DE59809163D1 - Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen - Google Patents
Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexenInfo
- Publication number
- DE59809163D1 DE59809163D1 DE59809163T DE59809163T DE59809163D1 DE 59809163 D1 DE59809163 D1 DE 59809163D1 DE 59809163 T DE59809163 T DE 59809163T DE 59809163 T DE59809163 T DE 59809163T DE 59809163 D1 DE59809163 D1 DE 59809163D1
- Authority
- DE
- Germany
- Prior art keywords
- mono
- hydroxyalkyl
- production
- complexes
- cyclen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- ZPDFIIGFYAHNSK-CTHHTMFSSA-K 2-[4,10-bis(carboxylatomethyl)-7-[(2r,3s)-1,3,4-trihydroxybutan-2-yl]-1,4,7,10-tetrazacyclododec-1-yl]acetate;gadolinium(3+) Chemical compound [Gd+3].OC[C@@H](O)[C@@H](CO)N1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 ZPDFIIGFYAHNSK-CTHHTMFSSA-K 0.000 abstract 1
- 229960003411 gadobutrol Drugs 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Inorganic materials [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 abstract 1
- RRBYUSWBLVXTQN-UHFFFAOYSA-N tricyclene Chemical compound C12CC3CC2C1(C)C3(C)C RRBYUSWBLVXTQN-UHFFFAOYSA-N 0.000 abstract 1
- RRBYUSWBLVXTQN-VZCHMASFSA-N tricyclene Natural products C([C@@H]12)C3C[C@H]1C2(C)C3(C)C RRBYUSWBLVXTQN-VZCHMASFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE59809163T DE59809163D1 (de) | 1997-06-02 | 1998-05-28 | Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19724186A DE19724186C2 (de) | 1997-06-02 | 1997-06-02 | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
PCT/DE1998/001523 WO1998055467A1 (de) | 1997-06-02 | 1998-05-28 | Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen |
DE59809163T DE59809163D1 (de) | 1997-06-02 | 1998-05-28 | Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen |
Publications (1)
Publication Number | Publication Date |
---|---|
DE59809163D1 true DE59809163D1 (de) | 2003-09-04 |
Family
ID=7831875
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19724186A Expired - Lifetime DE19724186C2 (de) | 1997-06-02 | 1997-06-02 | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
DE59809163T Expired - Lifetime DE59809163D1 (de) | 1997-06-02 | 1998-05-28 | Herstellung von mono- und 1,7-bis-n-hydroxyalkyl-cyclen und lithium-salz-komplexen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19724186A Expired - Lifetime DE19724186C2 (de) | 1997-06-02 | 1997-06-02 | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
Country Status (15)
Country | Link |
---|---|
US (1) | US5994536A (de) |
EP (1) | EP0986548B1 (de) |
JP (1) | JP4503709B2 (de) |
AT (1) | ATE246178T1 (de) |
AU (1) | AU8432798A (de) |
CA (1) | CA2291782C (de) |
DE (2) | DE19724186C2 (de) |
DK (1) | DK0986548T3 (de) |
ES (1) | ES2205523T3 (de) |
NO (1) | NO313459B1 (de) |
PT (1) | PT986548E (de) |
SI (1) | SI0986548T1 (de) |
TW (1) | TW450965B (de) |
WO (1) | WO1998055467A1 (de) |
ZA (1) | ZA984734B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6271325B1 (en) | 1999-05-17 | 2001-08-07 | Univation Technologies, Llc | Method of polymerization |
US6380328B1 (en) | 1999-12-10 | 2002-04-30 | Univation Technologies, Llc | Catalyst systems and their use in a polymerization process |
US6624107B2 (en) | 1999-10-22 | 2003-09-23 | Univation Technologies, Llc | Transition metal catalyst compounds having deuterium substituted ligand and catalyst systems thereof |
US6265505B1 (en) | 1999-11-18 | 2001-07-24 | Univation Technologies, Llc | Catalyst system and its use in a polymerization process |
US6274684B1 (en) | 1999-10-22 | 2001-08-14 | Univation Technologies, Llc | Catalyst composition, method of polymerization, and polymer therefrom |
US6300439B1 (en) | 1999-11-08 | 2001-10-09 | Univation Technologies, Llc | Group 15 containing transition metal catalyst compounds, catalyst systems and their use in a polymerization process |
US6417304B1 (en) | 1999-11-18 | 2002-07-09 | Univation Technologies, Llc | Method of polymerization and polymer produced therefrom |
US6300438B1 (en) | 1999-10-22 | 2001-10-09 | Univation Technolgies, Llc | Hafnium transition metal catalyst compounds, catalyst systems and their use in a polymerization process |
US6271323B1 (en) | 1999-10-28 | 2001-08-07 | Univation Technologies, Llc | Mixed catalyst compounds, catalyst systems and their use in a polymerization process |
US6281306B1 (en) * | 1999-12-16 | 2001-08-28 | Univation Technologies, Llc | Method of polymerization |
RU2311413C2 (ru) | 2000-09-29 | 2007-11-27 | Анормед, Инк. | Циклические полиамины, содержащие в кольце n атомов азота, защищенных по принципу "все, кроме одного (n-1)", и способы их получения |
DE10064467C2 (de) * | 2000-12-15 | 2002-10-31 | Schering Ag | Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung |
EP1999118B1 (de) | 2006-03-14 | 2012-10-17 | Mallinckrodt LLC | Metallkomplexe aus tetraazamacro-zyklischen derivaten |
DE102009053171B4 (de) | 2009-11-04 | 2011-07-21 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol) |
DE102009053252B3 (de) * | 2009-11-09 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer Membran |
WO2011054480A1 (de) | 2009-11-09 | 2011-05-12 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels keramischer membran |
DE102009057274B4 (de) | 2009-12-02 | 2011-09-01 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung mittels Trioxobicyclo-octan |
DE102010013833A1 (de) | 2010-03-29 | 2011-09-29 | Bayer Schering Pharma Aktiengesellschaft | Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal |
DE102010023105A1 (de) * | 2010-06-04 | 2011-12-08 | Bayer Schering Pharma Aktiengesellschaft | Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol |
WO2012027727A2 (en) * | 2010-08-26 | 2012-03-01 | Kunyuan Cui | Lipomacrocycles and uses thereof |
AU2012244791B2 (en) * | 2011-04-21 | 2017-04-27 | Bayer Intellectual Property Gmbh | Preparation of high-purity gadobutrol |
CN109803958B (zh) | 2016-09-27 | 2023-10-31 | 拜耳制药股份公司 | 生产考布曲钙的变型a的晶型的方法 |
CN106543094A (zh) * | 2016-11-04 | 2017-03-29 | 嘉实(湖南)医药科技有限公司 | 高纯度钆布醇的制备方法 |
KR101971435B1 (ko) | 2017-08-29 | 2019-04-24 | 주식회사 엔지켐생명과학 | 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법 |
KR102033964B1 (ko) * | 2018-01-19 | 2019-10-18 | 주식회사 엔지켐생명과학 | 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 |
KR20210112910A (ko) * | 2020-03-06 | 2021-09-15 | 주식회사 엔지켐생명과학 | 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5064633A (en) * | 1984-06-04 | 1991-11-12 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes, their formulations and use |
DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
DE4140779A1 (de) * | 1991-12-06 | 1993-06-09 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen |
US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
-
1997
- 1997-06-02 DE DE19724186A patent/DE19724186C2/de not_active Expired - Lifetime
-
1998
- 1998-05-28 DE DE59809163T patent/DE59809163D1/de not_active Expired - Lifetime
- 1998-05-28 CA CA002291782A patent/CA2291782C/en not_active Expired - Lifetime
- 1998-05-28 AT AT98934857T patent/ATE246178T1/de active
- 1998-05-28 EP EP98934857A patent/EP0986548B1/de not_active Expired - Lifetime
- 1998-05-28 PT PT98934857T patent/PT986548E/pt unknown
- 1998-05-28 JP JP50129999A patent/JP4503709B2/ja not_active Expired - Lifetime
- 1998-05-28 ES ES98934857T patent/ES2205523T3/es not_active Expired - Lifetime
- 1998-05-28 AU AU84327/98A patent/AU8432798A/en not_active Abandoned
- 1998-05-28 SI SI9830534T patent/SI0986548T1/xx unknown
- 1998-05-28 WO PCT/DE1998/001523 patent/WO1998055467A1/de active IP Right Grant
- 1998-05-28 DK DK98934857T patent/DK0986548T3/da active
- 1998-06-01 TW TW087108521A patent/TW450965B/zh not_active IP Right Cessation
- 1998-06-02 ZA ZA984734A patent/ZA984734B/xx unknown
- 1998-06-02 US US09/088,700 patent/US5994536A/en not_active Expired - Lifetime
-
1999
- 1999-12-01 NO NO19995870A patent/NO313459B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5994536A (en) | 1999-11-30 |
NO995870D0 (no) | 1999-12-01 |
DK0986548T3 (da) | 2003-11-17 |
NO313459B1 (no) | 2002-10-07 |
DE19724186C2 (de) | 2002-07-18 |
NO995870L (no) | 2000-02-01 |
ES2205523T3 (es) | 2004-05-01 |
AU8432798A (en) | 1998-12-21 |
TW450965B (en) | 2001-08-21 |
ZA984734B (en) | 1998-12-29 |
PT986548E (pt) | 2003-12-31 |
SI0986548T1 (en) | 2003-12-31 |
WO1998055467A1 (de) | 1998-12-10 |
EP0986548B1 (de) | 2003-07-30 |
JP2002508755A (ja) | 2002-03-19 |
EP0986548A1 (de) | 2000-03-22 |
CA2291782C (en) | 2009-05-26 |
DE19724186A1 (de) | 1998-12-03 |
CA2291782A1 (en) | 1998-12-10 |
JP4503709B2 (ja) | 2010-07-14 |
ATE246178T1 (de) | 2003-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AG, 13353 BERLIN, DE |
|
8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER SCHERING PHARMA AKIENGESELLSCHAFT, 13353, DE |