DE60119777D1 - Pyrazolverbindungen als protein-kinasehemmer - Google Patents
Pyrazolverbindungen als protein-kinasehemmerInfo
- Publication number
- DE60119777D1 DE60119777D1 DE60119777T DE60119777T DE60119777D1 DE 60119777 D1 DE60119777 D1 DE 60119777D1 DE 60119777 T DE60119777 T DE 60119777T DE 60119777 T DE60119777 T DE 60119777T DE 60119777 D1 DE60119777 D1 DE 60119777D1
- Authority
- DE
- Germany
- Prior art keywords
- protein kinase
- hemmer
- pyrazol compounds
- pyrazol
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25788700P | 2000-12-21 | 2000-12-21 | |
US257887P | 2000-12-21 | ||
US28694901P | 2001-04-27 | 2001-04-27 | |
US286949P | 2001-04-27 | ||
PCT/US2001/049594 WO2002059112A2 (en) | 2000-12-21 | 2001-12-20 | Pyrazole compounds useful as protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60119777D1 true DE60119777D1 (de) | 2006-06-22 |
DE60119777T2 DE60119777T2 (de) | 2007-05-03 |
Family
ID=26946273
Family Applications (8)
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DE60119774T Expired - Lifetime DE60119774T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als proteinkinasehemmer |
DE60123283T Expired - Lifetime DE60123283T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als protein- kinasehemmer |
DE60119776T Expired - Lifetime DE60119776T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als protein-kinase-inhibitoren |
DE60126828T Expired - Lifetime DE60126828T2 (de) | 2000-12-21 | 2001-12-19 | "pyrazolverbindungen, die sich als proteinkinaseinhibitoren eignen" |
DE60120219T Expired - Lifetime DE60120219T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als protein-kinase-inhibitoren |
DE60119777T Expired - Lifetime DE60119777T2 (de) | 2000-12-21 | 2001-12-20 | Pyrazolverbindungen als protein-kinasehemmer |
DE60126658T Expired - Lifetime DE60126658T2 (de) | 2000-12-21 | 2001-12-20 | Pyrazolverbindungen als proteinkinasehemmer |
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DE60119775T Expired - Lifetime DE60119775T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als proteinkinasehemmer |
DE60119774T Expired - Lifetime DE60119774T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als proteinkinasehemmer |
DE60123283T Expired - Lifetime DE60123283T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als protein- kinasehemmer |
DE60119776T Expired - Lifetime DE60119776T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als protein-kinase-inhibitoren |
DE60126828T Expired - Lifetime DE60126828T2 (de) | 2000-12-21 | 2001-12-19 | "pyrazolverbindungen, die sich als proteinkinaseinhibitoren eignen" |
DE60120219T Expired - Lifetime DE60120219T2 (de) | 2000-12-21 | 2001-12-19 | Pyrazolverbindungen als protein-kinase-inhibitoren |
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DE60126658T Expired - Lifetime DE60126658T2 (de) | 2000-12-21 | 2001-12-20 | Pyrazolverbindungen als proteinkinasehemmer |
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US (16) | US20030105090A1 (de) |
EP (10) | EP1345927B1 (de) |
JP (19) | JP4160389B2 (de) |
KR (8) | KR100947185B1 (de) |
CN (6) | CN100340555C (de) |
AP (2) | AP2003002825A0 (de) |
AR (4) | AR042169A1 (de) |
AT (9) | ATE340172T1 (de) |
AU (7) | AU2002255452B2 (de) |
BR (2) | BR0116493A (de) |
CA (8) | CA2432129C (de) |
CY (1) | CY1106297T1 (de) |
DE (8) | DE60119775T2 (de) |
DK (3) | DK1345922T3 (de) |
ES (7) | ES2375491T3 (de) |
HK (8) | HK1059776A1 (de) |
HU (5) | HUP0400908A3 (de) |
IL (8) | IL156407A0 (de) |
MX (8) | MXPA03005605A (de) |
MY (1) | MY140377A (de) |
NO (5) | NO328537B1 (de) |
NZ (8) | NZ526470A (de) |
PL (2) | PL210414B1 (de) |
PT (3) | PT1355905E (de) |
RU (1) | RU2355688C2 (de) |
SI (2) | SI1353916T1 (de) |
TW (2) | TWI313269B (de) |
WO (8) | WO2002066461A1 (de) |
Families Citing this family (367)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6982260B1 (en) | 1999-11-22 | 2006-01-03 | Warner-Lambert Company | Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes |
US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1317449B1 (de) | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazolverbindungen als protein-kinasehemmer |
AU2002228783A1 (en) * | 2000-12-05 | 2002-06-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
ATE340172T1 (de) * | 2000-12-21 | 2006-10-15 | Vertex Pharma | Pyrazolverbindungen als protein- kinasehemmer |
PE20021011A1 (es) * | 2001-03-23 | 2003-02-01 | Bayer Corp | Derivados quinazolinicos como inhibidores de la rho-quinasa |
ATE400274T1 (de) | 2001-04-10 | 2008-07-15 | Merck & Co Inc | Hemmstoffe der akt aktivität |
US7105667B2 (en) * | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
US7138404B2 (en) * | 2001-05-23 | 2006-11-21 | Hoffmann-La Roche Inc. | 4-aminopyrimidine derivatives |
US7115617B2 (en) | 2001-08-22 | 2006-10-03 | Amgen Inc. | Amino-substituted pyrimidinyl derivatives and methods of use |
US6939874B2 (en) | 2001-08-22 | 2005-09-06 | Amgen Inc. | Substituted pyrimidinyl derivatives and methods of use |
PL368347A1 (en) | 2001-09-26 | 2005-03-21 | Pharmacia Italia S.P.A. | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
WO2003026664A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
SE0104140D0 (sv) * | 2001-12-07 | 2001-12-07 | Astrazeneca Ab | Novel Compounds |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
AU2002361846A1 (en) * | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
WO2003057202A1 (en) * | 2002-01-10 | 2003-07-17 | F. Hoffmann-La Roche Ag | Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation |
TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
MXPA04007697A (es) * | 2002-02-06 | 2004-11-10 | Vertex Pharma | Compuestos de heteroarilo utiles como inhibidores de gsk-3. |
EP1485381B8 (de) * | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine als inhibitoren von proteinkinasen |
US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
DE60332433D1 (de) | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
WO2003086394A1 (en) | 2002-04-08 | 2003-10-23 | Merck & Co., Inc. | Inhibitors of akt activity |
JPWO2003104230A1 (ja) | 2002-06-07 | 2005-10-06 | 協和醗酵工業株式会社 | 二環性ピリミジン誘導体 |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
AU2003261204A1 (en) * | 2002-07-23 | 2004-02-09 | Smithkline Beecham Corporation | Pyrazolopyrimidines as kinase inhibitors |
IL166241A (en) | 2002-07-29 | 2011-12-29 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds for use in the treatment of autoimmune diseases |
SI1532145T1 (sl) * | 2002-08-02 | 2007-02-28 | Vertex Pharma | Pirazolni sestavki, koristni kot inhibitorji GSK-3 |
ES2273043T3 (es) * | 2002-08-02 | 2007-05-01 | Vertex Pharmaceuticals Incorporated | Composiciones de pirazol utiles como inhibidores de gsk-3. |
BR0314098A (pt) | 2002-09-05 | 2005-07-19 | Aventis Pharma Sa | Derivados da aminoindazóis a tìtulo de medicamentos e composições farmacêuticas que os contêm |
FR2844267B1 (fr) * | 2002-09-05 | 2008-02-15 | Aventis Pharma Sa | Nouveaux derives d'aminoindazoles a titre de medicaments et compositions pharmaceutiques les renfermant |
AU2003255482A1 (en) * | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
ES2440217T3 (es) | 2002-10-04 | 2014-01-28 | Prana Biotechnology Limited | Compuestos neurológicamente activos |
KR100490893B1 (ko) * | 2002-10-11 | 2005-05-23 | (주) 비엔씨바이오팜 | 2-메톡시-1,3,5-트리아진 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 |
GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
US7309701B2 (en) | 2002-11-19 | 2007-12-18 | Sanofi-Aventis Deutschland Gmbh | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
US7462613B2 (en) | 2002-11-19 | 2008-12-09 | Sanofi-Aventis Deutschland Gmbh | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them |
WO2004048365A1 (en) * | 2002-11-21 | 2004-06-10 | Chiron Corporation | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (pi) 3-kinase inhibitors and their use in the treatment of cancer |
WO2004072029A2 (en) * | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
WO2004087679A1 (en) * | 2003-04-01 | 2004-10-14 | Aponetics Ag | 2, 4, 6-trisubstituted pyrimidine derivatives useful for the treatment of neoplastic and autoimmune diseases |
US20060135541A1 (en) * | 2003-06-02 | 2006-06-22 | Astrazeneca Ab | (3-((Quinazolin-4-yl) amino)-1h-pyrazol-1-yl)acetamide derivatives and related compounds as aurora kinase inhibitors for the treatment of proliferative diseases such as cancer |
JP4869068B2 (ja) * | 2003-06-19 | 2012-02-01 | スミスクライン ビーチャム コーポレーション | 化合物 |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
CN1984660B (zh) * | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
GB0315966D0 (en) * | 2003-07-08 | 2003-08-13 | Cyclacel Ltd | Compounds |
PL1651612T3 (pl) | 2003-07-22 | 2012-09-28 | Astex Therapeutics Ltd | Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3) |
JP4886511B2 (ja) | 2003-07-30 | 2012-02-29 | ライジェル ファーマシューティカルズ, インコーポレイテッド | 2,4−ピリミジンジアミン化合物による自己免疫疾患の治療または予防方法 |
CA2533474A1 (en) * | 2003-07-30 | 2005-02-10 | Shudong Wang | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors |
US20050221357A1 (en) * | 2003-09-19 | 2005-10-06 | Mark Shannon | Normalization of gene expression data |
US20060024690A1 (en) * | 2003-09-19 | 2006-02-02 | Kao H P | Normalization of data using controls |
US7417726B2 (en) * | 2003-09-19 | 2008-08-26 | Applied Biosystems Inc. | Normalization of data using controls |
WO2005030131A2 (en) * | 2003-09-23 | 2005-04-07 | Replidyne, Inc | Bis-quinazoline compounds for the treatment of bacterial infections |
CA2542522A1 (en) | 2003-10-17 | 2005-05-06 | Astrazeneca Ab | 4-(pyrazol-3-ylamino) pyrimidine derivatives for use in the treatment of cancer |
AU2004297235A1 (en) * | 2003-12-04 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Quinoxalines useful as inhibitors of protein kinases |
WO2005056552A1 (en) * | 2003-12-09 | 2005-06-23 | Vertex Pharmaceuticals Incorporated | Naphthyridine derivatives and their use as modulators of muscarinic receptors |
US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
TW200530235A (en) | 2003-12-24 | 2005-09-16 | Renovis Inc | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof |
AU2005212438A1 (en) * | 2004-02-11 | 2005-08-25 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
EP1723427A2 (de) * | 2004-02-26 | 2006-11-22 | Bayer HealthCare AG | Diagnostika und therapeutika für mit glycogen-synthase-kinase 3 beta (gsk3b) in zusammenhang stehende krankheiten |
US7786165B2 (en) * | 2004-03-15 | 2010-08-31 | Takeda Pharmaceutical Company Limited | Aminophenylpropanoic acid derivative |
EP2522670A1 (de) * | 2004-04-07 | 2012-11-14 | Takeda Pharmaceutical Company Limited | Heterozyklische CRF-Rezeptor-Antagonisten |
JP2007533717A (ja) * | 2004-04-21 | 2007-11-22 | アストラゼネカ アクチボラグ | 化合物 |
US20050250829A1 (en) * | 2004-04-23 | 2005-11-10 | Takeda San Diego, Inc. | Kinase inhibitors |
MXPA06012613A (es) * | 2004-05-07 | 2007-01-31 | Amgen Inc | Derivados heterociclicos nitrogenados como moduladores de proteina cinasa y uso para el tratamiento de angiogenesis y cancer. |
US7793137B2 (en) | 2004-10-07 | 2010-09-07 | Cisco Technology, Inc. | Redundant power and data in a wired data telecommunincations network |
SI1771450T1 (sl) * | 2004-05-14 | 2008-06-30 | Millennium Pharm Inc | Spojine in postopki za inhibiranje mitotične progresije z inhibicijo kinaze Aurora |
AU2012200416B2 (en) * | 2004-05-14 | 2014-07-31 | Millennium Pharmaceuticals, Inc. | "Compounds and methods for inhibiting mitotic progression by inhibition of Aurora kinase" |
NZ551583A (en) * | 2004-05-14 | 2009-05-31 | Vertex Pharma | Prodrugs of pyrrolylpyrimidine ERK protein kinase inhibitors |
DE602005003951T4 (de) * | 2004-05-14 | 2012-10-11 | Millennium Pharmaceuticals, Inc. | Verbindungen und verfahren zur inhibierung der mitotischen progression durch hemmung von aurorakinase |
US20050255485A1 (en) * | 2004-05-14 | 2005-11-17 | Livak Kenneth J | Detection of gene duplications |
US20080009531A1 (en) * | 2004-05-20 | 2008-01-10 | Bayer Pharmaceuticals Corporation | 5-Anilino-4-Heteroarylpyrazole Derivatives Useful for the Treatment of Diabetes |
KR20070034519A (ko) * | 2004-05-27 | 2007-03-28 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 광감성 중합체 보호층용 현상제 |
EP1765325A4 (de) * | 2004-07-01 | 2009-08-12 | Synta Pharmaceuticals Corp | 2-substituierte heteroaryl-verbindungen |
JP2008505907A (ja) * | 2004-07-06 | 2008-02-28 | アンジオン バイオメディカ コーポレイション | 癌治療を目的として肝細胞増殖因子およびc−met活性を調整するキナゾリンモジュレーター |
WO2006023931A2 (en) | 2004-08-18 | 2006-03-02 | Takeda San Diego, Inc. | Kinase inhibitors |
TW200624431A (en) | 2004-09-24 | 2006-07-16 | Hoffmann La Roche | Phthalazinone derivatives, their manufacture and use as pharmaceutical agents |
US7285569B2 (en) | 2004-09-24 | 2007-10-23 | Hoff Hoffmann-La Roche Inc. | Tricycles, their manufacture and use as pharmaceutical agents |
EP1797048B1 (de) * | 2004-09-30 | 2011-08-17 | Tibotec Pharmaceuticals | Hiv-hemmende 5-carbo- oder heterozyklisch substituierte pyrimidine |
TW200626574A (en) * | 2004-09-30 | 2006-08-01 | Tibotec Pharm Ltd | HIV inhibiting 5-heterocyclyl pyrimidines |
BRPI0516748B8 (pt) * | 2004-09-30 | 2021-05-25 | Janssen Sciences Ireland Uc | pirimidinas 5-substituídas inibidoras de hiv e composição farmacêutica que as compreende |
WO2006044687A2 (en) | 2004-10-15 | 2006-04-27 | Takeda San Diego, Inc. | Kinase inhibitors |
US7491720B2 (en) | 2004-10-29 | 2009-02-17 | Banyu Pharmaceutical Co., Ltd. | Aminopyridine derivatives having Aurora A selective inhibitory action |
KR20070072562A (ko) * | 2004-10-29 | 2007-07-04 | 반유 세이야꾸 가부시끼가이샤 | 오로라 a 선택적 억제 활성을 갖는 신규한 아미노피리딘유도체 |
EP1809290A2 (de) | 2004-11-03 | 2007-07-25 | Vertex Pharmaceuticals Incorporated | Pyrimidinderivate als ionenkanalmodulatoren und verwendungsverfahren |
AU2005306458B2 (en) * | 2004-11-17 | 2011-02-17 | Miikana Therapeutics, Inc. | Kinase inhibitors |
ES2380550T3 (es) | 2004-11-24 | 2012-05-16 | Rigel Pharmaceuticals, Inc. | Compuestos de espiro-2,4-pirimidindiamina y sus usos |
US20060128710A1 (en) * | 2004-12-09 | 2006-06-15 | Chih-Hung Lee | Antagonists to the vanilloid receptor subtype 1 (VR1) and uses thereof |
JP2008525422A (ja) * | 2004-12-23 | 2008-07-17 | ファイザー・プロダクツ・インク | 抗癌剤として有用な複素芳香族誘導体 |
ATE519759T1 (de) | 2004-12-30 | 2011-08-15 | Exelixis Inc | Pyrimidinderivate als kinasemodulatoren und anwendungsverfahren |
US8110573B2 (en) * | 2004-12-30 | 2012-02-07 | Astex Therapeutics Limited | Pyrazole compounds that modulate the activity of CDK, GSK and aurora kinases |
US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
US7449458B2 (en) | 2005-01-19 | 2008-11-11 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US7528132B2 (en) * | 2005-01-26 | 2009-05-05 | Schering Corporation | Kinase inhibitors |
AU2006210710B2 (en) * | 2005-02-04 | 2009-12-10 | Astrazeneca Ab | Pyrazolylaminopyridine derivatives useful as kinase inhibitors |
DK1853588T3 (da) * | 2005-02-16 | 2008-09-15 | Astrazeneca Ab | Kemiske forbindelser |
ES2347172T3 (es) * | 2005-02-16 | 2010-10-26 | Astrazeneca Ab | Compuestos quimicos. |
US20080188483A1 (en) * | 2005-03-15 | 2008-08-07 | Irm Llc | Compounds and Compositions as Protein Kinase Inhibitors |
US20080161278A1 (en) * | 2005-03-23 | 2008-07-03 | Astrazeneca Ab | 2-Azetidinyl-4-(1H-Pyrazol-3-Ylamino) Pyrimidines as Inhibitors of Insulin-Like Growth Factor-1 Receptor Activity |
US7297700B2 (en) | 2005-03-24 | 2007-11-20 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
DE602006002271D1 (de) * | 2005-04-05 | 2008-09-25 | Astrazeneca Ab | Pyrimidinderivate zur verwendung als antikrebsmittel |
GB0507347D0 (en) * | 2005-04-12 | 2005-05-18 | Astrazeneca Ab | Chemical compounds |
KR20070113286A (ko) | 2005-04-14 | 2007-11-28 | 에프. 호프만-라 로슈 아게 | 아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도 |
WO2006115452A1 (en) * | 2005-04-27 | 2006-11-02 | Astrazeneca Ab | Use of pyrazolyl-pyrimidine derivatives in the treatment of pain |
CN101166732B (zh) * | 2005-04-28 | 2013-04-17 | 田边三菱制药株式会社 | 氰基吡啶衍生物及其作为药物的应用 |
WO2006119504A2 (en) | 2005-05-04 | 2006-11-09 | Renovis, Inc. | Fused heterocyclic compounds, and compositions and uses thereof |
WO2006117212A2 (en) | 2005-05-04 | 2006-11-09 | Develogen Aktiengesellschaft | Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders |
JP2008540391A (ja) * | 2005-05-05 | 2008-11-20 | アストラゼネカ アクチボラグ | ピラゾリルアミノ置換ピリミジン、および癌の処置におけるそれらの使用 |
AU2006248780B2 (en) * | 2005-05-16 | 2010-06-03 | Astrazeneca Ab | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors |
WO2006133426A2 (en) | 2005-06-08 | 2006-12-14 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
US20070203161A1 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
CA2612227C (en) | 2005-06-14 | 2014-04-22 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
EP1746096A1 (de) | 2005-07-15 | 2007-01-24 | 4Sc Ag | 2-Arylbenzothiazol-Analoge zur Verwendung als Antikrebsmittel |
CA2619517A1 (en) * | 2005-08-18 | 2007-02-22 | Michael Mortimore | Pyrazine kinase inhibitors |
WO2007023382A2 (en) * | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
ES2535854T3 (es) * | 2005-09-30 | 2015-05-18 | Miikana Therapeutics, Inc. | Compuestos de pirazol sustituidos |
UA96427C2 (en) * | 2005-09-30 | 2011-11-10 | Мийкана Терапьютикс, Инк. | Substituted pyrazole compounds |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス,インコーポレイティド | Pde阻害による神経新生の調節 |
EP1945631B8 (de) | 2005-10-28 | 2013-01-02 | AstraZeneca AB | 4-(3-aminopyrazol)pyrimidinderivate zur verwendung als tyrosinkinaseinhibitoren bei der behandlung von krebs |
EP1942879A1 (de) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
US8933077B2 (en) * | 2005-11-01 | 2015-01-13 | Array Biopharma Inc. | Glucokinase activators |
TW200734327A (en) * | 2005-11-03 | 2007-09-16 | Vertex Pharma | Aminopyrimidines useful as kinase inhibitors |
CN101360740A (zh) * | 2005-11-16 | 2009-02-04 | 沃泰克斯药物股份有限公司 | 可用作激酶抑制剂的氨基嘧啶 |
US8546404B2 (en) | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
US7572809B2 (en) * | 2005-12-19 | 2009-08-11 | Hoffmann-La Roche Inc. | Isoquinoline aminopyrazole derivatives |
US8399442B2 (en) | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
WO2007081978A2 (en) * | 2006-01-11 | 2007-07-19 | Angion Biomedica Corporation | Modulators of hepatocyte growth factor / c-met activity |
JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
ATE485268T1 (de) * | 2006-02-16 | 2010-11-15 | Schering Corp | Pyrrolidin-derivate als erk-hemmer |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
DK2004632T3 (da) | 2006-03-30 | 2014-06-16 | Janssen R & D Ireland | Hiv-inhiberende 5-amidosubstituerede pyrimidiner |
JP5255559B2 (ja) * | 2006-03-31 | 2013-08-07 | アボット・ラボラトリーズ | インダゾール化合物 |
WO2007116029A2 (en) | 2006-04-07 | 2007-10-18 | Novartis Ag | Combination comprising a) a pyrimidylaminobenzamide compound, and b) a thr315lle kinase inhibitor |
KR20080109096A (ko) | 2006-04-14 | 2008-12-16 | 프라나 바이오테크놀로지 리미티드 | 연령 관련 황반 변성(에이엠디)의 치료 방법 |
ES2433199T3 (es) * | 2006-04-27 | 2013-12-09 | Msd K.K. | Derivados de aminopirimidina que tienen actividad inhibidora selectiva de Aurora-A |
CA2651813A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
EP2026813A2 (de) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5-ht-rezeptor-vermittelte neurogenese |
CL2007001873A1 (es) | 2006-06-27 | 2008-01-04 | Takeda Pharmaceutical | Acido((3s))-6-((¨2,6-dimetil-4-(3-(metilsulfonil)-propoxi)bifenil-3-il)metoxi-2,3-dihidro-1-benzofuran-3-il)acetico o una sal del mismo |
JP2009542608A (ja) * | 2006-06-29 | 2009-12-03 | アステックス・セラピューティクス・リミテッド | 医薬組合せ剤 |
JP5523829B2 (ja) | 2006-06-29 | 2014-06-18 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
WO2008001886A1 (fr) * | 2006-06-30 | 2008-01-03 | Kyowa Hakko Kirin Co., Ltd. | Inhibiteur d'aurora |
JP2009541480A (ja) * | 2006-06-30 | 2009-11-26 | アストラゼネカ アクチボラグ | 癌の治療において有用なピリミジン誘導体 |
AU2007269540B2 (en) | 2006-07-05 | 2013-06-27 | Exelixis, Inc. | Methods of using IGF1R and Abl kinase modulators |
RU2009108280A (ru) | 2006-08-08 | 2010-09-20 | Санофи-Авентис (Fr) | Ариламиноарилалкилзамещенные имидазолидин-2,4-дионы, способы их получения, содержащие эти соединения лекарственные средства и их применение |
WO2008021038A2 (en) * | 2006-08-09 | 2008-02-21 | Millennium Pharmaceuticals, Inc. | Pyridobenzazepine compounds and methods for inhibiting mitotic progression |
US7832809B2 (en) * | 2006-08-11 | 2010-11-16 | Schlumberger Technology Corporation | Degradation assembly shield |
JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
SG175609A1 (en) | 2006-10-09 | 2011-11-28 | Takeda Pharmaceutical | Kinase inhibitors |
JP2010505961A (ja) * | 2006-10-09 | 2010-02-25 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
US8883790B2 (en) | 2006-10-12 | 2014-11-11 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8916552B2 (en) | 2006-10-12 | 2014-12-23 | Astex Therapeutics Limited | Pharmaceutical combinations |
WO2008053812A1 (fr) * | 2006-10-27 | 2008-05-08 | Mitsubishi Tanabe Pharma Corporation | Dérivé de cyanopyridine et son utilisation médicale |
DE602007004750D1 (de) | 2006-11-02 | 2010-03-25 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyridine und aminopyrimidine |
CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
DE602007007985D1 (de) * | 2006-12-19 | 2010-09-02 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
AU2007341227C1 (en) * | 2006-12-29 | 2013-08-29 | Janssen Sciences Ireland Uc | HIV inhibiting 6-substituted pyrimidines |
MX2009007006A (es) * | 2006-12-29 | 2009-07-09 | Tibotec Pharm Ltd | Pirimidinas 5,6-sustituidas inhibidoras del virus de inmunodeficiencia humana. |
EA200901065A1 (ru) | 2007-02-06 | 2010-02-26 | Новартис Аг | Ингибиторы pi 3-киназы и способы их применения |
EP2133095A4 (de) | 2007-03-05 | 2012-09-26 | Kyowa Hakko Kirin Co Ltd | Pharmazeutische zusammensetzung |
CA2680029A1 (en) * | 2007-03-09 | 2008-09-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
AU2008226457B2 (en) * | 2007-03-09 | 2014-03-20 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as inhibitors of protein kinases |
NZ579483A (en) | 2007-03-09 | 2012-07-27 | Vertex Pharma | Aminopyridines useful as inhibitors of protein kinases |
MX2009010037A (es) * | 2007-03-20 | 2009-11-05 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasas. |
WO2008117050A1 (en) * | 2007-03-27 | 2008-10-02 | Astrazeneca Ab | Pyrazolyl-amino-substituted pyrazines and their use for the treatment of cancer |
CA2683785A1 (en) | 2007-04-13 | 2008-10-23 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
CA2684447C (en) | 2007-04-18 | 2012-01-24 | Pfizer Products Inc. | Sulfonyl amide derivatives for the treatment of abnormal cell growth |
WO2008129255A1 (en) * | 2007-04-18 | 2008-10-30 | Astrazeneca Ab | 5-aminopyrazol-3-yl-3h-imidazo [4,5-b] pyridine derivatives and their use for the treatment of cancer |
MX2009011810A (es) | 2007-05-02 | 2010-01-14 | Vertex Pharma | Tiazoles y pirazoles utiles como inhibidores de cinasa. |
AU2008247594A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
MX2009011811A (es) * | 2007-05-02 | 2010-01-14 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasa. |
UA99459C2 (en) * | 2007-05-04 | 2012-08-27 | Астразенека Аб | 9-(pyrazol-3-yl)- 9h-purine-2-amine and 3-(pyraz0l-3-yl)-3h-imidazo[4,5-b]pyridin-5-amine derivatives and their use for the treatment of cancer |
JP2010526048A (ja) * | 2007-05-04 | 2010-07-29 | アストラゼネカ アクチボラグ | アミノ−チアゾリル−ピリミジン誘導体、および癌の治療のための該誘導体の使用 |
CA2687966A1 (en) * | 2007-05-24 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
KR101294731B1 (ko) * | 2007-06-04 | 2013-08-16 | 삼성디스플레이 주식회사 | 어레이 기판, 이를 갖는 표시패널 및 이의 제조방법 |
WO2008154026A1 (en) * | 2007-06-11 | 2008-12-18 | Miikana Therapeutics, Inc. | Substituted pyrazole compounds |
JP2010532756A (ja) * | 2007-07-06 | 2010-10-14 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | mTORC1及びmTORC2の両方の阻害剤を含む組み合わせ抗癌療法 |
WO2009007753A2 (en) * | 2007-07-11 | 2009-01-15 | Astrazeneca Ab | 4- (3-aminopyrazole) -pyrimidine derivativee and their use as tyrosine kinase inhibitors for the treatment of cancer |
KR20100038108A (ko) * | 2007-07-25 | 2010-04-12 | 브리스톨-마이어스 스큅 컴퍼니 | 트리아진 키나제 억제제 |
WO2009013545A2 (en) * | 2007-07-26 | 2009-01-29 | Astrazeneca Ab | Chemical compounds |
CA2694499A1 (en) * | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
TW200906818A (en) * | 2007-07-31 | 2009-02-16 | Astrazeneca Ab | Chemical compounds |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2009027736A2 (en) * | 2007-08-27 | 2009-03-05 | Astrazeneca Ab | 2,4 diaminopyrimid'lnes for the treatment of myeloproliferative disorders and cancer |
MX2010002772A (es) | 2007-09-21 | 2010-03-31 | Array Biopharma Inc | Derivados de piridin-2-il-amino-1,2,4-tiadiazol como activadores de glucocinasa para el tratamiento de diabetes mellitus. |
PT2214487E (pt) | 2007-10-11 | 2014-02-20 | Glaxosmithkline Llc | Novos inibidores de seh e sua utilização |
EP2224929B1 (de) | 2007-12-17 | 2016-05-04 | Janssen Pharmaceutica, N.V. | Imidazol-, oxazol- und thiazolpyrimidinmodulatoren von trpv1 |
US20090270418A1 (en) * | 2008-01-09 | 2009-10-29 | Marianne Sloss | Pyrazole pyrazine amine compounds as kinase inhibitors, compositions thereof and methods of treatment therewith |
WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2260031B1 (de) | 2008-02-21 | 2015-10-07 | Merck Sharp & Dohme Corp. | Verbindungen, bei denen es sich um erk-inhibitoren handelt |
AU2009216062B2 (en) * | 2008-02-22 | 2013-02-07 | Msd K.K. | Novel aminopyridine derivatives having Aurora A selective inhibitory action |
WO2009131598A1 (en) | 2008-04-21 | 2009-10-29 | Taigen Biotechnology Co., Ltd. | Heterocyclic compounds |
WO2010011411A1 (en) | 2008-05-27 | 2010-01-28 | The Trustees Of Columbia University In The City Of New York | Systems, methods, and media for detecting network anomalies |
JP2011522870A (ja) * | 2008-06-11 | 2011-08-04 | アストラゼネカ アクチボラグ | 癌および骨髄増殖性障害の処置に有用な三環式2,4−ジアミノ−l,3,5−トリアジン誘導体 |
AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
US8163763B2 (en) * | 2008-07-31 | 2012-04-24 | Genentech, Inc. | Pyrimidine compounds, compositions and methods of use |
MX2011002312A (es) * | 2008-09-03 | 2011-04-26 | Vertex Pharma | Co-cristales y formulaciones farmaceuticas que comprenden los mismos. |
CN105574346A (zh) * | 2008-09-05 | 2016-05-11 | 新基阿维罗米克斯研究公司 | 多肽偶联物与不可逆抑制剂的设计方法和检测方法 |
CN102264728B (zh) * | 2008-09-15 | 2015-02-04 | 加利福尼亚大学董事会 | 用于调节ire1、src和abl活性的方法和组合物 |
BRPI0919488A2 (pt) * | 2008-09-30 | 2015-12-01 | Astrazeneca Ab | composto, uso de um composto, método para tratar câncer em um animal de sangue quente, composição farmacêutica, e, processo para preparar um composto |
US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
WO2010056758A1 (en) * | 2008-11-12 | 2010-05-20 | Yangbo Feng | Quinazoline derivatives as kinase inhibitors |
TW201021855A (en) | 2008-11-13 | 2010-06-16 | Taigen Biotechnology Co Ltd | Lyophilization formulation |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
PA8851101A1 (es) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
JP5490137B2 (ja) * | 2008-12-19 | 2014-05-14 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | プロテインキナーゼ阻害薬としての二環式ピラゾール |
JP5738196B2 (ja) | 2008-12-22 | 2015-06-17 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | オーロラキナーゼ阻害剤および抗cd20抗体の併用 |
US8809343B2 (en) | 2008-12-26 | 2014-08-19 | Fudan University | Pyrimidine derivative, preparation method and use thereof |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
MY159327A (en) * | 2009-02-27 | 2016-12-25 | Ambit Biosciences Corp | Jak kinase modulating quinazoline derivatives and methods of use thereof |
CA2660962A1 (en) | 2009-03-31 | 2010-09-30 | Astellas Pharma Inc. | Novel pharmaceutical composition for treatment of schizophrenia |
US8399663B2 (en) | 2009-04-03 | 2013-03-19 | Astellas Pharma Inc. | Salt of 1,3,5-triazine-2,4,6-triamine derivative |
JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
BRPI1010887A2 (pt) * | 2009-06-08 | 2016-12-27 | California Capital Equity Llc | derivados de triazina e suas aplicações terapêuticas. |
BRPI1010881A2 (pt) * | 2009-06-08 | 2016-05-31 | California Capital Equity Llc | derivados de triazina e suas aplicações terapêuticas. |
JP2012529517A (ja) * | 2009-06-09 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | ベンジル置換トリアジン誘導体類及びそれらの治療応用 |
WO2010144550A1 (en) * | 2009-06-09 | 2010-12-16 | Abraxis Bioscience, Llc | Triazine derivatives and their therapeutical applications |
WO2010144522A1 (en) * | 2009-06-09 | 2010-12-16 | Abraxis Bioscience, Llc | Ureidophenyl substituted triazine derivatives and their therapeutical applications |
JP2012529519A (ja) * | 2009-06-09 | 2012-11-22 | アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー | スチリル−トリアジン誘導体類及びそれらの治療応用 |
WO2010146133A1 (en) * | 2009-06-18 | 2010-12-23 | Cellzome Limited | Heterocyclylaminopyrimidines as kinase inhibitors |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
TWI468402B (zh) * | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
US8785608B2 (en) | 2009-08-26 | 2014-07-22 | Sanofi | Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
RU2012114902A (ru) | 2009-09-16 | 2013-10-27 | Авила Терапьютикс, Инк. | Конъюгаты и ингибиторы протеинкиназы |
KR102009224B1 (ko) * | 2009-11-13 | 2019-08-09 | 인튜어티브 서지컬 오퍼레이션즈 인코포레이티드 | 여분의 닫힘 메커니즘을 구비한 단부 작동기 |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
WO2011082285A1 (en) | 2009-12-30 | 2011-07-07 | Avila Therapeutics, Inc. | Ligand-directed covalent modification of protein |
SA111320200B1 (ar) * | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
WO2011103089A1 (en) | 2010-02-19 | 2011-08-25 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6--methoxyphenyl)-5h -pyrimido[5,4-d][2]benzazepin-2yl]amino}-2-methoxybenzoate |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2571359A4 (de) * | 2010-05-20 | 2013-10-23 | Merck Sharp & Dohme | Neuartige prolylcarboxypeptidase-hemmer |
CA2798578C (en) | 2010-05-21 | 2015-12-29 | Chemilia Ab | Novel pyrimidine derivatives |
US8354420B2 (en) | 2010-06-04 | 2013-01-15 | Genentech, Inc. | Aminopyrimidine derivatives as LRRK2 inhibitors |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
CA2806008C (en) | 2010-07-29 | 2019-07-09 | Oryzon Genomics S.A. | Arylcyclopropylamine based demethylase inhibitors of lsd1 and their medical use |
EP2611794A1 (de) * | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | 4--azolylaminochinazolinderivate und verwendungsverfahren dafür |
ES2619850T3 (es) * | 2010-09-01 | 2017-06-27 | Ambit Biosciences Corporation | Sales de hidrobromuro de una pirazolilaminoquinazolina |
WO2012030918A1 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Adenosine a3 receptor modulating compounds and methods of use thereof |
JP5901634B2 (ja) * | 2010-09-01 | 2016-04-13 | アムビト ビオスシエンセス コルポラチオン | キナゾリン化合物及びその使用方法 |
WO2012030944A2 (en) * | 2010-09-01 | 2012-03-08 | Ambit Biosciences Corporation | Quinoline and isoquinoline compounds and methods of use thereof |
AU2011296078B2 (en) * | 2010-09-01 | 2015-06-18 | Ambit Biosciences Corporation | An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof |
EP2611793A1 (de) * | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | 2-cyclochinazolinderivate und verwendungsverfahren dafür |
WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
CN103313978B (zh) | 2010-11-10 | 2015-04-15 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂的吡唑氨基嘧啶衍生物 |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683703B1 (de) | 2011-03-08 | 2015-05-27 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
CA2830129C (en) | 2011-03-24 | 2016-07-19 | Chemilia Ab | Novel pyrimidine derivatives |
KR20140062079A (ko) * | 2011-08-25 | 2014-05-22 | 에프. 호프만-라 로슈 아게 | 세린/트레오닌 pak1 억제제 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
MX2014003501A (es) | 2011-09-22 | 2014-07-22 | Pfizer | Derivados de pirrolopirimidina y purina. |
EP2760862B1 (de) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren |
MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
JP6106685B2 (ja) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | C−jun−n−末端キナーゼ(jnk)の阻害剤 |
RU2014129740A (ru) | 2011-12-22 | 2016-02-10 | Ф.Хоффманн-Ля Рош Аг | Производные 2,4-диаминопиримидина в качестве ингибиторов серин/треонин киназы |
RU2014137448A (ru) * | 2012-02-17 | 2016-04-10 | Эббви Инк. | Диаминопиримидины, пригодные в качестве ингибиторов респираторно-синцитиального вируса человека (rsv) |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
TWI485146B (zh) * | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
EP2834232A1 (de) | 2012-03-16 | 2015-02-11 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazol-kinaseinhibitoren |
US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
SG10201704095UA (en) | 2012-04-24 | 2017-06-29 | Vertex Pharma | Dna-pk inhibitors |
KR20150013554A (ko) * | 2012-05-24 | 2015-02-05 | 셀좀 리미티드 | Tyk2 억제제로서의 헤테로시클릴 피리미딘 유사체 |
CA2880896C (en) | 2012-06-26 | 2021-11-16 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
WO2014008992A1 (en) * | 2012-07-10 | 2014-01-16 | Ares Trading S.A. | Pyrimidine pyrazolyl derivatives |
MY183976A (en) * | 2012-09-19 | 2021-03-17 | Taiho Pharmaceutical Co Ltd | Pharmaceutical composition for oral administration with improved dissolution and/or absorption |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
CN103191120B (zh) * | 2012-12-31 | 2015-11-25 | 刘强 | 一种嘧啶衍生物在制备预防和/或治疗和/或辅助治疗肿瘤的药物中的用途 |
CN103202843B (zh) * | 2012-12-31 | 2015-04-29 | 刘强 | 一种嘧啶衍生物在制备预防和/或治疗和/或辅助治疗癌症的药物中的用途 |
CN103059002B (zh) * | 2012-12-31 | 2015-04-22 | 中山大学 | 具有Aurora激酶抑制活性的嘧啶衍生物及其制备方法以及应用 |
CN103910716A (zh) * | 2013-01-07 | 2014-07-09 | 华东理工大学 | 2,4-二取代-环烷基[d]嘧啶类化合物及其用途 |
TR201901886T4 (tr) | 2013-03-12 | 2019-03-21 | Vertex Pharma | DNA-PK inhibitörleri. |
AP2015008707A0 (en) | 2013-03-14 | 2015-09-30 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
EP3521284B1 (de) | 2013-03-15 | 2020-12-02 | The Trustees of Columbia University in the City of New York | Pyrazin-verbindungen als map-kinasemodulatoren und verwendungen davon |
WO2014153509A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase |
WO2015003355A2 (en) * | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
EP3024456A4 (de) | 2013-07-26 | 2017-04-12 | Update Pharma Inc. | Kombinatorische verfahren zur verbesserung des therapeutischen nutzens von bisantren |
WO2015028848A1 (en) * | 2013-09-02 | 2015-03-05 | Piramal Enterprises Limited | Bicyclic heterocyclic compounds as multi-kinase inhibitors |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
PL3057953T3 (pl) | 2013-10-17 | 2019-01-31 | Vertex Pharmaceuticals Incorporated | Kokryształy (S)-N-metylo-8-(1-((2'-metylo-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK |
AU2014337122B2 (en) | 2013-10-18 | 2019-01-03 | Dana-Farber Cancer Institute, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
US10030004B2 (en) | 2014-01-01 | 2018-07-24 | Medivation Technologies Llc | Compounds and methods of use |
PT3116475T (pt) | 2014-03-13 | 2020-12-15 | Neuroderm Ltd | Composições de inibidores de dopa-descarboxilase |
US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
US9403801B2 (en) | 2014-03-28 | 2016-08-02 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
LT3125883T (lt) | 2014-04-04 | 2020-10-26 | Iomet Pharma Ltd. | Indolo dariniai, skirti panaudoti medicinoje |
WO2015155738A2 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
CN105367555B (zh) * | 2014-08-07 | 2019-06-25 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
EP3236959A4 (de) | 2014-12-23 | 2018-04-25 | Dana Farber Cancer Institute, Inc. | Hemmer der cyclinabhängigen kinase 7 (cdk7) |
WO2016106309A1 (en) | 2014-12-23 | 2016-06-30 | Axikin Pharmaceuticals, Inc. | 3,5-diaminopyrazole kinase inhibitors |
US10227343B2 (en) * | 2015-01-30 | 2019-03-12 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
EP3273966B1 (de) | 2015-03-27 | 2023-05-03 | Dana-Farber Cancer Institute, Inc. | Hemmer von cyclinabhängigen kinasen |
AU2016247858B2 (en) | 2015-04-17 | 2020-10-15 | Ludwig Institute For Cancer Research Ltd. | PLK4 inhibitors |
CN111362975B (zh) | 2015-05-28 | 2022-04-05 | 施万生物制药研发Ip有限责任公司 | 作为jak激酶抑制剂的萘啶化合物 |
JP2018135268A (ja) * | 2015-06-05 | 2018-08-30 | 大日本住友製薬株式会社 | 新規ヘテロアリールアミノ−3−ピラゾール誘導体およびその薬理学上許容される塩 |
EP3347018B1 (de) | 2015-09-09 | 2021-09-01 | Dana-Farber Cancer Institute, Inc. | Hemmer von cyclinabhängigen kinasen |
WO2017044434A1 (en) | 2015-09-11 | 2017-03-16 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
PT3386511T (pt) * | 2015-12-10 | 2021-07-14 | Ptc Therapeutics Inc | Métodos para tratamento da doença de huntington |
CN105399695B (zh) * | 2015-12-11 | 2019-04-19 | 浙江大学 | 三嗪类化合物及其制备方法和用途 |
CN105384702B (zh) * | 2015-12-11 | 2018-04-10 | 浙江大学 | 三取代均三嗪类化合物及其制备方法 |
CN105503754B (zh) * | 2015-12-11 | 2017-11-17 | 浙江大学 | 2‑氨基‑4‑苄基‑6‑吗啉‑1,3,5‑三嗪及其制备和应用 |
US10894784B2 (en) | 2015-12-18 | 2021-01-19 | Bayer Pharma Aktiengesellschaft | Heteroarylbenzimidazole compounds |
KR102489454B1 (ko) | 2016-03-14 | 2023-01-17 | 애퍼런트 파마슈티컬스 인크. | 피리미딘 및 그의 변이체, 및 그의 용도 |
WO2017165255A1 (en) | 2016-03-25 | 2017-09-28 | Afferent Pharmaceuticals Inc. | Pyrimidines and variants thereof, and uses therefor |
MX2018013191A (es) | 2016-04-28 | 2019-02-13 | Theravance Biopharma R&D Ip Llc | Compuestos de pirimidina como inhibidores de la quinasa jak. |
WO2017207534A1 (en) | 2016-06-03 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituted heteroarylbenzimidazole compounds |
TW201815418A (zh) | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
US10858319B2 (en) | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
WO2018089546A1 (en) * | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline ether compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
CN108239071B (zh) * | 2016-12-27 | 2020-12-04 | 沈阳药科大学 | 酰胺及硫代酰胺类衍生物及其制备方法和应用 |
FR3064275B1 (fr) | 2017-03-21 | 2019-06-07 | Arkema France | Procede de chauffage et/ou climatisation d'un vehicule |
EP3630731B1 (de) | 2017-05-30 | 2023-08-09 | Basf Se | Pyridine und pyrazine verbindungen zur bekampfung phytopathogener fungi |
WO2018226622A1 (en) | 2017-06-05 | 2018-12-13 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
JP7039802B2 (ja) | 2017-06-30 | 2022-03-23 | ベイジン タイド ファーマシューティカル カンパニー リミテッド | Rho-関連プロテインキナーゼ阻害剤、rho-関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用 |
CN111217797B (zh) | 2017-06-30 | 2021-02-05 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
JP2020525525A (ja) * | 2017-06-30 | 2020-08-27 | ベイジン タイド ファーマシューティカル カンパニー リミテッドBeijing Tide Pharmaceutical Co., Ltd. | Rho−関連プロテインキナーゼ阻害剤、rho−関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用 |
WO2019046163A1 (en) * | 2017-08-28 | 2019-03-07 | Zhihong Chen | SUBSTITUTED PYRIMIDINES, PHARMACEUTICAL COMPOSITIONS AND ASSOCIATED THERAPEUTIC METHODS |
EP3676264A1 (de) * | 2017-08-28 | 2020-07-08 | Acurastem Inc. | Pikfyve-kinase-inhibitoren |
IL274037B2 (en) | 2017-10-27 | 2023-11-01 | Theravance Biopharma R& D Ip Llc | A pyrimidine compound as a JAK kinase inhibitor |
MX2020004536A (es) * | 2017-11-23 | 2020-08-03 | Biomed X Gmbh | Derivados de pirimidina como inhibidores del receptor de tropomiosina quinasa (trka). |
EP3720560A4 (de) * | 2017-12-06 | 2022-01-05 | Ludwig Institute for Cancer Research Ltd | Verfahren zur behandlung von krebs mit plk4-inhibitoren |
CA3094703A1 (en) | 2018-03-27 | 2019-10-03 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
JP2021528470A (ja) * | 2018-06-25 | 2021-10-21 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | Taireファミリーキナーゼインヒビターおよびそれらの使用 |
EP3814360A1 (de) | 2018-06-27 | 2021-05-05 | PTC Therapeutics, Inc. | Heteroarylverbindungen zur behandlung von morbus huntington |
SG11202012674PA (en) | 2018-06-27 | 2021-01-28 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for treating huntington's disease |
JP2022529371A (ja) | 2019-04-24 | 2022-06-21 | セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー | 皮膚疾患の処置のためのピリミジンjak阻害剤 発明の背景 |
EP3958969B1 (de) | 2019-04-24 | 2024-01-10 | Theravance Biopharma R&D IP, LLC | Ester- und carbonatpyrimidinverbindungen als jak-kinase-inhibitoren |
CN114728949A (zh) * | 2019-08-01 | 2022-07-08 | 整体生物科学私人有限公司 | 作为激酶抑制剂的杂环化合物及其用途 |
US11787796B2 (en) | 2019-09-18 | 2023-10-17 | Takeda Pharmaceutical Company Limited | Plasma Kallikrein inhibitors and uses thereof |
CN110483493A (zh) * | 2019-09-19 | 2019-11-22 | 广东工业大学 | 一种二唑类衍生物及其制备方法和应用 |
US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
TW202237119A (zh) | 2020-12-10 | 2022-10-01 | 美商住友製藥腫瘤公司 | Alk﹘5抑制劑和彼之用途 |
JP2024510504A (ja) * | 2021-03-17 | 2024-03-07 | 武田薬品工業株式会社 | 血漿カリクレインの多環式インヒビター |
JP2024511466A (ja) * | 2021-03-26 | 2024-03-13 | スミトモ ファーマ オンコロジー, インコーポレイテッド | Alk-5阻害剤及びその使用 |
TW202309008A (zh) | 2021-05-11 | 2023-03-01 | 美商歐瑞克製藥公司 | 類polo激酶4抑制劑 |
UY39832A (es) | 2021-06-28 | 2023-01-31 | Blueprint Medicines Corp | Inhibidores de cdk2 |
CN116354938B (zh) * | 2021-12-28 | 2024-02-20 | 沈阳药科大学 | 一类喹唑啉衍生物与其类似物的制备方法及应用 |
CN114276302B (zh) * | 2022-01-11 | 2023-07-25 | 山东百启生物医药有限公司 | 一种制备2,4-二氨基喹唑啉衍生物的方法 |
WO2024003773A1 (en) | 2022-07-01 | 2024-01-04 | Pfizer Inc. | 2,7-naphthyridine compounds as mastl inhibitors |
CN117736198A (zh) * | 2022-09-21 | 2024-03-22 | 科辉智药生物科技(深圳)有限公司 | 大环含氮冠醚化合物及其作为蛋白激酶抑制剂的应用 |
CN115403568B (zh) * | 2022-09-21 | 2023-09-29 | 中山大学 | 一种喹唑啉类Aurora A共价抑制剂及其制备方法和应用 |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2585906A (en) | 1952-02-12 | Quaternary salts of pyrimdjines | ||
US3133081A (en) | 1964-05-12 | J-aminoindazole derivatives | ||
US18436A (en) * | 1857-10-20 | And saml | ||
US3935183A (en) | 1970-01-26 | 1976-01-27 | Imperial Chemical Industries Limited | Indazole-azo phenyl compounds |
BE754242A (fr) | 1970-07-15 | 1971-02-01 | Geigy Ag J R | Diamino-s-triazines et dinitro-s-triazines |
US3755332A (en) * | 1971-07-01 | 1973-08-28 | Ciba Geigy Corp | Substituted 4 indazolaminoquinolines |
US3998951A (en) | 1974-03-13 | 1976-12-21 | Fmc Corporation | Substituted 2-arylquinazolines as fungicides |
DE2458965C3 (de) | 1974-12-13 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel |
MA18829A1 (fr) | 1979-05-18 | 1980-12-31 | Ciba Geigy Ag | Derives de la pyrimidine,procedes pour leur preparation,compositions pharmaceutiques contenant ces composes et leur utilisation therapeutique |
DOP1981004033A (es) * | 1980-12-23 | 1990-12-29 | Ciba Geigy Ag | Procedimiento para proteger plantas de cultivo de la accion fitotoxica de herbicidas. |
SE8102194L (sv) | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
SE8102193L (sv) | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och dess anvendning |
JPS58124773A (ja) | 1982-01-20 | 1983-07-25 | Mitsui Toatsu Chem Inc | 5−メチルチオピリミジン誘導体とその製造法と農園芸用殺菌剤 |
EP0136976A3 (de) | 1983-08-23 | 1985-05-15 | Ciba-Geigy Ag | Verwendung von Phenylpyrimidinen als Pflanzenregulatoren |
DE3725638A1 (de) | 1987-08-03 | 1989-02-16 | Bayer Ag | Neue aryloxy (bzw. thio)aminopyrimidine |
JPH0532662A (ja) | 1990-11-09 | 1993-02-09 | Nissan Chem Ind Ltd | 置換ピラゾール誘導体および農園芸用殺菌剤 |
US5714493A (en) * | 1991-05-10 | 1998-02-03 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5597920A (en) | 1992-04-30 | 1997-01-28 | Neurogen Corporation | Gabaa receptor subtypes and methods for screening drug compounds using imidazoquinoxalines and pyrrolopyrimidines to bind to gabaa receptor subtypes |
JPH0665237A (ja) * | 1992-05-07 | 1994-03-08 | Nissan Chem Ind Ltd | 置換ピラゾール誘導体および農園芸用殺菌剤 |
JP3588116B2 (ja) | 1993-10-01 | 2004-11-10 | ノバルティス アクチェンゲゼルシャフト | 薬理活性のピリミジンアミン誘導体およびその製造方法 |
ATE262902T1 (de) | 1994-11-10 | 2004-04-15 | Millennium Pharm Inc | Verwendung von pyrazole verbindungen zur behandlung von glomerulonephritis, krebs, atherosklerose oder restenose |
IL117659A (en) | 1995-04-13 | 2000-12-06 | Dainippon Pharmaceutical Co | Substituted 2-phenyl pyrimidino amino acetamide derivative process for preparing the same and a pharmaceutical composition containing same |
US5935966A (en) | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
AU726058B2 (en) | 1995-09-01 | 2000-10-26 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
ID19609A (id) | 1996-07-13 | 1998-07-23 | Glaxo Group Ltd | Senyawa-senyawa heterosiklik |
JPH10130150A (ja) | 1996-09-05 | 1998-05-19 | Dainippon Pharmaceut Co Ltd | 酢酸アミド誘導体からなる医薬 |
GB9619284D0 (en) | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
ATE291022T1 (de) | 1996-10-02 | 2005-04-15 | Novartis Pharma Gmbh | Pyrimiderivate und verfahren zu ihrer herstellung |
CA2268098A1 (en) | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | Aspartate ester inhibitors of interleukin-1.beta. converting enzyme |
CN1138472C (zh) | 1997-10-10 | 2004-02-18 | 西托维亚公司 | 二肽型编程性细胞死亡抑制剂及其用途 |
US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
JP2000026421A (ja) | 1998-01-29 | 2000-01-25 | Kumiai Chem Ind Co Ltd | ジアリ―ルスルフィド誘導体及び有害生物防除剤 |
CN1297447A (zh) | 1998-02-17 | 2001-05-30 | 图拉列克股份有限公司 | 抗病毒嘧啶衍生物 |
EP1076563B1 (de) | 1998-03-16 | 2005-05-11 | Cytovia, Inc. | Dipeptid kaspase inhibitoren und deren verwendung |
CZ302486B6 (cs) | 1998-06-02 | 2011-06-15 | Osi Pharmaceuticals, Inc. | N-6-Substituovaný 7-deazapurin, zpusob jeho prípravy a farmaceutická kompozice s jeho obsahem |
JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | グリコーゲンシンターゼキナーゼ3のインヒビター |
WO2000003901A1 (de) * | 1998-07-16 | 2000-01-27 | Continental Teves Ag & Co. Ohg | Verfahren und vorrichtung zum ermitteln von kritischen fahrzuständen bei im fahrbetrieb befindlichen fahrzeugen |
CA2339188A1 (en) | 1998-08-21 | 2000-03-02 | Dupont Pharmaceuticals Company | Isoxazolo¬4,5-d|pyrimidines as crf antagonists |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
US7262201B1 (en) | 1998-10-08 | 2007-08-28 | Astrazeneca Ab | Quinazoline derivatives |
GB9828640D0 (en) | 1998-12-23 | 1999-02-17 | Smithkline Beecham Plc | Novel method and compounds |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
DE69926914T2 (de) | 1999-01-13 | 2006-06-29 | Warner-Lambert Co. Llc | 1-heterozyklus-substituierte diarylaminen |
BR0009507A (pt) | 1999-03-30 | 2002-01-15 | Novartis Ag | Derivados de ftalazina para o tratamento de doenças inflamatórias |
JP2003502424A (ja) * | 1999-06-17 | 2003-01-21 | シオノギ バイオリサーチ コーポレイション | Il−12産生の阻害物質 |
GB9914258D0 (en) | 1999-06-18 | 1999-08-18 | Celltech Therapeutics Ltd | Chemical compounds |
JP2003531103A (ja) | 1999-08-12 | 2003-10-21 | バーテックス ファーマシューティカルズ インコーポレイテッド | c−JUNN−末端キナーゼ(JNK)および他のタンパク質キナーゼの阻害剤 |
JP2003511378A (ja) * | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | トリアジン系キナーゼ阻害薬 |
EA200200411A1 (ru) | 1999-11-30 | 2002-10-31 | Пфайзер Продактс Инк. | 2,4-диаминопиримидиновые соединения, полезные в качестве иммуносупрессоров |
ES2269217T3 (es) | 1999-12-02 | 2007-04-01 | Osi Pharmaceuticals, Inc. | Compuestos especificos para los receptores a1, a2a y a3 de adenosina y sus usos. |
MY125768A (en) | 1999-12-15 | 2006-08-30 | Bristol Myers Squibb Co | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases |
US6376489B1 (en) | 1999-12-23 | 2002-04-23 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
US20020065270A1 (en) | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
JP4783532B2 (ja) | 2000-02-05 | 2011-09-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Erkのインヒビターとして有用なピラゾール組成物 |
EP1257546A1 (de) | 2000-02-17 | 2002-11-20 | Amgen Inc. | Kinase inhibitoren |
GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
CA2405043A1 (en) | 2000-04-03 | 2001-10-11 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
AU2001249865A1 (en) | 2000-04-18 | 2001-10-30 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinase |
JP3890184B2 (ja) * | 2000-05-15 | 2007-03-07 | Necパーソナルプロダクツ株式会社 | 電源装置及びその電力制御方法、情報処理機器 |
DE60133897D1 (de) | 2000-06-28 | 2008-06-19 | Astrazeneca Ab | Substituierte chinazolin-derivate und deren verwendung als aurora-2-kinase inhibitoren |
CN1518543A (zh) | 2000-08-31 | 2004-08-04 | �Ʒ� | 吡唑衍生物和它们作为蛋白激酶抑制剂的用途 |
DE60122176T2 (de) | 2000-09-15 | 2007-07-05 | Vertex Pharmaceuticals Inc., Cambridge | Isoxazole und ihre verwendung als erk-inhibitoren |
US6610677B2 (en) | 2000-09-15 | 2003-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1317449B1 (de) | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazolverbindungen als protein-kinasehemmer |
US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
US6613776B2 (en) | 2000-09-15 | 2003-09-02 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
AU2001293817A1 (en) | 2000-09-20 | 2002-04-02 | Merck Patent Gmbh | 4-amino-quinazolines |
US6641579B1 (en) | 2000-09-29 | 2003-11-04 | Spectrasonics Imaging, Inc. | Apparatus and method for ablating cardiac tissue |
DE10061863A1 (de) | 2000-12-12 | 2002-06-13 | Basf Ag | Verfahren zur Herstellung von Triethylendiamin (TEDA) |
US6716851B2 (en) | 2000-12-12 | 2004-04-06 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof |
WO2002047690A1 (en) | 2000-12-12 | 2002-06-20 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
ATE340172T1 (de) | 2000-12-21 | 2006-10-15 | Vertex Pharma | Pyrazolverbindungen als protein- kinasehemmer |
MY130778A (en) | 2001-02-09 | 2007-07-31 | Vertex Pharma | Heterocyclic inhibitiors of erk2 and uses thereof |
DE60223790D1 (de) | 2001-03-29 | 2008-01-10 | Vertex Pharma | Hemmer von c-jun-terminal kinase (jnk) und andere protein kinase |
MXPA03009378A (es) | 2001-04-13 | 2004-01-29 | Vertex Pharma | Inhibidores de cinasas c-jun n-terminales (jnk) y otras proteinas cinasas. |
US20030096813A1 (en) | 2001-04-20 | 2003-05-22 | Jingrong Cao | Compositions useful as inhibitors of GSK-3 |
WO2002092573A2 (en) | 2001-05-16 | 2002-11-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
WO2002102800A1 (en) | 2001-06-15 | 2002-12-27 | Vertex Pharmaceuticals Incorporated | 5-(2-aminopyrimidin-4-yl) benzisoxazoles as protein kinase inhibitors |
US6689778B2 (en) | 2001-07-03 | 2004-02-10 | Vertex Pharmaceuticals Incorporated | Inhibitors of Src and Lck protein kinases |
WO2003026664A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
US6569499B2 (en) | 2001-10-02 | 2003-05-27 | Xerox Corporation | Apparatus and method for coating photoreceptor substrates |
EP1474147B1 (de) | 2001-12-07 | 2010-05-05 | Vertex Pharmaceuticals Incorporated | Verbindungen auf pyrimidin-basis als gsk-3-hemmer |
WO2003078423A1 (en) | 2002-03-15 | 2003-09-25 | Vertex Pharmaceuticals, Inc. | Compositions useful as inhibitors of protein kinases |
US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
DE60332433D1 (de) | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
EP1485381B8 (de) | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine als inhibitoren von proteinkinasen |
US20030207873A1 (en) | 2002-04-10 | 2003-11-06 | Edmund Harrington | Inhibitors of Src and other protein kinases |
AU2003237121A1 (en) | 2002-04-26 | 2003-11-10 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
JP4570955B2 (ja) | 2002-07-09 | 2010-10-27 | バーテクス ファーマスーティカルズ インコーポレイテッド | プロテインキナーゼ阻害活性を持つイミダゾール類 |
ES2273043T3 (es) | 2002-08-02 | 2007-05-01 | Vertex Pharmaceuticals Incorporated | Composiciones de pirazol utiles como inhibidores de gsk-3. |
DE602007007985D1 (de) | 2006-12-19 | 2010-09-02 | Vertex Pharma | Als inhibitoren von proteinkinasen geeignete aminopyrimidine |
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