DE60141742D1 - Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten - Google Patents

Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten

Info

Publication number: DE60141742D1
Authority: DE; Germany
Prior art keywords: free; harnic; aggregate; acid oxidase; preparing non
Prior art date: 2000-02-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60141742T

Other languages

English (en)

Inventor

Merry R Sherman

Mark G Saifer

David L Williams

Michael S Hershfield

Susan J Kelly

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mountain View Pharmaceuticals Inc

Duke University

Original Assignee

Mountain View Pharmaceuticals Inc

Duke University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-10

Filing date

2001-02-07

Publication date

2010-05-20

2001-02-07 Application filed by Mountain View Pharmaceuticals Inc, Duke University filed Critical Mountain View Pharmaceuticals Inc

2010-05-20 Application granted granted Critical

2010-05-20 Publication of DE60141742D1 publication Critical patent/DE60141742D1/de

2021-02-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0044—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7)
- C12N9/0046—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on other nitrogen compounds as donors (1.7) with oxygen as acceptor (1.7.3)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

DE60141742T 2000-02-10 2001-02-07 Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten Expired - Lifetime DE60141742D1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/501,730 US6783965B1 (en)	2000-02-10	2000-02-10	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
PCT/US2001/040069 WO2001059078A2 (en)	2000-02-10	2001-02-07	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

Publications (1)

Publication Number	Publication Date
DE60141742D1 true DE60141742D1 (de)	2010-05-20

Family

ID=23994789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60141742T Expired - Lifetime DE60141742D1 (de)	2000-02-10	2001-02-07	Aggregat-freie harnsäureoxidase zur herstellung von nicht-immunogenen polymer-konjugaten

Country Status (28)

Country	Link
US (3)	US6783965B1 (de)
EP (3)	EP2305819B1 (de)
JP (2)	JP5165826B2 (de)
KR (3)	KR100884724B1 (de)
CN (2)	CN101735991B (de)
AT (1)	ATE463576T1 (de)
AU (3)	AU4997501A (de)
BE (1)	BE2013C045I2 (de)
BR (1)	BRPI0108386B8 (de)
CA (1)	CA2398679C (de)
CY (3)	CY1110142T1 (de)
CZ (1)	CZ304864B6 (de)
DE (1)	DE60141742D1 (de)
DK (3)	DK2196538T3 (de)
ES (2)	ES2524153T3 (de)
FR (1)	FR13C0036I2 (de)
HK (4)	HK1056742A1 (de)
HU (1)	HU227127B1 (de)
IL (3)	IL151065A0 (de)
LU (1)	LU92237I2 (de)
MX (1)	MXPA02007545A (de)
NZ (1)	NZ520434A (de)
PL (1)	PL208064B1 (de)
PT (2)	PT1254237E (de)
RU (3)	RU2281954C2 (de)
TW (2)	TW200914617A (de)
WO (1)	WO2001059078A2 (de)
ZA (1)	ZA200207206B (de)

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2000
- 2000-02-10 US US09/501,730 patent/US6783965B1/en not_active Expired - Lifetime
2001
- 2001-02-06 TW TW097145974A patent/TW200914617A/zh unknown
- 2001-02-06 TW TW090102540A patent/TWI322184B/zh not_active IP Right Cessation
- 2001-02-07 KR KR1020027010189A patent/KR100884724B1/ko active IP Right Grant
- 2001-02-07 EP EP10180428.4A patent/EP2305819B1/de not_active Expired - Lifetime
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- 2001-02-07 AU AU4997501A patent/AU4997501A/xx active Pending
- 2001-02-07 BR BRPI0108386A patent/BRPI0108386B8/pt not_active Application Discontinuation
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- 2001-02-07 KR KR1020087024272A patent/KR101054247B1/ko active IP Right Grant
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- 2001-02-07 EP EP01923265A patent/EP1254237B1/de not_active Expired - Lifetime
- 2001-02-07 RU RU2006107110/13A patent/RU2352354C2/ru active
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- 2001-02-07 KR KR1020077018682A patent/KR20070092329A/ko active Search and Examination
- 2001-02-07 MX MXPA02007545A patent/MXPA02007545A/es active IP Right Grant
- 2001-02-07 DK DK10158016.5T patent/DK2196538T3/en active
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- 2001-02-07 WO PCT/US2001/040069 patent/WO2001059078A2/en active Application Filing
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- 2001-02-07 DK DK10180428.4T patent/DK2305819T3/en active
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2002
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2003
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2009
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Also Published As

Publication number	Publication date
RU2006107110A (ru)	2007-09-20
CN101735991A (zh)	2010-06-16
HK1056742A1 (en)	2004-02-27
FR13C0036I1 (fr)	2013-08-09
AU2009212900A1 (en)	2009-10-01
KR20080098686A (ko)	2008-11-11
CY1117264T1 (el)	2017-04-26
EP2196538B1 (de)	2014-10-01
CA2398679A1 (en)	2001-08-16
KR100884724B1 (ko)	2009-02-19
HUP0204544A3 (en)	2007-05-02
KR20020087934A (ko)	2002-11-23
RU2557318C2 (ru)	2015-07-20
BR0108386C1 (pt)	2011-12-20
HK1143989A1 (en)	2011-01-21
WO2001059078A3 (en)	2002-03-07
HK1144701A1 (en)	2011-03-04
DK1254237T3 (da)	2010-07-19
DK2196538T3 (en)	2015-01-05
EP2305819B1 (de)	2014-11-12
CZ304864B6 (cs)	2014-12-17
EP2305819A1 (de)	2011-04-06
KR101054247B1 (ko)	2011-08-08
BR0108386B1 (pt)	2017-10-31
RU2009104003A (ru)	2010-08-20
ATE463576T1 (de)	2010-04-15
AU4997501A (en)	2001-08-20
BRPI0108386B8 (pt)	2021-05-25
FR13C0036I2 (fr)	2014-05-16
CY2013028I2 (el)	2015-11-04
TWI322184B (en)	2010-03-21
DK2305819T3 (en)	2015-01-05
BE2013C045I2 (de)	2020-06-24
EP1254237B1 (de)	2010-04-07
BR0108386A (pt)	2002-10-29
HU227127B1 (en)	2010-07-28
MXPA02007545A (es)	2002-12-13
IL193365A (en)	2011-08-31
NZ520434A (en)	2004-05-28
IL151065A0 (en)	2003-04-10
ZA200207206B (en)	2003-05-06
EP2196538A1 (de)	2010-06-16
PT2305819E (pt)	2015-06-01
CN100491532C (zh)	2009-05-27
LU92237I2 (fr)	2013-09-03
IL151065A (en)	2008-12-29
AU2001249975B2 (en)	2006-06-08
PL358539A1 (en)	2004-08-09
HK1155203A1 (en)	2012-05-11
US8921064B2 (en)	2014-12-30
CZ20022982A3 (cs)	2003-01-15
AU2009212900B2 (en)	2011-12-08
US20080057048A1 (en)	2008-03-06
JP5165826B2 (ja)	2013-03-21
CY1110142T1 (el)	2015-01-14
RU2281954C2 (ru)	2006-08-20
KR20070092329A (ko)	2007-09-12
ES2524153T3 (es)	2014-12-04
WO2001059078A2 (en)	2001-08-16
CY2013028I1 (el)	2015-11-04
PT1254237E (pt)	2010-06-07
US6783965B1 (en)	2004-08-31
IL193365A0 (en)	2009-02-11
JP2011188861A (ja)	2011-09-29
CA2398679C (en)	2015-11-17
ES2343105T8 (es)	2013-07-15
TW200914617A (en)	2009-04-01
HUP0204544A2 (en)	2003-05-28
JP2003521937A (ja)	2003-07-22
US20110287466A1 (en)	2011-11-24
CN101735991B (zh)	2013-09-11
EP1254237A2 (de)	2002-11-06
RU2352354C2 (ru)	2009-04-20
CN1423699A (zh)	2003-06-11
PL208064B1 (pl)	2011-03-31
ES2343105T3 (es)	2010-07-23
RU2557318C9 (ru)	2015-09-10
JP5341945B2 (ja)	2013-11-13
US7927852B2 (en)	2011-04-19

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