DE59410181D1 - Neue thiazolidindione und diese enthaltende arzneimittel - Google Patents

Neue thiazolidindione und diese enthaltende arzneimittel

Info

Publication number: DE59410181D1
Authority: DE; Germany
Prior art keywords: denotes; pct; alkyl; heteroatoms; sec
Prior art date: 1993-05-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE59410181T

Other languages

English (en)

Inventor

Alfred Mertens

Hans-Peter Wolff

Peter Freund

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Roche Diagnostics GmbH

Original Assignee

Roche Diagnostics GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-25

Filing date

1994-05-19

Publication date

2002-10-10

1994-05-19 Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH

1994-05-19 Priority to DE59410181T priority Critical patent/DE59410181D1/de

2002-10-10 Application granted granted Critical

2002-10-10 Publication of DE59410181D1 publication Critical patent/DE59410181D1/de

2014-05-20 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229940126601 medicinal product Drugs 0.000 title 1
229910052760 oxygen Inorganic materials 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
229910052721 tungsten Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

DE59410181T 1993-05-25 1994-05-19 Neue thiazolidindione und diese enthaltende arzneimittel Expired - Fee Related DE59410181D1 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE59410181T DE59410181D1 (de)	1993-05-25	1994-05-19	Neue thiazolidindione und diese enthaltende arzneimittel

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4317320A DE4317320A1 (de)	1993-05-25	1993-05-25	Neue Thiazolidindione und diese enthaltende Arzneimittel
DE59410181T DE59410181D1 (de)	1993-05-25	1994-05-19	Neue thiazolidindione und diese enthaltende arzneimittel
PCT/EP1994/001619 WO1994027995A1 (de)	1993-05-25	1994-05-19	Neue thiazolidindione und diese enthaltende arzneimittel

Publications (1)

Publication Number	Publication Date
DE59410181D1 true DE59410181D1 (de)	2002-10-10

Family

ID=6488833

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE4317320A Withdrawn DE4317320A1 (de)	1993-05-25	1993-05-25	Neue Thiazolidindione und diese enthaltende Arzneimittel
DE59410181T Expired - Fee Related DE59410181D1 (de)	1993-05-25	1994-05-19	Neue thiazolidindione und diese enthaltende arzneimittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE4317320A Withdrawn DE4317320A1 (de)	1993-05-25	1993-05-25	Neue Thiazolidindione und diese enthaltende Arzneimittel

Country Status (25)

Country	Link
US (1)	US5599826A (de)
EP (1)	EP0700397B1 (de)
JP (1)	JP3162721B2 (de)
KR (1)	KR100243783B1 (de)
CN (1)	CN1040324C (de)
AT (1)	ATE223409T1 (de)
AU (1)	AU682699B2 (de)
CA (1)	CA2163028C (de)
CL (1)	CL2004001167A1 (de)
CY (1)	CY2415B1 (de)
CZ (1)	CZ285927B6 (de)
DE (2)	DE4317320A1 (de)
DK (1)	DK0700397T3 (de)
ES (1)	ES2180581T3 (de)
FI (1)	FI955685A (de)
HU (1)	HU217065B (de)
NO (1)	NO307832B1 (de)
NZ (1)	NZ267410A (de)
PL (1)	PL180046B1 (de)
PT (1)	PT700397E (de)
RO (1)	RO114328B1 (de)
RU (1)	RU2122002C1 (de)
SK (1)	SK282618B6 (de)
UA (1)	UA41362C2 (de)
WO (1)	WO1994027995A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH07138258A (ja) *	1993-11-16	1995-05-30	Taiho Yakuhin Kogyo Kk	チアゾリジンジオン誘導体又はその塩
DE69627164T2 (de) *	1995-07-31	2004-01-29	Shionogi & Co	Pyrrolydin-derivate mit einer phospholipase a2 inhibierenden wirkung
JPH09176162A (ja) *	1995-12-22	1997-07-08	Toubishi Yakuhin Kogyo Kk	チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物
DE19619819A1 (de) *	1996-05-16	1997-11-20	Boehringer Mannheim Gmbh	Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltenden Arzneimittel
DE19711616A1 (de) *	1997-03-20	1998-09-24	Boehringer Mannheim Gmbh	Verbessertes Verfahren zur Herstellung von Thiazolidindionen
DE19711617A1 (de) *	1997-03-20	1998-09-24	Boehringer Mannheim Gmbh	Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US6028088A (en) *	1998-10-30	2000-02-22	The University Of Mississippi	Flavonoid derivatives
GB9824893D0 (en) *	1998-11-12	1999-01-06	Smithkline Beckman Corp	Novel method of treatment
WO2000030628A2 (en) *	1998-11-20	2000-06-02	Genentech, Inc.	Method of inhibiting angiogenesis
PT1078923E (pt)	1999-08-02	2006-07-31	Hoffmann La Roche	Processo para a preparacao de derivados de benzotiofeno
US6531609B2 (en)	2000-04-14	2003-03-11	Hoffmann-La Roche Inc.	Process for the preparation of thiazolidinedione derivatives
ATE398611T1 (de) *	2000-05-08	2008-07-15	Hoffmann La Roche	Para-amin substituierte phenylamid glukokinase activatoren
SI1296656T1 (sl)	2000-06-27	2006-12-31	Hoffmann La Roche	Postopek priprave sestavka
ATE370130T1 (de) *	2000-12-25	2007-09-15	Ono Pharmaceutical Co	Dihydronaphthalinderivat verbindungen und arzneimittel, die diese verbindungen als wirkstoff enthalten
CA2441941A1 (en) *	2001-04-06	2002-10-17	F. Hoffmann-La Roche Ag	Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth
PL208074B1 (pl) *	2001-05-15	2011-03-31	Hoffmann La Roche	Pochodne oksazolu, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych oksazolu
JP2003040877A (ja) *	2001-07-24	2003-02-13	Sumika Fine Chemicals Co Ltd	５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法
US7102000B2 (en) *	2002-03-08	2006-09-05	Incyte San Diego Inc.	Heterocyclic amide derivatives for the treatment of diabetes and other diseases
ES2291688T3 (es) *	2002-07-03	2008-03-01	F. Hoffmann-La Roche Ag	Derivados de oxazol y su empleo como sensibilizadores a la insulina.
SI1537091T1 (sl) *	2002-08-30	2010-12-31	Hoffmann La Roche	Nove 2-ariltiazolne spojine kot agonisti pparalpha in ppargamma
NZ537979A (en) *	2002-09-12	2007-08-31	Hoffmann La Roche	N-substituted-1H-indol-5-propionic acid compounds as PPAR agonists useful for the treatment of diabetes
WO2004048371A1 (en) *	2002-11-25	2004-06-10	F.Hoffmann-La Roche Ag	Indolyl derivatives
MXPA05013732A (es)	2003-06-26	2006-03-08	Hoffmann La Roche	Proceso para preparacion de sensibilizador de insulina y compuesto intermediario del mismo.
CN101693202B (zh) *	2009-10-21	2011-04-20	沧州那瑞化学科技有限公司	盐酸吡咯列酮关键中间体加氢反应催化剂及加氢反应方法
WO2013082106A1 (en)	2011-12-02	2013-06-06	The General Hospital Corporation	Differentiation into brown adipocytes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1003445B (zh) *	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
WO1986007056A1 (en) *	1985-05-21	1986-12-04	Pfizer Inc.	Hypoglycemic thiazolidinediones
GB8713861D0 (en) *	1987-06-13	1987-07-15	Beecham Group Plc	Compounds
EP0374149B1 (de) *	1988-03-04	1994-04-20	Kurt H. Volk, Incorporated	Gegenstand für den unmittelbaren versand per post mit einer postversandfähigen antwortkarte
HU217432B (hu) *	1988-03-08	2000-01-28	Pfizer Inc.	Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények
AU650465B2 (en) *	1990-07-03	1994-06-23	Yamanouchi Pharmaceutical Co., Ltd.	Bisheterocyclic compound
FR2688220A1 (fr) *	1992-03-06	1993-09-10	Adir	Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

1993
- 1993-05-25 DE DE4317320A patent/DE4317320A1/de not_active Withdrawn
1994
- 1994-05-19 EP EP94918342A patent/EP0700397B1/de not_active Expired - Lifetime
- 1994-05-19 US US08/578,561 patent/US5599826A/en not_active Expired - Fee Related
- 1994-05-19 KR KR1019950705207A patent/KR100243783B1/ko not_active IP Right Cessation
- 1994-05-19 DK DK94918342T patent/DK0700397T3/da active
- 1994-05-19 PT PT94918342T patent/PT700397E/pt unknown
- 1994-05-19 WO PCT/EP1994/001619 patent/WO1994027995A1/de active IP Right Grant
- 1994-05-19 SK SK1461-95A patent/SK282618B6/sk not_active IP Right Cessation
- 1994-05-19 PL PL94311752A patent/PL180046B1/pl not_active IP Right Cessation
- 1994-05-19 NZ NZ267410A patent/NZ267410A/en not_active IP Right Cessation
- 1994-05-19 AU AU69704/94A patent/AU682699B2/en not_active Ceased
- 1994-05-19 CA CA002163028A patent/CA2163028C/en not_active Expired - Fee Related
- 1994-05-19 JP JP50018495A patent/JP3162721B2/ja not_active Expired - Fee Related
- 1994-05-19 UA UA95114968A patent/UA41362C2/uk unknown
- 1994-05-19 RU RU95122667A patent/RU2122002C1/ru not_active IP Right Cessation
- 1994-05-19 AT AT94918342T patent/ATE223409T1/de not_active IP Right Cessation
- 1994-05-19 DE DE59410181T patent/DE59410181D1/de not_active Expired - Fee Related
- 1994-05-19 CZ CZ952999A patent/CZ285927B6/cs not_active IP Right Cessation
- 1994-05-19 CN CN94192240A patent/CN1040324C/zh not_active Expired - Fee Related
- 1994-05-19 RO RO95-01981A patent/RO114328B1/ro unknown
- 1994-05-19 ES ES94918342T patent/ES2180581T3/es not_active Expired - Lifetime
- 1994-05-19 HU HU9503376A patent/HU217065B/hu not_active IP Right Cessation
1995
- 1995-11-24 NO NO954762A patent/NO307832B1/no unknown
- 1995-11-24 FI FI955685A patent/FI955685A/fi not_active Application Discontinuation
2003
- 2003-09-11 CY CY0300064A patent/CY2415B1/xx unknown
2004
- 2004-05-20 CL CL200401167A patent/CL2004001167A1/es unknown

Also Published As

Publication number	Publication date
CL2004001167A1 (es)	2005-05-20
WO1994027995A1 (de)	1994-12-08
NO954762L (no)	1995-11-24
AU682699B2 (en)	1997-10-16
CY2415B1 (en)	2004-11-12
PL311752A1 (en)	1996-03-18
CA2163028A1 (en)	1994-12-08
EP0700397A1 (de)	1996-03-13
JPH08510456A (ja)	1996-11-05
KR960702460A (ko)	1996-04-27
DE4317320A1 (de)	1994-12-01
CZ285927B6 (cs)	1999-11-17
DK0700397T3 (da)	2003-01-06
SK146195A3 (en)	1996-06-05
CA2163028C (en)	2003-11-25
CZ299995A3 (en)	1996-03-13
FI955685A0 (fi)	1995-11-24
RU2122002C1 (ru)	1998-11-20
NO307832B1 (no)	2000-06-05
SK282618B6 (sk)	2002-10-08
ES2180581T3 (es)	2003-02-16
HU217065B (hu)	1999-11-29
NZ267410A (en)	1996-12-20
US5599826A (en)	1997-02-04
FI955685A (fi)	1995-11-24
KR100243783B1 (ko)	2000-03-02
UA41362C2 (uk)	2001-09-17
CN1124488A (zh)	1996-06-12
AU6970494A (en)	1994-12-20
HUT75099A (en)	1997-04-28
CN1040324C (zh)	1998-10-21
JP3162721B2 (ja)	2001-05-08
NO954762D0 (no)	1995-11-24
RO114328B1 (ro)	1999-03-30
HU9503376D0 (en)	1996-01-29
PL180046B1 (en)	2000-12-29
ATE223409T1 (de)	2002-09-15
EP0700397B1 (de)	2002-09-04
PT700397E (pt)	2002-12-31

Legal Events

Date	Code	Title	Description
2003-10-02	8364	No opposition during term of opposition
2010-03-25	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE59410181D1 (de)	2002-10-10	Neue thiazolidindione und diese enthaltende arzneimittel
NZ602099A (en)	2014-06-27	Stat3 inhibitor containing quinolinecarboxamide derivative as active ingredient
NO952129L (no)	1995-12-01	Oksalylamino-benzofuran- og benzotienyl-derivater
WO2007125321A3 (en)	2007-12-27	Purine and deazapurine derivatives as pharmaceutical compounds
PE20040801A1 (es)	2004-11-25	Derivados de pirazina y piridina 5-sustituidos como activadores de glucoquinasa
KR940019699A (ko)	1994-09-14	옥사졸리딘디온 유도체, 그의 제조방법 및 용도
DK0773930T3 (da)	2001-03-19	Aromatiske aminoethere som midler til lindring af smerte
HUP0100388A2 (hu)	2003-08-28	Készítmények és eljárások csontritkulás kezelésére és a koleszterinszint csökkentésére
EA200300333A1 (ru)	2003-10-30	Новые тиадиазолы и оксадиазолы и их применение в качестве ингибиторов фосфодиэстеразы-7
SE9701304D0 (sv)	1997-04-09	Compounds
RU2004131680A (ru)	2005-06-27	Производные бензофурана
HUP0105407A2 (hu)	2003-10-28	Triazolo[1,5-a]kinolinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények, valamint intermedierek
RU2005100761A (ru)	2005-09-10	Амидзамещенные производные ксантина, обладающие модуляторной активностью в отношении биосинтеза глюкозы из неуглеводных субстратов
LV11832A (lv)	1997-08-20	O-acil-4-fenilcikloheksanoli to salis zalu lidzekli kas satur minetas vielas un to pielietojums
NO158459C (no)	1988-09-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutanderivater.
ATE246177T1 (de)	2003-08-15	Katecholhydrazon-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die diese enthalten
SE9702534D0 (sv)	1997-07-01	Compounds
HUP0204168A2 (hu)	2003-04-28	Butin-diol-származékok, ilyeneket tartalmazó gyógyszerkészítmény és előállítása
MX9305918A (es)	1994-05-31	Derivados de n-(2-amino-2-oxoetil)butanodiamida inhibidores de la renina procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
SE9701396D0 (sv)	1997-04-15	Compounds
KR880012587A (ko)	1988-11-28	치환된 퀴녹살릴-이미다졸리딘-2,4-디온, 이의 제조 방법, 및 약제 및 약제학적 제제로서의 이의 용도
KR900014339A (ko)	1990-10-23	헤테로시클릭 화합물, 그의 제조방법, 이를 함유하는 제약 조성물 및 의약으로서의 용도
ATE167873T1 (de)	1998-07-15	Neue heterocyclische acyldipeptide, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DE68903893T2 (de)	1993-07-08	20,21-dinoreburnamenin-derivate, substituiert in position 15 durch eine aminogruppe und deren salze, verfahren zu deren herstellung und die auf diese weise erhaltenen zwischenverbindungen, deren anwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen.
KR970032864A (ko)	1997-07-22	골다공증 치료제