DE60031921D1 - Verfahren zu Herstellung von Epigallocatechin Gallate - Google Patents

Verfahren zu Herstellung von Epigallocatechin Gallate

Info

Publication number
DE60031921D1
DE60031921D1 DE60031921T DE60031921T DE60031921D1 DE 60031921 D1 DE60031921 D1 DE 60031921D1 DE 60031921 T DE60031921 T DE 60031921T DE 60031921 T DE60031921 T DE 60031921T DE 60031921 D1 DE60031921 D1 DE 60031921D1
Authority
DE
Germany
Prior art keywords
egcg
weight
epigallocatechin gallate
green tea
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60031921T
Other languages
English (en)
Other versions
DE60031921T2 (de
Inventor
David Carl Burdick
Heinz Egger
Andrew George Gum
Ingo Koschinski
Elena Muelchi
Isabelle Prevot-Halter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE60031921D1 publication Critical patent/DE60031921D1/de
Publication of DE60031921T2 publication Critical patent/DE60031921T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
    • A23F3/20—Removing unwanted substances
    • A23F3/205—Using flocculating or adsorbing agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
DE60031921T 1999-08-16 2000-08-11 Verfahren zu Herstellung von Epigallocatechin Gallate Expired - Lifetime DE60031921T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99116032 1999-08-16
EP99116032 1999-08-16

Publications (2)

Publication Number Publication Date
DE60031921D1 true DE60031921D1 (de) 2007-01-04
DE60031921T2 DE60031921T2 (de) 2007-09-20

Family

ID=8238779

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031921T Expired - Lifetime DE60031921T2 (de) 1999-08-16 2000-08-11 Verfahren zu Herstellung von Epigallocatechin Gallate

Country Status (11)

Country Link
US (2) US7012149B2 (de)
EP (2) EP1767097A3 (de)
JP (1) JP4643808B2 (de)
KR (2) KR100847171B1 (de)
CN (1) CN1166661C (de)
AT (1) ATE346059T1 (de)
BR (1) BRPI0003578C1 (de)
CA (1) CA2315886C (de)
DE (1) DE60031921T2 (de)
ES (1) ES2275463T3 (de)
IN (1) IN190860B (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60031921T2 (de) * 1999-08-16 2007-09-20 Dsm Ip Assets B.V. Verfahren zu Herstellung von Epigallocatechin Gallate
KR20030010011A (ko) * 2001-07-25 2003-02-05 (주)엔바이오솔루션 녹차로부터 얻어진 에피갈로카테킨 갈레이트의 추출방법
KR100497003B1 (ko) * 2002-08-30 2005-06-23 주식회사 바이오랜드 안구표면 질환 치료용 양막을 보존하기 위한 양막보존액 조성물
US20050008712A1 (en) * 2003-07-08 2005-01-13 Debasis Bagchi Compositions incorporating high-caffeine green tea extract and related methods for promoting healthy body weight
WO2005025527A1 (de) 2003-09-09 2005-03-24 Dsm Ip Assets B.V. Oral wirkendes im wesentlichen wasserfreies topisches mittel enthaltend ein oder mehrere oxidationsempfindliche stoffe
US7303773B2 (en) 2003-10-21 2007-12-04 The Procter & Gamble Company Process for enriching extracts of natural theanine
KR101202565B1 (ko) * 2003-12-02 2012-11-19 가오 가부시키가이샤 용기포장음료
WO2005072523A2 (en) * 2004-02-02 2005-08-11 I.M.T. Interface Multigrad Technology Ltd. Biological material and methods and solutions for preservation thereof
BRPI0511227A (pt) * 2004-06-04 2007-11-27 Horizon Science Pty Ltd extrato de melaço, extrato de lodo de açúcar, extrato do caldo e/ou da espuma coletada do tanque de clarificação, extrato de talos de cana de açúcar fibrados/residuais do campo de beterraba sacarina ou de cana de açúcar, extrato de bagaço e extrato de polpa de beterraba sacarina que tem caracterìsticas redutoras do ig ou da taxa de queima; método para a extração dos fitoquìmicos não nutrientes que têm propriedades redutoras do ig ou da taxa de queima das correntes de resìduos de processamento do açúcar e de outros produtos em processo e do lodo da moenda de cana de açúcar; método para diminuir o ig de um produto alimentìcio; produto que contém sacarose com baixo ig; método para a obtenção de produtos alimentìcios que têm um ig ou uma taxa de queima inferior; método para melhorar a saúde; método para diminuir o ig de um produto que contém sacarose; produto com baixo ig; fitoquìmico purificado extraìdo da cana de açúcar ou da beterraba sacarina; adoçante com baixo ig e adoçante
EP2450084B1 (de) 2005-06-03 2014-02-19 Horizon Science Pty Ltd Substanzen mit Körpermasseumverteilungseigenschaften
WO2006131326A2 (en) * 2005-06-07 2006-12-14 Dsm Ip Assets B.V. Novel use of (-)-epigallocatechin gallate
KR100659138B1 (ko) * 2005-09-16 2006-12-19 (주)아모레퍼시픽 유효성분으로 갈로카테킨 갈레이트를 함유하는 보습용피부외용제 조성물
DE102005056652A1 (de) * 2005-11-25 2007-05-31 Südzucker AG Mannheim/Ochsenfurt Präparat enthaltend eine polyphenolhaltige Zusammensetzung und Isomaltulose
JP4807563B2 (ja) * 2005-12-06 2011-11-02 株式会社 伊藤園 容器詰め飲料及びその製造方法
ES2280141B1 (es) * 2006-02-27 2008-10-01 Natraceutical, S.A. "proceso para la obtencion de polvo de cacao rico en polifenoles y bajo contenido en materia grasa y polvo de cacao obtenido".
EP1989943B1 (de) * 2006-03-02 2011-06-01 Kao Corporation Verfahren zur herstellung von gereinigtem teeextrakt
CN101553582A (zh) * 2006-09-19 2009-10-07 视界科技有限公司 从甘蔗中获得的提取物及其生产方法
US8518458B2 (en) 2006-09-21 2013-08-27 Immune Guard, LLC Tea-derived compositions and methods of using same for cardiovascular health
US8465782B2 (en) 2006-09-21 2013-06-18 Immune Guard, LLC Methods and materials for reducing risk of cold and/or flu
CN101134941B (zh) * 2007-07-27 2013-03-06 东华大学 米曲霉高效制备egcg水解酶及生产egc和没食子酸的方法
JP4866815B2 (ja) * 2007-09-05 2012-02-01 花王株式会社 精製緑茶抽出物の製造法
CN101492440B (zh) * 2008-01-24 2012-10-03 上海新康制药厂 茶多酚中主要儿茶素成分分离纯化方法及其糖苷酶活性
WO2009114738A2 (en) * 2008-03-12 2009-09-17 Hypres, Inc. Digital radio-frequency tranceiver system and method
JP5307649B2 (ja) * 2009-02-20 2013-10-02 花王株式会社 精製茶抽出物の製造方法
TR200907338A1 (tr) * 2009-09-28 2011-04-21 Yedi̇tepe Üni̇versi̇tesi̇ Doğal bileşenler içeren bir film şeridi.
CN101703130B (zh) * 2009-12-03 2012-05-02 应维强 绿茶提取物的生产工艺
JP5858697B2 (ja) * 2010-12-15 2016-02-10 オルガノ株式会社 ガレート型カテキンの精製方法及び精製装置
CN102558129B (zh) * 2010-12-15 2015-02-18 奥加诺株式会社 没食子酸酯型儿茶素的提纯方法以及提纯装置
CA2860448C (en) 2011-02-08 2019-09-10 Horizon Science Pty Ltd Molasses extract enriched in polyphenols and uses thereof
FR2973249B1 (fr) 2011-03-28 2014-02-07 Centre Nat Rech Scient Utilisation de l'epigallocatechine gallate comme agent antiviral contre les infections par le virus de l'hepatite c
JP2012217356A (ja) * 2011-04-05 2012-11-12 Coca-Cola Co 容器詰飲料
CN102276570B (zh) * 2011-06-23 2013-10-16 辽宁科技大学 一种提纯表没食子儿茶素没食子酸酯（egcg）的方法
CN102432577B (zh) * 2011-11-10 2013-03-20 湖南农业大学 表儿茶素没食子酸酯（ecg）单体的分离纯化方法
CN102603699A (zh) * 2012-02-29 2012-07-25 桂林三宝药业有限公司 从油茶饼中提取表没食子儿茶素没食子酸酯的方法
JP6239622B2 (ja) 2012-08-28 2017-11-29 ザ プロダクト メーカーズ （オーストラリア） プロプライエタリー リミテッド 抽出方法
CN104273521B (zh) * 2013-07-03 2016-08-24 江南大学 一种基于糖基化酪蛋白的茶多酚纳米胶囊及其制备方法
RU2016107746A (ru) 2013-08-09 2017-09-11 Сантори Холдингз Лимитед Средство, способствующее абсорбции гидрокситирозола и его производных in vivo, и применение такого средства
EP3035949B1 (de) 2013-08-16 2023-10-04 Poly Gain Pte Ltd Aus zuckerrohr gewonnene extrakte und verwendungen
CN103613575B (zh) * 2013-11-29 2016-05-25 桂林莱茵生物科技股份有限公司 一种高含量egcg的提纯方法
CN103772339B (zh) * 2014-01-01 2016-01-13 恩施职业技术学院 一种从茶叶下脚料中提取表没食子儿茶素没食子酸酯的方法
CN103910705B (zh) * 2014-03-20 2015-10-28 苏州市职业大学 从绿茶的下脚料中快速提取分离纯化表没食子儿茶素没食子酸酯的方法
CN104016958B (zh) * 2014-05-14 2016-01-20 芜湖天远科技开发有限责任公司 一种高纯度表没食子儿茶素没食子酸酯的制备方法
CN104311522B (zh) * 2014-09-09 2016-08-24 湖南农业大学 一种从茶叶中分离制备egcg的方法
CN104447668A (zh) * 2014-12-12 2015-03-25 中国医科大学 一种用氢键型大孔树脂制备高纯度egcg的方法
CN104820059B (zh) * 2015-04-22 2016-07-06 湖南农业大学 一种快速筛选含有EGCG3"Me茶树资源的方法
CN115778928A (zh) 2015-08-28 2023-03-14 康霈生技股份有限公司 用于减少局部脂肪的医药组成物及其用途
US11318110B2 (en) 2015-08-28 2022-05-03 Caliway Biopharmaceuticals Co., Ltd. Pharmaceutical composition for reducing local fat and uses thereof
CN106168608A (zh) * 2016-08-25 2016-11-30 江苏天晟药业股份有限公司 一种茶多酚中egcg含量的检测方法
ES2895273T3 (es) 2016-12-21 2022-02-18 Suntory Holdings Ltd Alimentos y bebidas que contienen galato de epigalocatequina y ciclo(prolil-treonina)
KR102428987B1 (ko) * 2017-05-16 2022-08-04 (주)아모레퍼시픽 차나무의 추출물을 함유하는 조성물
CN107897427A (zh) * 2017-10-31 2018-04-13 中华全国供销合作总社杭州茶叶研究所 一种茶叶多产物同步模块化分离的方法
CN111601794A (zh) 2017-12-05 2020-08-28 克里斯托莫菲克斯技术私人有限公司 从绿茶提取物或绿茶粉中分离没食子酸化的表儿茶素(egcg和ecg)的方法
CN109293617A (zh) * 2018-11-21 2019-02-01 云南农业大学 Egcg晶型i及其制备方法
CN110663788A (zh) * 2019-10-06 2020-01-10 杏辉天力（杭州）药业有限公司 一种茶叶提取物及其工业化制备方法和用途
BE1026780B1 (de) * 2019-12-16 2021-02-26 Tea Res Institute Chinese Academy Of Agricultural Sciences Verfahren zur chargenweisen Abscheidung und Reinigung eines Polyester-Catechins mittels Gelchromatographie

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5721975B2 (de) 1975-03-10 1982-05-11
JPS6013780A (ja) * 1983-07-05 1985-01-24 Mitsui Norin Kk 茶カテキン類の製造方法
EP0167399A3 (de) 1984-07-06 1987-08-26 General Foods Corporation Entkoffeinierung von fermentiertem nichtgetrocknetem Tee
JPS6261569A (ja) 1985-09-12 1987-03-18 Morinaga & Co Ltd 無色又は淡い色をした飲料の製造法
JPS63214183A (ja) * 1987-03-03 1988-09-06 Mitsui Norin Kk アンジオテンシン１変換酵素阻害剤
US4806379A (en) * 1987-06-05 1989-02-21 General Foods Corporation Process for producing a green leaf essence
US5043100A (en) * 1987-07-23 1991-08-27 Rutgers, The State University Of New Jersey Process for manufacture of natural antioxidant products from tea and spent tea
JPH02311474A (ja) * 1989-05-29 1990-12-27 Itouen:Kk 茶カテキン類の製造方法
JP2727471B2 (ja) * 1989-09-14 1998-03-11 三井農林株式会社 インフルエンザウィルス感染予防剤
US5021253A (en) * 1989-12-13 1991-06-04 The Dow Chemical Company Decaffeination of liquid medium
JPH0725670B2 (ja) 1990-07-18 1995-03-22 株式会社ロッテ 抗歯周病剤
CN1067359A (zh) 1991-06-01 1992-12-30 中国医学科学院药物研究所 绿茶茶素的生产方法
JP3002919B2 (ja) * 1991-11-25 2000-01-24 太陽化学株式会社 胃炎，胃または十二指腸潰瘍防止組成物
ATE141039T1 (de) 1991-12-19 1996-08-15 Nestle Sa Antioxidantienherstellung
JP3052172B2 (ja) 1992-04-07 2000-06-12 株式会社 伊藤園 茶カテキン類の製造方法
US5391568A (en) * 1992-07-10 1995-02-21 American Health Foundation Inhibition of lung tumorigenesis by administration of a polyphenol
US5306486A (en) * 1993-03-01 1994-04-26 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic sunscreen composition containing green tea and a sunscreen
JP3052174B2 (ja) * 1993-08-26 2000-06-12 株式会社 伊藤園 茶カテキン類の製造方法
CA2128293C (en) * 1993-12-06 2002-09-03 Masayuki Tanabe Fruit polyphenols and medicinal compositions containing them
IT1275905B1 (it) 1995-03-14 1997-10-24 Indena Spa Frazioni polifenoliche di te', loro uso e formulazioni che le contengono
US6063428A (en) * 1996-02-26 2000-05-16 The Procter & Gamble Company Green tea extract subjected to cation exchange treatment and nanofiltration to improve clarity and color
JPH09227374A (ja) * 1996-02-28 1997-09-02 Taiyo Kagaku Co Ltd ストレスタンパク質産生抑制組成物
US5804567A (en) * 1996-07-18 1998-09-08 Cancer Institute (Hospital), Chinese Academy Of Medical Sciences Method of increasing the effectiveness of anti-metabolites
JPH1067771A (ja) 1996-08-26 1998-03-10 Nippon Youriyokuso Kk カフェイン低含有のカテキン類の製造方法
US5968973A (en) * 1996-11-18 1999-10-19 Cancer Institute (Hospital), Chinese Academy Of Medical Sciences Method for treating hyperplasia
US6210679B1 (en) * 1999-01-07 2001-04-03 Hauser, Inc. Method for isolation of caffeine-free catechins from green tea
US6576275B1 (en) * 1999-02-02 2003-06-10 Archer-Daniels-Midland Company Process for extracting polyphenolic antioxidants from purine-containing plants
US6410052B1 (en) * 1999-03-30 2002-06-25 Purdue Research Foundation Tea catechins in sustained release formulations as cancer specific proliferation inhibitors
US6428818B1 (en) * 1999-03-30 2002-08-06 Purdue Research Foundation Tea catechin formulations and processes for making same
DE60031921T2 (de) * 1999-08-16 2007-09-20 Dsm Ip Assets B.V. Verfahren zu Herstellung von Epigallocatechin Gallate
KR100379323B1 (ko) * 2000-02-29 2003-04-08 삼아약품 주식회사 카테킨을 포함하는 관상동맥 재협착 예방 및 치료용 약학조성물
US6254898B1 (en) * 2000-05-25 2001-07-03 Protective Factors, Inc. Nutraceutical composition for protection against solar radiation
US6713096B2 (en) * 2002-01-04 2004-03-30 Melaleuca, Inc. Dietary supplements and methods for treating pain and inflammation
US7122573B2 (en) * 2002-12-06 2006-10-17 Sri International Analogs of green tea polyphenols as chemotherapeutic and chemopreventive agents

Also Published As

Publication number Publication date
US20030083270A1 (en) 2003-05-01
EP1767097A2 (de) 2007-03-28
ATE346059T1 (de) 2006-12-15
BR0003578B1 (pt) 2014-04-08
CA2315886C (en) 2010-05-25
BR0003578A (pt) 2002-06-18
CN1286252A (zh) 2001-03-07
JP2001097968A (ja) 2001-04-10
CA2315886A1 (en) 2001-02-16
EP1077211A3 (de) 2001-03-28
EP1077211A2 (de) 2001-02-21
JP4643808B2 (ja) 2011-03-02
CN1166661C (zh) 2004-09-15
KR20010050080A (ko) 2001-06-15
US7312199B2 (en) 2007-12-25
US7012149B2 (en) 2006-03-14
BRPI0003578C1 (pt) 2021-05-25
EP1077211B1 (de) 2006-11-22
KR100847171B1 (ko) 2008-07-17
US20060069046A1 (en) 2006-03-30
ES2275463T3 (es) 2007-06-16
DE60031921T2 (de) 2007-09-20
EP1767097A3 (de) 2007-04-04
KR20080059115A (ko) 2008-06-26
IN190860B (de) 2003-08-30
BRPI0003578B8 (pt) 2016-05-10

Similar Documents

Publication Publication Date Title
DE60031921D1 (de) Verfahren zu Herstellung von Epigallocatechin Gallate
JP2001097968A5 (de)
JP3115691B2 (ja) 低カフェイン含量茶ポリフェノールの製造法
WO2003061563A3 (en) Method of preparing delta-9 tetrahydrocannabinol
IE851918L (en) An indole derivative.
ATE220326T1 (de) Grüntee-extrakte enthaltend catechole und koffein
CA2031384A1 (en) Active component concentrates and new active component combinations from ginkgo biloba leaves, their method of preparation and pharmaceuticals containing the active component concentrates or the active component combinations
EP0417385A3 (en) Preventive and curative medicament against infection with influenza virus, containing tea or tea polyphenols
AU2500795A (en) A process for the preparation of pesticide-poor concentrates of active components of plants
JPS55105677A (en) Production of catechins
DE69016532T2 (de) Zahnbelag verhindernde Mittel.
EP1770090A4 (de) Tea-polyphenol-zusammensetzung und verfahren zu deren herstellung
EP0400219A3 (de) Verwendung von Creosot als antispastischer Wirkstoff
US7510736B2 (en) Method for selectively and sequentially extracting catechins from green tea leaf
KR100690928B1 (ko) 에피갈로카테킨 갈레이트의 분리정제방법
JPS5430575A (en) Filter medium
KR20030060723A (ko) 차엽으로부터 카페인, 에피갈로카테킨, 에피카테킨,에피갈로카테킨갈레이트, 에피카테킨갈레이트의 분리 및제조방법
An et al. Inhibiory effect of novel flavan-3-ol isolated theobroma cacao L. husk on glucosyltransferase
RU97111748A (ru) Способ выделения дигидрокверцетина
JPS5247226A (en) Vibration-absorbing structure for steering wheel
JPS5762210A (en) Agent for controlling plant blights
ES275283U (es) Eje y pieza de sujecion para ruedas de patines, triciclos y similares
SU1834019A1 (ru) Лыжи
IT8321015V0 (it) Rotella per bastoncini da sci adelasticita' differenziata.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition