DE60024312D1 - Vorrichtung und verfahren zur verbesserung des mikronadel-haut-piercing - Google Patents

Vorrichtung und verfahren zur verbesserung des mikronadel-haut-piercing

Info

Publication number
DE60024312D1
DE60024312D1 DE60024312T DE60024312T DE60024312D1 DE 60024312 D1 DE60024312 D1 DE 60024312D1 DE 60024312 T DE60024312 T DE 60024312T DE 60024312 T DE60024312 T DE 60024312T DE 60024312 D1 DE60024312 D1 DE 60024312D1
Authority
DE
Germany
Prior art keywords
skin
microprotrusions
stretching
micronadel
improving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60024312T
Other languages
English (en)
Other versions
DE60024312T2 (de
Inventor
C Trautman
J Cormier
P Eng
Wei-Qi Lin
L Kim
L Sendelbeck
P Neukermans
P Edwards
Wai-Loong Lim
I Poutiatine
Richard Gyory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE60024312D1 publication Critical patent/DE60024312D1/de
Application granted granted Critical
Publication of DE60024312T2 publication Critical patent/DE60024312T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/425Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
DE60024312T 1999-12-10 2000-12-07 Transdermale Wirkstoffabgabe von makromolekularen Wirkstoffen und Vorrichtung hierfür Expired - Lifetime DE60024312T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17270399P 1999-12-10 1999-12-10
US172703P 1999-12-10
US21687700P 2000-07-07 2000-07-07
US216877P 2000-07-07
PCT/US2000/033318 WO2001041863A1 (en) 1999-12-10 2000-12-07 Device and method for enhancing microprotrusion skin piercing

Publications (2)

Publication Number Publication Date
DE60024312D1 true DE60024312D1 (de) 2005-12-29
DE60024312T2 DE60024312T2 (de) 2006-08-17

Family

ID=26868367

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60024312T Expired - Lifetime DE60024312T2 (de) 1999-12-10 2000-12-07 Transdermale Wirkstoffabgabe von makromolekularen Wirkstoffen und Vorrichtung hierfür

Country Status (10)

Country Link
US (2) US7087035B2 (de)
EP (1) EP1239916B1 (de)
AT (1) ATE310561T1 (de)
AU (1) AU2074301A (de)
CY (1) CY1105306T1 (de)
DE (1) DE60024312T2 (de)
DK (1) DK1239916T3 (de)
ES (1) ES2253278T3 (de)
HK (1) HK1048604B (de)
WO (1) WO2001041863A1 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
MXPA03001694A (es) 2000-08-24 2004-11-01 Johnson & Johnson Metodo para toma de muestra transdermal de acido nucleico.
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
BR0113749A (pt) * 2000-09-08 2004-06-22 Alza Corp Métodos para inibir a diminuição no fluxo de droga transdérmica por inibição do fechamento das vias
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6663820B2 (en) * 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US20050176084A1 (en) * 2001-12-17 2005-08-11 Burkoth Terry L. Non-or minimally invasive monitoring methods
HUP0402605A2 (hu) 2001-12-20 2005-06-28 Alza Corporation Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén
US20030130621A1 (en) * 2002-01-04 2003-07-10 Bryan Vincent E. Spinal needle system
US20030130614A1 (en) * 2002-01-09 2003-07-10 Johnson Lanny L. Device for delivering liquid medications or nutrients and gases to local tissue
AU2003209645A1 (en) * 2002-03-04 2003-09-16 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
ES2437565T3 (es) * 2003-06-30 2014-01-13 Alza Corporation Formulaciones para microproyecciones revestidas que contienen contraiones no volátiles
WO2005049107A2 (en) * 2003-11-18 2005-06-02 Nanapass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
AU2004298717A1 (en) * 2003-12-18 2005-06-30 Novo Nordisk A/S Nozzle device with skin stretching means
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2005094526A2 (en) * 2004-03-24 2005-10-13 Corium International, Inc. Transdermal delivery device
US7591806B2 (en) 2004-05-18 2009-09-22 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
CN101060882B (zh) 2004-11-18 2010-06-16 3M创新有限公司 微针阵列施放器和保持器
AU2005306422A1 (en) 2004-11-18 2006-05-26 3M Innovative Properties Company Low-profile microneedle array applicator
US8280476B2 (en) * 2005-03-29 2012-10-02 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
JP5301985B2 (ja) 2005-04-07 2013-09-25 スリーエム イノベイティブ プロパティズ カンパニー ツールフィードバック感知のためのシステム及び方法
US20060253078A1 (en) * 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
US20070270738A1 (en) * 2005-04-25 2007-11-22 Wu Jeffrey M Method of treating ACNE with stratum corneum piercing patch
US20080009802A1 (en) * 2005-04-25 2008-01-10 Danilo Lambino Method of treating acne with stratum corneum piercing device
US8048017B2 (en) * 2005-05-18 2011-11-01 Bai Xu High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
US8043250B2 (en) * 2005-05-18 2011-10-25 Nanomed Devices, Inc. High-aspect-ratio microdevices and methods for transdermal delivery and sampling of active substances
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
EP1901799B1 (de) * 2005-06-27 2012-06-13 3M Innovative Properties Company Applikator für mikronadelanordnungen
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
EP1957145A4 (de) * 2005-11-30 2011-03-23 3M Innovative Properties Co Mikronadelanordnungen und anwendungsverfahren
CA2633767A1 (en) 2005-12-20 2007-06-28 Torben Stroem Hansen Skin retention device for a medical jet injection unit
US7658728B2 (en) * 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US20080058726A1 (en) * 2006-08-30 2008-03-06 Arvind Jina Methods and Apparatus Incorporating a Surface Penetration Device
US10525246B2 (en) 2006-12-22 2020-01-07 Nanomed Skincare, Inc. Microdevice and method for transdermal delivery and sampling of active substances
US20080214987A1 (en) * 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
AU2008209537B2 (en) * 2007-01-22 2013-01-31 Corium Pharma Solutions, Inc. Applicators for microneedle arrays
US20080234628A1 (en) * 2007-03-22 2008-09-25 Wanda Dent Multiple part electrotransport drug delivery device
CA2686093C (en) 2007-04-16 2018-05-08 Corium International, Inc. Solvent-cast microneedle arrays containing active
JP5249204B2 (ja) * 2007-04-27 2013-07-31 テルモ株式会社 穿刺器具
US20090093775A1 (en) * 2007-10-03 2009-04-09 Raju Remesh S O Govinda Microstructures
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (ja) * 2007-10-11 2013-04-10 キヤノン株式会社 画像処理システム並びに画像処理方法
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
US9066738B2 (en) * 2008-07-14 2015-06-30 Syneron Medical Ltd. Devices and methods for percutaneous energy delivery
US20110006458A1 (en) * 2009-04-24 2011-01-13 Corium International, Inc. Methods for manufacturing microprojection arrays
US20110009782A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
WO2011011392A2 (en) * 2009-07-20 2011-01-27 Ams Research Corporation Needleless injection device components, systems, and methods
EP2566535A4 (de) * 2010-05-03 2013-12-18 Izhar Halahmi Abgabevorrichtung zur verabreichung eines bioaktiven wirkstoffs
WO2011140240A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Applicators for microneedles
AU2011248108B2 (en) 2010-05-04 2016-05-26 Corium Pharma Solutions, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
JP5562138B2 (ja) * 2010-06-24 2014-07-30 シスメックス株式会社 微細孔形成装置
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
IT1403293B1 (it) * 2010-12-27 2013-10-17 Fond Don Carlo Gnocchi Onlus Apparecchiatura ad aghi per la somministrazione transdermica di farmaci.
US8301238B2 (en) 2011-03-31 2012-10-30 Incline Therapeutics, Inc. Two-part electrotransport device
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
US8428708B1 (en) 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
EP2510911A1 (de) * 2011-04-13 2012-10-17 Sanofi-Aventis Deutschland GmbH Vorrichtung zur intraokularen Injektion
US20120310155A1 (en) * 2011-05-31 2012-12-06 Jeremy Heiser Apparatus and method for dermal delivery
WO2013053022A1 (en) 2011-10-12 2013-04-18 The University Of Queensland Delivery device
EP3542850A1 (de) 2012-12-14 2019-09-25 Mindera Corporation Verfahren und vorrichtungen zur erkennung und erfassung von biomarkern
RU2698095C2 (ru) 2012-12-21 2019-08-22 Кориум Интернэшнл, Инк. Микроматрица для доставки терапевтического средства и способы использования
US9717893B2 (en) 2013-02-13 2017-08-01 Hisamitsu Pharmaceutical Co., Ltd. Microneedle array
KR102295456B1 (ko) * 2013-02-28 2021-08-27 소렌토 쎄라퓨틱스, 인코포레이티드 경피 약물 전달 장치
CN105142711B (zh) 2013-03-12 2019-01-22 考里安国际公司 微突起施加器
CA2903459C (en) 2013-03-15 2024-02-20 Corium International, Inc. Multiple impact microprojection applicators and methods of use
JP6700170B2 (ja) 2013-03-15 2020-05-27 コリウム, インコーポレイテッド 治療剤の送達のためのマイクロアレイおよび使用の方法
ES2761580T3 (es) 2013-03-15 2020-05-20 Corium Inc Micromatrices para suministro de agente terapéutico, métodos de uso y métodos de fabricación
EP2968116A1 (de) 2013-03-15 2016-01-20 Corium International, Inc. Mikroarray mit polymerfreien mikrostrukturen, verfahren zur herstellung und verfahren zur verwendung
WO2015119906A1 (en) 2014-02-05 2015-08-13 Amgen Inc. Drug delivery system with electromagnetic field generator
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
GB201420946D0 (en) * 2014-11-25 2015-01-07 Kirby Andrew J And Xobaderm Ltd Flexible device incorporating microperforators
CA2975275C (en) 2015-02-02 2023-08-29 Vaxxas Pty Limited Microprojection array applicator and method
EP3260159A1 (de) 2015-02-13 2017-12-27 MEDRx Co., Ltd. Mikronadeleinsetzvorrichtung und mikronadelpflasteranwendungsvorrichtung
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP3738642A1 (de) 2015-12-21 2020-11-18 MEDRx Co., Ltd. Mikronadelpatchapplikator
WO2017143345A1 (en) 2016-02-19 2017-08-24 Zp Opco, Inc. Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
CN110709250B (zh) 2017-03-31 2022-10-11 瓦克萨斯私人有限公司 用于涂覆表面的设备和方法
WO2018204503A1 (en) 2017-05-03 2018-11-08 Z Surgical Llc Minimal-access percutaneous and self-retracting surgical system
EP3639010A4 (de) 2017-06-13 2021-03-17 Vaxxas Pty Limited Qualitätskontrolle von substratbeschichtungen
AU2018309562A1 (en) 2017-08-04 2020-02-20 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
EP3672570A1 (de) 2017-08-23 2020-07-01 Zosano Pharma Corporation Verfahren zur schnellen erreichung therapeutischer konzentrationen von zolmitriptan zur behandlung von migräne und cluster-kopfschmerzen
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
JP1632957S (de) 2018-10-30 2019-06-03
CN109621093A (zh) * 2018-11-28 2019-04-16 王英华 检疫用简便注射装置
EP4076187A1 (de) * 2019-12-18 2022-10-26 Uprax Microsolutions B.V. Applikatoren und verfahren zum aufbringen eines mikronadelpflasters auf die haut eines menschen und mikronadelpflaster

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) 1964-09-08 Means for vaccinating
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
US4340480A (en) 1978-05-15 1982-07-20 Pall Corporation Process for preparing liquophilic polyamide membrane filter media and product
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4753651A (en) 1982-08-30 1988-06-28 Alza Corporation Self-driven pump
EP0132940A1 (de) * 1983-06-17 1985-02-13 Avvari Rangaswamy Arterielle Punktionseinheit
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4588580B2 (en) 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4655766A (en) 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4698062A (en) 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US4832953A (en) 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5077104A (en) 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
AU657681B2 (en) 1990-03-30 1995-03-23 Alza Corporation Device and method for iontophoretic drug delivery
US5242406A (en) 1990-10-19 1993-09-07 Sil Medics Ltd. Liquid delivery device particularly useful for delivering drugs
WO1992007618A1 (en) 1990-10-29 1992-05-14 Alza Corporation Iontophoretic drug delivery electrode and method of hydrating the same
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
AT397466B (de) * 1992-03-18 1994-04-25 Diem Karl Spritze mit einem rohrartigen gehäuse zur aufnahme einer ampulle
US5310404A (en) 1992-06-01 1994-05-10 Alza Corporation Iontophoretic delivery device and method of hydrating same
CA2205444A1 (en) 1994-12-09 1996-06-13 Novartis Ag Transdermal system
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
ATE234129T1 (de) 1996-06-18 2003-03-15 Alza Corp Vorrichtung zur verbesserung der transdermalen verabreichung von medikamenten oder der abnahme von körperflüssigkeiten
ES2200187T3 (es) 1996-07-03 2004-03-01 Altea Therapeutics Corporation Microporacion mecanica multiple de la piel o de la mucosa.
JP4054381B2 (ja) 1996-09-17 2008-02-27 デカ・プロダクツ・リミテッド・パートナーシップ 移送による薬伝達システム
ES2195190T3 (es) 1996-12-20 2003-12-01 Alza Corp Dispositivo y metodo para mejorar el flujo de agente transdermico.
US6083196A (en) * 1997-12-11 2000-07-04 Alza Corporation Device for enhancing transdermal agent flux
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
EP1187653B1 (de) * 1999-06-04 2010-03-31 Georgia Tech Research Corporation Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten

Also Published As

Publication number Publication date
CY1105306T1 (el) 2010-03-03
DK1239916T3 (da) 2006-04-03
ES2253278T3 (es) 2006-06-01
HK1048604B (zh) 2006-05-04
US20020032415A1 (en) 2002-03-14
EP1239916A1 (de) 2002-09-18
HK1048604A1 (en) 2003-04-11
AU2074301A (en) 2001-06-18
WO2001041863A1 (en) 2001-06-14
EP1239916B1 (de) 2005-11-23
ATE310561T1 (de) 2005-12-15
US7087035B2 (en) 2006-08-08
US20050085766A1 (en) 2005-04-21
DE60024312T2 (de) 2006-08-17

Similar Documents

Publication Publication Date Title
DE60024312D1 (de) Vorrichtung und verfahren zur verbesserung des mikronadel-haut-piercing
DE69839969D1 (de) Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
ZA200204597B (en) Skin treatment apparatus for sustained transdermal drug delivery.
ATE478610T1 (de) Vorrichtung zur reparatur von arterien
ATE260066T1 (de) Vorrichtung zur extraktion undurchlässiger, verformbarer portionspackungen
HUP0303558A2 (en) Apparatus and method for piercing skin with microprotrusions
DE50012682D1 (de) Kompressionsmanschette zur Behandlung von Beinleiden
ATE363711T1 (de) Verfahren und vorrichtung zur prädiktiven quantisierung von stimmhaften sprachsignalen
ATE294058T1 (de) Verfahren und vorrichtung zum herstellen von gegenständen und zum einbringen von etiketten in eine form
DE69404785D1 (de) Vorrichtung zur Behandlung von Oberflächen
ATE519396T1 (de) Gerät zum anbringen von künstlichen fingernägeln
DE58904988D1 (de) Verfahren zur bespannung von schlaegern fuer ballspiele sowie vorrichtung zur durchfuehrung des verfahrens.
ATE285678T1 (de) Verfahren und vorrichtung zum einfrieren von gewebe
ATE536210T1 (de) Verfahren zur aufkonzentrierung fluidgetragener pathogene
NO994775D0 (no) FremgangsmÕte for festing av balleemballasjer til baller og en festeinnretning for Õ utföre fremgangsmÕten
WO2001065990A3 (en) Methods and apparatus for foot scrubbing
ATE254872T1 (de) Vorrichtung und verfahren zum halten von strumpfwaren
ATE187661T1 (de) Verfahren zur durchführung einer behandlung in der anwesenheit einer zentrifugalen kraft sowie vorrichtung dafür
DE60104379D1 (de) Verfahren und Vorrichtung zur Aktivierung von Textilien
DE69403871D1 (de) Vorrichtung zur Behandlung von Oberflächen
EP0970622A3 (de) Vorrichtung und Verfahren zur Lebensmittelbehandlung
DE3672998D1 (de) Verfahren zum testen von dampfsterilisatoren sowie vorrichtung zur durchfuehrung des verfahrens.
DE59909064D1 (de) Vorrichtung zum paarweisen halten von socken oder strümpfen
DE3865109D1 (de) Verfahren zum behandeln von laenglichen landbauprodukten, wie z.b. gemuesen, sowie vorrichtung zur durchfuehrung des verfahrens.
ATE380908T1 (de) Vorrichtung zum beseitigen und verhindern von pflanzlichem bewuchs

Legal Events

Date Code Title Description
8364 No opposition during term of opposition