DE60115383D1 - Hochreine lipopeptide, lipopeptid mizellen, deren herstellung und arzneimittel - Google Patents

Hochreine lipopeptide, lipopeptid mizellen, deren herstellung und arzneimittel

Info

Publication number
DE60115383D1
DE60115383D1 DE60115383T DE60115383T DE60115383D1 DE 60115383 D1 DE60115383 D1 DE 60115383D1 DE 60115383 T DE60115383 T DE 60115383T DE 60115383 T DE60115383 T DE 60115383T DE 60115383 D1 DE60115383 D1 DE 60115383D1
Authority
DE
Germany
Prior art keywords
discloses
daptomycin
micelles
lipopeptide
purifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60115383T
Other languages
English (en)
Other versions
DE60115383T2 (de
Inventor
J Kelleher
Jan-Ji Lai
P Decourcey
D Lynch
Maurizio Zenoni
R Tagliani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cubist Pharmaceuticals LLC
Original Assignee
Cubist Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26873002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60115383(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cubist Pharmaceuticals LLC filed Critical Cubist Pharmaceuticals LLC
Publication of DE60115383D1 publication Critical patent/DE60115383D1/de
Application granted granted Critical
Publication of DE60115383T2 publication Critical patent/DE60115383T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE60115383T 2000-01-20 2001-01-18 Hochreine lipopeptide, lipopeptid mizellen, deren herstellung und arzneimittel Expired - Lifetime DE60115383T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17717000P 2000-01-20 2000-01-20
US177170P 2000-01-20
US09/735,191 US6696412B1 (en) 2000-01-20 2000-11-28 High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US735191 2000-11-28
PCT/US2001/001748 WO2001053330A2 (en) 2000-01-20 2001-01-18 High purity lipopeptides, lipopeptide micelles, processes for preparing same and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DE60115383D1 true DE60115383D1 (de) 2006-01-05
DE60115383T2 DE60115383T2 (de) 2006-08-17

Family

ID=26873002

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60115383T Expired - Lifetime DE60115383T2 (de) 2000-01-20 2001-01-18 Hochreine lipopeptide, lipopeptid mizellen, deren herstellung und arzneimittel
DE60140631T Expired - Lifetime DE60140631D1 (de) 2000-01-20 2001-01-18 Verfahren zur aufreinigung von daptomycin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60140631T Expired - Lifetime DE60140631D1 (de) 2000-01-20 2001-01-18 Verfahren zur aufreinigung von daptomycin

Country Status (25)

Country Link
US (7) US6696412B1 (de)
EP (6) EP2264047B1 (de)
JP (2) JP5303087B2 (de)
KR (4) KR20070044079A (de)
CN (5) CN101240013B (de)
AT (2) ATE311405T1 (de)
AU (1) AU784937B2 (de)
BR (1) BRPI0107731B8 (de)
CA (2) CA2398726C (de)
CY (2) CY1109846T1 (de)
CZ (2) CZ305004B6 (de)
DE (2) DE60115383T2 (de)
DK (2) DK1586580T3 (de)
ES (4) ES2336336T3 (de)
HK (6) HK1054240A1 (de)
HU (1) HUP0203969A2 (de)
IL (3) IL150733A0 (de)
IS (1) IS6470A (de)
MX (1) MXPA02007132A (de)
NO (1) NO20023476L (de)
NZ (1) NZ520324A (de)
PL (3) PL226956B1 (de)
PT (2) PT2264047E (de)
RU (1) RU2311460C9 (de)
WO (1) WO2001053330A2 (de)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
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US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
NZ571597A (en) 2000-12-18 2010-05-28 Cubist Pharm Inc Method for preparing crystalline and crystal-like forms of purified daptomycin lipopeptides
WO2003017924A2 (en) 2001-08-06 2003-03-06 Cubist Pharmaceuticals, Inc. Lipopeptide stereoisomers, methods for preparing same, and useful intermediates
EP1932853A1 (de) 2001-08-06 2008-06-18 Cubist Pharmaceutical Inc. Neue Depsipeptide und Herstellungsverfahren dafür
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CA2488803C (en) 2002-06-06 2013-08-13 Vicuron Pharmaceuticals Inc. Use of ramoplanin to treat diseases associated with the use of antibiotics
WO2004019907A1 (en) * 2002-08-29 2004-03-11 Activbiotics, Inc. Methods and reagents for treating infections of clostridium difficile and diseases associated therewith
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EP1860943A4 (de) * 2005-03-10 2008-06-18 Smithkline Beecham Corp Neuartiges verfahren
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AU2010216475B2 (en) * 2009-02-19 2015-07-09 Xellia Pharmaceuticals Aps Process for purifying lipopeptides
CN101830970B (zh) * 2009-03-12 2012-06-27 成都雅途生物技术有限公司 一种高纯度达托霉素(Daptomycin)的纯化制备方法
CN101899094B (zh) * 2009-06-01 2012-11-21 安徽丰原发酵技术工程研究有限公司 一种高纯达托霉素的制备方法
WO2011002258A2 (ko) * 2009-07-02 2011-01-06 한양대학교 산학협력단 아르기닌 기제 양친성 펩티드 마이셀
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JP2023517926A (ja) 2020-03-12 2023-04-27 バクスター・インターナショナル・インコーポレイテッド ソルビトールとマンニトールの組み合わせを含むダプトマイシン製剤
CN113929743A (zh) * 2020-06-29 2022-01-14 鲁南制药集团股份有限公司 一种制备达托霉素杂质rs-1和杂质rs-3的方法
CN113929747A (zh) * 2020-06-29 2022-01-14 鲁南制药集团股份有限公司 一种制备达托霉素杂质RS-7a的方法
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