DE60132171D1 - Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung - Google Patents
Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendungInfo
- Publication number
- DE60132171D1 DE60132171D1 DE60132171T DE60132171T DE60132171D1 DE 60132171 D1 DE60132171 D1 DE 60132171D1 DE 60132171 T DE60132171 T DE 60132171T DE 60132171 T DE60132171 T DE 60132171T DE 60132171 D1 DE60132171 D1 DE 60132171D1
- Authority
- DE
- Germany
- Prior art keywords
- tocotrienole
- tocopherole
- chrome
- side chain
- chain derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/76—Benzo[c]pyrans
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/502,592 US6770672B1 (en) | 1998-09-23 | 2000-02-11 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
PCT/US2001/004168 WO2001058889A1 (en) | 2000-02-11 | 2001-02-09 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60132171D1 true DE60132171D1 (de) | 2008-02-14 |
Family
ID=23998504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60132171T Expired - Lifetime DE60132171D1 (de) | 2000-02-11 | 2001-02-09 | Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung |
Country Status (14)
Country | Link |
---|---|
US (2) | US7312232B2 (de) |
EP (1) | EP1254130B1 (de) |
JP (1) | JP2004504268A (de) |
KR (1) | KR100847678B1 (de) |
CN (1) | CN1243000C (de) |
AT (1) | ATE382615T1 (de) |
AU (2) | AU3680501A (de) |
CA (1) | CA2399802C (de) |
DE (1) | DE60132171D1 (de) |
IL (2) | IL151108A0 (de) |
NZ (1) | NZ520798A (de) |
RU (1) | RU2263672C2 (de) |
WO (1) | WO2001058889A1 (de) |
ZA (1) | ZA200206243B (de) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6703384B2 (en) | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
ATE382615T1 (de) | 2000-02-11 | 2008-01-15 | Res Dev Foundation | Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung |
EP1339413B1 (de) * | 2000-11-14 | 2009-10-07 | Vital Health Sciences Pty Ltd. | Zusammensetzungen umfassend Komplexe von Tocopherolphosphatderivaten |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
US8008345B2 (en) * | 2001-07-27 | 2011-08-30 | Vital Health Sciences Pty. Ltd. | Dermal therapy using phosphate derivatives of electron transfer agents |
CN1604772A (zh) * | 2001-12-13 | 2005-04-06 | 生命健康科学有限公司 | 化合物的透皮转运 |
US20030236301A1 (en) * | 2001-12-19 | 2003-12-25 | Bob Sanders | Liposomal delivery of vitamin E based compounds |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
EP1589964B1 (de) * | 2003-01-17 | 2011-11-23 | Vital Health Sciences Pty Ltd. | Verbindungen mit proliferationshemmenden eigenschaften |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
GB0313612D0 (en) | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
WO2005026181A2 (en) * | 2003-09-15 | 2005-03-24 | Dsm Ip Assets B.V. | A NEW ROUTE TO α-TOCOPHEROL, α-TOCOPHERYL ALKANOATES AND PRECURSORS THEREOF |
JP4847437B2 (ja) * | 2004-03-03 | 2011-12-28 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | アルカロイド製剤 |
EP1858508A4 (de) * | 2005-03-03 | 2009-01-07 | Vital Health Sciences Pty Ltd | Verbindungen mit krebshemmenden eigenschaften |
KR20080019228A (ko) | 2005-06-17 | 2008-03-03 | 바이탈 헬스 사이언시즈 피티와이 리미티드 | 하나 이상의 디 및/또는 모노-(전자전달제) 인산염 유도체또는 그의 착염을 함유하는 담체 |
CA2631653A1 (en) * | 2005-12-23 | 2007-06-28 | Vital Health Sciences Pty Ltd. | Compounds having cytokine modulating properties |
US20080009545A1 (en) * | 2006-02-21 | 2008-01-10 | The Ohio State University Research Foundation | Anticancer agents |
WO2007143081A2 (en) | 2006-06-02 | 2007-12-13 | The Ohio State University Research Foundation | Therapeutic agents for the treatment of lymphoid malignancies |
US8288369B2 (en) * | 2006-06-27 | 2012-10-16 | University Of South Florida | Delta-tocotrienol treatment and prevention of pancreatic cancer |
US20100292316A1 (en) * | 2007-07-18 | 2010-11-18 | Research Development Foundation | Improved therapeutic methods and compositions comprising chroman ring compounds |
JP5616798B2 (ja) | 2008-03-14 | 2014-10-29 | スティーブン・ジョン・ラルフStephen John RALPH | ミトコンドリア由来の抗ガン化合物 |
EP2419414A4 (de) * | 2009-04-13 | 2013-12-04 | Univ Ohio State Res Found | Mittel zur aktivierung der protein-phosphatase 2a |
WO2010121111A1 (en) | 2009-04-17 | 2010-10-21 | The Ohio State University Research Foundation | Antiadhesion agents |
US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
WO2011120084A1 (en) | 2010-03-30 | 2011-10-06 | Phosphagenics Limited | Transdermal delivery patch |
US8309768B2 (en) | 2010-11-29 | 2012-11-13 | The Ohio State University Research Foundation | FTY720-derived anticancer agents |
EP2685992A4 (de) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | Aminochinoline als kinasehemmer |
RU2613110C2 (ru) * | 2012-05-18 | 2017-03-15 | Те Огайо Стейт Юниверсити | Способы улучшения функции печени |
EP2858642A4 (de) * | 2012-06-06 | 2015-12-02 | Unither Virology Llc | Neuartige iminozucker und deren anwendungen |
JP2015529692A (ja) * | 2012-06-13 | 2015-10-08 | サイテク・テクノロジー・コーポレーシヨン | 置換クロマン化合物を含む安定剤組成物および使用方法 |
PL3041831T3 (pl) | 2013-09-06 | 2021-07-19 | Research Development Foundation | Postacie soli alfa-TEA: kompozycje i zastosowania do leczenia choroby |
US9993456B2 (en) | 2013-09-13 | 2018-06-12 | The Board Of Trustees Of The University Of Arkansas | Preparation and use of a composition for prevention and mitigation of the effects of radiation |
US20160324914A1 (en) | 2015-05-05 | 2016-11-10 | Tocol Pharmaceuticals, Llc | Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation |
CN105078963B (zh) * | 2015-09-29 | 2018-06-22 | 中山大学 | α-生育酚在制备治疗血吸虫病药物中的应用 |
CA3007587C (en) | 2015-12-09 | 2023-12-05 | Phosphagenics Limited | Pharmaceutical formulation |
KR102647670B1 (ko) | 2016-12-21 | 2024-03-15 | 아베초 바이오테크놀로지 리미티드 | 방법 |
KR20180002728U (ko) | 2017-03-10 | 2018-09-19 | 주식회사 두울온돌침대 | 전열 매트리스 |
WO2022087735A1 (en) * | 2020-10-28 | 2022-05-05 | Hermay Labs Corporation | Labile and coherent redox-silent analogues for vitamin e enhancement |
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FR2754713B1 (fr) | 1996-10-22 | 1999-01-08 | Roc Sa | Utilisation de complexes pour la preparation de compositions pour le traitement des peaux sensibles, procede de preparation et compositions hypoallergeniques |
IL131628A0 (en) | 1997-03-04 | 2001-01-28 | Wisconsin Alumni Res Found | Method of suppressing tumor growth with combinations of isoprenoids and statins |
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US5917060A (en) * | 1997-12-17 | 1999-06-29 | Basf Aktiengesellschaft | Preparation of chromanyl derivatives |
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US6703384B2 (en) * | 1998-09-23 | 2004-03-09 | Research Development Foundation | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof |
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FR2784988B1 (fr) * | 1998-10-23 | 2002-09-20 | Adir | Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5990322A (en) | 1999-03-09 | 1999-11-23 | Sk Corporation | Alpha-tocopherol cyclopropylates, the new vitamin E derivatives and method for producing the same |
US6127382A (en) | 1999-08-16 | 2000-10-03 | Allergan Sales, Inc. | Amines substituted with a tetrahydroquinolinyl group an aryl or heteroaryl group and an alkyl group, having retinoid-like biological activity |
ATE382615T1 (de) | 2000-02-11 | 2008-01-15 | Res Dev Foundation | Tocopherole, tocotrienole, andere chrome und seitenketten-derivate und ihre verwendung |
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US7045324B2 (en) * | 2002-04-19 | 2006-05-16 | Research Development Foundation | Tocopherol associated protein and uses thereof |
-
2001
- 2001-02-09 AT AT01909008T patent/ATE382615T1/de not_active IP Right Cessation
- 2001-02-09 CN CNB018075363A patent/CN1243000C/zh not_active Expired - Fee Related
- 2001-02-09 KR KR1020027010387A patent/KR100847678B1/ko not_active IP Right Cessation
- 2001-02-09 JP JP2001558439A patent/JP2004504268A/ja not_active Ceased
- 2001-02-09 CA CA002399802A patent/CA2399802C/en not_active Expired - Fee Related
- 2001-02-09 WO PCT/US2001/004168 patent/WO2001058889A1/en active IP Right Grant
- 2001-02-09 NZ NZ520798A patent/NZ520798A/en not_active IP Right Cessation
- 2001-02-09 DE DE60132171T patent/DE60132171D1/de not_active Expired - Lifetime
- 2001-02-09 IL IL15110801A patent/IL151108A0/xx active IP Right Grant
- 2001-02-09 EP EP01909008A patent/EP1254130B1/de not_active Expired - Lifetime
- 2001-02-09 AU AU3680501A patent/AU3680501A/xx active Pending
- 2001-02-09 AU AU2001236805A patent/AU2001236805B2/en not_active Ceased
- 2001-02-09 RU RU2002124135/04A patent/RU2263672C2/ru not_active IP Right Cessation
-
2002
- 2002-08-06 ZA ZA200206243A patent/ZA200206243B/xx unknown
- 2002-08-06 IL IL151108A patent/IL151108A/en not_active IP Right Cessation
-
2003
- 2003-08-20 US US10/644,418 patent/US7312232B2/en not_active Expired - Fee Related
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2007
- 2007-10-22 US US11/876,612 patent/US7608638B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1254130A1 (de) | 2002-11-06 |
US20040235938A1 (en) | 2004-11-25 |
CA2399802C (en) | 2009-12-08 |
AU2001236805B2 (en) | 2005-07-14 |
EP1254130B1 (de) | 2008-01-02 |
RU2002124135A (ru) | 2004-01-10 |
IL151108A (en) | 2006-08-01 |
ATE382615T1 (de) | 2008-01-15 |
IL151108A0 (en) | 2003-04-10 |
KR20030005186A (ko) | 2003-01-17 |
EP1254130A4 (de) | 2003-04-23 |
ZA200206243B (en) | 2009-10-28 |
US20080119514A1 (en) | 2008-05-22 |
KR100847678B1 (ko) | 2008-07-23 |
AU3680501A (en) | 2001-08-20 |
CA2399802A1 (en) | 2001-08-16 |
CN1243000C (zh) | 2006-02-22 |
RU2263672C2 (ru) | 2005-11-10 |
WO2001058889A1 (en) | 2001-08-16 |
US7312232B2 (en) | 2007-12-25 |
US7608638B2 (en) | 2009-10-27 |
JP2004504268A (ja) | 2004-02-12 |
NZ520798A (en) | 2004-05-28 |
CN1529701A (zh) | 2004-09-15 |
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