DE60128540D1 - Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen - Google Patents

Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen

Info

Publication number
DE60128540D1
DE60128540D1 DE60128540T DE60128540T DE60128540D1 DE 60128540 D1 DE60128540 D1 DE 60128540D1 DE 60128540 T DE60128540 T DE 60128540T DE 60128540 T DE60128540 T DE 60128540T DE 60128540 D1 DE60128540 D1 DE 60128540D1
Authority
DE
Germany
Prior art keywords
relaxin
treatment
vascular disorders
vasodilation
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60128540T
Other languages
English (en)
Other versions
DE60128540T2 (de
Inventor
Kirk P Conrad
Martyn Lewis
Elaine N Unemori
Xinfan Huang
Carol A Tozzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medicine And Dentistry Of Ne Us, University of
University of Pittsburgh
Corthera Inc
Original Assignee
Rutgers State University of New Jersey
University of Pittsburgh
BAS Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey, University of Pittsburgh, BAS Medical Inc filed Critical Rutgers State University of New Jersey
Publication of DE60128540D1 publication Critical patent/DE60128540D1/de
Application granted granted Critical
Publication of DE60128540T2 publication Critical patent/DE60128540T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
DE60128540T 2000-02-09 2001-02-09 Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen Expired - Lifetime DE60128540T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US18140800P 2000-02-09 2000-02-09
US181408P 2000-02-09
US20028400P 2000-04-28 2000-04-28
US200284P 2000-04-28
US24221600P 2000-10-20 2000-10-20
US242216P 2000-10-20
PCT/US2001/004370 WO2001058468A1 (en) 2000-02-09 2001-02-09 Use of relaxin to treat diseases related to vasoconstriction

Publications (2)

Publication Number Publication Date
DE60128540D1 true DE60128540D1 (de) 2007-07-05
DE60128540T2 DE60128540T2 (de) 2008-01-31

Family

ID=27391410

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60128540T Expired - Lifetime DE60128540T2 (de) 2000-02-09 2001-02-09 Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen

Country Status (8)

Country Link
US (2) US6723702B2 (de)
EP (1) EP1253929B1 (de)
AT (1) ATE362770T1 (de)
AU (1) AU2001236886A1 (de)
CA (1) CA2397200C (de)
DE (1) DE60128540T2 (de)
HK (1) HK1051001A1 (de)
WO (1) WO2001058468A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762202B2 (en) * 2000-05-09 2004-07-13 Nitromed, Inc. Infrared thermography and methods of use
NZ523613A (en) * 2000-06-27 2005-02-25 Anges Mg Inc Pharmaceutical compositions for angiogenic therapy
US20040265238A1 (en) * 2003-06-27 2004-12-30 Imtiaz Chaudry Inhalable formulations for treating pulmonary hypertension and methods of using same
ITFI20030328A1 (it) * 2003-12-24 2005-06-25 Mario Bigazzi Uso della relaxina come adiuvante nella differenziazione
US7878978B2 (en) 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
ES2635691T3 (es) * 2004-03-19 2017-10-04 University Of Pittsburgh Uso de relaxina para aumentar la distensibilidad arterial
EP1729817B1 (de) 2004-03-30 2014-03-05 Industry-Academic Cooperation Foundation Relaxin-gen enthaltendes genverabreichungssystem und pharmazeutische zusammensetzung, die relaxin verwendet
AU2005247332A1 (en) 2004-04-30 2005-12-08 Corthera, Inc. Methods and compositions for control of fetal growth via modulation of relaxin
JP2008526875A (ja) * 2005-01-07 2008-07-24 グラクソ グループ リミテッド 新規使用
SG161267A1 (en) 2005-04-12 2010-05-27 Intradigm Corp Composition and methods of rnai therapeutics for treatment of cancer and other neovascularization diseases
US7893244B2 (en) 2005-04-12 2011-02-22 Intradigm Corporation Composition and methods of RNAi therapeutics for treatment of cancer and other neovascularization diseases
US20060281669A1 (en) * 2005-06-13 2006-12-14 Yue Samuel K Method and compositions for the treatment of diabetes and related complications
WO2007027168A1 (en) * 2005-08-29 2007-03-08 Carrier Corporation Compressor muffler
ZA200900316B (en) * 2006-07-25 2010-05-26 Alcon Res Ltd Antagonists of endothelial differentiation gene subfamily 3 (EDG-3, S1P3) receptors for prevention and treatment of ocular disorders
KR101379529B1 (ko) * 2007-05-11 2014-03-31 코닝 인코포레이티드 향상된 단부 지지 조건을 이용한 아이소파이프 새그 조절
JP2011520902A (ja) * 2008-05-16 2011-07-21 コーセラ，インコーポレーテッド 創傷の治癒を促進する方法
MY159803A (en) 2008-05-16 2017-02-15 Corthera Inc Treating dyspnea associated with accurate heart failure with relaxin
JP5727938B2 (ja) 2008-11-24 2015-06-03 コーセラ，インコーポレーテッド 子癇前症の発症リスクの高さを試験する方法
US20100234827A1 (en) * 2009-03-13 2010-09-16 Sigg Daniel C Method of treating heart failure
WO2011112791A1 (en) 2010-03-10 2011-09-15 Corthera, Inc Modulating aquaporins with relaxin
EP2605789B1 (de) 2010-08-17 2019-06-05 Ambrx, Inc. Modifizierte relaxinpolypeptide und ihre verwendungen
CA2840552A1 (en) * 2011-07-01 2013-01-10 Bayer Intellectual Property Gmbh Relaxin fusion polypeptides and uses thereof
EP2739647B1 (de) * 2011-08-04 2016-07-20 Relaxera GmbH & Co. KG i.G. c/o Immundiagnostik AG Verfahren zur herstellung von humanem relaxin-2
WO2013033324A2 (en) * 2011-08-31 2013-03-07 University Of Florida Research Foundation, Inc. Materials and methods for modulating activity of bone marrow derived cells
US9393288B2 (en) 2012-05-29 2016-07-19 The University Of Vermont And State Agricultural College Methods of treating diseases associated with PPARγ
JP2015528019A (ja) * 2012-07-31 2015-09-24 ノバルティス アーゲー セレラキシンを使用する炎症の処置
US9381231B2 (en) 2012-10-09 2016-07-05 University Of Florida Research Foundation, Inc. Use of relaxin to restore maternal physiology in pregnancies conceived by assisted reproductive technologies
ES2903257T3 (es) 2015-12-09 2022-03-31 Scripps Research Inst Proteínas de fusión de inmunoglobulina de relaxina y métodos de uso

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3003917A (en) * 1959-01-14 1961-10-10 Nat Drug Co Wound healing composition
DE3236264A1 (de) * 1982-09-30 1984-04-05 Serono Pharmazeutische Präparate GmbH, 7800 Freiburg Verfahren zur gewinnung von relaxin
CH661662A5 (en) * 1984-04-16 1987-08-14 Georg L Prof Dr Floersheim Product for the treatment of the skin and of the connective tissue
US4910317A (en) * 1987-07-14 1990-03-20 Warner-Lambert Company Benzofurans and benzothiophenes having antiallergic activity and method of use thereof
ATE88352T1 (de) * 1988-02-26 1993-05-15 Genentech Inc Humanes relaxinpraeparat.
US5166191A (en) 1991-08-19 1992-11-24 Genentech, Inc. Use of relaxin in cardiovascular therapy
CA2145515A1 (en) * 1993-07-27 1995-02-09 Mario Bigazzi Use of relaxin as therapeutic or preventing agent
JPH09502726A (ja) 1993-09-14 1997-03-18 マリンクロット・メディカル・インコーポレイテッド 血管障害を防ぐポリペプチドを用いる治療的処置
DE69624925T2 (de) * 1995-08-15 2003-09-04 Connetics Corp Verwendung von relaxin zur stimulierung der angiogenese
US6251863B1 (en) * 1998-09-08 2001-06-26 Samuel K. Yue Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin

Also Published As

Publication number Publication date
CA2397200A1 (en) 2001-08-16
DE60128540T2 (de) 2008-01-31
WO2001058468A1 (en) 2001-08-16
US20040266685A1 (en) 2004-12-30
ATE362770T1 (de) 2007-06-15
EP1253929B1 (de) 2007-05-23
CA2397200C (en) 2010-11-23
US20020019349A1 (en) 2002-02-14
HK1051001A1 (en) 2003-07-18
EP1253929A4 (de) 2003-03-05
EP1253929A1 (de) 2002-11-06
US6723702B2 (en) 2004-04-20
AU2001236886A1 (en) 2001-08-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CORTHERA INC., (N. D. GES. D. STAATES DELAWARE, US

Owner name: THE UNIVERSITY OF MEDICINE AND DENTISTRY OF NE, US

Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH, US