DE60032367D1 - Aktivierbare rekombinante neurotoxine - Google Patents

Aktivierbare rekombinante neurotoxine

Info

Publication number
DE60032367D1
DE60032367D1 DE60032367T DE60032367T DE60032367D1 DE 60032367 D1 DE60032367 D1 DE 60032367D1 DE 60032367 T DE60032367 T DE 60032367T DE 60032367 T DE60032367 T DE 60032367T DE 60032367 D1 DE60032367 D1 DE 60032367D1
Authority
DE
Germany
Prior art keywords
neurotoxine
active recombinant
polypeptides
nucleic acids
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60032367T
Other languages
English (en)
Other versions
DE60032367T3 (de
DE60032367T2 (de
Inventor
Oliver Dolly
Yan Li
Chion Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22535688&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60032367(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of DE60032367D1 publication Critical patent/DE60032367D1/de
Publication of DE60032367T2 publication Critical patent/DE60032367T2/de
Publication of DE60032367T3 publication Critical patent/DE60032367T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
DE60032367T 1999-08-25 2000-08-25 Aktivierbare rekombinante neurotoxine Expired - Lifetime DE60032367T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15071099P 1999-08-25 1999-08-25
US150710P 1999-08-25
PCT/US2000/023427 WO2001014570A1 (en) 1999-08-25 2000-08-25 Activatable recombinant neurotoxins

Publications (3)

Publication Number Publication Date
DE60032367D1 true DE60032367D1 (de) 2007-01-25
DE60032367T2 DE60032367T2 (de) 2007-09-27
DE60032367T3 DE60032367T3 (de) 2011-03-10

Family

ID=22535688

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60032367T Expired - Lifetime DE60032367T3 (de) 1999-08-25 2000-08-25 Aktivierbare rekombinante neurotoxine

Country Status (13)

Country Link
US (16) US7132259B1 (de)
EP (6) EP1206554B2 (de)
JP (1) JP2003507073A (de)
KR (1) KR100876060B1 (de)
CN (1) CN1214114C (de)
AT (1) ATE348178T1 (de)
AU (1) AU777556B2 (de)
BR (1) BR0012759A (de)
CA (1) CA2380457A1 (de)
DE (1) DE60032367T3 (de)
ES (1) ES2277854T5 (de)
HK (1) HK1046020B (de)
WO (1) WO2001014570A1 (de)

Families Citing this family (206)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192596B2 (en) * 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
GB9617671D0 (en) 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US8012491B2 (en) 1996-08-23 2011-09-06 Syntaxin, Ltd. Recombinant toxin fragments
US8790897B2 (en) * 1998-08-25 2014-07-29 Syntaxin Ltd. Treatment of mucus hypersecretion
US20040071736A1 (en) * 1998-08-25 2004-04-15 Health Protection Agency Methods and compounds for the treatment of mucus hypersecretion
US7132259B1 (en) * 1999-08-25 2006-11-07 Allergan, Inc. Activatable recombinant neurotoxins
US20090018081A1 (en) * 1999-08-25 2009-01-15 Allergan, Inc. Activatable clostridial toxins
US7740868B2 (en) 1999-08-25 2010-06-22 Allergan, Inc. Activatable clostridial toxins
US20080032931A1 (en) * 1999-08-25 2008-02-07 Steward Lance E Activatable clostridial toxins
GB9922554D0 (en) * 1999-09-23 1999-11-24 Microbiological Res Authority Inhibition of secretion from non-neuronal cells
US7138127B1 (en) * 2000-01-19 2006-11-21 Allergan, Inc. Clostridial toxin derivatives and methods for treating pain
US7273722B2 (en) * 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
GB0111146D0 (en) * 2001-05-04 2001-06-27 Imp College Innovations Ltd Methods
US7374896B2 (en) * 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
US8022172B2 (en) * 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7332567B2 (en) * 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
US7022329B2 (en) * 2002-02-25 2006-04-04 Allergan, Inc. Method for treating neurogenic inflammation pain with botulinum toxin and substance P components
EP1531859A4 (de) * 2002-05-31 2005-12-07 Univ Jefferson Zusammensetzungen und verfahren für den transepithelialen molekültransport
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8039587B2 (en) 2003-10-24 2011-10-18 Gencia Corporation Methods and compositions for delivering polynucleotides
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US7514088B2 (en) 2005-03-15 2009-04-07 Allergan, Inc. Multivalent Clostridial toxin derivatives and methods of their use
US7811584B2 (en) * 2004-06-30 2010-10-12 Allergan, Inc. Multivalent clostridial toxins
AU2005279741B2 (en) 2004-09-01 2011-10-06 Allergan, Inc. Degradable clostridial toxins
DE102004043009A1 (de) * 2004-09-06 2006-03-23 Toxogen Gmbh Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
WO2006068794A2 (en) * 2004-11-22 2006-06-29 New York University Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof
US8603779B2 (en) 2004-12-01 2013-12-10 Syntaxin, Ltd. Non-cytotoxic protein conjugates
GB0426397D0 (en) 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
GB0426394D0 (en) 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
US8399400B2 (en) 2004-12-01 2013-03-19 Syntaxin, Ltd. Fusion proteins
US8778634B2 (en) 2004-12-01 2014-07-15 Syntaxin, Ltd. Non-cytotoxic protein conjugates
US7659092B2 (en) 2004-12-01 2010-02-09 Syntaxin, Ltd. Fusion proteins
US8512984B2 (en) 2004-12-01 2013-08-20 Syntaxin, Ltd. Non-cytotoxic protein conjugates
DE102005002978B4 (de) * 2005-01-21 2013-04-25 Merz Pharma Gmbh & Co. Kgaa Rekombinante Expression von Proteinen in einer disulfidverbrückten, zweikettigen Form
AU2006225116B2 (en) * 2005-03-15 2012-04-19 Allergan, Inc. Modified Clostridial toxins with altered targeting capabilities for Clostridial toxin target cells
US8021859B2 (en) 2005-03-15 2011-09-20 Allergan, Inc. Modified clostridial toxins with altered targeting capabilities for clostridial toxin target cells
DE102005019302A1 (de) * 2005-04-26 2006-11-16 Toxogen Gmbh Carrier zum Targeting von Nervenzellen
WO2008008082A2 (en) 2005-09-19 2008-01-17 Allergan, Inc. Clostridial toxin activatable clostridial toxins
US8168206B1 (en) 2005-10-06 2012-05-01 Allergan, Inc. Animal protein-free pharmaceutical compositions
EP2001902B1 (de) 2006-03-14 2013-03-27 Allergan, Inc. Modifizierte clostridiale toxine mit geänderten targeting-fähigkeiten für die target-zellen von clostridialem toxin
GB0610867D0 (en) 2006-06-01 2006-07-12 Syntaxin Ltd Treatment of pain
CA2658260A1 (en) * 2006-07-11 2008-01-17 Allergan, Inc. Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells
WO2008105901A2 (en) * 2006-07-11 2008-09-04 Allergan, Inc. Modified clostridial toxins with enhanced translocation capability and enhanced targeting activity
CA2657521A1 (en) 2006-07-11 2008-01-17 Allergan, Inc. Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for non-clostridial toxin target cells
JP2010500967A (ja) * 2006-07-20 2010-01-14 ザ ジェネラル ホスピタル コーポレイション コンビナトリアルターゲティングを通じたプロトキシンの選択的活性化のための方法、組成物、およびキット
WO2011039584A2 (en) * 2009-10-01 2011-04-07 Nikos Tsopanoglou Peptides
JP2011514308A (ja) * 2007-10-23 2011-05-06 アラーガン、インコーポレイテッド 改変クロストリジウム毒素を用いる泌尿生殖器神経学的障害の治療方法
JP2011514307A (ja) * 2007-10-23 2011-05-06 アラーガン、インコーポレイテッド 改変クロストリジウム毒素を用いる慢性神経性炎症の治療方法
CN102356091A (zh) 2008-03-14 2012-02-15 阿勒根公司 基于免疫的血清型a肉毒杆菌毒素活性测定
KR101604515B1 (ko) * 2008-03-14 2016-03-17 알러간, 인코포레이티드 면역-기반 보툴리눔 독소 세로타입 ａ 활성 검정
ES2614990T3 (es) * 2008-06-12 2017-06-02 Ipsen Bioinnovation Limited Proteínas de fusión para uso en el tratamiento de acromegalia
US8796216B2 (en) 2008-06-12 2014-08-05 Syntaxin Limited Suppression of neuroendocrine diseases
US20100034853A1 (en) * 2008-08-05 2010-02-11 Solstice Neurosciences, Inc. Compositions of activated botulinum toxin type B
US20100034854A1 (en) * 2008-08-05 2010-02-11 Solstice Neurosciences, Inc. Compositions of activated botulinum holotoxin type B (150 KD)
US20100112006A1 (en) * 2008-11-03 2010-05-06 Solstice Neurosciences, Inc. Compositions of activated botulinum holotoxin type B (150 kD)
WO2010051039A1 (en) * 2008-11-03 2010-05-06 Solstice Neurosciences, Inc. Compositions of activated botulinum toxin type b
KR20110106346A (ko) 2008-12-10 2011-09-28 알러간, 인코포레이티드 클로스트리디움 독소 약제학적 조성물
EP2202518A1 (de) 2008-12-19 2010-06-30 Merz Pharma GmbH & Co.KGaA In-Vivo-Assay zur Quantifizierung der clostridiellen Neurotoxinaktivität
US9492505B2 (en) 2009-01-21 2016-11-15 University Of Florida Research Foundation, Inc. Satiation peptide administration
EP2218783A1 (de) 2009-02-05 2010-08-18 Merz Pharma GmbH & Co. KGaA Neuartiges Verfahren zur Herstellung von Neurotoxinen
GB0903006D0 (en) 2009-02-23 2009-04-08 Syntaxin Ltd Modified non-cytotoxic proteases
SI2406371T1 (sl) 2009-03-13 2018-10-30 Allergan, Inc. Celice, koristne za teste aktivnosti botulinskega toksina serotipa a na podlagi imunologije
DK3281953T3 (da) 2009-03-13 2020-01-20 Allergan Inc Immun-baserede omdirigerede endopeptidase-aktivitetsassays
JP5689113B2 (ja) * 2009-04-27 2015-03-25 メルツ ファルマ ゲーエムベーハー ウント コンパニー カーゲーアーアー ニューロトキシンポリペプチドの量の測定とその触媒及びタンパク質分解活性の測定のための手段及び方法
CA2771298A1 (en) * 2009-08-14 2011-02-17 Allergan, Inc. Methods of treating cancer using glucagon-like hormone retargeted endopeptidases
CA2771289A1 (en) * 2009-08-14 2011-02-17 Allergan, Inc. Methods of treating cancer using galanin retargeted endpeptidases
KR20120107926A (ko) * 2009-08-14 2012-10-04 알러간, 인코포레이티드 오피오이드 재표적화된 엔드펩티다아제를 사용하여 암을 치료하는 방법
WO2011041779A1 (en) 2009-10-02 2011-04-07 Allergan, Inc. In vitro method of determining changes in a protein environment
MX2012006985A (es) 2009-12-16 2012-09-12 Allergan Inc Toxinas clostridium modificadas que comprenden un dominio de enlace al sitio de escision de la proteasa integrado.
PL2526200T3 (pl) 2010-01-22 2016-10-31 Test in vitro do oznaczania ilościowego aktywności neurotoksyny klostridialnej
JP5956350B2 (ja) 2010-01-25 2016-07-27 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 単鎖タンパク質をそれらの２鎖形態に細胞内変換する方法
WO2011091419A2 (en) * 2010-01-25 2011-07-28 New York Universiy Recombinant derivatives of botulinum neurotoxins engineered for trafficking studies and neuronal delivery
US8989186B2 (en) 2010-06-08 2015-03-24 Brocade Communication Systems, Inc. Virtual port grouping for virtual cluster switching
US9461840B2 (en) 2010-06-02 2016-10-04 Brocade Communications Systems, Inc. Port profile management for virtual cluster switching
US9716672B2 (en) 2010-05-28 2017-07-25 Brocade Communications Systems, Inc. Distributed configuration management for virtual cluster switching
US9001824B2 (en) 2010-05-18 2015-04-07 Brocade Communication Systems, Inc. Fabric formation for virtual cluster switching
US8867552B2 (en) 2010-05-03 2014-10-21 Brocade Communications Systems, Inc. Virtual cluster switching
US9270486B2 (en) 2010-06-07 2016-02-23 Brocade Communications Systems, Inc. Name services for virtual cluster switching
MX369263B (es) 2010-05-20 2019-11-04 Allergan Inc Toxinas de clostridium degradables.
US9246703B2 (en) 2010-06-08 2016-01-26 Brocade Communications Systems, Inc. Remote port mirroring
US9628293B2 (en) 2010-06-08 2017-04-18 Brocade Communications Systems, Inc. Network layer multicasting in trill networks
US9608833B2 (en) 2010-06-08 2017-03-28 Brocade Communications Systems, Inc. Supporting multiple multicast trees in trill networks
US9807031B2 (en) 2010-07-16 2017-10-31 Brocade Communications Systems, Inc. System and method for network configuration
EP2603518B1 (de) * 2010-08-11 2015-06-17 Merz Pharma GmbH & Co. KGaA Selektive herstellung von rekombinanten neurotoxin-polypeptiden
US20130330369A1 (en) 2010-10-08 2013-12-12 Allergan, Inc. Reduction Of Antibody Response Against Botulinum Neurotoxin And Variants Thereof
WO2012051447A1 (en) 2010-10-14 2012-04-19 Allergan, Inc. Targeted delivery of targeted exocytosis modulators to the sphenopalatine ganglion for treatment of headache disorders
US20120207734A1 (en) * 2011-02-14 2012-08-16 Allergan, Inc. Methods of Inhibiting Aberrant Blood Vessel Formation Using Opioid Retargeted Endpeptidases
WO2012112434A1 (en) * 2011-02-14 2012-08-23 Allergan, Inc. Inhibiting aberrant blood vessel formation using retargeted endopeptidases
WO2012112420A1 (en) 2011-02-14 2012-08-23 Allergan, Inc. Treatments using psma ligand endopeptidases
US20120244188A1 (en) 2011-03-25 2012-09-27 Allergan, Inc. Treatment of Sensory Disturbance Disorders
US20120251575A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Involuntary Movement Disorders
US20120251573A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Neuroendocrine Disorders
US20120251574A1 (en) 2011-03-28 2012-10-04 Allergan, Inc. Endopeptidase and Neurotoxin Combination Treatment of Multiple Medical Conditions
US20120258132A1 (en) 2011-03-29 2012-10-11 Allergan, Inc. Vagal Nerve-Based Disorders
US20120251518A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Sexual Dysfunction Disorders
US20120251515A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Cosmesis Disorders
US20120251519A1 (en) 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Smooth Muscle Disorders
US9270572B2 (en) 2011-05-02 2016-02-23 Brocade Communications Systems Inc. Layer-3 support in TRILL networks
US9764009B2 (en) 2011-06-13 2017-09-19 Allergan, Inc. Treatment of psychological trauma
US9401861B2 (en) 2011-06-28 2016-07-26 Brocade Communications Systems, Inc. Scalable MAC address distribution in an Ethernet fabric switch
US9407533B2 (en) 2011-06-28 2016-08-02 Brocade Communications Systems, Inc. Multicast in a trill network
US8948056B2 (en) 2011-06-28 2015-02-03 Brocade Communication Systems, Inc. Spanning-tree based loop detection for an ethernet fabric switch
US8885641B2 (en) 2011-06-30 2014-11-11 Brocade Communication Systems, Inc. Efficient trill forwarding
US9736085B2 (en) 2011-08-29 2017-08-15 Brocade Communications Systems, Inc. End-to end lossless Ethernet in Ethernet fabric
US9699117B2 (en) 2011-11-08 2017-07-04 Brocade Communications Systems, Inc. Integrated fibre channel support in an ethernet fabric switch
US9450870B2 (en) 2011-11-10 2016-09-20 Brocade Communications Systems, Inc. System and method for flow management in software-defined networks
EP2793934B1 (de) 2011-12-23 2017-08-23 Merz Pharma GmbH & Co. KGaA Neuartiges verfahren zur herstellung von di-ketten-proteinen zur verwendung bei menschen
US20130171122A1 (en) 2011-12-29 2013-07-04 Allergan, Inc. Endopeptidase and neurotoxin combination treatment of bladder disorders
US10451621B2 (en) 2011-12-31 2019-10-22 Allergan, Inc. Highly sensitive cell-based assay to detect the presence of active botulinum neurotoxin serotype-A
US8995272B2 (en) 2012-01-26 2015-03-31 Brocade Communication Systems, Inc. Link aggregation in software-defined networks
US9742693B2 (en) 2012-02-27 2017-08-22 Brocade Communications Systems, Inc. Dynamic service insertion in a fabric switch
US9154416B2 (en) 2012-03-22 2015-10-06 Brocade Communications Systems, Inc. Overlay tunnel in a fabric switch
US9374301B2 (en) 2012-05-18 2016-06-21 Brocade Communications Systems, Inc. Network feedback in software-defined networks
US10277464B2 (en) 2012-05-22 2019-04-30 Arris Enterprises Llc Client auto-configuration in a multi-switch link aggregation
EP2853066B1 (de) 2012-05-23 2017-02-22 Brocade Communications Systems, Inc. Layer-3-überlagerungs-gateways
US9602430B2 (en) 2012-08-21 2017-03-21 Brocade Communications Systems, Inc. Global VLANs for fabric switches
US20140056870A1 (en) 2012-08-27 2014-02-27 Allergan, Inc. Fusion proteins
US9005628B2 (en) * 2012-10-04 2015-04-14 Dublin City University Biotherapy for pain
WO2014066916A2 (en) 2012-10-28 2014-05-01 Revance Therapeutics, Inc. Compositions and methods for safe treatment of rhinitis
GB201219602D0 (en) 2012-10-31 2012-12-12 Syntaxin Ltd Recombinant clostridium botulinum neurotoxins
US9401872B2 (en) 2012-11-16 2016-07-26 Brocade Communications Systems, Inc. Virtual link aggregations across multiple fabric switches
RU2673910C2 (ru) * 2012-11-21 2018-12-03 Ипсен Байоинновейшн Лимитед Способ производства протеолитически процессированного полипептида
EP2934571B1 (de) 2012-12-18 2018-05-30 Allergan, Inc. Prophylaktische behandlung von herpesrezidiven
US9548926B2 (en) 2013-01-11 2017-01-17 Brocade Communications Systems, Inc. Multicast traffic load balancing over virtual link aggregation
US9350680B2 (en) 2013-01-11 2016-05-24 Brocade Communications Systems, Inc. Protection switching over a virtual link aggregation
US9413691B2 (en) 2013-01-11 2016-08-09 Brocade Communications Systems, Inc. MAC address synchronization in a fabric switch
US9565113B2 (en) 2013-01-15 2017-02-07 Brocade Communications Systems, Inc. Adaptive link aggregation and virtual link aggregation
US9315549B2 (en) 2013-01-28 2016-04-19 New York University Treatment methods using atoxic neurotoxin derivatives
US9565099B2 (en) 2013-03-01 2017-02-07 Brocade Communications Systems, Inc. Spanning tree in fabric switches
US9401818B2 (en) 2013-03-15 2016-07-26 Brocade Communications Systems, Inc. Scalable gateways for a fabric switch
US9565028B2 (en) 2013-06-10 2017-02-07 Brocade Communications Systems, Inc. Ingress switch multicast distribution in a fabric switch
US9699001B2 (en) 2013-06-10 2017-07-04 Brocade Communications Systems, Inc. Scalable and segregated network virtualization
GB201312317D0 (en) 2013-07-09 2013-08-21 Syntaxin Ltd Cationic neurotoxins
US9806949B2 (en) 2013-09-06 2017-10-31 Brocade Communications Systems, Inc. Transparent interconnection of Ethernet fabric switches
US9912612B2 (en) 2013-10-28 2018-03-06 Brocade Communications Systems LLC Extended ethernet fabric switches
US9216210B2 (en) * 2013-12-23 2015-12-22 Dublin City University Multiprotease therapeutics for chronic pain
US9548873B2 (en) 2014-02-10 2017-01-17 Brocade Communications Systems, Inc. Virtual extensible LAN tunnel keepalives
US9975929B2 (en) 2014-03-05 2018-05-22 Merz Pharma Gmbh & Co. Kgaa Recombinant clostridial neurotoxins with increased duration of effect
US10581758B2 (en) 2014-03-19 2020-03-03 Avago Technologies International Sales Pte. Limited Distributed hot standby links for vLAG
US10476698B2 (en) 2014-03-20 2019-11-12 Avago Technologies International Sales Pte. Limited Redundent virtual link aggregation group
US10063473B2 (en) 2014-04-30 2018-08-28 Brocade Communications Systems LLC Method and system for facilitating switch virtualization in a network of interconnected switches
EP3760186A1 (de) 2014-04-30 2021-01-06 Allergan, Inc. Formulierungen von biologischen stoffen zur intravesikalen instillation
US9800471B2 (en) 2014-05-13 2017-10-24 Brocade Communications Systems, Inc. Network extension groups of global VLANs in a fabric switch
US11484580B2 (en) 2014-07-18 2022-11-01 Revance Therapeutics, Inc. Topical ocular preparation of botulinum toxin for use in ocular surface disease
US10616108B2 (en) 2014-07-29 2020-04-07 Avago Technologies International Sales Pte. Limited Scalable MAC address virtualization
JP6585157B2 (ja) 2014-07-31 2019-10-02 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 膀胱内注入用の生物製剤の処方
US9544219B2 (en) 2014-07-31 2017-01-10 Brocade Communications Systems, Inc. Global VLAN services
US9807007B2 (en) 2014-08-11 2017-10-31 Brocade Communications Systems, Inc. Progressive MAC address learning
US9524173B2 (en) 2014-10-09 2016-12-20 Brocade Communications Systems, Inc. Fast reboot for a switch
US9699029B2 (en) 2014-10-10 2017-07-04 Brocade Communications Systems, Inc. Distributed configuration management in a switch group
WO2016094555A1 (en) 2014-12-09 2016-06-16 New York University Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
US10900955B2 (en) 2014-12-19 2021-01-26 Merz Pharma Gmbh & Co. Kgaa Means and methods for the determination of the biological activity of BoNT/E in cells
US9626255B2 (en) 2014-12-31 2017-04-18 Brocade Communications Systems, Inc. Online restoration of a switch snapshot
US9628407B2 (en) 2014-12-31 2017-04-18 Brocade Communications Systems, Inc. Multiple software versions in a switch group
US9942097B2 (en) 2015-01-05 2018-04-10 Brocade Communications Systems LLC Power management in a network of interconnected switches
US10003552B2 (en) 2015-01-05 2018-06-19 Brocade Communications Systems, Llc. Distributed bidirectional forwarding detection protocol (D-BFD) for cluster of interconnected switches
PL3242884T3 (pl) 2015-01-09 2021-08-16 Ipsen Bioinnovation Limited Kationowe neurotoksyny
TWI704156B (zh) * 2015-03-04 2020-09-11 德商曼茲法瑪股份有限公司 用於增進肉毒桿菌神經毒素進入細胞之特定攝取的方法
US9807005B2 (en) 2015-03-17 2017-10-31 Brocade Communications Systems, Inc. Multi-fabric manager
US10038592B2 (en) 2015-03-17 2018-07-31 Brocade Communications Systems LLC Identifier assignment to a new switch in a switch group
US10579406B2 (en) 2015-04-08 2020-03-03 Avago Technologies International Sales Pte. Limited Dynamic orchestration of overlay tunnels
TW201718627A (zh) 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
US10439929B2 (en) 2015-07-31 2019-10-08 Avago Technologies International Sales Pte. Limited Graceful recovery of a multicast-enabled switch
BR112018003794A2 (pt) * 2015-08-27 2018-09-25 Massachusetts Inst Technology composições e métodos para o tratamento da dor
US10171303B2 (en) 2015-09-16 2019-01-01 Avago Technologies International Sales Pte. Limited IP-based interconnection of switches with a logical chassis
GB201517450D0 (en) 2015-10-02 2015-11-18 Ipsen Biopharm Ltd Method
US9912614B2 (en) 2015-12-07 2018-03-06 Brocade Communications Systems LLC Interconnection of switches based on hierarchical overlay tunneling
WO2017125487A1 (en) 2016-01-20 2017-07-27 Merz Pharma Gmbh & Co. Kgaa Novel recombinant clostridial neurotoxins with increased duration of effect
US11311633B2 (en) 2016-04-16 2022-04-26 University Of Florida Research Foundation, Incorporated Satiation peptides for weight loss and altered taste sensitivity
EP3263710A1 (de) * 2016-07-01 2018-01-03 Ipsen Biopharm Limited Herstellung von aktivierten clostridien-neurotoxinen
EP3504226A1 (de) * 2016-08-24 2019-07-03 President and Fellows of Harvard College Manipuliertes botulinumneurotoxin
EP3290437A1 (de) 2016-08-31 2018-03-07 Merz Pharma GmbH & Co. KGaA Neuartige rekombinante clostridienneurotoxine mit verkürzter wirkungsdauer
US10369190B2 (en) 2016-09-13 2019-08-06 Allergan, Inc. Non-protein clostridial toxin compositions
EP3312193A1 (de) 2016-10-19 2018-04-25 Merz Pharma GmbH & Co. KGaA Neuartige rekombinante botulinumneurotoxine mit beschleunigter wirkung
EP3333179A1 (de) 2016-12-07 2018-06-13 Merz Pharma GmbH & Co. KGaA Neuartiges rekombinantes botulinumneurotoxin mit beschleunigtem wirkungseintritt
EP3335719A1 (de) 2016-12-14 2018-06-20 Merz Pharma GmbH & Co. KGaA Neuartige rekombinante botulinumneurotoxine mit einer stabilisierten leichten kette
WO2018233813A1 (en) 2017-06-20 2018-12-27 Merz Pharma Gmbh & Co. Kgaa NOVEL RECOMBINANT BOTULINUM TOXINS WITH INCREASED DURATION
US11155802B2 (en) 2017-07-06 2021-10-26 Merz Pharma Gmbh & Co. Kgaa Recombinant botulinum neurotoxins with increased duration of effect
US20210008156A1 (en) 2017-10-26 2021-01-14 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum neurotoxins with increased duration of effect
US20200354706A1 (en) 2017-11-22 2020-11-12 Merz Pharma Gmbh & Co. Kgaa Novel recombinant botulinum toxin with increased duration of effect
EP3723784A4 (de) * 2017-12-15 2022-01-12 The Medical College of Wisconsin, Inc. Modifizierte clostridienneurotoxine als impfstoffe und konjugatimpfstoffplattformen
CN112351992A (zh) 2017-12-20 2021-02-09 阿勒根公司 肉毒杆菌毒素细胞结合结构域多肽及其用于皮肤再生的方法
WO2019243376A1 (en) 2018-06-18 2019-12-26 Ipsen Biopharm Limited Intramuscular injection of botulinum toxin for the treatment of vulvodynia
GB201815817D0 (en) 2018-09-28 2018-11-14 Ispen Biopharm Ltd Clostridial neurotoxins comprising and exogenous activation loop
GB201815844D0 (en) 2018-09-28 2018-11-14 Ipsen Biopharm Ltd Therapeutic & comestic uses of botulinum neurotoxin serotype e
US20220357314A1 (en) 2018-09-28 2022-11-10 Ipsen Biopharm Limited Cell-based Clostridal Neurotoxin Assays
GB201900621D0 (en) 2019-01-16 2019-03-06 Ipsen Biopharm Ltd Labelled polypeptides
GB201907016D0 (en) 2019-05-17 2019-07-03 Ipsen Biopharm Ltd Screening method to determine suitability for participation in a clinical trial
GB201914034D0 (en) 2019-09-30 2019-11-13 Ipsen Biopharm Ltd Treatment of neurological disorders
GB202001353D0 (en) 2020-01-31 2020-03-18 Ipsen Biopharm Ltd Treatment of skin conditions
GB202100566D0 (en) 2021-01-15 2021-03-03 Ipsen Biopharm Ltd Treatment of brain damage
CN114957482A (zh) * 2021-02-26 2022-08-30 重庆誉颜制药有限公司 一种经修饰的神经毒素的单链多肽及其用途
GB202103372D0 (en) 2021-03-11 2021-04-28 Ipsen Biopharm Ltd Modified clostridial neurotoxins
GB202104294D0 (en) 2021-03-26 2021-05-12 Ipsen Biopharm Ltd Clostridial neurotoxins comprising an exogenous activation loop
BR112023018473A2 (pt) 2021-03-30 2023-11-14 Ipsen Biopharm Ltd Neurotoxinas clostridiais cataliticamente inativas para o tratamento de dor e distúrbios inflamatórios
EP4313120A1 (de) 2021-03-30 2024-02-07 Ipsen Biopharm Limited Behandlung von schmerzen und entzündlichen erkrankungen
GB202116795D0 (en) 2021-11-22 2022-01-05 Ipsen Biopharm Ltd Treatment of visceral pain
WO2023105289A1 (en) 2021-12-06 2023-06-15 Dublin City University Methods and compositions for the treatment of pain
TW202339791A (zh) * 2022-04-01 2023-10-16 大陸商重慶譽顏製藥有限公司 一種肉毒毒素蛋白組合物、製備方法及其應用
GB202213479D0 (en) 2022-09-14 2022-10-26 Ipsen Biopharm Ltd Cell-free clostridial neurotoxin assays
CN116063535B (zh) * 2022-09-14 2023-09-26 北京市疾病预防控制中心 一种抗体或其抗原结合片段及其制备方法和应用
GB202214232D0 (en) 2022-09-28 2022-11-09 Ispen Biopharm Ltd Clostridial neurotoxins comprising an activating exogenous protease cleavage site
GB202214229D0 (en) 2022-09-28 2022-11-09 Ipsen Biopharm Ltd Clostridial neurotoxins comprising an activating endosomal protease cleavage site
WO2024069191A1 (en) 2022-09-30 2024-04-04 Ipsen Biopharm Limited Clostridial neurotoxin for use in a treatment of bladder pain syndrome

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5135736A (en) 1988-08-15 1992-08-04 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5919665A (en) † 1989-10-31 1999-07-06 Ophidian Pharmaceuticals, Inc. Vaccine for clostridium botulinum neurotoxin
AU1350792A (en) * 1991-01-16 1992-08-27 General Hospital Corporation, The Human galanin
GB9305735D0 (en) 1993-03-19 1993-05-05 North John R Novel agent for controlling cell activity
DE69511860T2 (de) 1994-05-31 2000-02-10 Allergan Inc Modifizierung von clostridium-toxinen und ihre anwendung als transport proteine
GB9508204D0 (en) * 1995-04-21 1995-06-07 Speywood Lab Ltd A novel agent able to modify peripheral afferent function
US7192596B2 (en) 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
GB9617671D0 (en) * 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
WO1998008540A1 (en) 1996-08-28 1998-03-05 Ophidian Pharmaceuticals, Inc. Multivalent vaccine for clostridium botulinum neurotoxin
US5939070A (en) * 1996-10-28 1999-08-17 Wisconsin Alumni Research Foundation Hybrid botulinal neurotoxins
GB9721189D0 (en) 1997-10-08 1997-12-03 Speywood Lab The Limited Analgesic conjugates
EP1073455B1 (de) 1998-04-29 2003-10-08 Allergan, Inc. Zusammensetzungen und methode zum verlängung der wirkung des clostridiumsneurotoxins
US20040071736A1 (en) * 1998-08-25 2004-04-15 Health Protection Agency Methods and compounds for the treatment of mucus hypersecretion
GB9818548D0 (en) * 1998-08-25 1998-10-21 Microbiological Res Authority Treatment of mucas hypersecretion
WO2000023427A1 (de) 1998-10-20 2000-04-27 Basf Aktiengesellschaft Verfahren zur herstellung von gegebenenfalls substituierten 1-methyl-6-halogenalkyluracilen
US6776990B2 (en) * 1999-04-08 2004-08-17 Allergan, Inc. Methods and compositions for the treatment of pancreatitis
US20080032931A1 (en) * 1999-08-25 2008-02-07 Steward Lance E Activatable clostridial toxins
US7132259B1 (en) 1999-08-25 2006-11-07 Allergan, Inc. Activatable recombinant neurotoxins
US7740868B2 (en) * 1999-08-25 2010-06-22 Allergan, Inc. Activatable clostridial toxins
US20030180289A1 (en) * 1999-09-23 2003-09-25 Foster Keith Alan Inhibition of secretion from non-neuronal cells
US6500436B2 (en) * 2000-01-19 2002-12-31 Allergan, Inc. Clostridial toxin derivatives and methods for treating pain
US7138127B1 (en) * 2000-01-19 2006-11-21 Allergan, Inc. Clostridial toxin derivatives and methods for treating pain
US6641820B1 (en) * 2000-01-19 2003-11-04 Allergan, Inc. Clostridial toxin derivatives and methods to treat pain
US6827931B1 (en) * 2000-10-20 2004-12-07 Allergan, Inc. Method for treating endocrine disorders
US6831059B2 (en) * 2000-10-20 2004-12-14 Allergan, Inc. Compositions and methods for treating gonadotrophin related illnesses
JP2005519061A (ja) 2002-01-10 2005-06-30 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー パピローマウイルス感染症を治療するための、ｃｏｘ−２阻害剤と抗ウイルス剤との組み合わせ使用
GB0321344D0 (en) 2003-09-11 2003-10-15 Health Prot Agency Re-targeted toxin conjugates
US7811584B2 (en) * 2004-06-30 2010-10-12 Allergan, Inc. Multivalent clostridial toxins
US20060024331A1 (en) 2004-08-02 2006-02-02 Ester Fernandez-Salas Toxin compounds with enhanced membrane translocation characteristics
DE102004043009A1 (de) 2004-09-06 2006-03-23 Toxogen Gmbh Transportprotein zum Einbringen chemischer Verbindungen in Nervenzellen
PL1830872T3 (pl) * 2004-12-01 2011-09-30 Sec Dep For Health Białka fuzyjne
GB0426397D0 (en) 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
US7659092B2 (en) * 2004-12-01 2010-02-09 Syntaxin, Ltd. Fusion proteins
AU2005311098B2 (en) 2004-12-01 2011-08-11 Allergan, Inc. Non-cytotoxic protein conjugates
GB0426394D0 (en) * 2004-12-01 2005-01-05 Health Prot Agency Fusion proteins
AU2006225116B2 (en) * 2005-03-15 2012-04-19 Allergan, Inc. Modified Clostridial toxins with altered targeting capabilities for Clostridial toxin target cells

Also Published As

Publication number Publication date
KR20020034178A (ko) 2002-05-08
EP2267010B1 (de) 2014-05-07
EP2267010A2 (de) 2010-12-29
US7749514B2 (en) 2010-07-06
US20090004224A1 (en) 2009-01-01
US7985411B2 (en) 2011-07-26
CA2380457A1 (en) 2001-03-01
US7422877B2 (en) 2008-09-09
US20070259401A1 (en) 2007-11-08
EP1206554B1 (de) 2006-12-13
US7132259B1 (en) 2006-11-07
DE60032367T3 (de) 2011-03-10
EP2267009B1 (de) 2014-10-29
US20090030182A1 (en) 2009-01-29
WO2001014570A1 (en) 2001-03-01
EP2264052A3 (de) 2011-04-20
US20080161226A1 (en) 2008-07-03
HK1046020A1 (en) 2002-12-20
US20080311622A1 (en) 2008-12-18
EP2267009A3 (de) 2011-04-20
EP1206554B2 (de) 2010-10-20
US7897157B2 (en) 2011-03-01
US8119370B2 (en) 2012-02-21
EP2267009A2 (de) 2010-12-29
US20090005313A1 (en) 2009-01-01
US8003351B2 (en) 2011-08-23
US20060099672A1 (en) 2006-05-11
KR100876060B1 (ko) 2008-12-26
US7959933B2 (en) 2011-06-14
EP2267008A2 (de) 2010-12-29
CN1371424A (zh) 2002-09-25
US20090030188A1 (en) 2009-01-29
EP1700918A2 (de) 2006-09-13
AU7573100A (en) 2001-03-19
ES2277854T3 (es) 2007-08-01
HK1046020B (zh) 2007-05-11
DE60032367T2 (de) 2007-09-27
CN1214114C (zh) 2005-08-10
EP1700918A3 (de) 2007-09-05
US7419676B2 (en) 2008-09-02
US20080081355A1 (en) 2008-04-03
AU777556B2 (en) 2004-10-21
EP2264052A2 (de) 2010-12-22
US20090087458A1 (en) 2009-04-02
US7709228B2 (en) 2010-05-04
JP2003507073A (ja) 2003-02-25
US20090081730A1 (en) 2009-03-26
EP2267008B1 (de) 2014-07-02
US8273358B2 (en) 2012-09-25
US20090042270A1 (en) 2009-02-12
BR0012759A (pt) 2002-04-02
US20080221012A1 (en) 2008-09-11
US8071110B2 (en) 2011-12-06
EP2267010A3 (de) 2011-04-20
US8211671B2 (en) 2012-07-03
US20090069238A1 (en) 2009-03-12
ES2277854T5 (es) 2011-02-04
ATE348178T1 (de) 2007-01-15
EP1206554A1 (de) 2002-05-22
EP1700918B1 (de) 2014-01-15
US20080182294A1 (en) 2008-07-31
EP2267008A3 (de) 2011-04-20

Similar Documents

Publication Publication Date Title
DE60032367D1 (de) Aktivierbare rekombinante neurotoxine
ATE394484T1 (de) Smad 6 und dessen anwendungen
DE60141546D1 (de) Polypeptide enthaltend extrazellulären Domäne von IL-20RA und/oderr IL-20RB
WO2001053312A8 (en) Novel nucleic acids and polypeptides
WO2001053455A3 (en) Novel nucleic acids and polypeptides
WO2001075067A3 (en) Novel nucleic acids and polypeptides
WO2001057188A3 (en) Novel nucleic acids and polypeptides
WO2001057190A3 (en) Novel nucleic acids and polypeptides
WO2001066689A3 (en) Novel nucleic acids and polypeptides
DE60235761D1 (de) Isoform des vegfs
WO2004009834A3 (en) Novel nucleic acids and secreted polypeptides
DE60142508D1 (de) Menschliche aminoacyl-trna synthetase polypeptide zur regulation der angiogenese
WO2001088088A3 (en) Novel nucleic acids and polypeptides
WO2003054152A3 (en) Novel nucleic acids and polypeptides
WO2003025148A3 (en) Novel nucleic acids and polypeptides
WO2002070539A3 (en) Novel nucleic acids and polypeptides
WO2002081731A3 (en) Novel nucleic acids and polypeptides
WO2002059260A3 (en) Nucleic acids and polypeptides
NO20073914L (no) Biologisk aktive peptider
WO2002018424A3 (en) Nucleic acids and polypeptides
WO2001079449A3 (en) Novel nucleic acids and polypeptides
WO2003080795A3 (en) Novel nucleic acids and secreted polypeptides
WO2002044340A3 (en) Novel nucleic acids and polypeptides
DK0942992T3 (da) O-fucosyltransferase
WO2003025142A3 (en) Novel nucleic acids and secreted polypeptides

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings