DE60132442D1 - Diagnostischer assay mit dem makrophagen-inhibitorischen-zytokin-1 (mic-1) - Google Patents
Diagnostischer assay mit dem makrophagen-inhibitorischen-zytokin-1 (mic-1)Info
- Publication number
- DE60132442D1 DE60132442D1 DE60132442T DE60132442T DE60132442D1 DE 60132442 D1 DE60132442 D1 DE 60132442D1 DE 60132442 T DE60132442 T DE 60132442T DE 60132442 T DE60132442 T DE 60132442T DE 60132442 D1 DE60132442 D1 DE 60132442D1
- Authority
- DE
- Germany
- Prior art keywords
- mic
- methods
- diagnostic assay
- cancer
- miscarriage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ7037A AUPQ703700A0 (en) | 2000-04-20 | 2000-04-20 | Diagnostic assay and method of treatment |
| AUPP703700 | 2000-04-20 | ||
| AUPP746500 | 2000-05-11 | ||
| AUPQ7465A AUPQ746500A0 (en) | 2000-05-11 | 2000-05-11 | Diagnostic assay |
| PCT/AU2001/000456 WO2001081928A1 (en) | 2000-04-20 | 2001-04-20 | Diagnostic assay and method of treatment involving macrophage inhibitory cytokine -1 (mic-1) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132442D1 true DE60132442D1 (de) | 2008-03-06 |
| DE60132442T2 DE60132442T2 (de) | 2009-01-22 |
Family
ID=25646308
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60142372T Expired - Lifetime DE60142372D1 (de) | 2000-04-20 | 2001-04-20 | Diagnostischer Assay mit makrophagenhemmendem Zytokin-1 (MIC-1) |
| DE60132442T Expired - Lifetime DE60132442T2 (de) | 2000-04-20 | 2001-04-20 | Diagnostischer assay mit dem makrophagen-inhibitorischen-zytokin-1 (mic-1) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60142372T Expired - Lifetime DE60142372D1 (de) | 2000-04-20 | 2001-04-20 | Diagnostischer Assay mit makrophagenhemmendem Zytokin-1 (MIC-1) |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7514221B2 (de) |
| EP (2) | EP1279039B1 (de) |
| JP (1) | JP4920851B2 (de) |
| AT (2) | ATE384265T1 (de) |
| AU (2) | AU5018201A (de) |
| CA (1) | CA2405680C (de) |
| DE (2) | DE60142372D1 (de) |
| ES (2) | ES2346918T3 (de) |
| WO (1) | WO2001081928A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100475642B1 (ko) * | 2001-12-29 | 2005-03-10 | 한국생명공학연구원 | 암 발생 및 전이에 관여하는 단백질의 당쇄 변화를측정하여 암을 진단하는 방법 및 이를 이용한 진단킷트 |
| CA2390820A1 (en) | 2002-06-17 | 2003-12-17 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| US7919084B2 (en) | 2002-06-17 | 2011-04-05 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
| US20040253207A1 (en) * | 2002-11-08 | 2004-12-16 | Barnes-Jewish Hospital | Methods and compositions for prostate epithelial cell differentiation |
| US7323346B2 (en) * | 2003-08-14 | 2008-01-29 | The General Hospital Corporation | Screening for gestational disorders |
| KR100679666B1 (ko) * | 2004-01-20 | 2007-02-07 | 한국생명공학연구원 | 인간 대식세포 억제 사이토카인-1 특이적 단일클론항체,이를 분비하는 하이브리도마 및 이를 포함하는 위암 진단키트 |
| AU2005232335B2 (en) * | 2004-04-13 | 2009-09-03 | St Vincent's Hospital Sydney Limited | Method for modulating appetite |
| US8192735B2 (en) | 2004-04-13 | 2012-06-05 | St Vincent's Hospital Sydney Limited | Method for modulating appetite |
| US20070237713A1 (en) | 2006-04-04 | 2007-10-11 | Fan Rong A | PCan065 Antibody Compositions and Methods of Use |
| EP2047275B1 (de) | 2006-08-04 | 2011-06-01 | Medizinische Hochschule Hannover | Verfahren zur risikobewertung von herzeingriffen auf gdf-15-basis |
| BRPI0817233A2 (pt) * | 2007-09-28 | 2012-11-06 | Intrexon Corp | construções terapêuticas de gene de trca e bireatores para a expressão de moléculas bioterapêuticas, e usos das mesmas |
| CA2701945A1 (en) * | 2007-10-22 | 2009-04-30 | Samuel Norbert Breit | Methods of prognosis of overall survival using mic-1 |
| CA2740632A1 (en) | 2008-10-31 | 2010-05-06 | St. Vincent's Hospital Sydney Limited | Methods of prognosis in chronic kidney disease |
| GB0902737D0 (en) | 2009-02-19 | 2009-04-01 | Univ Gent | GDF15 as a differential marker for spondyloarthropathy |
| GB0902793D0 (en) | 2009-02-20 | 2009-04-08 | Univ Gent | GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes |
| US9212221B2 (en) * | 2010-03-03 | 2015-12-15 | Detroit R & D, Inc. | Form-specific antibodies for NAG-1 (MIC-1, GDF-15), H6D and other TGF-β subfamily and heart disease and cancer diagnoses |
| US20130058931A1 (en) | 2010-03-11 | 2013-03-07 | University Of Louisville Research Foundation, Inc. | Methods of predicting and decreasing the risk of pregnancy loss |
| CA2806304A1 (en) * | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| EP2830646B1 (de) * | 2012-03-27 | 2018-03-07 | NGM Biopharmaceuticals, Inc. | Zusammensetzungen und verfahren zur behandlung von stoffwechselerkrankungen |
| EA038645B1 (ru) | 2012-12-21 | 2021-09-28 | Авео Фармасьютикалз, Инк. | Антитела к gdf15 |
| AU2014212640B2 (en) | 2013-01-30 | 2017-10-19 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use in treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| UA123432C2 (uk) | 2014-07-30 | 2021-04-07 | Нджм Біофармасьютікалз, Інк. | Димер та спосіб його застосування для лікування метаболічних розладів |
| AU2015339130C1 (en) | 2014-10-31 | 2021-03-18 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| WO2017150314A1 (ja) | 2016-02-29 | 2017-09-08 | 公立大学法人横浜市立大学 | 去勢抵抗性前立腺癌を検出する方法及び検出試薬 |
| MY194669A (en) | 2016-03-31 | 2022-12-12 | Ngm Biopharmaceuticals Inc | Binding Proteins and Methods of use Thereof |
| WO2018187767A1 (en) * | 2017-04-06 | 2018-10-11 | The Regents Of The University Of California | Predicting, diagnosing, and treating nausea and vomiting of pregnancy |
| JP7127422B2 (ja) | 2017-08-30 | 2022-08-30 | 東ソー株式会社 | 癌を検出する方法及び検出試薬 |
| JP7325837B2 (ja) * | 2018-01-15 | 2023-08-15 | ナンヤン テクノロジカル ユニヴァーシティー | 尿代謝物と毒素を検知するための超疎水性プラットフォーム |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US59431A (en) * | 1866-11-06 | Improved door-fastener | ||
| WO1994003599A1 (en) | 1992-08-04 | 1994-02-17 | Sagami Chemical Research Center | HUMAN cDNA AND PROTEIN WHICH SAID cDNA CODES FOR |
| US6180602B1 (en) | 1992-08-04 | 2001-01-30 | Sagami Chemical Research Center | Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent |
| JPH07250688A (ja) | 1994-01-28 | 1995-10-03 | Sagami Chem Res Center | ＴＧＦ−βスーパーファミリー蛋白質をコードするヒト新規ｃＤＮＡ |
| JPH07258293A (ja) | 1994-03-23 | 1995-10-09 | Asahi Chem Ind Co Ltd | 新規な蛋白質ならびにその製造方法 |
| US6521227B1 (en) | 1999-11-18 | 2003-02-18 | Peter L. Hudson | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides |
| AU1830195A (en) | 1994-12-15 | 1996-07-03 | Human Genome Sciences, Inc. | Prostatic growth factor |
| US5994102A (en) | 1994-12-15 | 1999-11-30 | Human Genome Sciences, Inc. | Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides |
| ES2324433T3 (es) | 1995-06-22 | 2009-08-06 | St Vincent's Hospital Sydney Limited | Tgf-beta novedoso similar a citocina. |
| EP1074620A1 (de) * | 1999-08-06 | 2001-02-07 | HyGene AG | Monomer Protein der TGF-beta Familie |
| WO1999006445A1 (en) * | 1997-07-31 | 1999-02-11 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-15 |
| AU1276899A (en) * | 1997-10-23 | 1999-05-10 | Fibrogen, Inc. | Type ix collagen antibody and related uses |
| US6465181B2 (en) * | 1999-03-25 | 2002-10-15 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the prostate |
| WO2000070051A1 (en) | 1999-05-17 | 2000-11-23 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh | NEUROPROTECTIVE PROPERTIES OF GDF-15, A NOVEL MEMBER OF THE TGF-β SUPERFAMILY |
-
2001
- 2001-04-20 ES ES07023699T patent/ES2346918T3/es not_active Expired - Lifetime
- 2001-04-20 AU AU5018201A patent/AU5018201A/xx active Pending
- 2001-04-20 AT AT01923411T patent/ATE384265T1/de active
- 2001-04-20 JP JP2001578963A patent/JP4920851B2/ja not_active Expired - Lifetime
- 2001-04-20 AT AT07023699T patent/ATE470863T1/de active
- 2001-04-20 US US10/257,597 patent/US7514221B2/en not_active Expired - Lifetime
- 2001-04-20 DE DE60142372T patent/DE60142372D1/de not_active Expired - Lifetime
- 2001-04-20 DE DE60132442T patent/DE60132442T2/de not_active Expired - Lifetime
- 2001-04-20 EP EP01923411A patent/EP1279039B1/de not_active Expired - Lifetime
- 2001-04-20 WO PCT/AU2001/000456 patent/WO2001081928A1/en active IP Right Grant
- 2001-04-20 CA CA2405680A patent/CA2405680C/en not_active Expired - Lifetime
- 2001-04-20 AU AU2001250182A patent/AU2001250182B2/en not_active Expired
- 2001-04-20 ES ES01923411T patent/ES2300325T3/es not_active Expired - Lifetime
- 2001-04-20 EP EP07023699A patent/EP1914554B1/de not_active Expired - Lifetime
-
2009
- 2009-02-24 US US12/379,485 patent/US7968303B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE384265T1 (de) | 2008-02-15 |
| DE60132442T2 (de) | 2009-01-22 |
| ES2346918T3 (es) | 2010-10-21 |
| DE60142372D1 (de) | 2010-07-22 |
| EP1279039A1 (de) | 2003-01-29 |
| EP1279039A4 (de) | 2005-05-25 |
| JP2003532079A (ja) | 2003-10-28 |
| ATE470863T1 (de) | 2010-06-15 |
| EP1914554A2 (de) | 2008-04-23 |
| US7968303B2 (en) | 2011-06-28 |
| AU2001250182B2 (en) | 2006-06-08 |
| EP1914554B1 (de) | 2010-06-09 |
| ES2300325T3 (es) | 2008-06-16 |
| CA2405680C (en) | 2018-02-13 |
| WO2001081928A1 (en) | 2001-11-01 |
| JP4920851B2 (ja) | 2012-04-18 |
| EP1914554A3 (de) | 2008-08-06 |
| US20040053325A1 (en) | 2004-03-18 |
| EP1279039B1 (de) | 2008-01-16 |
| US7514221B2 (en) | 2009-04-07 |
| AU5018201A (en) | 2001-11-07 |
| US20090291889A1 (en) | 2009-11-26 |
| CA2405680A1 (en) | 2001-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: GRAF VON STOSCH PATENTANWALTSGESELLSCHAFT MBH, 805 |