DE602004022508D1 - Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen - Google Patents
Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungenInfo
- Publication number
- DE602004022508D1 DE602004022508D1 DE602004022508T DE602004022508T DE602004022508D1 DE 602004022508 D1 DE602004022508 D1 DE 602004022508D1 DE 602004022508 T DE602004022508 T DE 602004022508T DE 602004022508 T DE602004022508 T DE 602004022508T DE 602004022508 D1 DE602004022508 D1 DE 602004022508D1
- Authority
- DE
- Germany
- Prior art keywords
- manufactured
- mold
- test agent
- dimensional
- micro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 5
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000002207 metabolite Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44053903P | 2003-01-16 | 2003-01-16 | |
PCT/US2004/001098 WO2004065616A2 (en) | 2003-01-16 | 2004-01-16 | Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004022508D1 true DE602004022508D1 (de) | 2009-09-24 |
Family
ID=32771828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004022508T Expired - Lifetime DE602004022508D1 (de) | 2003-01-16 | 2004-01-16 | Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen |
Country Status (5)
Country | Link |
---|---|
US (2) | US7670797B2 (de) |
EP (1) | EP1589814B1 (de) |
AT (1) | ATE439039T1 (de) |
DE (1) | DE602004022508D1 (de) |
WO (1) | WO2004065616A2 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7759113B2 (en) * | 1999-04-30 | 2010-07-20 | The General Hospital Corporation | Fabrication of tissue lamina using microfabricated two-dimensional molds |
EP1589814B1 (de) | 2003-01-16 | 2009-08-12 | The General Hospital Corporation | Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen |
WO2005089480A2 (en) | 2004-03-19 | 2005-09-29 | Stuart Arthur Bateman | Activation method |
US8741555B2 (en) * | 2004-05-14 | 2014-06-03 | Organ Recovery Systems, Inc. | Apparatus and method for perfusion and determining the viability of an organ |
US8075904B2 (en) * | 2004-08-11 | 2011-12-13 | California Institute Of Technology | High aspect ratio template and method for producing same for central and peripheral nerve repair |
US7837913B2 (en) * | 2004-08-11 | 2010-11-23 | California Institute Of Technology | High aspect ratio template and method for producing same |
CA2589526C (en) | 2005-01-21 | 2014-12-02 | Commonwealth Scientific And Industrial Research Organisation | Activation method using modifying agent |
WO2007050902A1 (en) | 2005-10-26 | 2007-05-03 | Total Record Inc | Acellular bioabsorbable tissue regeneration matrices produced by incubating acellular blood products |
US8603806B2 (en) * | 2005-11-02 | 2013-12-10 | The Ohio State Universtiy Research Foundation | Materials and methods for cell-based assays |
US10176887B1 (en) | 2005-11-14 | 2019-01-08 | Organ Recovery Systems, Inc. | Ex vivo methods for drug discovery, development and testing |
HUE036378T2 (hu) * | 2006-04-10 | 2018-07-30 | Wisconsin Alumni Res Found | Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére |
US20090239303A1 (en) * | 2006-04-24 | 2009-09-24 | Rhoades Lawrence J | Ultrasonic Machining Fabrication of Guided Tissue Generation Surfaces and Tissue Scaffolds |
EP2029766A4 (de) * | 2006-06-08 | 2010-02-10 | Univ North Carolina | Pulsung von gallenkammern bei hepatozyten aus sandwich-kulturen |
EP3192369B1 (de) | 2007-04-12 | 2018-12-12 | The General Hospital Corporation | Biomimetisches gefässnetz |
US8765364B2 (en) * | 2007-05-18 | 2014-07-01 | Lifeline Scientific, Inc. | Ex vivo methods for validating substance testing with human organs and/or tissues |
US8771930B2 (en) * | 2007-05-18 | 2014-07-08 | Lifeline Scientific, Inc. | Ex vivo methods for testing toxicity of substances using donated human organs or tissues |
EP2183353B1 (de) | 2007-08-22 | 2015-04-29 | ProBioGen AG | Kultursystem und verfahren zum testen von immunogenität und immunfunktion in vitro |
ES2639183T3 (es) | 2007-09-19 | 2017-10-25 | The Charles Stark Draper Laboratory, Inc. | Estructuras microfluídicas con sección transversal circular |
US20110033887A1 (en) * | 2007-09-24 | 2011-02-10 | Fang Nicholas X | Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network |
US20090234332A1 (en) * | 2008-03-17 | 2009-09-17 | The Charles Stark Draper Laboratory, Inc | Artificial microvascular device and methods for manufacturing and using the same |
US8685432B2 (en) * | 2008-03-25 | 2014-04-01 | University Of Utah Research Foundation | Controlled release tissue graft combination biomaterials |
KR102481683B1 (ko) | 2008-07-16 | 2022-12-28 | 칠드런'즈 메디컬 센터 코포레이션 | 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법 |
WO2011002926A2 (en) | 2009-07-01 | 2011-01-06 | The General Hospital Corporation | Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
US20110082563A1 (en) * | 2009-10-05 | 2011-04-07 | The Charles Stark Draper Laboratory, Inc. | Microscale multiple-fluid-stream bioreactor for cell culture |
US20110186165A1 (en) * | 2009-10-05 | 2011-08-04 | Borenstein Jeffrey T | Three-dimensional microfluidic platforms and methods of use and manufacture thereof |
WO2011119637A1 (en) | 2010-03-22 | 2011-09-29 | Stemina Biomarker Discovery, Inc. | Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics |
EP2404672A1 (de) * | 2010-07-06 | 2012-01-11 | Universiteit Twente | Multiwell-System mit hohem Durchsatz zum Kultivieren von in-vitro oder in-vivo 3D-Gewebekonstrukten, Verfahren zum Herstellen des Multiwell-Systems und Verfahren zur Herstellung von 3D-Gewebekonstrukten aus Zellen, die das Multiwell-System verwenden |
US9725689B2 (en) | 2010-10-08 | 2017-08-08 | Terumo Bct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
WO2012071578A2 (en) * | 2010-11-24 | 2012-05-31 | Bc Genesis Llc | Pharmacology bioassays for drug discovery, toxicity evaluation and in vitro cancer research using a 3d nano-cellulose scaffold and living tissue |
DK2681306T3 (en) | 2011-02-28 | 2019-04-23 | Harvard College | CELL CULTURE SYSTEM |
EP3425391A1 (de) * | 2011-11-04 | 2019-01-09 | inRegen | Arzneimittelscreening- und -potenztests |
US20130143230A1 (en) * | 2011-12-02 | 2013-06-06 | The Trustees Of The Stevens Institute Of Technology | Microfluidic-based cell-culturing platform and method |
EP2788119A1 (de) | 2011-12-05 | 2014-10-15 | Research Triangle Institute | Modell für den menschlichen atemweg mit mehreren fluidischen pfaden |
US20140308688A1 (en) | 2011-12-08 | 2014-10-16 | Research Triangle Institute | Human emulated response with microfluidic enhanced systems |
US9725687B2 (en) | 2011-12-09 | 2017-08-08 | President And Fellows Of Harvard College | Integrated human organ-on-chip microphysiological systems |
US9861663B2 (en) * | 2012-02-23 | 2018-01-09 | Technion Research & Development Foundation Ltd. | Ex-vivo vascularized implant composition comprising poly-l-lactic acid, polylactic-co-glycolic-acid and olfactory bulb cells |
CN104428672B (zh) * | 2012-04-26 | 2017-08-29 | 蒂斯由斯股份有限公司 | 测定和/或监测三维细胞培养物系统的条件的方法和进行所述方法的光学传感器设备 |
WO2014123978A2 (en) | 2013-02-05 | 2014-08-14 | University Of Utah Research Foundation | Implantable devices for bone or joint defects |
EP3019587A2 (de) * | 2013-07-12 | 2016-05-18 | CN Bio Innovations Limited | Leberinfektion |
CN104278008B (zh) | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
EP3024582A4 (de) | 2013-07-22 | 2017-03-08 | President and Fellows of Harvard College | Anordnung mikrofluidischer kartuschen |
US10041045B2 (en) | 2013-09-20 | 2018-08-07 | Hackensack University Medical Center | Microfluidic three-dimensional osteocyte network reconstructed with microbeads as scaffold |
WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
CA2934662C (en) | 2013-12-20 | 2024-02-20 | President And Fellows Of Harvard College | Low shear microfluidic devices and methods of use and manufacturing thereof |
EP3108846B1 (de) * | 2014-02-19 | 2021-06-23 | J. Morita Manufacturing Corporation | Element für medizinisches instrument |
WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
GB2546424A (en) | 2014-07-14 | 2017-07-19 | Harvard College | Systems and methods for improved performance of fluidic and microfluidic systems |
CN106715676A (zh) | 2014-09-26 | 2017-05-24 | 泰尔茂比司特公司 | 按计划供养 |
US20170307595A1 (en) * | 2014-10-22 | 2017-10-26 | The General Hospital Corporation | Methods and devices to study metabolism |
EP3223831B1 (de) * | 2014-11-25 | 2020-06-24 | President and Fellows of Harvard College | Verfahren zur erzeugung von podozyten aus pluripotenten stammzellen und dadurch hergestellte zellen |
JP6517031B2 (ja) * | 2015-02-05 | 2019-05-22 | キヤノンメディカルシステムズ株式会社 | 医用画像処理装置および磁気共鳴イメージング装置 |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
JP6841609B2 (ja) | 2015-07-10 | 2021-03-10 | 3スキャン インコーポレイテッド | 組織学的染色の空間的多重化 |
WO2017019542A1 (en) | 2015-07-24 | 2017-02-02 | President And Fellows Of Harvard College | Radial microfluidic devices and methods of use |
CN108884436B (zh) | 2015-08-13 | 2021-11-05 | 北昊干细胞与再生医学研究院有限公司 | 诱导的扩展的多潜能干细胞、制备及使用方法 |
CN115708731A (zh) | 2015-08-14 | 2023-02-24 | 通用医疗公司 | 用于使用在活组织中提供连通的仿生结构的系统和方法 |
BR112018003614A2 (pt) | 2015-08-26 | 2018-09-25 | EMULATE, Inc. | conjunto distribuidor de perfusão |
CN108934168B (zh) | 2015-11-30 | 2022-05-03 | 北昊干细胞与再生医学研究院有限公司 | 用于将非多能细胞重编程为多能干细胞的改进方法 |
EP3181700A1 (de) * | 2015-12-18 | 2017-06-21 | Safeguard Biosystems Holdings Ltd. | Dreidimensionales polymer netzwerk mit darin befindlichen kanälen |
WO2017184222A1 (en) * | 2016-04-22 | 2017-10-26 | Curators Of The University Of Missouri | Chemical library diversity enhancement through in vitro library pre-metabolism |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
US11702634B2 (en) | 2017-03-31 | 2023-07-18 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
US20200277567A1 (en) | 2017-05-31 | 2020-09-03 | BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd | Methods for chemically induced lineage reprogramming |
KR102062465B1 (ko) | 2017-09-25 | 2020-01-03 | 아주대학교산학협력단 | 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법 |
WO2019059702A2 (ko) * | 2017-09-25 | 2019-03-28 | 아주대학교산학협력단 | 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법 |
WO2019191299A1 (en) | 2018-03-27 | 2019-10-03 | San Diego State University | In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering |
CN117752862A (zh) * | 2018-05-25 | 2024-03-26 | 通用医疗公司 | 复杂可植入维生装置的增材制造 |
WO2020051159A1 (en) * | 2018-09-05 | 2020-03-12 | Zymtronix Catalytic Systems, Inc. | Immobilized enzymes and microsomes on magnetic scaffolds |
EP3927417A4 (de) * | 2019-02-19 | 2022-11-16 | Iontox LLC | Verfahren zur vorhersage der toxizität bei wiederholter dosis mittels einer integrierten organplattform |
US10945034B2 (en) | 2019-07-11 | 2021-03-09 | International Business Machines Corporation | Video fractal cross correlated action bubble transition |
CA3155890A1 (en) * | 2019-10-16 | 2021-04-22 | Wisconsin Alumni Research Foundation | MECHANICALLY STABLE HIGH CELL DENSITY HONEYCOMB RETINAL SCAFFOLD DESIGN FOR PHOTORECEPTOR CELL TRANSPLANTATION AND RETINAL PIGMENT HELIUM EPIT THERAPY |
CN115698262A (zh) | 2020-03-30 | 2023-02-03 | 阿卜杜拉国王科技大学 | 用于控制细胞身份的组合物和方法 |
WO2023018634A1 (en) * | 2021-08-12 | 2023-02-16 | Merck Sharp & Dohme Llc | Dosage regimen for administration of belzutifan |
WO2023056408A1 (en) * | 2021-09-30 | 2023-04-06 | University Of Southern California | Human hepatocyte culture medium and conditioned medium of in vitro cultured human hepatocytes and uses thereof |
WO2023076285A1 (en) * | 2021-10-25 | 2023-05-04 | Satellite Biosciences, Inc. | Engineered tissue constructs for the treatment of hyperammonemia |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3907687A (en) | 1968-12-07 | 1975-09-23 | Baxter Laboratories Inc | Plate dialyzer |
US3684097A (en) | 1970-07-02 | 1972-08-15 | Gen Electric | Blood component exchange device |
US3839204A (en) | 1972-04-27 | 1974-10-01 | Gen Electric | Integral blood heat and component exchange device and two flow path membrane blood gas exchanger |
FR2197565B1 (de) | 1972-08-30 | 1975-03-07 | Rhone Poulenc Ind | |
US3892533A (en) | 1973-03-02 | 1975-07-01 | Sci Med | Oxygenator gas distribution header |
NL7310808A (nl) | 1973-08-06 | 1975-02-10 | Josef Augustinus Elizabeth Spa | Inrichting voor het uitwisselen van stoffen tussen twee zich aan weerszijden van een membraan bevindende |
US4008047A (en) | 1974-12-26 | 1977-02-15 | North Star Research Institute | Blood compatible polymers for blood oxygenation devices |
DE2622684B2 (de) | 1976-05-21 | 1979-03-15 | Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt | Membranaustauscher |
US4191182A (en) * | 1977-09-23 | 1980-03-04 | Hemotherapy Inc. | Method and apparatus for continuous plasmaphersis |
US4229290A (en) * | 1978-03-14 | 1980-10-21 | Raj Ghen M G | Compact low surface area dialyzer method and apparatus |
GB2072047B (en) | 1979-08-21 | 1984-03-14 | Lidorenko N S | Gas-permeable membrane method of making it and blood oxygenator based on the use thereof |
AU2336784A (en) | 1982-12-07 | 1984-07-05 | Bellhouse Brian John | Transfer membrane apparatus |
US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
JPH0342927Y2 (de) | 1987-02-09 | 1991-09-09 | ||
IT1202689B (it) | 1987-03-25 | 1989-02-09 | Franco Maria Montevecchi | Procedimento e dispositivo per la circolazione extracorporea del sangue e per assistenza cardiovascolare |
US5225161A (en) | 1988-10-20 | 1993-07-06 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
US5316724A (en) | 1989-03-31 | 1994-05-31 | Baxter International Inc. | Multiple blood path membrane oxygenator |
US5204055A (en) | 1989-12-08 | 1993-04-20 | Massachusetts Institute Of Technology | Three-dimensional printing techniques |
US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5222982A (en) | 1991-02-11 | 1993-06-29 | Ommaya Ayub K | Spinal fluid driven artificial organ |
US5263924A (en) | 1991-09-25 | 1993-11-23 | Baxter International Inc. | Integrated low priming volume centrifugal pump and membrane oxygenator |
CA2074671A1 (en) * | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
US5549674A (en) | 1992-03-02 | 1996-08-27 | The Regents Of The University Of Michigan | Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo |
US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
CA2119064A1 (en) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
DE4320198C1 (de) | 1993-06-18 | 1994-07-14 | Fresenius Ag | Vorrichtung zum Gasaustausch, insbesondere zum Oxygenieren von Blut |
US6200802B1 (en) | 1993-10-08 | 2001-03-13 | Arch Development Corporation | Human peroxisome proliferator activated receptor gamma: compositions and methods |
US5518680A (en) | 1993-10-18 | 1996-05-21 | Massachusetts Institute Of Technology | Tissue regeneration matrices by solid free form fabrication techniques |
US6176874B1 (en) * | 1993-10-18 | 2001-01-23 | Masschusetts Institute Of Technology | Vascularized tissue regeneration matrices formed by solid free form fabrication techniques |
US5626759A (en) | 1994-08-01 | 1997-05-06 | Regents Of The University Of Colorado | Blood treatment device with moving membrane |
DE4433376C1 (de) | 1994-09-20 | 1996-04-04 | Peter M Prof Dr Kunz | Verfahren zum Entrosten von Oberflächen auf organischer Basis und Verfahren zur Herstellung des eingesetzten Mittels |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
US7008634B2 (en) | 1995-03-03 | 2006-03-07 | Massachusetts Institute Of Technology | Cell growth substrates with tethered cell growth effector molecules |
BE1009306A5 (fr) | 1995-04-28 | 1997-02-04 | Baxter Int | Bioreacteur. |
US5665596A (en) | 1995-07-31 | 1997-09-09 | Becton, Dickinson And Company | Device for cell co-culture and method for its use in culturing cells |
US6573063B2 (en) | 1995-10-04 | 2003-06-03 | Cytoscan Sciences, Llc | Methods and systems for assessing biological materials using optical and spectroscopic detection techniques |
US5869243A (en) * | 1996-03-05 | 1999-02-09 | Rhode Island Hospital | Immortalized hepatocytes |
US5817343A (en) | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
US5885829A (en) | 1996-05-28 | 1999-03-23 | The Regents Of The University Of Michigan | Engineering oral tissues |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
ATE260076T1 (de) | 1996-09-05 | 2004-03-15 | Childrens Medical Center | Nierenprothese |
WO1999049807A2 (en) | 1997-01-16 | 1999-10-07 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | A device and method for performing a biological modification of a fluid |
US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
US6287558B1 (en) | 1997-08-01 | 2001-09-11 | Biohybrio Technologies Llc | Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule |
CA2227827A1 (en) | 1998-01-23 | 1999-07-23 | Unknown | In vitro artificial cornea and sclera |
DE69903800T2 (de) * | 1998-03-18 | 2003-10-02 | Massachusetts Inst Technology | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
US6143293A (en) | 1998-03-26 | 2000-11-07 | Carnegie Mellon | Assembled scaffolds for three dimensional cell culturing and tissue generation |
CA2330104A1 (en) | 1998-04-09 | 1999-10-21 | Charlotte-Mecklenberg Hospital Authority | Creation of three-dimensional tissues |
WO1999057306A2 (en) * | 1998-05-01 | 1999-11-11 | Queen's University At Kingston | Method for diagnosing a vascular condition |
US20020035459A1 (en) | 1998-09-14 | 2002-03-21 | George M. Grass | Pharmacokinetic-based drug design tool and method |
US6547994B1 (en) | 1998-11-13 | 2003-04-15 | Therics, Inc. | Rapid prototyping and manufacturing process |
US6165486A (en) | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
IT1304503B1 (it) | 1998-12-24 | 2001-03-19 | In Te C S R L | Uso di una membrana selettiva in un dispositivo biomedicale per iltrattamento extracorporeo di sangue e di altri liquidi organici. |
US6479072B1 (en) | 1999-02-11 | 2002-11-12 | The General Hospital Corporation | Microfabricated membranes and matrices |
US20020090725A1 (en) | 2000-11-17 | 2002-07-11 | Simpson David G. | Electroprocessed collagen |
US7371400B2 (en) | 2001-01-02 | 2008-05-13 | The General Hospital Corporation | Multilayer device for tissue engineering |
EP1187909B1 (de) * | 1999-04-30 | 2005-02-02 | Massachusetts General Hospital | Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen |
US20030129736A1 (en) | 1999-07-15 | 2003-07-10 | Eduardo Mitrani | Device and method for performing a biological modification of a fluid |
IL147990A0 (en) | 1999-08-05 | 2002-09-12 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
US6525242B1 (en) | 1999-11-02 | 2003-02-25 | The University Of Connecticut | Propagation of human hepatocytes in non-human mammals |
US6479064B1 (en) | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
WO2001068135A2 (en) | 2000-03-14 | 2001-09-20 | The University Of Western Ontario | Compositions and methods for affecting osteogenesis |
US7776021B2 (en) | 2000-04-28 | 2010-08-17 | The Charles Stark Draper Laboratory | Micromachined bilayer unit for filtration of small molecules |
US6458275B1 (en) | 2000-06-05 | 2002-10-01 | Harvard Apparatus, Inc. | Multi-well equilibrium dialysis system |
AU2001294671A1 (en) | 2000-09-25 | 2002-04-08 | The Board Of Trustees Of The University Of Illinois | Microfabrication of membranes for the growth of cells |
US6607910B1 (en) * | 2000-11-13 | 2003-08-19 | Synthecon, Inc. | Two chamber cell culture vessel |
RU2286177C2 (ru) | 2000-11-28 | 2006-10-27 | Арт ов Ксен Лимитед | Устройство для поддержания безопасного давления газа в заданных пределах и экономии использования газа во время процесса газообмена |
US7449180B2 (en) * | 2001-02-06 | 2008-11-11 | John Kisiday | Macroscopic scaffold containing amphiphilic peptides encapsulating cells |
NL1017570C2 (nl) | 2001-03-12 | 2002-09-13 | Stichting Hogeschool Van Utrec | Bloedbehandelingsinrichting. |
US20020173033A1 (en) * | 2001-05-17 | 2002-11-21 | Kyle Hammerick | Device and method or three-dimensional spatial localization and functional interconnection of different types of cells |
MXPA04004018A (es) * | 2001-10-31 | 2004-07-23 | Bristol Myers Squibb Co | Metodos de separacion por exclusion para toxicidad de compuestos de prueba. |
BR0214217A (pt) | 2001-11-16 | 2004-09-21 | Childrens Medical Center | Aumento de função de órgão |
US20030121594A1 (en) * | 2001-12-28 | 2003-07-03 | Brill Russell P. | Method for manufacture of tubular multilayer structure from fiber-resin material |
AU2003205241A1 (en) * | 2002-01-22 | 2003-09-02 | The Penn State Research Foundation | Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems |
DE10203237B4 (de) | 2002-01-28 | 2006-08-17 | Siemens Ag | Verfahren zur Magnetresonanz-Bildgebung mit automatischer Anpassung des Messfeldes |
AU2003265228A1 (en) | 2002-03-12 | 2003-12-22 | Surface Logix, Inc. | Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound |
WO2004006840A2 (en) * | 2002-07-12 | 2004-01-22 | The Regents Of The University Of California | Three dimensional cell patterned bioploymer scaffolds and method of making the same |
WO2004026115A2 (en) | 2002-09-23 | 2004-04-01 | The General Hospital Corporation | Theree-dimensional construct for the design and fabrication of physiological fluidic networks |
US20040147016A1 (en) * | 2002-09-30 | 2004-07-29 | Rowley Jonathan A. | Programmable scaffold and methods for making and using the same |
US7264723B2 (en) | 2002-11-01 | 2007-09-04 | Sandia Corporation | Dialysis on microchips using thin porous polymer membranes |
EP1589814B1 (de) * | 2003-01-16 | 2009-08-12 | The General Hospital Corporation | Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen |
EP1673167A2 (de) * | 2003-09-15 | 2006-06-28 | Tecan Trading AG | Mikrofluidvorrichtungen und verfahren zur durchführung von auf zellen basierenden analysen |
EP1773978B1 (de) * | 2004-05-19 | 2014-04-02 | Massachusetts Institute Of Technology | Perfundierte dreidimensionale zellen-/gewebeerkrankungsmodelle |
US20100240086A1 (en) * | 2009-03-20 | 2010-09-23 | Dmitry Kashanin | Biochip assembly and assay method thereof |
-
2004
- 2004-01-16 EP EP04702899A patent/EP1589814B1/de not_active Expired - Lifetime
- 2004-01-16 DE DE602004022508T patent/DE602004022508D1/de not_active Expired - Lifetime
- 2004-01-16 WO PCT/US2004/001098 patent/WO2004065616A2/en active Application Filing
- 2004-01-16 AT AT04702899T patent/ATE439039T1/de not_active IP Right Cessation
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2005
- 2005-07-15 US US11/183,115 patent/US7670797B2/en not_active Expired - Lifetime
-
2010
- 2010-02-17 US US12/707,469 patent/US8173361B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1589814A2 (de) | 2005-11-02 |
US20110008765A1 (en) | 2011-01-13 |
WO2004065616A2 (en) | 2004-08-05 |
EP1589814B1 (de) | 2009-08-12 |
EP1589814A4 (de) | 2007-04-25 |
WO2004065616A3 (en) | 2004-11-18 |
US8173361B2 (en) | 2012-05-08 |
US20060019326A1 (en) | 2006-01-26 |
ATE439039T1 (de) | 2009-08-15 |
US7670797B2 (en) | 2010-03-02 |
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