DE60129865D1 - Verfahren zur Herstellung von Dihydroxyestern und ihren Derivaten - Google Patents

Verfahren zur Herstellung von Dihydroxyestern und ihren Derivaten

Info

Publication number: DE60129865D1
Authority: DE; Germany
Prior art keywords: derivatives; preparation; dihydroxy esters; dihydroxy; esters
Prior art date: 2000-05-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60129865T

Other languages

English (en)

Other versions

DE60129865T2 (de

Inventor

Robert Antony Holt

Christopher David Reeve

Andrew John Blacker

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca UK Ltd

Original Assignee

AstraZeneca UK Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-09

Filing date

2001-05-01

Publication date

2007-09-20

2001-05-01 Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd

2007-09-20 Application granted granted Critical

2007-09-20 Publication of DE60129865D1 publication Critical patent/DE60129865D1/de

2008-05-08 Publication of DE60129865T2 publication Critical patent/DE60129865T2/de

2021-05-02 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

DE60129865T 2000-05-09 2001-05-01 Verfahren zur Herstellung von Dihydroxyestern und ihren Derivaten Expired - Lifetime DE60129865T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0011120.3A GB0011120D0 (en)	2000-05-09	2000-05-09	Process
GB0011120		2000-05-09

Publications (2)

Publication Number	Publication Date
DE60129865D1 true DE60129865D1 (de)	2007-09-20
DE60129865T2 DE60129865T2 (de)	2008-05-08

Family

ID=9891211

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DE60141424T Expired - Lifetime DE60141424D1 (de)	2000-05-09	2001-05-01	Verfahren zur Herstellung von Dihydroxyestern und ihren Derivaten
DE60129865T Expired - Lifetime DE60129865T2 (de)	2000-05-09	2001-05-01	Verfahren zur Herstellung von Dihydroxyestern und ihren Derivaten
DE60120685T Expired - Lifetime DE60120685T2 (de)	2000-05-09	2001-05-01	Verfahren zur herstellung von dihydroxyestern und ihren derivaten

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60141424T Expired - Lifetime DE60141424D1 (de)	2000-05-09	2001-05-01	Verfahren zur Herstellung von Dihydroxyestern und ihren Derivaten

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60120685T Expired - Lifetime DE60120685T2 (de)	2000-05-09	2001-05-01	Verfahren zur herstellung von dihydroxyestern und ihren derivaten

Country Status (34)

Country	Link
US (4)	US7157255B2 (de)
EP (3)	EP1282719B1 (de)
JP (1)	JP4733901B2 (de)
KR (2)	KR100914675B1 (de)
CN (1)	CN1196793C (de)
AR (2)	AR028074A1 (de)
AT (3)	ATE458823T1 (de)
AU (2)	AU5238301A (de)
BR (1)	BR0110667A (de)
CA (2)	CA2677945A1 (de)
CY (3)	CY1105376T1 (de)
CZ (3)	CZ302632B6 (de)
DE (3)	DE60141424D1 (de)
DK (3)	DK1657310T3 (de)
EE (1)	EE05062B1 (de)
ES (3)	ES2289722T3 (de)
GB (1)	GB0011120D0 (de)
HK (3)	HK1051708A1 (de)
HU (1)	HUP0302216A3 (de)
IL (4)	IL152608A0 (de)
IS (1)	IS2290B (de)
MX (1)	MXPA02010955A (de)
MY (1)	MY127751A (de)
NO (1)	NO20025377L (de)
NZ (1)	NZ522407A (de)
PL (3)	PL208379B1 (de)
PT (3)	PT1657310E (de)
RU (1)	RU2266961C2 (de)
SI (3)	SI1726658T1 (de)
SK (2)	SK287524B6 (de)
TW (1)	TWI240753B (de)
UA (1)	UA73774C2 (de)
WO (1)	WO2001085975A1 (de)
ZA (1)	ZA200208937B (de)

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GB0011120D0 (en)	2000-05-09	2000-06-28	Avecia Ltd	Process
WO2001094337A1 (fr) *	2000-06-05	2001-12-13	Kaneka Corporation	Procede de preparation de derives optiquement actifs d'acide 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl] acetique
NL1015744C2 (nl) *	2000-07-19	2002-01-22	Dsm Nv	Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
DK1417180T3 (da) *	2001-07-13	2007-04-10	Astrazeneca Uk Ltd	Fremstilling af aminopyrimidinforbindelser
EP1323717A1 (de)	2001-12-27	2003-07-02	Dsm N.V.	Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten
GB0211751D0 (en) *	2002-05-22	2002-07-03	Avecia Ltd	Compound and process
EP1375493A1 (de)	2002-06-17	2004-01-02	Dsm N.V.	Verfahren zur Herstellung von Dioxanessigsäureester
AU2003259188B2 (en) *	2002-07-19	2008-03-06	Aryx Therapeutics, Inc.	Materials and methods for treating hypercholesterolemia
GB0218781D0 (en)	2002-08-13	2002-09-18	Astrazeneca Ab	Chemical process
CA2509344C (en)	2002-12-16	2011-10-04	Astrazeneca Uk Limited	Process for the preparation of pyrimidine compounds
GB0312896D0 (en) *	2003-06-05	2003-07-09	Astrazeneca Ab	Chemical process
UY28501A1 (es)	2003-09-10	2005-04-29	Astrazeneca Uk Ltd	Compuestos químicos
GB0324791D0 (en) *	2003-10-24	2003-11-26	Astrazeneca Ab	Chemical process
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TW200831469A (en) *	2006-12-01	2008-08-01	Astrazeneca Uk Ltd	Chemical process
CN101624609B (zh) *	2009-07-31	2013-04-17	浙江九洲药业股份有限公司	酶催化制备(s)-3-取代戊二酸单酯类化合物的方法
US8093306B2 (en) *	2010-12-22	2012-01-10	Rentech, Inc.	Integrated biorefinery for production of liquid fuels
US8168686B2 (en)	2010-12-22	2012-05-01	Rentech, Inc.	Integrated biorefinery for production of liquid fuels
CN102373250B (zh) *	2011-11-08	2012-08-22	张家港市信谊化工有限公司	阿伐他汀钙侧链中间体的制备方法
CN102618596A (zh) *	2012-03-20	2012-08-01	中国药科大学	一种非水相体系中生物转化制备关附庚素的方法
WO2014203045A1 (en)	2013-06-20	2014-12-24	Lupin Limited	A novel, green and cost effective process for synthesis of tert-butyl (3r,5s)-6-oxo-3,5-dihydroxy-3,5-o-isopropylidene-hexanoate
CN105503816B (zh) *	2016-02-17	2018-02-13	中节能万润股份有限公司	一种固体(4R‑cis)‑6‑甲酰基‑2,2‑二甲基‑1,3‑二氧己环‑4‑乙酸叔丁酯的制备方法
CN108530416B (zh) *	2017-11-02	2020-05-12	江苏阿尔法药业有限公司	一种瑞舒伐他汀中间体的制备方法
CN109574830B (zh) *	2019-01-04	2021-04-13	浙江宏元药业股份有限公司	一种瑞舒伐他汀钙中间体及其制备方法和应用
KR102384854B1 (ko)	2021-06-15	2022-04-11	한대성	풀빅산 및 일라이트를 이용한 침대

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DK1417180T3 (da) *	2001-07-13	2007-04-10	Astrazeneca Uk Ltd	Fremstilling af aminopyrimidinforbindelser
EP1323717A1 (de)	2001-12-27	2003-07-02	Dsm N.V.	Prozess für die Herstellung von 2-(6-Substituierten-1,3-Dioxan-4-yl) Essigsäure Derivaten
DK1478650T3 (da) *	2002-02-25	2010-01-25	Biocon Ltd	Nye boronatestere
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EP1375493A1 (de)	2002-06-17	2004-01-02	Dsm N.V.	Verfahren zur Herstellung von Dioxanessigsäureester
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2000
- 2000-05-09 GB GBGB0011120.3A patent/GB0011120D0/en not_active Ceased
2001
- 2001-01-05 UA UA2002129795A patent/UA73774C2/uk unknown
- 2001-05-01 EP EP01925699A patent/EP1282719B1/de not_active Expired - Lifetime
- 2001-05-01 CN CNB018124895A patent/CN1196793C/zh not_active Expired - Lifetime
- 2001-05-01 JP JP2001582563A patent/JP4733901B2/ja not_active Expired - Lifetime
- 2001-05-01 PT PT06002032T patent/PT1657310E/pt unknown
- 2001-05-01 SI SI200130963T patent/SI1726658T1/sl unknown
- 2001-05-01 PL PL387244A patent/PL208379B1/pl not_active IP Right Cessation
- 2001-05-01 AT AT06019415T patent/ATE458823T1/de active
- 2001-05-01 PL PL359336A patent/PL208359B1/pl not_active IP Right Cessation
- 2001-05-01 DK DK06002032T patent/DK1657310T3/da active
- 2001-05-01 DE DE60141424T patent/DE60141424D1/de not_active Expired - Lifetime
- 2001-05-01 AU AU5238301A patent/AU5238301A/xx active Pending
- 2001-05-01 EE EEP200200628A patent/EE05062B1/xx not_active IP Right Cessation
- 2001-05-01 SI SI200130591T patent/SI1282719T1/sl unknown
- 2001-05-01 WO PCT/GB2001/001915 patent/WO2001085975A1/en active Application Filing
- 2001-05-01 RU RU2002132884/13A patent/RU2266961C2/ru not_active IP Right Cessation
- 2001-05-01 CZ CZ20023675A patent/CZ302632B6/cs not_active IP Right Cessation
- 2001-05-01 HU HU0302216A patent/HUP0302216A3/hu unknown
- 2001-05-01 MX MXPA02010955A patent/MXPA02010955A/es active IP Right Grant
- 2001-05-01 IL IL15260801A patent/IL152608A0/xx unknown
- 2001-05-01 ES ES06002032T patent/ES2289722T3/es not_active Expired - Lifetime
- 2001-05-01 CA CA002677945A patent/CA2677945A1/en not_active Abandoned
- 2001-05-01 DE DE60129865T patent/DE60129865T2/de not_active Expired - Lifetime
- 2001-05-01 CZ CZ20110204A patent/CZ302674B6/cs not_active IP Right Cessation
- 2001-05-01 EP EP06002032A patent/EP1657310B1/de not_active Expired - Lifetime
- 2001-05-01 AU AU2001252383A patent/AU2001252383B2/en not_active Ceased
- 2001-05-01 AT AT01925699T patent/ATE330020T1/de active
- 2001-05-01 AT AT06002032T patent/ATE369437T1/de active
- 2001-05-01 DK DK06019415.6T patent/DK1726658T3/da active
- 2001-05-01 DK DK01925699T patent/DK1282719T3/da active
- 2001-05-01 SI SI200130758T patent/SI1657310T1/sl unknown
- 2001-05-01 PT PT01925699T patent/PT1282719E/pt unknown
- 2001-05-01 ES ES01925699T patent/ES2264981T3/es not_active Expired - Lifetime
- 2001-05-01 DE DE60120685T patent/DE60120685T2/de not_active Expired - Lifetime
- 2001-05-01 NZ NZ522407A patent/NZ522407A/en not_active IP Right Cessation
- 2001-05-01 SK SK5088-2008A patent/SK287524B6/sk not_active IP Right Cessation
- 2001-05-01 US US10/275,092 patent/US7157255B2/en not_active Expired - Lifetime
- 2001-05-01 CA CA2408004A patent/CA2408004C/en not_active Expired - Fee Related
- 2001-05-01 PL PL387243A patent/PL208377B1/pl not_active IP Right Cessation
- 2001-05-01 ES ES06019415T patent/ES2340190T3/es not_active Expired - Lifetime
- 2001-05-01 EP EP06019415A patent/EP1726658B1/de not_active Expired - Lifetime
- 2001-05-01 KR KR1020027014987A patent/KR100914675B1/ko not_active IP Right Cessation
- 2001-05-01 KR KR1020087005996A patent/KR100996977B1/ko not_active IP Right Cessation
- 2001-05-01 CZ CZ20110205A patent/CZ302675B6/cs not_active IP Right Cessation
- 2001-05-01 SK SK1589-2002A patent/SK286746B6/sk not_active IP Right Cessation
- 2001-05-01 BR BR0110667-8A patent/BR0110667A/pt not_active IP Right Cessation
- 2001-05-01 PT PT06019415T patent/PT1726658E/pt unknown
- 2001-05-03 AR ARP010102091A patent/AR028074A1/es active IP Right Grant
- 2001-05-04 TW TW090110741A patent/TWI240753B/zh not_active IP Right Cessation
- 2001-05-08 MY MYPI20012105A patent/MY127751A/en unknown
2002
- 2002-11-03 IL IL152608A patent/IL152608A/en not_active IP Right Cessation
- 2002-11-04 ZA ZA200208937A patent/ZA200208937B/en unknown
- 2002-11-07 IS IS6609A patent/IS2290B/is unknown
- 2002-11-08 NO NO20025377A patent/NO20025377L/no not_active Application Discontinuation
2003
- 2003-06-05 HK HK03103991A patent/HK1051708A1/xx not_active IP Right Cessation
2006
- 2006-04-27 US US11/412,047 patent/US7416865B2/en not_active Expired - Lifetime
- 2006-09-12 CY CY20061101301T patent/CY1105376T1/el unknown
- 2006-09-22 HK HK06110633A patent/HK1090090A1/xx not_active IP Right Cessation
2007
- 2007-02-09 HK HK07101586.1A patent/HK1096998A1/xx not_active IP Right Cessation
- 2007-10-05 CY CY20071101270T patent/CY1106910T1/el unknown
2008
- 2008-07-23 US US12/178,424 patent/US7732171B2/en not_active Expired - Fee Related
- 2008-08-12 IL IL193404A patent/IL193404A/en not_active IP Right Cessation
- 2008-08-12 IL IL193405A patent/IL193405A/en not_active IP Right Cessation
- 2008-09-15 AR ARP080104001A patent/AR070946A2/es not_active Application Discontinuation
2010
- 2010-04-27 CY CY20101100376T patent/CY1109991T1/el unknown
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Also Published As

Publication number	Publication date
KR100914675B1 (ko)	2009-08-28
CZ302675B6 (cs)	2011-08-24
EE05062B1 (et)	2008-08-15
TWI240753B (en)	2005-10-01
US7416865B2 (en)	2008-08-26
PL208379B1 (pl)	2011-04-29
EP1726658A3 (de)	2008-12-24
CA2408004C (en)	2010-04-13
ATE369437T1 (de)	2007-08-15
HK1051708A1 (en)	2003-08-15
NO20025377L (no)	2003-01-07
US20080280336A1 (en)	2008-11-13
US7888083B2 (en)	2011-02-15
EP1282719A1 (de)	2003-02-12
AR028074A1 (es)	2003-04-23
CZ302632B6 (cs)	2011-08-10
SK15892002A3 (sk)	2003-04-01
DE60120685D1 (de)	2006-07-27
PL208359B1 (pl)	2011-04-29
HUP0302216A3 (en)	2011-03-28
SI1657310T1 (sl)	2007-12-31
JP4733901B2 (ja)	2011-07-27
IS6609A (is)	2002-11-07
CY1105376T1 (el)	2010-04-28
US7157255B2 (en)	2007-01-02
EE200200628A (et)	2004-04-15
PT1282719E (pt)	2006-09-29
GB0011120D0 (en)	2000-06-28
PL359336A1 (en)	2004-08-23
ZA200208937B (en)	2003-08-28
WO2001085975A1 (en)	2001-11-15
HK1096998A1 (en)	2007-06-15
NO20025377D0 (no)	2002-11-08
US7732171B2 (en)	2010-06-08
CY1109991T1 (el)	2014-09-10
CZ302674B6 (cs)	2011-08-24
DE60129865T2 (de)	2008-05-08
JP2003532427A (ja)	2003-11-05
ES2289722T3 (es)	2008-02-01
DE60120685T2 (de)	2007-06-14
US20060194297A1 (en)	2006-08-31
CA2408004A1 (en)	2001-11-15
IL193404A (en)	2010-04-29
ATE330020T1 (de)	2006-07-15
PT1657310E (pt)	2007-09-26
PL208377B1 (pl)	2011-04-29
CY1106910T1 (el)	2012-09-26
IL193405A0 (en)	2009-02-11
KR100996977B1 (ko)	2010-11-26
HUP0302216A2 (hu)	2003-10-28
IS2290B (is)	2007-10-15
IL152608A0 (en)	2003-06-24
AR070946A2 (es)	2010-05-19
ATE458823T1 (de)	2010-03-15
DE60141424D1 (de)	2010-04-08
RU2266961C2 (ru)	2005-12-27
EP1726658B1 (de)	2010-02-24
CZ20023675A3 (cs)	2003-02-12
SK287524B6 (sk)	2011-01-04
IL193404A0 (en)	2009-02-11
IL152608A (en)	2009-05-04
BR0110667A (pt)	2003-03-25
MY127751A (en)	2006-12-29
EP1657310A1 (de)	2006-05-17
EP1726658A2 (de)	2006-11-29
EP1657310B1 (de)	2007-08-08
CN1440461A (zh)	2003-09-03
MXPA02010955A (es)	2003-05-27
ES2340190T3 (es)	2010-05-31
KR20030032949A (ko)	2003-04-26
AU2001252383B2 (en)	2005-04-14
SK286746B6 (sk)	2009-04-06
SI1726658T1 (sl)	2010-05-31
SI1282719T1 (sl)	2006-10-31
DK1726658T3 (da)	2010-05-17
IL193405A (en)	2010-04-29
KR20080042129A (ko)	2008-05-14
US20030134900A1 (en)	2003-07-17
EP1282719B1 (de)	2006-06-14
ES2264981T3 (es)	2007-02-01
US20100209984A1 (en)	2010-08-19
UA73774C2 (en)	2005-09-15
DK1282719T3 (da)	2006-10-02
DK1657310T3 (da)	2007-10-29
PT1726658E (pt)	2010-04-15
AU5238301A (en)	2001-11-20
HK1090090A1 (en)	2006-12-15
NZ522407A (en)	2004-06-25
CA2677945A1 (en)	2001-11-15
CN1196793C (zh)	2005-04-13

Legal Events

Date	Code	Title	Description
2008-08-28	8364	No opposition during term of opposition

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