DE60137512D1 - Zusammensetzungen und verfahren zum nachweis und zur quantifizierung von cox-2-aktivität und 2-arachidonylglycerin-metaboliten - Google Patents

Zusammensetzungen und verfahren zum nachweis und zur quantifizierung von cox-2-aktivität und 2-arachidonylglycerin-metaboliten

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Publication number
DE60137512D1
DE60137512D1 DE60137512T DE60137512T DE60137512D1 DE 60137512 D1 DE60137512 D1 DE 60137512D1 DE 60137512 T DE60137512 T DE 60137512T DE 60137512 T DE60137512 T DE 60137512T DE 60137512 D1 DE60137512 D1 DE 60137512D1
Authority
DE
Germany
Prior art keywords
cox
activity
methods
detecting
metabolites
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60137512T
Other languages
English (en)
Inventor
Lawrence J Marnett
Kevin R Kozak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Application granted granted Critical
Publication of DE60137512D1 publication Critical patent/DE60137512D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
DE60137512T 2000-08-07 2001-08-07 Zusammensetzungen und verfahren zum nachweis und zur quantifizierung von cox-2-aktivität und 2-arachidonylglycerin-metaboliten Expired - Lifetime DE60137512D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22366500P 2000-08-07 2000-08-07
US30297501P 2001-07-03 2001-07-03
PCT/US2001/024762 WO2002012549A1 (en) 2000-08-07 2001-08-07 Compositions and methods for detecting and quantifying cox-2 activity and 2-arachidonylglycerol metabolites

Publications (1)

Publication Number Publication Date
DE60137512D1 true DE60137512D1 (de) 2009-03-12

Family

ID=26918005

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60137512T Expired - Lifetime DE60137512D1 (de) 2000-08-07 2001-08-07 Zusammensetzungen und verfahren zum nachweis und zur quantifizierung von cox-2-aktivität und 2-arachidonylglycerin-metaboliten
DE60137335T Expired - Lifetime DE60137335D1 (de) 2000-08-07 2001-08-07 Nachweis der COX-2 Aktivität und von Anandamid-Metaboliten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60137335T Expired - Lifetime DE60137335D1 (de) 2000-08-07 2001-08-07 Nachweis der COX-2 Aktivität und von Anandamid-Metaboliten

Country Status (7)

Country Link
US (3) US20020106707A1 (de)
EP (2) EP1307538B1 (de)
AT (2) ATE421595T1 (de)
AU (3) AU2001284753B2 (de)
CA (2) CA2422306A1 (de)
DE (2) DE60137512D1 (de)
WO (2) WO2002012445A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050123970A1 (en) * 2001-04-25 2005-06-09 Can Ozbal High throughput autosampler
WO2009059286A1 (en) * 2007-11-02 2009-05-07 Biotrove, Inc. Devices and methods for coupling mass spectrometry devices with chromatography systems
US8414774B2 (en) * 2001-04-25 2013-04-09 Agilent Technologies, Inc. Systems and methods for high-throughput screening of fluidic samples
WO2003007875A2 (en) * 2001-07-16 2003-01-30 Hoegestaett Edward Compounds with analgesic, antipyretic and/or anti-inflammatory activity
US6864282B2 (en) * 2002-08-05 2005-03-08 Allergan, Inc. 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma
CA2495587A1 (en) * 2002-08-22 2004-03-04 Cornell Research Foundation, Inc. Multifunctional cox-2 inhibitors
NO20035683D0 (no) * 2003-12-18 2003-12-18 Amersham Health As Optisk avbildning av prostatakreft
GB0402719D0 (en) * 2004-02-07 2004-03-10 Royal College Of Surgeons Ie A method of detecting incomplete inhibition of enzymes in individuals undergoing enzyme inhibitor therapy
US20060135609A1 (en) 2004-10-21 2006-06-22 Duke University Ophthamological drugs
US20070254920A1 (en) * 2006-04-26 2007-11-01 Aerie Pharmaceuticals, Inc. Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
WO2009105481A1 (en) * 2008-02-19 2009-08-27 The Buck Institute For Age Research Mao-b elevation as an early parkinson's disease biomarker
US20150183737A1 (en) * 2012-07-20 2015-07-02 Vanderbilt University Compositions and methods for substrate-selective inhibition of endocannabinoid oxygenation
WO2016091659A2 (en) * 2014-12-09 2016-06-16 Nestec S.A. Uses of bioactive lipids
US10960013B2 (en) 2016-03-04 2021-03-30 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
ES2953032T3 (es) * 2017-09-01 2023-11-07 Univ East Carolina Métodos ex vivo para la activación de las células inmunológicas
CN109900830B (zh) * 2019-04-02 2021-07-23 天地恒一制药股份有限公司 采用hplc分离测定塞来昔布中磺酰胺类杂质的方法及应用

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632627A (en) 1968-01-05 1972-01-04 Smith Kline French Lab Glyceride derivatives of prostaglandins
JPS4920766B1 (de) 1970-11-10 1974-05-27
CA932324A (en) 1971-10-22 1973-08-21 Gordon Maxwell Glyceride and phosphatide derivatives of prostaglandins
JPS59156299A (ja) * 1983-02-28 1984-09-05 Noda Sangyo Kagaku Kenkyusho Ｎ−アセチルヘキソサミンの定量法及びその定量用試薬
US4675281A (en) 1984-07-09 1987-06-23 Lands William E M Quantification of hydroperoxides using prostaglandin H synthase
US5362476A (en) * 1984-10-18 1994-11-08 Board Of Regents, The University Of Texas System Alkyl phosphonate polyazamacrocyclic cheates for MRI
US5047354A (en) 1987-10-30 1991-09-10 Foegh Marie L Thromboxane B2 assay for coronary artery thrombosis
US5162504A (en) * 1988-06-03 1992-11-10 Cytogen Corporation Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients
WO1992022668A1 (en) * 1991-06-14 1992-12-23 Vanderbilt University Method and compositions to assess oxidative stress in vivo
US5858696A (en) 1991-06-14 1999-01-12 Vanderbilt University Method and compositions to assess oxidative stress in vivo
US5316906A (en) * 1991-08-23 1994-05-31 Molecular Probes, Inc. Enzymatic analysis using substrates that yield fluorescent precipitates
US5589575A (en) 1992-07-23 1996-12-31 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture Purification of hapten-carrier generated antibodies
US5837479A (en) 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
ATE123151T1 (de) 1992-10-21 1995-06-15 Edith Dr Dr Huland Verfahren zur quantitativen bestimmung von krankheitsspezifischen antigenen und vorrichtung zur durchführung des verfahrens.
US5543297A (en) * 1992-12-22 1996-08-06 Merck Frosst Canada, Inc. Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5475021A (en) * 1993-12-03 1995-12-12 Vanderbilt University Compounds and compositions for inhibition of cyclooxygenase activity
US5459239A (en) 1994-01-24 1995-10-17 Merck Frosst Canada Inc. Peptide sequences and antipeptide antisera for detecting human cyclooxygenase-1 and cyclooxygenase-2 proteins
US5686269A (en) * 1994-07-28 1997-11-11 The Mclean Hospital Corporation Method of diagnosing Alzheimer's disease by detecting the level of cathepsin D in cerebrospinal fluid
US5999843A (en) * 1995-01-03 1999-12-07 Omnicorder Technologies, Inc. Detection of cancerous lesions by their effect on the spatial homogeneity of skin temperature
US5731343A (en) * 1995-02-24 1998-03-24 The Scripps Research Institute Method of use of radicicol for treatment of immunopathological disorders
FR2732597B1 (fr) 1995-04-05 1997-05-16 Oreal Utilisation dans une composition en tant qu'activateur et/ou stabilisateur de cyclooxygenase d'au moins un derive de pyrimidine substitue en 6
JPH0977664A (ja) * 1995-09-13 1997-03-25 Yakult Honsha Co Ltd シクロオキシゲナーゼ−２特異的阻害剤及び抗炎症剤
NZ322674A (en) * 1995-10-17 1999-08-30 Searle & Co Method of detecting cyclooxygenase-2
US5945675A (en) 1996-03-18 1999-08-31 Pacific Northwest Research Foundation Methods of screening for a tumor or tumor progression to the metastatic state
US5891622A (en) 1996-09-30 1999-04-06 Oxford Biomedical Research, Inc. Assessment of oxidative stress in vivo
IL121659A (en) 1996-10-25 2000-07-16 Bayer Ag Method for determining CPSA in a blood sample
US5973191A (en) * 1996-12-30 1999-10-26 Vanderbilt University Selective inhibitors of prostaglandin endoperoxide synthase-2
DZ2479A1 (fr) 1997-05-05 2003-02-01 Pfizer Composés inhibiteurs sélectifs de cox-2 anti-inflammatoires et compositions pharmaceutiques les contenant.
US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US5874235A (en) 1997-07-18 1999-02-23 The Johns Hopkins University Screening assays for cancer chemopreventative agents
US6207700B1 (en) * 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use

Also Published As

Publication number Publication date
ATE421595T1 (de) 2009-02-15
CA2422306A1 (en) 2002-02-14
AU2001284753B2 (en) 2006-10-26
WO2002012445A1 (en) 2002-02-14
AU8474701A (en) 2002-02-18
AU8475301A (en) 2002-02-18
EP1307538A4 (de) 2005-03-02
CA2422803A1 (en) 2002-02-14
US7189504B2 (en) 2007-03-13
US20020106707A1 (en) 2002-08-08
WO2002012549A1 (en) 2002-02-14
EP1307585B1 (de) 2009-01-21
EP1307538B1 (de) 2009-01-07
EP1307538A1 (de) 2003-05-07
US20020064804A1 (en) 2002-05-30
EP1307585A4 (de) 2005-03-02
EP1307585A1 (de) 2003-05-07
DE60137335D1 (de) 2009-02-26
US20060110786A1 (en) 2006-05-25
ATE420201T1 (de) 2009-01-15
US7628975B2 (en) 2009-12-08

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