DE60130640D1 - 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen - Google Patents
2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungenInfo
- Publication number
- DE60130640D1 DE60130640D1 DE60130640T DE60130640T DE60130640D1 DE 60130640 D1 DE60130640 D1 DE 60130640D1 DE 60130640 T DE60130640 T DE 60130640T DE 60130640 T DE60130640 T DE 60130640T DE 60130640 D1 DE60130640 D1 DE 60130640D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- vitamin
- group
- diseases
- alkylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US540686 | 2000-03-31 | ||
US09/540,686 US6392071B1 (en) | 1997-03-17 | 2000-03-31 | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
PCT/US2001/010317 WO2001074766A1 (en) | 2000-03-31 | 2001-03-29 | 2-alkylidene-19-nor-vitamin d compounds and their therapeutic uses |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60130640D1 true DE60130640D1 (de) | 2007-11-08 |
DE60130640T2 DE60130640T2 (de) | 2008-07-17 |
Family
ID=24156520
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60130640T Expired - Lifetime DE60130640T2 (de) | 2000-03-31 | 2001-03-29 | 2-alkylidene-19-nor-vitamin d verbindungen und ihre therapeutische verwendungen |
Country Status (14)
Country | Link |
---|---|
US (5) | US6392071B1 (de) |
EP (1) | EP1268416B1 (de) |
JP (1) | JP4022071B2 (de) |
KR (1) | KR20020091167A (de) |
AT (1) | ATE374178T1 (de) |
AU (2) | AU2001247905B2 (de) |
CA (1) | CA2404548C (de) |
DE (1) | DE60130640T2 (de) |
DK (1) | DK1268416T3 (de) |
ES (1) | ES2291305T3 (de) |
IL (1) | IL152020A (de) |
MX (1) | MXPA02009590A (de) |
NZ (1) | NZ522160A (de) |
WO (1) | WO2001074766A1 (de) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
US6627622B2 (en) | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
WO2003051828A2 (en) * | 2001-12-13 | 2003-06-26 | Wisconsin Alumni Research Foundation | (20s)-1alpha-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
US20030195175A1 (en) * | 2002-03-25 | 2003-10-16 | Deluca Hector F. | Use of carbon-2-modified-vitamin D analogs to induce the formation of new bone |
US7402688B2 (en) | 2002-10-10 | 2008-07-22 | Wisconsin Alumni Research Foundation | 2,2-Di-substituted 1alpha,25-dihydroxy-19-norvitamin D derivative |
RU2317992C2 (ru) | 2003-02-25 | 2008-02-27 | Кей Эн Си Лэборэтериз Ко., Лтд. | Новые промежуточные соединения для синтеза производных витамина d |
ZA200506204B (en) * | 2003-04-10 | 2006-10-25 | Wisconsin Alumni Res Found | 2-propylidene-19-nor-vitamin D compounds |
WO2004098507A2 (en) * | 2003-04-30 | 2004-11-18 | Bioxell S.P.A. | 1,3 aclyated 24-keto-vitamin d3 compounds and methods of use thereof |
ATE350043T1 (de) * | 2003-07-03 | 2007-01-15 | Wisconsin Alumni Res Found | 2-methylen-19-nor-20(s)-25-methyl-1alpha- hydroxycalciferol und seine verwendungen |
US6894037B2 (en) * | 2003-07-03 | 2005-05-17 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses |
US20050009792A1 (en) * | 2003-07-08 | 2005-01-13 | Deluca Hector F. | (20S)-1alpha-hydroxy-2-methylene-19-nor-vitamin D3 and its uses |
WO2005018658A1 (en) * | 2003-08-20 | 2005-03-03 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
WO2005027916A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors |
WO2005027928A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vit amin d derivatives for the treatment of hypocalcemic tetany or hyproparathyroidism |
WO2005027922A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | 2-alkylidene-19-nor-vitamin d derivatives for the treatment of hypogonadism or andropause |
JP2007505881A (ja) * | 2003-09-19 | 2007-03-15 | ファイザー・プロダクツ・インク | 2−アルキリデン−19−ノル−ビタミンd誘導体およびエストロゲンアゴニスト/アンタゴニストの組合せを含む医薬組成物および方法 |
WO2005027918A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a cyclooxgenase-2 inhibitor |
US7214670B2 (en) * | 2003-09-24 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 to increase the life expectancy of human beings |
US7704980B2 (en) * | 2003-10-08 | 2010-04-27 | Wisconsin Alumni Research Foundation | Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds |
EP1694333A2 (de) * | 2003-11-25 | 2006-08-30 | Deltanoid Pharmaceuticals, Inc. | Verfahren zur reduzierung des körperfetts mit vitamin-d-verbindungen |
MXPA06005887A (es) * | 2003-11-25 | 2006-06-27 | Wisconsin Alumni Res Found | Analogos de vitamina d para la prevencion y el tratamiento de la obesidad. |
US8404667B2 (en) | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
WO2005079464A2 (en) * | 2004-02-17 | 2005-09-01 | Wisconsin Alumni Research Foundation | Vitamin d receptor antagonists and their use in treating asthma |
US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
US20080293647A1 (en) | 2004-11-12 | 2008-11-27 | Luciano Adorini | Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer |
US8604008B2 (en) * | 2004-11-22 | 2013-12-10 | Wisconsin Alumni Research Foundation | 2-methylene-19,21-dinor-1α-hydroxy-bishomopregnacalciferol |
AU2005309818A1 (en) * | 2004-11-22 | 2006-06-01 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(20R)-1-alpha-hydroxy-bishomopregnacalciferol |
MX2007006543A (es) * | 2004-11-22 | 2007-07-25 | Wisconsin Alumni Res Found | 2-metilen-19,26,27-trinor-(20s)-1a-hidroxivitamina d3 y sus usos. |
NZ555563A (en) * | 2004-11-22 | 2009-02-28 | Wisconsin Alumni Res Found | 2-methylene-19-nor-(20S)-1alpha-hydroxy-trishomopregnacalciferol |
US7241752B2 (en) * | 2004-11-22 | 2007-07-10 | Wisconsin Alumni Research Foundation | 17,20(E)-dehydro vitamin D analogs and their uses |
WO2006086608A1 (en) * | 2005-02-11 | 2006-08-17 | Wisconsin Alumni Research Foundation | 2-METHYLENE-19-NOR-(20S-24EPI)-1α,25-DIHYDROXYVITAMIN-D2 |
AU2006213727B2 (en) * | 2005-02-11 | 2011-08-18 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20S-24S) - 1alpha, 25-dihydroxyvitamin-D2 |
CA2603328A1 (en) * | 2005-03-29 | 2006-10-05 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-(23s)-25-dehydro-1.alpha.-hydroxyvitamin d3-26,23-lactone and 2-methylene-19-nor-(23r)-25-dehydro-1.alpha.-hydroxyvitamin d3-26,23-lactone |
WO2006119309A2 (en) * | 2005-05-03 | 2006-11-09 | Wisconsin Alumni Research Foundation | 19,26,27-TRINOR-1α,25-DIHYDROXYVITAMIN D3 COMPOUNDS |
EP1931324B1 (de) | 2005-08-30 | 2015-01-28 | Wisconsin Alumni Research Foundation | Des-c,d-analoga von 1alpha,25-dihydroxy-19-norvitamin d3 |
US7528122B2 (en) * | 2006-02-02 | 2009-05-05 | Wisconsin Alumni Research Foundation | Vitamin D analog—NEL, methods and uses thereof |
US7803789B2 (en) * | 2006-02-02 | 2010-09-28 | Wisconsin Alumni Research Foundation | Vitamin D analog—RAK, methods and uses thereof |
EP2010483A2 (de) * | 2006-04-05 | 2009-01-07 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen sowie verfahren zu ihrer herstellung und verwendung |
US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
JP2009532459A (ja) * | 2006-04-06 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | 1,2または3,2複素環を有する19−ノル−ビタミンdアナログ |
NZ570814A (en) * | 2006-04-06 | 2011-11-25 | Wisconsin Alumni Res Found | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
US8404666B2 (en) | 2006-04-06 | 2013-03-26 | Wisconsin Alumni Research Foundation | 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof |
CA2645185A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof |
MX2008012913A (es) * | 2006-04-06 | 2009-03-06 | Wisconsin Alumni Res Found | 2-metilen-1a,25-dihidroxi-18,19,21-trinorvitamina d3 y sus usos. |
AU2007234717B2 (en) * | 2006-04-06 | 2012-04-19 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
CA2648521A1 (en) * | 2006-04-10 | 2008-02-28 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-n0r-vitamin d compounds with a 1,1-dimethylpropyl side chain |
WO2008089093A2 (en) * | 2007-01-12 | 2008-07-24 | Quatrx Pharmaceuticals Company | Efficient processes for preparing steroids and vitamin d derivatives with the unnatural configuration at c20 (20 alpha-methyl) from pregnenolone |
US8377913B2 (en) * | 2007-11-20 | 2013-02-19 | Abbvie Inc. | Vitamin D receptor activators and methods of making |
WO2009094426A1 (en) * | 2008-01-22 | 2009-07-30 | Wisconsin Alumni Reasearch Foundation | 13.13-dimethyl-des-c,d analogs of 1alpha, 25-dihydroxy-19-nor-vitamin d3 compounds and topical composition dosage forms and methods of treating skin conditions |
WO2009111695A1 (en) * | 2008-03-06 | 2009-09-11 | Wisconsin Alumni Research Foundation | Methods of increasing epidermal skin thickness by topical administration of a 19-nor containing vitamin d compound |
US8222236B2 (en) * | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
US7893043B2 (en) * | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
US7888339B2 (en) * | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
EA201691980A1 (ru) | 2009-01-27 | 2017-07-31 | БЕРГ ЭлЭлСи | Способы уменьшения побочных эффектов, связанных с химиотерапией |
WO2011019617A2 (en) | 2009-08-14 | 2011-02-17 | Cytotech Labs, Llc | Vitamin d3 and analogs thereof for treating alopecia |
JP5814247B2 (ja) * | 2009-10-02 | 2015-11-17 | ウィスコンシン・アルムニ・リサーチ・ファウンデーションWisconsin Alumni Research Foundation | 1−デソキシ−2−メチレン−19−ノル−ビタミンd類似体及びそれらの使用 |
WO2011041596A2 (en) | 2009-10-02 | 2011-04-07 | Wisconsin Alumni Research Foundation | 19-nor-vitamin d analogs with 1,2-or 3,2-cyclopentene ring |
CA2777938C (en) * | 2009-10-21 | 2017-11-14 | Wisconsin Alumni Research Foundation | Method of preventing type 1 diabetes |
CA2794006C (en) * | 2010-03-23 | 2017-11-28 | Wisconsin Alumni Research Foundation | (20s)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-hydroxyvitamin d3 |
US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
CA2793727C (en) * | 2010-03-23 | 2017-01-03 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1.alpha.,25-dihydroxyvitamin d3 |
EP2714656B1 (de) | 2011-06-03 | 2017-05-03 | Wisconsin Alumni Research Foundation | (22e) -2-methylen-26,27-cyclo-22-dehydro-1alpha-hydroxy-19-norvitamin-d3-derivate |
EP2721004B1 (de) * | 2011-06-14 | 2017-07-26 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylen-19-nor-vitamin-d-analoga und ihre verwendung |
US8455467B2 (en) | 2011-10-21 | 2013-06-04 | Wisconsin Alumni Research Foundation | 2-methylene-vitamin D analogs and their uses |
EP2768804B1 (de) | 2011-10-21 | 2018-02-28 | Wisconsin Alumni Research Foundation | 2-methylen-vitamin-d-analoge und ihre verwendungen |
US20130295083A1 (en) * | 2012-05-02 | 2013-11-07 | Wisconsin Alumni Research Foundation | 2a-Methyl-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2AMD) or 2 methylene-19-nor-(20S)-1a,25-dihydroxyvitamin D3 (2MD) Support Survival and Function of Transplanted Islet Cells In Type 1 Diabetes |
US8785422B2 (en) | 2012-06-06 | 2014-07-22 | Wisconsin Alumni Research Foundation | A-ring modified 19-nor-vitamin D analogs and their uses |
SG10201709894RA (en) | 2013-05-29 | 2018-01-30 | Berg Llc | Preventing or mitigating chemotherapy induced alopecia using vitamin d |
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GB2114570B (en) | 1981-11-02 | 1985-08-07 | Res Inst Medicine Chem | Chemical compounds |
US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
US4800198A (en) * | 1985-04-23 | 1989-01-24 | Wisconsin Alumni Research Foundation | Method of inducing the differentiation of malignant cells with secosterol |
US4851401A (en) | 1988-07-14 | 1989-07-25 | Wisconsin Alumni Research Foundation | Novel cyclopentano-vitamin D analogs |
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CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
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AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
ES2123505T3 (es) | 1990-09-07 | 1999-01-16 | Wisconsin Alumni Res Found | Nuevo uso de compuestos de 19-nor-vitamina d 1alfa-hidroxilada para tratar la psoriasis. |
US5089641A (en) * | 1991-03-11 | 1992-02-18 | Wisconsin Alumni Research Foundation | Synthesis of 1α-hydroxy-secosterol compounds |
US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
ZA924811B (en) | 1991-06-28 | 1993-12-29 | Endorecherche Inc | Controlled release systems and low dose androgens |
DE69400495T2 (de) | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
WO1996001811A1 (en) | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
JPH10509715A (ja) | 1994-11-21 | 1998-09-22 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | 18,19−ジノル−ビタミンd 化合物 |
US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
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DE69634357T2 (de) | 1995-06-06 | 2006-01-12 | Merck & Co., Inc. | Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten |
WO1997000242A1 (de) * | 1995-06-14 | 1997-01-03 | Schering Aktiengesellschaft | Neue vitamin d-derivate mit substituenten an c-25, verfahren zu ihrer herstellung, zwischenprodukte und die verwendung zur herstellung von arzneimitteln |
AU1152997A (en) * | 1995-12-28 | 1997-07-28 | Chugai Seiyaku Kabushiki Kaisha | Malignant tumor metastasis inhibitors |
US5849960A (en) * | 1996-11-26 | 1998-12-15 | Shell Oil Company | Highly branched primary alcohol compositions, and biodegradable detergents made therefrom |
US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
US6573256B2 (en) * | 1996-12-30 | 2003-06-03 | Bone Care International, Inc. | Method of inhibiting angiogenesis using active vitamin D analogues |
US6316642B1 (en) * | 1997-03-17 | 2001-11-13 | Wisconsin Alumni Research Foundation | 26,27-Homologated-20-EPI-2alkyl-19-nor-vitamin D compounds |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
US6306844B1 (en) * | 1997-03-17 | 2001-10-23 | Wisconsin Alumni Research Foundation | Use of 2α-methyl-19-nor-20(S)-1α, 25-dihydroxyvitamin D3 to increase bone strength |
US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
US5936105A (en) | 1997-06-13 | 1999-08-10 | Tetrionics, Inc. | 14-EPI-19-nor-vitamin D compounds and methods |
US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
US5962707A (en) | 1998-08-18 | 1999-10-05 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D3 compounds with calcemic activity |
AU6527201A (en) * | 2000-05-31 | 2001-12-11 | Wisconsin Alumni Res Found | 2-ethyl and 2-ethylidene-19-nor-vitamin d compounds |
BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
US6835723B2 (en) * | 2001-12-13 | 2004-12-28 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol in crystalline form |
US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
-
2000
- 2000-03-31 US US09/540,686 patent/US6392071B1/en not_active Expired - Lifetime
-
2001
- 2001-03-29 KR KR1020027013007A patent/KR20020091167A/ko not_active Application Discontinuation
- 2001-03-29 DE DE60130640T patent/DE60130640T2/de not_active Expired - Lifetime
- 2001-03-29 IL IL152020A patent/IL152020A/en not_active IP Right Cessation
- 2001-03-29 MX MXPA02009590A patent/MXPA02009590A/es active IP Right Grant
- 2001-03-29 CA CA002404548A patent/CA2404548C/en not_active Expired - Fee Related
- 2001-03-29 NZ NZ522160A patent/NZ522160A/en not_active IP Right Cessation
- 2001-03-29 AT AT01920897T patent/ATE374178T1/de active
- 2001-03-29 AU AU2001247905A patent/AU2001247905B2/en not_active Ceased
- 2001-03-29 WO PCT/US2001/010317 patent/WO2001074766A1/en active IP Right Grant
- 2001-03-29 AU AU4790501A patent/AU4790501A/xx active Pending
- 2001-03-29 DK DK01920897T patent/DK1268416T3/da active
- 2001-03-29 ES ES01920897T patent/ES2291305T3/es not_active Expired - Lifetime
- 2001-03-29 JP JP2001572461A patent/JP4022071B2/ja not_active Expired - Fee Related
- 2001-03-29 EP EP01920897A patent/EP1268416B1/de not_active Expired - Lifetime
- 2001-10-31 US US10/001,711 patent/US6537981B2/en not_active Expired - Lifetime
-
2003
- 2003-01-28 US US10/352,745 patent/US6696431B2/en not_active Expired - Lifetime
-
2004
- 2004-02-17 US US10/780,103 patent/US7094774B2/en not_active Expired - Lifetime
-
2006
- 2006-08-18 US US11/507,092 patent/US20090143342A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL152020A (en) | 2008-03-20 |
US6537981B2 (en) | 2003-03-25 |
EP1268416B1 (de) | 2007-09-26 |
CA2404548A1 (en) | 2001-10-11 |
NZ522160A (en) | 2004-11-26 |
US6392071B1 (en) | 2002-05-21 |
MXPA02009590A (es) | 2004-03-26 |
US20090143342A1 (en) | 2009-06-04 |
JP4022071B2 (ja) | 2007-12-12 |
US20030181427A1 (en) | 2003-09-25 |
IL152020A0 (en) | 2003-04-10 |
AU2001247905B2 (en) | 2005-05-19 |
JP2003529581A (ja) | 2003-10-07 |
KR20020091167A (ko) | 2002-12-05 |
US6696431B2 (en) | 2004-02-24 |
US20020087015A1 (en) | 2002-07-04 |
ATE374178T1 (de) | 2007-10-15 |
DE60130640T2 (de) | 2008-07-17 |
WO2001074766A1 (en) | 2001-10-11 |
AU4790501A (en) | 2001-10-15 |
ES2291305T3 (es) | 2008-03-01 |
US20040167104A1 (en) | 2004-08-26 |
DK1268416T3 (da) | 2008-02-04 |
CA2404548C (en) | 2009-07-21 |
US7094774B2 (en) | 2006-08-22 |
EP1268416A1 (de) | 2003-01-02 |
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