DE60121813D1 - Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten - Google Patents
Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthaltenInfo
- Publication number
- DE60121813D1 DE60121813D1 DE60121813T DE60121813T DE60121813D1 DE 60121813 D1 DE60121813 D1 DE 60121813D1 DE 60121813 T DE60121813 T DE 60121813T DE 60121813 T DE60121813 T DE 60121813T DE 60121813 D1 DE60121813 D1 DE 60121813D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- new
- compositions containing
- medical compositions
- chinuclidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200003130 | 2000-12-28 | ||
ES200003130 | 2000-12-28 | ||
PCT/EP2001/015168 WO2002053564A2 (en) | 2000-12-28 | 2001-12-20 | Quinuclidine derivatives and their use as m3 antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60121813D1 true DE60121813D1 (de) | 2006-09-07 |
DE60121813T2 DE60121813T2 (de) | 2007-09-20 |
Family
ID=8496180
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60121813T Expired - Lifetime DE60121813T2 (de) | 2000-12-28 | 2001-12-20 | Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten |
Country Status (34)
Country | Link |
---|---|
US (4) | US7122558B2 (de) |
EP (1) | EP1353919B1 (de) |
JP (1) | JP4295985B2 (de) |
KR (1) | KR100869721B1 (de) |
CN (1) | CN1250545C (de) |
AR (1) | AR032072A1 (de) |
AT (1) | ATE334128T1 (de) |
AU (1) | AU2002238471B2 (de) |
BG (1) | BG66162B1 (de) |
BR (1) | BR0116624A (de) |
CA (1) | CA2433128C (de) |
CY (1) | CY1105719T1 (de) |
CZ (1) | CZ301209B6 (de) |
DE (1) | DE60121813T2 (de) |
DK (1) | DK1353919T3 (de) |
EC (1) | ECSP034672A (de) |
EE (1) | EE05404B1 (de) |
ES (1) | ES2266291T3 (de) |
HK (1) | HK1055739A1 (de) |
HU (1) | HUP0303524A3 (de) |
IL (2) | IL156558A0 (de) |
MX (1) | MXPA03005862A (de) |
MY (1) | MY136067A (de) |
NO (1) | NO328772B1 (de) |
NZ (1) | NZ526674A (de) |
PE (1) | PE20020721A1 (de) |
PL (1) | PL363807A1 (de) |
PT (1) | PT1353919E (de) |
RU (1) | RU2282629C2 (de) |
SI (1) | SI1353919T1 (de) |
SK (1) | SK287414B6 (de) |
UA (1) | UA75626C2 (de) |
WO (1) | WO2002053564A2 (de) |
ZA (1) | ZA200305008B (de) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
IL156499A0 (en) | 2000-12-22 | 2004-01-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
JP4295985B2 (ja) * | 2000-12-28 | 2009-07-15 | ラボラトリオス・アルミラル・ソシエダッド・アノニマ | 新規なキヌクリジン誘導体およびそれを含む医薬組成物 |
GB0118373D0 (en) * | 2001-07-27 | 2001-09-19 | Glaxo Group Ltd | Novel therapeutic method |
ES2203327B1 (es) | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
ES2204295B1 (es) | 2002-07-02 | 2005-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de quinuclidina-amida. |
JP2006502985A (ja) | 2002-07-08 | 2006-01-26 | ランバクシー ラボラトリーズ リミテッド | ムスカリン性受容体拮抗剤として有用な3,6−二置換アザビシクロ[3.1.0]ヘキサン誘導体 |
EP1545508A4 (de) * | 2002-08-09 | 2009-11-25 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo ¬3.1.0 hexan-derivate als muscarinische rezeptor-antagonisten |
TW200800953A (en) | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
EP1618091A1 (de) | 2003-04-09 | 2006-01-25 | Ranbaxy Laboratories, Ltd. | Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren |
JP2006522787A (ja) * | 2003-04-11 | 2006-10-05 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体 |
AR044134A1 (es) | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
CN100445281C (zh) * | 2003-05-02 | 2008-12-24 | 诺瓦提斯公司 | 与毒蕈碱性m3受体结合的奎宁环衍生物 |
AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
DE602004021921D1 (de) | 2003-05-28 | 2009-08-20 | Theravance Inc | Azabicycloalkanverbindungen als muscarinrezeptor antagonisten |
JP2007524641A (ja) | 2003-07-11 | 2007-08-30 | セラヴァンス, インコーポレーテッド | 置換4−アミノ−1−ベンジルピペリジン化合物 |
US20050026887A1 (en) * | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a steroid |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
ES2239546B1 (es) * | 2004-03-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos esteres de quinuclidina cuaternizados. |
MY144753A (en) | 2004-04-27 | 2011-10-31 | Glaxo Group Ltd | Muscarinic acetylcholine receptor antagonists |
EP1747219A4 (de) * | 2004-05-13 | 2010-05-26 | Glaxo Group Ltd | Antagonisten des muscarinischen acetylcholinrezeptors |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
DE602005018969D1 (de) * | 2004-05-31 | 2010-03-04 | Almirall Sa | Zusammensetzungen mit Antimuskarin-Wirkstoffen und Corticosteroiden |
WO2006035303A1 (en) * | 2004-09-29 | 2006-04-06 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
WO2006047427A1 (en) * | 2004-10-25 | 2006-05-04 | Schering Corporation | M1 and/or m3 receptor antagonists in combination with other actives for treating respiratory disorders |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
EP2532679B1 (de) | 2005-10-21 | 2017-04-12 | Novartis AG | Menschliche Antikörper gegen IL13 und therapeutische Verwendungen |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
AR060607A1 (es) | 2006-04-21 | 2008-07-02 | Novartis Ag | Derivados de purina,composiciones farmaceuticas que los contienen, metodo de preparacion y usos en enfermedades obstructivas o inflamatorias de las vias respiratorias. |
ES2298049B1 (es) * | 2006-07-21 | 2009-10-20 | Laboratorios Almirall S.A. | Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano. |
EP2081933B1 (de) | 2006-09-29 | 2011-03-23 | Novartis AG | Pyrazolopyrimidine als pi3k-lipidkinasehemmer |
TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
BRPI0720799A2 (pt) | 2007-01-10 | 2014-03-11 | Irm Llc | Compostos e composições como inibidores de protease de ativação de canal. |
CA2678193A1 (en) | 2007-02-09 | 2008-08-14 | Astellas Pharma Inc. | Aza-bridged-ring compound |
UY30916A1 (es) * | 2007-02-15 | 2008-09-30 | Argenta Discovery Ltd | Derivados del 1-[sustituido]--3-[sustituido]-1-azona-biciclo[2,2,2]octano y sus enantiomeros |
BRPI0811562A2 (pt) | 2007-05-07 | 2014-12-09 | Novartis Ag | Compostos orgânicos |
KR101517574B1 (ko) * | 2007-09-07 | 2015-05-07 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | 무스카린 수용체 길항제로서 유용한 구아니딘을 함유하는 화합물 |
CA2608561A1 (en) * | 2007-10-29 | 2009-04-29 | Carl Paluszkiewicz | Motorcycle wind deflector accessory support |
CA2707857C (en) | 2007-12-10 | 2016-09-13 | Novartis Ag | Spirocyclic amiloride analogues |
JP2011506477A (ja) | 2007-12-14 | 2011-03-03 | セラヴァンス, インコーポレーテッド | ムスカリン受容体拮抗薬として有用なアミジン含有化合物 |
AU2009203693B2 (en) | 2008-01-11 | 2012-06-07 | Novartis Ag | Pyrimidines as kinase inhibitors |
EP2100599A1 (de) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
EP2100598A1 (de) * | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung |
US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
GB0808707D0 (en) * | 2008-05-13 | 2008-06-18 | Argenta Discovery Ltd | New compounds 275 |
GB0808708D0 (en) * | 2008-05-13 | 2008-06-18 | Astrazeneca Ab | New compounds 274 |
US8329729B2 (en) | 2008-05-13 | 2012-12-11 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic M3 receptor antagonists |
BRPI0915018A2 (pt) | 2008-06-10 | 2015-10-27 | Novartis Ag | compostos orgânicos |
US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
GB0814729D0 (en) * | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
PL2391366T3 (pl) | 2009-01-29 | 2013-04-30 | Novartis Ag | Podstawione benzimidazole do leczenia gwiaździaków |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
AU2010283806A1 (en) | 2009-08-12 | 2012-03-01 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
EP2467141B1 (de) | 2009-08-17 | 2018-10-31 | Intellikine, LLC | Heterocyclische verbindungen und ihre verwendung |
AU2010284972A1 (en) | 2009-08-20 | 2012-03-08 | Novartis Ag | Heterocyclic oxime compounds |
WO2011050325A1 (en) | 2009-10-22 | 2011-04-28 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
EP2386555A1 (de) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | Neue Cyclohexylaminderivate mit Aktivitäten von Beta2-adrenergem Agonisten und M3-Muskarin-Antagonisten |
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US20130324526A1 (en) | 2011-02-10 | 2013-12-05 | Novartis Ag | [1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
EP2678016B1 (de) | 2011-02-23 | 2016-08-10 | Intellikine, LLC | Heterocyclische verbindungen und ihre verwendung |
KR20140014184A (ko) | 2011-02-25 | 2014-02-05 | 아이알엠 엘엘씨 | Trk 억제제로서의 화합물 및 조성물 |
EP2510928A1 (de) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten |
UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
BR112014006223A8 (pt) | 2011-09-15 | 2018-01-09 | Novartis Ag | 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação |
JP6165733B2 (ja) | 2011-09-16 | 2017-07-19 | ノバルティス アーゲー | N−置換ヘテロシクリルカルボキサミド類 |
US9034879B2 (en) | 2011-09-16 | 2015-05-19 | Novartis Ag | Heterocyclic compounds for the treatment of CF |
WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
EP2793893A4 (de) | 2011-11-23 | 2015-07-08 | Intellikine Llc | Verbesserte behandlungspläne unter verwendung von mtor-inhibitoren |
US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
AU2013243097A1 (en) | 2012-04-03 | 2014-10-09 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
JP6218940B2 (ja) * | 2013-07-13 | 2017-10-25 | ベイジン エフエスウェルカム テクノロジー ディベロップメント カンパニー リミテッド | キニン系化合物、その光学異性体及びその製造方法と医薬用途 |
WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
MX2016013981A (es) | 2014-04-24 | 2016-11-15 | Novartis Ag | Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa. |
JP6433509B2 (ja) | 2014-04-24 | 2018-12-05 | ノバルティス アーゲー | ホスファチジルイノシトール3−キナーゼ阻害薬としてのアミノピラジン誘導体 |
US9862711B2 (en) | 2014-04-24 | 2018-01-09 | Novartis Ag | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
ES2831416T3 (es) | 2014-07-31 | 2021-06-08 | Novartis Ag | Terapia de combinación de un inhibidor de MET y un inhibidor de EGFR |
AU2020290094B2 (en) | 2019-06-10 | 2024-01-18 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF, COPD, and bronchiectasis |
EP4021572A1 (de) | 2019-08-28 | 2022-07-06 | Novartis AG | Substituierte 1,3-phenylheteroarylderivate und ihre verwendung zur behandlung von krankheiten |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
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IL156499A0 (en) | 2000-12-22 | 2004-01-04 | Almirall Prodesfarma Ag | Quinuclidine carbamate derivatives and their use as m3 antagonists |
JP4295985B2 (ja) * | 2000-12-28 | 2009-07-15 | ラボラトリオス・アルミラル・ソシエダッド・アノニマ | 新規なキヌクリジン誘導体およびそれを含む医薬組成物 |
-
2001
- 2001-12-20 JP JP2002555087A patent/JP4295985B2/ja not_active Expired - Fee Related
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2003
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2006
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2010
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