y10T428/31768—Natural source-type polyamide [e.g., casein, gelatin, etc.]
DE8888402228T 1987-08-20 1988-09-05 Kristalle aus menschlichem serumalbumin und verfahren zu deren herstellung. Expired - Fee Related DE3878239T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/087,281 US4833233A (en) 1987-08-20 1987-08-20 Human serum albumin crystals and method of preparation
EP88402228A EP0357857B1 (de) 1987-08-20 1988-09-05 Kristalle aus menschlichem Serumalbumin und Verfahren zu deren Herstellung

Publications (2)

Publication Number Publication Date
DE3878239D1 DE3878239D1 (de) 1993-03-18
DE3878239T2 true DE3878239T2 (de) 1993-09-09

Family

ID=22204235

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888402228T Expired - Fee Related DE3878239T2 (de) 1987-08-20 1988-09-05 Kristalle aus menschlichem serumalbumin und verfahren zu deren herstellung.

Country Status (7)

Country Link
US (1) US4833233A (de)
EP (1) EP0357857B1 (de)
JP (1) JPH064677B2 (de)
AU (1) AU604958B2 (de)
CA (1) CA1336530C (de)
DE (1) DE3878239T2 (de)
FR (1) FR2619567B1 (de)

Families Citing this family (40)

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DE3927345A1 (de) * 1989-08-18 1991-02-21 Biotechnolog Forschung Gmbh Verfahren zur strukturbestimmung von peptiden
US5866114A (en) * 1992-06-09 1999-02-02 Chiron Corporation Crystallization of M-CSFα
US5728553A (en) * 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
US5554522A (en) * 1994-04-28 1996-09-10 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Dihydrodipicolinate reductase crystals and three dimensional structure
US5585466A (en) * 1994-12-06 1996-12-17 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Crystals of serum albumin for use in genetic engineering and rational drug design
US5641681A (en) * 1995-04-17 1997-06-24 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Device and method for screening crystallization conditions in solution crystal growth
US5978740A (en) * 1995-08-09 1999-11-02 Vertex Pharmaceuticals Incorporated Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them
US6128582A (en) 1996-04-30 2000-10-03 Vertex Pharmaceuticals Incorporated Molecules comprising an IMPDH-like binding pocket and encoded data storage medium capable of graphically displaying them
US6153579A (en) 1996-09-12 2000-11-28 Vertex Pharmaceuticals, Incorporated Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
US6020162A (en) * 1997-06-13 2000-02-01 The Rockefeller University Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof
US5872011A (en) * 1997-06-13 1999-02-16 The Rockefeller University Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof
US6183121B1 (en) 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
US7383135B1 (en) * 1998-05-04 2008-06-03 Vertex Pharmaceuticals Incorporated Methods of designing inhibitors for JNK kinases
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US20020042046A1 (en) * 1999-02-25 2002-04-11 Vertex Pharmaceuticals, Incorporated Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7244396B2 (en) * 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
EP1701159A3 (de) * 1999-04-06 2007-07-25 University of Alabama Verfahren zum Screening von Kristallisationsbedingungen für das Kristallwachstum von Proteinen in Lösung
MXPA01009999A (es) * 1999-04-06 2003-07-14 Uab Research Foundation Metodo para examinar las condiciones de cristalizacion en el crecimiento de cristales en solucion.
US20030022383A1 (en) * 1999-04-06 2003-01-30 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
EP1358209B1 (de) * 2001-02-09 2006-12-27 Genentech, Inc. Kristallisierung von igf-1
US7691872B2 (en) * 2001-03-20 2010-04-06 University Of Kentucky Research Foundation Methods and compositions for optimizing blood and tissue stability of camptothecin and other albumin-binding therapeutic compounds
US7670429B2 (en) * 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
NZ529767A (en) * 2001-06-13 2005-10-28 Taurus Hsa Llc Purification of human serum albumin
KR20030022917A (ko) * 2001-09-11 2003-03-19 크리스탈지노믹스(주) 소테이즈의 결정화 방법
US20040137518A1 (en) * 2002-01-31 2004-07-15 Lambert Millard Hurst CRYSTALLIZED PPARa LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME
US20070026528A1 (en) * 2002-05-30 2007-02-01 Delucas Lawrence J Method for screening crystallization conditions in solution crystal growth
WO2004005898A1 (en) * 2002-07-10 2004-01-15 Uab Research Foundation Method for distinguishing between biomolecule and non-biomolecule crystals
JP3567988B2 (ja) * 2002-07-11 2004-09-22 独立行政法人理化学研究所 生体高分子の結晶化条件探査方法及び探査装置
CA2506317A1 (en) * 2002-11-18 2004-06-03 Taurus Hsa Llc Method for continuous, automated blending of solutions from acids and bases
US7087719B2 (en) * 2002-11-19 2006-08-08 Gtc Biotherapeutics, Inc. Method for the crystallization of human serum albumin
WO2004102151A2 (en) * 2003-05-06 2004-11-25 New Century Pharmaceuticals Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on therir albumin binding properties
US20070043509A1 (en) * 2003-11-03 2007-02-22 Carter Daniel C Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
US7507552B1 (en) 2004-04-16 2009-03-24 Takeda San Diego, Inc. Crystallization of histone deacetylase 2
US8176808B2 (en) * 2007-09-13 2012-05-15 Foster-Miller, Inc. Robot arm assembly
WO2013036829A1 (en) 2011-09-09 2013-03-14 Genentech, Inc Treatment of th17 mediated inflammatory diseases

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286954A (de) * 1962-01-03
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
US3790552A (en) * 1972-03-16 1974-02-05 Us Health Method of removing hepatitis-associated antigen from a protein fraction using polyethylene glycol
DK25877A (da) * 1977-01-21 1978-08-15 Nordisk Insulinlab Fremgangsmaade til udvinding af renset albumin fra blodplasma
US4197238A (en) * 1977-04-12 1980-04-08 The Green Cross Corporation Method of preparation of human albumin using polyethylene glycol
US4164496A (en) * 1978-08-23 1979-08-14 American National Red Cross Preparation of albumin using PEG and EDTA
US4489133A (en) * 1982-11-16 1984-12-18 The Board Of Trustees Of The Leland Stanford Jr. University Two-dimensional crystallization technique
US4668584A (en) * 1985-12-23 1987-05-26 General Electric Company Method for forming 2-D crystals of proteins and macromolecules

Also Published As

Publication number Publication date
AU604958B2 (en) 1991-01-03
CA1336530C (en) 1995-08-01
DE3878239D1 (de) 1993-03-18
AU2109888A (en) 1989-02-23
JPH064677B2 (ja) 1994-01-19
EP0357857A1 (de) 1990-03-14
FR2619567A1 (fr) 1989-02-24
JPH01238599A (ja) 1989-09-22
FR2619567B1 (fr) 1995-02-17
US4833233A (en) 1989-05-23
EP0357857B1 (de) 1993-02-03

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee