DE60120193D1 - Pyrazolverbindungen als protein-kinasehemmer - Google Patents

Pyrazolverbindungen als protein-kinasehemmer

Info

Publication number
DE60120193D1
DE60120193D1 DE60120193T DE60120193T DE60120193D1 DE 60120193 D1 DE60120193 D1 DE 60120193D1 DE 60120193 T DE60120193 T DE 60120193T DE 60120193 T DE60120193 T DE 60120193T DE 60120193 D1 DE60120193 D1 DE 60120193D1
Authority
DE
Germany
Prior art keywords
protein kinase
hemmer
pyrazol compounds
pyrazol
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60120193T
Other languages
English (en)
Other versions
DE60120193T2 (de
Inventor
Ronald Knegtel
David Bebbington
Hayley Binch
Julian Golec
Sanjay Patel
Jean-Damien Charrier
David Kay
Robert Davies
Pan Li
Marion Wannamaker
Cornelia Forster
Albert C Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27398347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60120193(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Application granted granted Critical
Publication of DE60120193D1 publication Critical patent/DE60120193D1/de
Publication of DE60120193T2 publication Critical patent/DE60120193T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
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    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE60120193T 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer Expired - Lifetime DE60120193T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US23279500P 2000-09-15 2000-09-15
US232795P 2000-09-15
US25788700P 2000-12-21 2000-12-21
US257887P 2000-12-21
US28694901P 2001-04-27 2001-04-27
US286949P 2001-04-27
PCT/US2001/028740 WO2002022601A1 (en) 2000-09-15 2001-09-14 Pyrazole compounds useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60120193D1 true DE60120193D1 (de) 2006-07-06
DE60120193T2 DE60120193T2 (de) 2007-03-29

Family

ID=27398347

Family Applications (8)

Application Number Title Priority Date Filing Date
DE60128709T Expired - Lifetime DE60128709T2 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase-inhibitoren
DE60119749T Expired - Lifetime DE60119749T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60110616T Expired - Lifetime DE60110616T3 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120193T Expired - Lifetime DE60120193T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60124744T Expired - Lifetime DE60124744T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120198T Expired - Lifetime DE60120198T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119748T Expired - Lifetime DE60119748T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120194T Expired - Lifetime DE60120194T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE60128709T Expired - Lifetime DE60128709T2 (de) 2000-09-15 2001-09-14 Triazol-verbindungen als protein-kinase-inhibitoren
DE60119749T Expired - Lifetime DE60119749T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60110616T Expired - Lifetime DE60110616T3 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Family Applications After (4)

Application Number Title Priority Date Filing Date
DE60124744T Expired - Lifetime DE60124744T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120198T Expired - Lifetime DE60120198T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60119748T Expired - Lifetime DE60119748T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer
DE60120194T Expired - Lifetime DE60120194T2 (de) 2000-09-15 2001-09-14 Pyrazolverbindungen als protein-kinasehemmer

Country Status (24)

Country Link
US (7) US6696452B2 (de)
EP (8) EP1318997B1 (de)
JP (9) JP4105947B2 (de)
KR (4) KR20030032035A (de)
CN (3) CN100355750C (de)
AP (1) AP2003002762A0 (de)
AT (8) ATE327991T1 (de)
AU (9) AU2001290914A1 (de)
BR (1) BR0114088A (de)
CA (8) CA2422378C (de)
DE (8) DE60128709T2 (de)
DK (1) DK1318997T3 (de)
ES (3) ES2242771T5 (de)
HK (8) HK1057543A1 (de)
HU (4) HUP0401819A3 (de)
IL (6) IL154784A0 (de)
MX (8) MXPA03002299A (de)
NO (4) NO327708B1 (de)
NZ (4) NZ525014A (de)
PE (1) PE20020451A1 (de)
PL (1) PL361676A1 (de)
PT (2) PT1317448E (de)
TW (1) TWI303636B (de)
WO (8) WO2002022607A1 (de)

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DE69638073D1 (de) * 1996-09-04 2009-12-24 Intertrust Tech Corp Zuverlässige Infrastrukturhilfssysteme, Verfahren und Techniken für sicheren elektronischen Handel, elektronische Transaktionen, Handelsablaufsteuerung und Automatisierung, verteilte Verarbeitung und Rechteverwaltung
US6184226B1 (en) * 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
US6982260B1 (en) 1999-11-22 2006-01-03 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
CA2395593C (en) 1999-12-24 2011-08-02 Aventis Pharma Limited Azaindoles
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
ES2242771T5 (es) * 2000-09-15 2011-10-14 Vertex Pharmaceuticals Incorporated Compuestos de pirazol útiles como inhibidores de proteína quinasas.
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