DE502004009527D1 - Arzneimittel enthaltend substituierte 2-heteroaryl-aminoessigsäure-verbindungen - Google Patents

Arzneimittel enthaltend substituierte 2-heteroaryl-aminoessigsäure-verbindungen

Info

Publication number: DE502004009527D1
Authority: DE; Germany
Prior art keywords: optionally substituted; heteroaryl; specifically; aryl; mono
Prior art date: 2003-02-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE502004009527T

Other languages

English (en)

Inventor

Michael Przewosny

Werner Englberger

Bernd Sundermann

Klaus Schiene

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Gruenenthal GmbH

Original Assignee

Gruenenthal GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-13

Filing date

2004-02-05

Publication date

2009-07-09

2004-02-05 Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH

2009-07-09 Publication of DE502004009527D1 publication Critical patent/DE502004009527D1/de

2024-02-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000002253 acid Substances 0.000 title abstract 3
-1 AMINO Chemical class 0.000 title 1
230000002378 acidificating effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
125000001072 heteroaryl group Chemical group 0.000 abstract 4
229920006395 saturated elastomer Polymers 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
125000001931 aliphatic group Chemical group 0.000 abstract 2
230000000202 analgesic effect Effects 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
150000004677 hydrates Chemical class 0.000 abstract 2
150000003840 hydrochlorides Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
159000000000 sodium salts Chemical class 0.000 abstract 2
239000012453 solvate Substances 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 1
241000699670 Mus sp. Species 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
230000000954 anitussive effect Effects 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000002075 anti-alcohol Effects 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000001773 anti-convulsant effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
230000036436 anti-hiv Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000000648 anti-parkinson Effects 0.000 abstract 1
230000001139 anti-pruritic effect Effects 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
229960003965 antiepileptics Drugs 0.000 abstract 1
239000000939 antiparkinson agent Substances 0.000 abstract 1
239000003908 antipruritic agent Substances 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
230000001966 cerebroprotective effect Effects 0.000 abstract 1
PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
239000003176 neuroleptic agent Substances 0.000 abstract 1
230000000701 neuroleptic effect Effects 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
230000001777 nootropic effect Effects 0.000 abstract 1
125000003367 polycyclic group Chemical group 0.000 abstract 1
238000000159 protein binding assay Methods 0.000 abstract 1
230000020341 sensory perception of pain Effects 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
229940125725 tranquilizer Drugs 0.000 abstract 1
239000003204 tranquilizing agent Substances 0.000 abstract 1
230000002936 tranquilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

DE502004009527T 2003-02-13 2004-02-05 Arzneimittel enthaltend substituierte 2-heteroaryl-aminoessigsäure-verbindungen Expired - Lifetime DE502004009527D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10306203A DE10306203A1 (de)	2003-02-13	2003-02-13	Arzneimittel enthaltend substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
PCT/EP2004/001061 WO2004071380A2 (de)	2003-02-13	2004-02-05	Arzneimittel enthaltend substituierte 2-heteroaryl-aminoessigsäure-verbindungen

Publications (1)

Publication Number	Publication Date
DE502004009527D1 true DE502004009527D1 (de)	2009-07-09

Family

ID=32747842

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE10306203A Withdrawn DE10306203A1 (de)	2003-02-13	2003-02-13	Arzneimittel enthaltend substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
DE502004009527T Expired - Lifetime DE502004009527D1 (de)	2003-02-13	2004-02-05	Arzneimittel enthaltend substituierte 2-heteroaryl-aminoessigsäure-verbindungen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE10306203A Withdrawn DE10306203A1 (de)	2003-02-13	2003-02-13	Arzneimittel enthaltend substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen

Country Status (6)

Country	Link
US (1)	US7754754B2 (de)
EP (1)	EP1596852B1 (de)
AT (1)	ATE432073T1 (de)
DE (2)	DE10306203A1 (de)
ES (1)	ES2327843T3 (de)
WO (1)	WO2004071380A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2010139481A1 (en) *	2009-06-04	2010-12-09	Merz Pharma Gmbh & Co. Kgaa	Glycine b antagonists

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9027210D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
GB9426078D0 (en) *	1994-12-23	1995-02-22	Cadbury Schweppes Plc	Process for manufacture of reduced fat chocolate
DE19549825B4 (de) *	1995-09-02	2010-11-04	Südzucker AG Mannheim/Ochsenfurt	Zuckerfreie Hartkaramellen
JP2000514797A (ja) *	1996-06-28	2000-11-07	ユニバーシティオブサザンカリフォルニア	有機ホウ素誘導体を用いるアミンおよびアミノ酸の合成方法
US6602817B1 (en)	1998-10-23	2003-08-05	University Of Southern California	Combination approach to chiral reagents or catalysts having amine or amino alcohol ligands
US6096782A (en) *	1996-11-22	2000-08-01	Athena Neurosciences, Inc.	N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
TR199902826T2 (xx) *	1997-04-18	2000-02-21	Mcneil-Ppc,Inc.	D��k kalorili, lezzetli fiber-i�eren, �eker muadili
US5952205A (en) *	1998-02-06	1999-09-14	Neose Technologies, Inc.	Process for processing sucrose into glucose and fructose
AU2001234560A1 (en) *	2000-01-25	2001-08-07	The Procter And Gamble Company	Solid-supported process for making n-substituted peptide mimetic compounds
US6783790B1 (en) *	2000-05-19	2004-08-31	Hershey Foods Corporation	Process utilizing agar-agar in a high temperature, short time processing of high solids confectionery products
DE10059864A1 (de) *	2000-11-30	2002-06-13	Gruenenthal Gmbh	Substituierte Amino-furan-2-yl-essigsäure- und Amino-thien-2-yl-essigsäure-Derivate

2003
- 2003-02-13 DE DE10306203A patent/DE10306203A1/de not_active Withdrawn
2004
- 2004-02-05 WO PCT/EP2004/001061 patent/WO2004071380A2/de active Application Filing
- 2004-02-05 ES ES04708322T patent/ES2327843T3/es not_active Expired - Lifetime
- 2004-02-05 EP EP04708322A patent/EP1596852B1/de not_active Expired - Lifetime
- 2004-02-05 DE DE502004009527T patent/DE502004009527D1/de not_active Expired - Lifetime
- 2004-02-05 AT AT04708322T patent/ATE432073T1/de active
2005
- 2005-08-12 US US11/202,074 patent/US7754754B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE10306203A1 (de)	2004-08-26
ATE432073T1 (de)	2009-06-15
EP1596852B1 (de)	2009-05-27
WO2004071380A2 (de)	2004-08-26
US7754754B2 (en)	2010-07-13
EP1596852A2 (de)	2005-11-23
WO2004071380A3 (de)	2005-01-06
US20060025473A1 (en)	2006-02-02
ES2327843T3 (es)	2009-11-04

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2013-01-14

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