DE60045751D1 - Therapeutische Behandlung androgenrezeptorbedingter Leiden - Google Patents

Therapeutische Behandlung androgenrezeptorbedingter Leiden

Info

Publication number
DE60045751D1
DE60045751D1 DE60045751T DE60045751T DE60045751D1 DE 60045751 D1 DE60045751 D1 DE 60045751D1 DE 60045751 T DE60045751 T DE 60045751T DE 60045751 T DE60045751 T DE 60045751T DE 60045751 D1 DE60045751 D1 DE 60045751D1
Authority
DE
Germany
Prior art keywords
androgen receptor
therapeutic treatment
related conditions
prostate cancer
provides methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60045751T
Other languages
English (en)
Inventor
James M Frincke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harbor Biosciences Inc
Original Assignee
Harbor Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harbor Biosciences Inc filed Critical Harbor Biosciences Inc
Application granted granted Critical
Publication of DE60045751D1 publication Critical patent/DE60045751D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/004—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0048—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
DE60045751T 1999-09-30 2000-09-28 Therapeutische Behandlung androgenrezeptorbedingter Leiden Expired - Lifetime DE60045751D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15734799P 1999-09-30 1999-09-30
US15727599P 1999-09-30 1999-09-30
US16611699P 1999-11-16 1999-11-16

Publications (1)

Publication Number Publication Date
DE60045751D1 true DE60045751D1 (de) 2011-04-28

Family

ID=27387982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60045751T Expired - Lifetime DE60045751D1 (de) 1999-09-30 2000-09-28 Therapeutische Behandlung androgenrezeptorbedingter Leiden

Country Status (9)

Country Link
US (7) US7776845B2 (de)
EP (4) EP1228083A2 (de)
AT (1) ATE501722T1 (de)
AU (1) AU7736300A (de)
CA (3) CA2669753C (de)
DE (1) DE60045751D1 (de)
DK (1) DK1955700T3 (de)
PT (1) PT1955700E (de)
WO (1) WO2001023405A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070129282A1 (en) * 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
US20060079492A1 (en) * 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US20080015174A1 (en) * 1998-11-24 2008-01-17 Reading Christopher L Metabolic Disease Treatments
CA2669753C (en) 1999-09-30 2012-06-26 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
AU2001241779A1 (en) 2000-02-25 2001-09-03 Hollis-Eden Pharmaceuticals, Inc. Method of treatment of prostate cancer
FR2831441B1 (fr) 2001-10-25 2003-12-26 Oreal Utilisation cosmetique de derives de la dhea
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
CA2496867A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
ATE452641T1 (de) 2002-09-05 2010-01-15 Pantarhei Bioscience Bv Orale pharmazeutische zusammensetzung enthaltend 15-hydroxytestosteron und seine derivate
EP1615944A4 (de) * 2003-04-01 2010-08-11 Harbor Biosciences Inc Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren
EP1807118B8 (de) * 2004-09-29 2014-04-23 Harbor Therapeutics, Inc. Steroidanaloga sowie charakterisierungs- und behandlungsverfahren
US7910755B2 (en) 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) * 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
ES2389743T3 (es) * 2006-04-22 2012-10-31 Harbor Biosciences, Inc. Medicamentos y usos
EP1854465A1 (de) * 2006-05-12 2007-11-14 Alexander Tobias Teichmann Verwendung von 4,17 beta-dihydroxyandrost-4-ene-3-one zur Behandlung von Krebs
US8460240B2 (en) * 2006-08-07 2013-06-11 W. L. Gore & Associates, Inc. Inflatable toroidal-shaped balloons
US20080125711A1 (en) * 2006-08-07 2008-05-29 Alpini Alfred A Catheter balloons with integrated non-distensible seals
US8486926B2 (en) * 2006-11-17 2013-07-16 Harbor Therapeutics, Inc. Steroid tetrol solid state forms
US20080153792A1 (en) * 2006-11-17 2008-06-26 Frincke James M Drug Identification and Treatment Method
US8354396B2 (en) * 2006-11-17 2013-01-15 Harbor Therapeutics, Inc. Drug identification and treatment method
US8217025B2 (en) * 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
US20080221074A1 (en) * 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
EP2185112A4 (de) * 2007-08-21 2012-01-18 Harbor Biosciences Inc Stabilisierte therapeutische zusammensetzungen und formulierungen
EP2949361B1 (de) * 2007-11-13 2017-03-22 Athenion AG C-19-steroide zur behandlung der cellulite
CN103467554A (zh) 2008-02-05 2013-12-25 哈博生物科学公司 药学固体形式
PL2273994T3 (pl) 2008-04-03 2016-05-31 Neurmedix Inc Postacie w stanie stałym leku
EP2300489B1 (de) * 2008-06-06 2015-11-11 Harbor Therapeutics, Inc. Verfahren zur herstellung von 17-alkinyl-7-hydroxysteroiden und verwandten verbindungen
EP2334686B1 (de) 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin-analoga und ihre synthese
US20100227841A1 (en) * 2008-09-24 2010-09-09 Harbor BioSciencs, Inc. Patient populations and treatment methods
US20100075937A1 (en) * 2008-09-24 2010-03-25 Hollis-Eden Pharmaceuticals, Inc. Patient populations and treatment methods
US20100222315A1 (en) * 2008-09-24 2010-09-02 Harbor BioSciencs, Inc. Patient populations and treatment methods
CA2761389A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
CA2782266A1 (en) * 2009-11-30 2011-06-03 Harbor Biosciences, Inc. Anticancer compounds and screening method
AU2014236135A1 (en) * 2013-03-14 2015-09-10 Thomas Jefferson University Androgen receptor down-regulating agents and uses thereof
US9808472B2 (en) 2013-08-12 2017-11-07 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
AU2014369834B2 (en) 2013-12-24 2018-12-20 President And Fellows Of Harvard College Cortistatin analogues and syntheses and uses thereof
EP3294298A4 (de) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin-analoga, synthese und verwendungen
EP3316889A4 (de) 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin-analoga sowie synthese und verwendungen davon

Family Cites Families (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2332486A (en) 1935-02-23 1943-10-19 Schering Corp Acyl compounds of polycyclic alcohols with germinal gland hormone characteristics and a method for producing the same
US2308833A (en) 1935-06-18 1943-01-19 Ciba Pharm Prod Inc Polynuclear cyclic oxyketones and derivatives thereof and process of making same
US2243887A (en) 1935-11-09 1941-06-03 Schering Corp Tertiary carbinols of the cyclopentano-polyhydrophenanthrene series and a method of producing the same
US2251939A (en) 1935-11-22 1941-08-12 Schering Corp Tertiary alcohols of the cyclopentano polyhydro phenanthrene series and a method of producing the same
US2308834A (en) 1936-06-15 1943-01-19 Ciba Pharm Prod Inc Polynuclear cyclic oxyketones and derivatives thereof and process of making same
CH202847A (de) 1937-06-26 1939-02-15 Chem Ind Basel Verfahren zur Darstellung von Acetylen-Derivaten der Cyclopentanopolyhydrophenanthren-Reihe.
US2267258A (en) 1937-08-12 1941-12-23 Ciba Pharm Prod Inc Derivatives of saturated and unsaturated compounds of the cyclopentanopolyhydrophenanthrene series and process of producing same
US2266778A (en) 1937-10-05 1941-12-23 Schering Corp Unsaturated compounds of the cyclopentanopolyhydrophenanthrene series with an unsaturated side chain in the cyclopentano nucleus and a process for their manufacture
US2318105A (en) 1938-07-23 1943-05-04 Ciba Pharm Prod Inc Hydrated acetylene derivatives of the cyclopentanopolyhydrophenanthrene series and process of preparing same
US2357364A (en) 1940-03-22 1944-09-05 Squibb & Sons Inc Keto derviatives of 17-ethynyl-17-hydroxy-perhydrocyclopentenophenanthrenes and process of preparing them
US2713062A (en) 1952-08-08 1955-07-12 Schering Ag 3-methyl-17-ethinyl androstandiols
NL88180C (de) 1953-08-26
US2868811A (en) * 1955-07-21 1959-01-13 Sterling Drug Inc 3beta-acyloxy-17beta-hydroxy-17alpha-ethynyl-5-androstenes and androstanes and theirpreparation
US2830063A (en) 1955-07-21 1958-04-08 Sterling Drug Inc 3beta-cycloalkylacyloxy -17beta-hydroxy-17alpha-ethynyl-5-androstenes and androstanes and their preparation
US2844602A (en) 1956-01-31 1958-07-22 Syntex Sa 4-methyl testosterone compounds
CH366275A (de) 1956-02-07 1962-12-31 Syntex Sa Verfahren zur Herstellung von Steroiden
US3262949A (en) 1956-11-13 1966-07-26 Syntex Corp 7-methyl androstane compounds
US2833793A (en) 1957-09-30 1958-05-06 Searle & Co 17-oxygenated derivatives of 5-androstene-1, 3-diol
US2838500A (en) 1957-11-29 1958-06-10 Upjohn Co 6-fluoro steroids
US2911418A (en) 1959-01-02 1959-11-03 Searle & Co 16-halo 17-oxygenated androst-5-en-3-ols and esters
US3029263A (en) 1959-12-24 1962-04-10 Upjohn Co 7-methyl-4, 6-androstadienes
US3045032A (en) 1960-02-08 1962-07-17 Schering Corp Fluorinated androstanes
US3014935A (en) 1960-06-15 1961-12-26 Searle & Co 5alpha-estrane-3alpha, 17beta-diols and esters thereof
US3148198A (en) 1960-09-06 1964-09-08 Searle & Co 3, 17-bisoxygenated 16alpha, 16beta-difluoroandrostenes and process
US3210249A (en) 1962-02-01 1965-10-05 Merck Ag Fa E Pharmaceutical composition comprising 7-methoxy-17alpha-methyl-testosterone
BE639453A (de) 1962-06-18
US3187023A (en) 1962-10-18 1965-06-01 Schering Corp 16, 16-difluoro-17alpha-halogenoethinyl androstanes
US3200113A (en) * 1963-01-09 1965-08-10 Sterling Drug Inc 7-cyano steroids and derivatives thereof
US3176030A (en) 1963-10-16 1965-03-30 Lasdon Foundation Inc 16alpha-lowerhydrocarbon-androsten-16beta-ol-3-one and 16-alpha-lowerhydrocarbon-androsten-16beta-ol-3-ol compounds
DE1240859B (de) 1963-11-09 1967-05-24 Schering Ag Verfahren zur Herstellung von Androstan-1alpha, 3alpha, 17beta-triol und seinen Estern
GB1093125A (en) 1963-11-28 1967-11-29 Novo Terapeutisk Labor As Improvements in or relating to new and therapeutically active derivatives of 1,2-cyclopentanoperhydrophen-anthrene
US3522243A (en) 1964-03-17 1970-07-28 Sterling Drug Inc Omega-amino 1-alkynyl steroids and reduction products thereof
BE666194A (de) 1964-06-30
DE1235316B (de) 1964-11-17 1967-03-02 Schering Ag Verfahren zur Herstellung von 17alpha-AEthinyl-delta 1,3,5(10)-oestratrien-3, 16alpha17beta-triol sowie seiner Ester und AEther
US3299107A (en) * 1965-02-12 1967-01-17 Searle & Co 17-(unsaturated hydrocarbon-substituted)-3-hydroxyimino-5alpha-androstan-17beta-ols,alkyl and acyl derivatives thereof
US3357888A (en) 1965-04-07 1967-12-12 Upjohn Co 4, 7-dimethyl androstene derivatives
DE1593090A1 (de) 1966-09-26 1970-06-04 Merck Ag E 17 alpha-Cyanaethinylsteroide sowie Verfahren zu ihrer Herstellung
BE754111A (fr) 1969-07-29 1971-01-29 Upjohn Co Nouveaux 7alpha- et 7beta-methyl-3alpha,5alpha- cycloandrostanes et composes analogues 19-nor et leur procede de preparation
US3654320A (en) 1970-03-24 1972-04-04 Upjohn Co Organic processes
US3711606A (en) 1970-09-02 1973-01-16 Crown Zellerbach Corp Enhancing tissue penetration of physiologically active steroidal agents with dmso
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3869467A (en) 1972-06-05 1975-03-04 Hoffmann La Roche 17-{62 -Hydroxy-17-{60 -methyl-5-{60 -androstano{9 3,2-c{9 or{8 2,3-d{9 isoxazoles
US3962275A (en) 1972-06-05 1976-06-08 Hoffmann-La Roche Inc. 7-oxa steroids
US3734935A (en) 1972-07-21 1973-05-22 American Home Prod Biologically active 17alpha-ethynyl-16,17-dihydroxy-13-alkygonanes
US3944546A (en) * 1972-08-04 1976-03-16 E. R. Squibb & Sons, Inc. Cyanomethylthioacetylcephalosporins
US3976691A (en) 1972-12-11 1976-08-24 E. I. Du Pont De Nemours And Company Dialkylaminosulfur trifluorides as fluorinating agents
NL7305171A (de) 1973-04-13 1974-10-15
DK290774A (de) 1973-06-08 1975-02-03 Schering Ag
US4071625A (en) 1974-05-13 1978-01-31 Richardson-Merrell Inc. 19-Oxygenated-5α-androstanes for the enhancement of libido
YU243975A (en) 1974-10-14 1982-06-30 Schering Ag Process for obtaining 7-hydroxyestradiols
US4059630A (en) 1976-02-26 1977-11-22 The Johns Hopkins University Anti-androgenic steroids
GB1523965A (en) 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
DE2705917C3 (de) 1977-02-09 1980-05-08 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 3 ß , 16 ß -Dihydroxy-5-androsten- 17-on durch mikrobiologische Hydrolyse
DE2817157A1 (de) 1978-04-17 1979-10-25 Schering Ag Verwendung von antioestrogenen und antigonadotrop wirkenden antiandrogenen zur prophylaxe und therapie der prostatahyperplasie
US4268441A (en) 1979-03-13 1981-05-19 Interx Research Corporation Prodrugs for improved bioavailability of certain Δ4 -3-ketosteroidal sex hormones
NZ193564A (en) 1979-05-02 1985-01-31 Aruba Pty Ltd Steroid alkaloids from solanum sodomeum and pharmaceutical compositions
DE2943776A1 (de) 1979-10-26 1981-05-14 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
US4542129A (en) 1982-08-16 1985-09-17 Norman Orentreich DHEA Formulations and methods for treating dry skin
US5656621A (en) 1983-08-02 1997-08-12 Research Corporation Tech., Inc. Steroids useful as anti-cancer and anti-obesity agents
US5714481A (en) 1983-08-02 1998-02-03 Research Corporation Technologies, Inc. Derivatives of 5-androsten-17 ones and 5-androstan-17-ones
US5157031A (en) 1983-08-02 1992-10-20 Research Corporation Technologies, Inc. Method for prophylaxis of obesity
US5804576A (en) 1983-08-02 1998-09-08 Research Corporation Technologies, Inc. Derivatives of 5-androsten-17-ones and 5-androstan-17-ones
AU582122B2 (en) 1983-08-02 1989-03-16 Research Corporation Steroids useful as anti-cancer,anti-obesity, anti-hyperglycemic,anti-autoimmune and anti-hyperchlesterolemic agents
US4666898A (en) 1983-12-28 1987-05-19 Jackson Lab. Treatment of obesity, diabetes and other symptoms of hypercorticoidism using etiocholanolones
SE8403905D0 (sv) 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US4659695A (en) 1985-02-08 1987-04-21 Fernand Labrie Method of treatment of prostate cancer
US4602008A (en) 1984-12-14 1986-07-22 Progenics, Inc. Alkylated etiocholanolones and use as an anti-diabetic, anti-obesity and erythropoietic agent
JPS62175497A (ja) 1986-01-28 1987-08-01 Wakunaga Pharmaceut Co Ltd 胆汁酸誘導体およびその製造法
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
NL194728C (nl) 1987-04-16 2003-01-07 Hollis Eden Pharmaceuticals Farmaceutisch preparaat geschikt voor de profylaxe of therapie van een retrovirale infectie of een complicatie of gevolg daarvan.
US5075464A (en) * 1987-04-22 1991-12-24 Merrell Dow Pharmaceuticals Inc. 17β-(cyclopropylamino)androstene derivatives
US5175154A (en) 1987-11-25 1992-12-29 Research Corporation Technologies, Inc. 5 α-pregnan-20-ones and 5-pregnen-20-ones and related compounds
US5028631A (en) 1987-11-25 1991-07-02 Schwartz Arthur G Homoandrostan-17-one and homoandrosten-17-ones
US5001119A (en) 1987-11-25 1991-03-19 Schwartz Arthur G 16-substituted androstanes and 16-substituted androstenes
US4898694A (en) * 1987-11-25 1990-02-06 Schwartz Arthur G 17-Hydroxy-steroids
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US4989694A (en) 1988-03-09 1991-02-05 Hitachi, Ltd. Elevator group supervisory system
US5614620A (en) 1988-03-30 1997-03-25 Arch Development Corporation DNA binding proteins including androgen receptor
US5208263A (en) * 1988-09-30 1993-05-04 Arch Development Corporation Anti-androgen compounds
US5043165A (en) 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
US5461042A (en) 1988-12-30 1995-10-24 Loria; Roger M. Regulation of the immune system
US5407684A (en) 1988-12-30 1995-04-18 Virginia Commonwealth University Use of DHEA as a medicinal
US5077284A (en) 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5372996A (en) 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
DE3918543A1 (de) 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
DK0595796T3 (da) 1989-07-07 2003-05-05 Endorech Inc Fremgangsmåde til behandling af androgen-relaterede sygdomme
ATE170753T1 (de) 1989-07-07 1998-09-15 Endorecherche Inc Androgenderivate zur hemming der aktivität der sexualsteroide
US4978532A (en) 1989-08-11 1990-12-18 Pharmedic Co. Dosage form for administration of dehydroepiandrosterone
US4970204A (en) 1989-08-23 1990-11-13 Smithkline Beecham Corporation 3-substituted nitro-steroid derivatives as 5-α-reductase inhibitors
US5837269A (en) 1989-09-25 1998-11-17 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
US5518725A (en) 1989-09-25 1996-05-21 University Of Utah Research Foundation Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
US5919465A (en) 1989-09-25 1999-07-06 University Of Utah Research Foundation Methods for augmenting immunological responses through the administration of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S)
US5824313A (en) 1989-09-25 1998-10-20 University Of Utah Research Foundation Vaccine compositions and method for induction of mucosal immune response via systemic vaccination
CA2066716A1 (en) 1989-09-25 1991-03-26 Raymond A. Daynes Use of steroid hormones in compositions for inducing t cell lymphokine production
US5562910A (en) 1989-09-25 1996-10-08 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
DE3938296A1 (de) 1989-11-17 1991-05-23 Waldinger Maschinenbau Gmbh Verfahren und vorrichtung zum verpacken langgestreckter packungen wie arzneimittelampullen in verpackungshuellen
US5641768A (en) 1989-11-17 1997-06-24 Loria; Roger M. 5-androstene 3β, 17β diol for treatment
CA2028759A1 (en) 1989-11-22 1991-05-23 Jean-Marie Cassal Steroids
SE465524B (sv) * 1990-02-08 1991-09-23 Asea Brown Boveri Anordning foer oeverlast- och kortslutningsskydd i elektriska anlaeggningar
US5137882A (en) 1990-06-11 1992-08-11 Holt Dennis A Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
US5807848A (en) 1990-08-29 1998-09-15 Humanetics Corporation Use of dehydroepeiandrosterone-3-carboxylates to control body weight
US5292730A (en) 1990-08-29 1994-03-08 Humanetics Corporation Modulation of immune system with Δ5-androstenes
US5641766A (en) 1990-08-29 1997-06-24 Humanetics Corporation UP-regulation of immune system with Δ 5-Androstenes
US5707983A (en) 1990-08-29 1998-01-13 Humanetics Corporation Treatment of alzheimer's disease and modulation of immune system with Δ5-androstenes
US5585371A (en) 1990-08-29 1996-12-17 Humanetics Corporation Treatment of immune system with Δ5-androstenes
US5506223A (en) 1990-08-29 1996-04-09 Humanetics Corporation Δ5-androstenes useful for promoting weight maintenance or weight loss and treatment process
JP2973031B2 (ja) 1990-08-29 1999-11-08 ヒューマネティックス コーポレーション 減量を促進するための置換δ５−アントロステンを含む医薬
US5681964A (en) 1990-10-23 1997-10-28 University Of Kentucky Research Foundation Permeable, non-irritating prodrugs of nonsteroidal and steroidal agents
US5925774A (en) 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
US5110810A (en) 1991-02-08 1992-05-05 Virginia Commonwealth University Method of using dehydroepiandrosterone and dehydroepiandrosterone-sulfate as inhibitors of platelet aggregation
US5162198A (en) 1991-02-08 1992-11-10 Virginia Commonwealth University Method of using dehydroepiandrosterone and dehydroepiandrosterone-sulfate as inhibitors of thrombuxane production and platelet aggregation
US5206008A (en) 1991-04-15 1993-04-27 Virginia Commonwealth University Enhancement of immune response
US5338837A (en) 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
US5627270A (en) 1991-12-13 1997-05-06 Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
AU676470B2 (en) 1992-02-24 1997-03-13 East Carolina University Method of inhibiting carcinogenesis by treatment with dehydroepiandrosterone and analogs thereof
ATE253645T1 (de) 1992-04-01 2003-11-15 Univ Johns Hopkins Med Verfahren zur bestimmung von säugetier nukleinsäuren aus stuhlproben und dafür benötigte reagenzien
US5780676A (en) 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US5922701A (en) 1992-05-01 1999-07-13 University Of Utah Research Foundation Method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue
US5686438A (en) 1993-03-09 1997-11-11 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5237064A (en) 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
AU680818B2 (en) 1992-05-21 1997-08-14 Endorecherche Inc. Improved antiandrogens
UA35589C2 (uk) 1992-05-21 2001-04-16 Андорешерш Інк. ІНГІБІТОРИ ТЕСТОСТЕРОН 5-<font face="Symbol">a</font>-РЕДУКТАЗИ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ІНГІБУВАННЯ АКТИВНОСТІ ТЕСТОСТЕРОН 5-<font face="Symbol">a</font>-РЕДУКТАЗИ
JPH0653542A (ja) 1992-07-30 1994-02-25 Eastman Kodak Japan Kk 発光ダイオードアレイ
FR2696934B1 (fr) 1992-10-20 1995-06-02 Conservatoire Nal Arts Metiers Dérivés de stéroïdes naturels 3B hydroxyles ayant des propriétés de déclenchement et de stimulation de l'immunité, composition les contenant et procédé pour les obtenir.
US5561124A (en) 1992-11-18 1996-10-01 Webb; Robert L. 17-α-acyl steroids which inhibit 5-α-reductase
AU686120B2 (en) 1993-01-19 1998-02-05 Endorecherche Inc. Therapeutic methods & delivery systems utilizing sex steroid precursors and novel steroidal derivatives and pharmaceutical compositions thereof
US5776923A (en) 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
EP0688220B1 (de) 1993-03-09 2004-11-24 University of Utah Research Foundation Verwendung von dhea oder dessen derivate zur herstellung eines medikaments zur vorbeugung von progressiver gewebe-nekrose, reperfusionsschädigung, bakterieller translokation und vom atemnotsyndrom bei erwachsenen
US5587369A (en) 1993-03-09 1996-12-24 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5635496A (en) 1993-03-09 1997-06-03 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5846963A (en) 1995-06-07 1998-12-08 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5811418A (en) 1993-03-09 1998-09-22 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome
US5977095A (en) 1993-03-09 1999-11-02 University Of Utah Research Foundation Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and respiratory distress syndrome
US5387583A (en) * 1993-04-20 1995-02-07 Loria; Roger M. Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof
US5504074A (en) 1993-08-06 1996-04-02 Children's Medical Center Corporation Estrogenic compounds as anti-angiogenic agents
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
US5922703A (en) 1993-09-24 1999-07-13 The Procter & Gamble Company Urethane-containing aminosteroid compounds
NZ274082A (en) 1993-09-24 1998-07-28 Procter & Gamble 14-aminosteroid derivatives substituted in position-3 by a deoxy and oxygen substituted monosaccharide residue
EP0721956B1 (de) 1993-09-29 2000-08-02 Nissin Shokuhin Kabushiki Kaisha In stellung 21 substituierte steroide
US5478566A (en) 1993-09-29 1995-12-26 Loria; Roger M. Stimulation of cytokine production
JP3862295B2 (ja) 1993-09-30 2006-12-27 独立行政法人理化学研究所 抗肥満剤
AU7978794A (en) 1993-10-13 1995-05-04 Neurocrine Biosciences, Inc. 3,17-dihydroxy-3,7,16 and/or 17-methyl-androst-5-ene compounds, derivatives thereof, and their use
US5677336A (en) 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
US5424563A (en) * 1993-12-27 1995-06-13 Harris Corporation Apparatus and method for increasing breakdown voltage ruggedness in semiconductor devices
WO1995018821A2 (en) 1994-01-06 1995-07-13 Sri International Novel antiandrogenic agents and related pharmaceutical compositions and methods of use
US5527788A (en) 1994-01-18 1996-06-18 Louisiana State Univ. Medical Center Foundation Method and composition for treating obesity comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent
DK0752860T3 (da) 1994-02-14 2000-11-13 Euro Celtique Sa Androstaner og pregnaner til allosterisk modulering af GABA-receptor
US5939545A (en) 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
US5567830A (en) 1994-02-14 1996-10-22 Cocensys, Inc. Process for synthesis of acetylenic carbinols
US5574022A (en) 1994-04-14 1996-11-12 The Center For Innovative Technology Method of attenuating physical damage to the spinal cord
US5681835A (en) 1994-04-25 1997-10-28 Glaxo Wellcome Inc. Non-steroidal ligands for the estrogen receptor
US5523346A (en) 1994-06-10 1996-06-04 W. L. Gore & Associates, Inc. Seeded microemulsion polymerization for the production of small polymer particles
US5665756A (en) * 1994-08-03 1997-09-09 Hoechst Marion Roussel, Inc. Aminoalkyloximes useful in the treatment of depression and obsessive compulsive disorders
US5792757A (en) 1994-08-04 1998-08-11 Pherin Pharmaceuticals 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function
US5559107A (en) 1994-10-20 1996-09-24 Gates; Stephen Regulation of immune response
US5776921A (en) 1994-10-20 1998-07-07 Gates; Stephen Compositions for regulation of immune responses
US5693647A (en) 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US6696459B1 (en) 1994-12-22 2004-02-24 Ligand Pharmaceuticals Inc. Steroid receptor modulator compounds and methods
US5656613A (en) 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
US5886005A (en) 1995-01-17 1999-03-23 Merck & Co., Inc. 4-Aza-19-norandrostane derivatives
US5660835A (en) 1995-02-24 1997-08-26 East Carolina University Method of treating adenosine depletion
US5856340A (en) 1995-02-28 1999-01-05 Eli Lilly And Company Method of treating estrogen dependent cancers
US6150336A (en) 1995-05-29 2000-11-21 Pfizer Inc. Steroidal glycosides
AU725214B2 (en) 1995-06-06 2000-10-05 Euro-Celtique S.A. Neuroactive steroids of the androstane and pregnane series
US5859000A (en) 1995-06-07 1999-01-12 University Of Utah Research Foundation Method for reducing mast cell mediated allergic reactions
US5591736A (en) 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
US5736537A (en) 1995-09-12 1998-04-07 Estee Lauder, Inc. Dehydroep:androsterone sailcylate useful against skin atrophy
HUP9801834A3 (en) 1995-10-12 2000-06-28 Supergen Inc Emeryville Liposome formulations of 5beta steroids
ES2192221T3 (es) 1995-10-30 2003-10-01 Oleoyl Estrone Developments S Monoesteres de oleato de estrogenos para el tratamiento de la obesidad o el sobrepeso.
US5824668A (en) 1996-11-07 1998-10-20 Supergen, Inc. Formulation for administration of steroid compounds
US5981744A (en) 1995-12-11 1999-11-09 G. D. Searle And Co. Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
US5744453A (en) 1996-01-05 1998-04-28 Mintz; Clifford S. Polyamine conjugates for treatment of infection
US5863910A (en) 1996-01-12 1999-01-26 Bolonick; Joel Treatment of chronic inflammatory disorders of the gastrointestinal tract
TW442286B (en) 1996-02-28 2001-06-23 Pfizer New therapeutic uses of estrogen agonists
DK0925064T3 (da) * 1996-04-11 2003-10-20 Roger M Loria 5-Androsten-3-beta,17-alpha-diol som inhibitor for tumorvækst
US5789170A (en) 1996-05-23 1998-08-04 Wisconsin Alumni Research Foundation Specific co-activator for human androgen receptor
GB9612990D0 (en) 1996-06-20 1996-08-21 Stanford Rock Ltd Compositions and methods for the treatment of chronic infections
EP0918774B9 (de) 1996-06-27 2002-04-10 Ligand Pharmaceuticals Incorporated Androgen rezeptor modulator verbindungen und verfahren
US5709878A (en) 1996-08-02 1998-01-20 Rosenbaum; Jerry Transdermal delivery of dehydroepiandrosterone
US5930728A (en) 1996-08-29 1999-07-27 Ericsson Inc. Up converted home base station
US6054432A (en) 1996-09-12 2000-04-25 Asta Medica Aktiengesellschaft Means for treating prostate hypertrophy and prostate cancer
US5891865A (en) 1996-10-04 1999-04-06 Wisconsin Alumni Research Foundation Treatment of arthritic disease induced by infectious agents
US5872147A (en) 1996-12-05 1999-02-16 Bio-Technology General Corp. Use of oxandrolone in the treatment of chronic obstructive pulmonary disease
US5945412A (en) 1996-12-09 1999-08-31 Merck & Co., Inc. Methods and compositions for preventing and treating bone loss
US5795880A (en) 1996-12-30 1998-08-18 Louisiana State University Medical Center Foundation Method and composition for treating obesity and related disorders in animals comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent
US5994334A (en) 1997-02-05 1999-11-30 University Of Maryland Androgen synthesis inhibitors
US6093722A (en) 1997-02-26 2000-07-25 Sankyo Company, Limited Method for treating prostate cancer
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US5912240A (en) * 1997-04-10 1999-06-15 Loria; Roger M. 5-androstene 3β, 17α diol as an inhibitor of tumor growth
WO1998050041A1 (en) 1997-05-06 1998-11-12 Imarx Pharmaceutical Corp. Novel prodrugs comprising fluorinated amphiphiles
AU7980098A (en) 1997-06-20 1999-01-04 Elena Y. Enioutina Method to enhance innate immunity defense mechanisms by treatment with plan t-derived alkaloids
US5859900A (en) * 1997-08-19 1999-01-12 At&T Corp Universal call access with reverse billing
US5994335A (en) 1997-10-17 1999-11-30 The University Of Maryland, Baltimore 17-azolyl steroids useful as androgen synthesis inhibitors
US5869090A (en) 1998-01-20 1999-02-09 Rosenbaum; Jerry Transdermal delivery of dehydroepiandrosterone
US6573289B1 (en) 1998-04-23 2003-06-03 Takeda Chemical Industries, Ltd. Naphthalene derivatives, their production and use
EP1083904A2 (de) * 1998-06-11 2001-03-21 Endorecherche Inc. Pharmazeutische zusammensetzungen und verwendungen von androst-5-ene-3 beta,17 beta-diol
EP1098976A2 (de) 1998-07-17 2001-05-16 University Of Rochester Androgenrezeptorkoaktivatoren
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
JP2002531397A (ja) 1998-11-24 2002-09-24 ホリス − イーデン ファーマスーティカルズ、 インコーポレイテッド Ｃ型肝炎ウイルスおよび他のトガウイルスの処置における１７−ケトステロイド化合物ならびにそれらの誘導体、代謝物および前駆体の使用
NZ511720A (en) * 1998-11-24 2002-12-20 Hollis Eden Pharmaceuticals Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in the treatment of malaria and the treatment of African and American trypanosomiasis
US20060079492A1 (en) 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US20080015174A1 (en) 1998-11-24 2008-01-17 Reading Christopher L Metabolic Disease Treatments
US20030060425A1 (en) 1998-11-24 2003-03-27 Ahlem Clarence N. Immune modulation method using steroid compounds
US20070129282A1 (en) 1998-11-24 2007-06-07 Ahlem Clarence N Pharmaceutical treatments and compositions
AU1923500A (en) 1998-11-27 2000-06-19 Hollis-Eden Pharmaceuticals, Inc. Use of 17-ketosteroid compounds and derivatives, metabolites and precursors thereof in treatment of toxoplasmosis and in the treatment of cryptosporidiosis
US6767903B1 (en) 1998-12-23 2004-07-27 Schering Ag New7α, 17α-bis-alkylated testosterone derivatives and their use in long-term therapy of androgen-dependent diseases
ES2252996T3 (es) 1999-01-13 2006-05-16 Warner-Lambert Company Llc Derivados de bencenosulfonamida y su uso como inhibidores de mek.
ATE259825T1 (de) 1999-03-23 2004-03-15 Hollis Eden Pharmaceuticals Hemihydrat von 16.alpha.-bromoepiandrosterone
DE19929715A1 (de) 1999-06-24 2000-12-28 Schering Ag 11ß-langkettig-substituierte Estratriene, Verfahren zur Herstellung , pharmazeutische Präparate, die diese 11ß-langkettig-substituierten Estratriene enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
CA2315614C (en) 1999-07-29 2004-11-02 Pfizer Inc. Pyrazoles
CA2669753C (en) 1999-09-30 2012-06-26 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
US6506769B2 (en) 1999-10-06 2003-01-14 Boehringer Ingelheim Pharmaceuticals, Inc. Heterocyclic compounds useful as inhibitors of tyrosine kinases
WO2001030802A2 (en) 1999-10-25 2001-05-03 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatments comprising administration of certain steroids for blood cell deficiencies
US6608053B2 (en) 2000-04-27 2003-08-19 Yamanouchi Pharmaceutical Co., Ltd. Fused heteroaryl derivatives
CA2424581A1 (en) 2000-10-06 2002-04-11 Aeson Therapeutics Inc. Compounds useful for treating hypertriglyceridemia
US20030232797A1 (en) 2002-06-06 2003-12-18 Forbes Medi-Tech Inc. Novel derivatives of androstane and androstene with ascorbic acid and use thereof in treating or preventing various conditions, diseases, and disorders
US20050101581A1 (en) 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
EP1615944A4 (de) 2003-04-01 2010-08-11 Harbor Biosciences Inc Antiandrogene mit marginaler agonistenwirkung und anwendungsverfahren
EP1807118B8 (de) 2004-09-29 2014-04-23 Harbor Therapeutics, Inc. Steroidanaloga sowie charakterisierungs- und behandlungsverfahren
US7910755B2 (en) 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses
US20060073099A1 (en) 2004-10-01 2006-04-06 Frincke James M Treatment screening methods
JP2008052552A (ja) * 2006-08-25 2008-03-06 Brother Ind Ltd プリンタ制御装置、プログラム、及び記録媒体
US20080221074A1 (en) 2006-11-17 2008-09-11 Jaime Flores-Riveros Drug Screen and Treatment Method
US20080153792A1 (en) 2006-11-17 2008-06-26 Frincke James M Drug Identification and Treatment Method
US8217025B2 (en) 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods

Also Published As

Publication number Publication date
EP2322182A1 (de) 2011-05-18
DK1955700T3 (da) 2011-05-23
US20080176823A1 (en) 2008-07-24
PT1955700E (pt) 2011-05-04
US8076316B2 (en) 2011-12-13
EP1832598A2 (de) 2007-09-12
CA2670236A1 (en) 2001-04-05
US7863261B2 (en) 2011-01-04
ATE501722T1 (de) 2011-04-15
US20080058301A1 (en) 2008-03-06
WO2001023405A2 (en) 2001-04-05
EP1955700A3 (de) 2008-12-10
EP1955700B1 (de) 2011-03-16
CA2386095A1 (en) 2001-04-05
WO2001023405A3 (en) 2002-05-30
US20110098260A1 (en) 2011-04-28
EP1955700B9 (de) 2011-09-07
EP1955700A2 (de) 2008-08-13
US20120071454A1 (en) 2012-03-22
CA2670236C (en) 2012-06-05
US7776845B2 (en) 2010-08-17
US8367646B2 (en) 2013-02-05
CA2669753C (en) 2012-06-26
CA2669753A1 (en) 2001-04-05
US20100240633A1 (en) 2010-09-23
US7691835B2 (en) 2010-04-06
EP1832598A3 (de) 2008-01-02
US7906497B2 (en) 2011-03-15
US7696189B1 (en) 2010-04-13
US20080021006A1 (en) 2008-01-24
AU7736300A (en) 2001-04-30
EP1228083A2 (de) 2002-08-07

Similar Documents

Publication Publication Date Title
DE60045751D1 (de) Therapeutische Behandlung androgenrezeptorbedingter Leiden
BRPI0006634B8 (pt) composição tópica compreendendo extrato de matricária no tratamento e prevenção de distúrbios inflamatórios
DE69830072D1 (de) Radioaktive zusammensetzungen zur behandlung von prostatatumoren
BR9812122A (pt) Combinação de inibidor da tirosina quinase e castração quìmica para tratar câncer da próstata
TR200102499T2 (tr) Neoplazi tedavisinde bir kombinasyon terapisi olarak bir siklooksijenaz-2 inhibitörü ve bir veya daha fazla antineoplastik ajan kullanma yöntemi
TR200200204T2 (tr) MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.
UY26130A1 (es) Compuestos para tratar la obesidad
EP1401479A4 (de) Nachweis und therapie von empfindlichem plaque mit photodynamischen verbindungen
DE69703294T2 (de) Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten
PT971713E (pt) Utilizacao de inibidores da colinesterase para tratamento de desordens da atencao
CY1110113T1 (el) Φωσφολιπιδιου παραγωγα βαλπροϊκου οξεος και μειγματα αυτων
NO20000752D0 (no) Metode for forhindring eller behandling av østrogen-avhengige sykdommer og forstyrrelser
DE69921852D1 (de) Kombinationstherapie enthaltend bestrahlung und einen cox-2 hemmer in der behandlung von neoplasie
BRPI0411319A (pt) compostos terapeuticamente ativos e sua utilização
BR0109211A (pt) Compostos com atividade 5-ht1a úteis para o tratamento de distúrbios da retina externa
ATE413179T1 (de) Therapeutische verwendungen von steroiden bei blutzellmangelzustaenden
DE60216300D1 (de) Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
BR0201862A (pt) Composições e métodos para tratar ou prevenir convulsões ou ataques apoplécticos
ATE381327T1 (de) Cethylmyristat und cetylpalmitat zurbehandlung von ekzemen und/oder psoriasis
ATE541565T1 (de) Topische verwendung von muskarinischen und opioiden mitteln zur behandlung von tinnitus
MXPA03011270A (es) Uso de antagonistas rank para tratar cancer.
FR2825273B1 (fr) Composition pour le traitement des signes cutanes du vieillissement
DE60018704D1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
TR200200278T2 (tr) Kalsilitik bileşimler
ATE333277T1 (de) Behandlung von dyskinesie