DE60144375D1 - 7-, 8- und 9-substitutierte tetracyclinverbindungen - Google Patents

7-, 8- und 9-substitutierte tetracyclinverbindungen

Info

Publication number
DE60144375D1
DE60144375D1 DE60144375T DE60144375T DE60144375D1 DE 60144375 D1 DE60144375 D1 DE 60144375D1 DE 60144375 T DE60144375 T DE 60144375T DE 60144375 T DE60144375 T DE 60144375T DE 60144375 D1 DE60144375 D1 DE 60144375D1
Authority
DE
Germany
Prior art keywords
substituted
compounds
tetracyclin
tetracycline compounds
substituted tetracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60144375T
Other languages
English (en)
Inventor
Mark L Nelson
Darrell Koza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TRUSTEES OF TUFTS COLLEGE MEDFORD
Tufts University
Original Assignee
TRUSTEES OF TUFTS COLLEGE MEDFORD
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/021366 external-priority patent/WO2002012170A1/en
Application filed by TRUSTEES OF TUFTS COLLEGE MEDFORD, Tufts University filed Critical TRUSTEES OF TUFTS COLLEGE MEDFORD
Application granted granted Critical
Publication of DE60144375D1 publication Critical patent/DE60144375D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE60144375T 2000-07-07 2001-06-29 7-, 8- und 9-substitutierte tetracyclinverbindungen Expired - Lifetime DE60144375D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21665600P 2000-07-07 2000-07-07
PCT/US2000/021366 WO2002012170A1 (en) 2000-08-04 2000-08-04 8-substituted tetracycline compounds
PCT/US2001/020558 WO2002004404A2 (en) 2000-07-07 2001-06-29 7,8 and 9-substituted tetracycline compounds

Publications (1)

Publication Number Publication Date
DE60144375D1 true DE60144375D1 (de) 2011-05-19

Family

ID=26680300

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60144375T Expired - Lifetime DE60144375D1 (de) 2000-07-07 2001-06-29 7-, 8- und 9-substitutierte tetracyclinverbindungen

Country Status (8)

Country Link
US (1) US6624168B2 (de)
EP (2) EP1303479B1 (de)
JP (1) JP4963771B2 (de)
AT (1) ATE504562T1 (de)
AU (1) AU2001271556A1 (de)
CA (1) CA2415086A1 (de)
DE (1) DE60144375D1 (de)
WO (1) WO2002004404A2 (de)

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US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
CN102336680A (zh) * 1999-09-14 2012-02-01 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6833365B2 (en) * 2000-01-24 2004-12-21 Trustees Of Tufts College Tetracycline compounds for treatment of Cryptosporidium parvum related disorders
IL151971A0 (en) * 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
DE60102815D1 (de) * 2000-05-15 2004-05-19 Paratek Pharm Innc 7-substituierte kondensierte ring-tetrazyclin- verbindungen
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
WO2001098236A2 (en) * 2000-06-16 2001-12-27 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EP3461808A1 (de) 2000-07-07 2019-04-03 Trustees of Tufts College 9-substituierte minocyclinverbindungen
CN102336679A (zh) * 2000-07-07 2012-02-01 塔夫茨大学信托人 7-取代的四环素化合物
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
EP1241160A1 (de) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
EP1955996A1 (de) * 2001-03-13 2008-08-13 Paratek Pharmaceuticals, Inc. 7, 9-substituierte Tetracyclin-Verbindungen
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
CA2440757A1 (en) 2001-03-14 2002-09-19 Michael Draper Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332549A1 (de) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Neue Tetracyclinverbindungen und deren medizinischen Anwendung
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP2322501B1 (de) * 2002-01-08 2015-08-05 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
CN102531948A (zh) * 2002-03-08 2012-07-04 帕拉特克药品公司 氨基-甲基取代的四环素类化合物
EP2481723A3 (de) * 2002-03-21 2013-02-13 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
CN1700922A (zh) * 2002-07-12 2005-11-23 帕拉特克药品公司 3、10或12a位取代的四环素化合物
AU2003287217B2 (en) 2002-10-24 2010-03-04 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate RNA
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2298323A3 (de) * 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
WO2005070878A1 (en) 2004-01-15 2005-08-04 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
JP5242161B2 (ja) 2004-05-21 2013-07-24 プレジデント アンド フェローズ オブ ハーバード カレッジ テトラサイクリンおよびそれらの類似物の合成
AU2014250722B2 (en) * 2004-05-21 2016-05-26 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
AU2012202559B2 (en) * 2004-05-21 2014-07-17 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
EP2284152A3 (de) 2004-10-25 2011-10-05 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
US7858601B2 (en) 2004-10-25 2010-12-28 Paratek Pharmaceuticals, Inc. 4-substituted tetracyclines and methods of use thereof
WO2006084265A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS
AU2006214543A1 (en) * 2005-02-15 2006-08-24 Wyeth 9-substituted tetracyclines
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
EP2016044B1 (de) 2006-04-07 2020-06-10 President and Fellows of Harvard College Pentacylin-derivate zur behandlung von infektionen
EP2537934A3 (de) 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Verfahren zur Regelung der Genexpression oder von Genprodukten mit substituierten Tetracyclinverbindungen
US7763735B2 (en) 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
PL2120963T3 (pl) 2006-12-21 2019-05-31 Paratek Pharm Innc Podstawione związki tetracyklinowe do leczenia zaburzeń zapalnych skóry
MX2009006846A (es) 2006-12-21 2009-08-20 Paratek Pharm Innc Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias.
AU2008239606A1 (en) * 2007-04-12 2008-10-23 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
CA2688662A1 (en) * 2007-04-27 2008-11-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
EP2176216B1 (de) 2007-07-06 2012-04-25 Paratek Pharmaceuticals, Inc. Verfahren zur synthese von 9-substituiertem minocyclin
CA2706475C (en) 2007-11-29 2016-05-03 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
EP2262754A4 (de) 2008-03-05 2012-03-14 Paratek Pharm Innc Minocyclinverbindungen und anwendungsverfahren dafür
AU2009236631A1 (en) * 2008-04-14 2009-10-22 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CN102177134B (zh) 2008-08-08 2014-04-16 麻州四期制药公司 C7-氟取代的四环素化合物
CN102215681A (zh) * 2008-09-19 2011-10-12 帕拉特克药品公司 用于治疗类风湿性关节炎的四环素化合物和相关的治疗方法
EP2424834B1 (de) 2009-04-30 2018-07-11 President and Fellows of Harvard College Synthese von tetracyclinen und deren zwischenprodukte
CA2761241C (en) 2009-05-08 2018-02-27 Tetraphase Pharmaceuticals, Inc. Tetracycline compounds
NO2470500T3 (de) 2009-08-28 2018-03-03
TW201245116A (en) * 2010-08-12 2012-11-16 Tetraphase Pharmaceuticals Inc Tetracycline analogs
MX364400B (es) 2012-08-31 2019-04-24 Tetraphase Pharmaceuticals Inc Compuestos de tetraciclina.
RU2668535C2 (ru) * 2016-09-22 2018-10-01 Федеральное государственное бюджетное научное учреждение "Уральский федеральный аграрный научно-исследовательский центр Уральского отделения Российской академии наук" (ФГБНУ УрФАНИЦ УрО РАН) Способ профилактики маститов у высокопродуктивных коров
WO2018075767A1 (en) 2016-10-19 2018-04-26 Tetraphase Pharmaceuticals, Inc. Crystalline forms of eravacycline
BR112019008897A2 (pt) 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.

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US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
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Also Published As

Publication number Publication date
EP2166000A1 (de) 2010-03-24
EP1303479B1 (de) 2011-04-06
JP4963771B2 (ja) 2012-06-27
AU2001271556A1 (en) 2002-01-21
WO2002004404A3 (en) 2002-06-13
US6624168B2 (en) 2003-09-23
JP2004502750A (ja) 2004-01-29
US20020111335A1 (en) 2002-08-15
WO2002004404A2 (en) 2002-01-17
ATE504562T1 (de) 2011-04-15
CA2415086A1 (en) 2002-01-17
EP1303479A2 (de) 2003-04-23

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