DE602004022508D1 - Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen - Google Patents

Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen

Info

Publication number
DE602004022508D1
DE602004022508D1 DE602004022508T DE602004022508T DE602004022508D1 DE 602004022508 D1 DE602004022508 D1 DE 602004022508D1 DE 602004022508 T DE602004022508 T DE 602004022508T DE 602004022508 T DE602004022508 T DE 602004022508T DE 602004022508 D1 DE602004022508 D1 DE 602004022508D1
Authority
DE
Germany
Prior art keywords
manufactured
mold
test agent
dimensional
micro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004022508T
Other languages
English (en)
Inventor
Joseph P M D Vacanti
Robert Rubin
Wing Cheung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of DE602004022508D1 publication Critical patent/DE602004022508D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082Supracellular entities, e.g. tissue, organisms
    • G01N33/5088Supracellular entities, e.g. tissue, organisms of vertebrates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing
DE602004022508T 2003-01-16 2004-01-16 Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen Expired - Lifetime DE602004022508D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44053903P 2003-01-16 2003-01-16
PCT/US2004/001098 WO2004065616A2 (en) 2003-01-16 2004-01-16 Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications

Publications (1)

Publication Number Publication Date
DE602004022508D1 true DE602004022508D1 (de) 2009-09-24

Family

ID=32771828

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004022508T Expired - Lifetime DE602004022508D1 (de) 2003-01-16 2004-01-16 Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen

Country Status (5)

Country Link
US (2) US7670797B2 (de)
EP (1) EP1589814B1 (de)
AT (1) ATE439039T1 (de)
DE (1) DE602004022508D1 (de)
WO (1) WO2004065616A2 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759113B2 (en) * 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
EP1589814B1 (de) 2003-01-16 2009-08-12 The General Hospital Corporation Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
WO2005089480A2 (en) 2004-03-19 2005-09-29 Stuart Arthur Bateman Activation method
US8741555B2 (en) * 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
US8075904B2 (en) * 2004-08-11 2011-12-13 California Institute Of Technology High aspect ratio template and method for producing same for central and peripheral nerve repair
US7837913B2 (en) * 2004-08-11 2010-11-23 California Institute Of Technology High aspect ratio template and method for producing same
CA2589526C (en) 2005-01-21 2014-12-02 Commonwealth Scientific And Industrial Research Organisation Activation method using modifying agent
WO2007050902A1 (en) 2005-10-26 2007-05-03 Total Record Inc Acellular bioabsorbable tissue regeneration matrices produced by incubating acellular blood products
US8603806B2 (en) * 2005-11-02 2013-12-10 The Ohio State Universtiy Research Foundation Materials and methods for cell-based assays
US10176887B1 (en) 2005-11-14 2019-01-08 Organ Recovery Systems, Inc. Ex vivo methods for drug discovery, development and testing
HUE036378T2 (hu) * 2006-04-10 2018-07-30 Wisconsin Alumni Res Found Humán embrionális õssejtek felhasználási módszerei a gyógyászatban alkalmazott vegyületek és egyéb vegyszerek toxicitásának értékelésére
US20090239303A1 (en) * 2006-04-24 2009-09-24 Rhoades Lawrence J Ultrasonic Machining Fabrication of Guided Tissue Generation Surfaces and Tissue Scaffolds
EP2029766A4 (de) * 2006-06-08 2010-02-10 Univ North Carolina Pulsung von gallenkammern bei hepatozyten aus sandwich-kulturen
EP3192369B1 (de) 2007-04-12 2018-12-12 The General Hospital Corporation Biomimetisches gefässnetz
US8765364B2 (en) * 2007-05-18 2014-07-01 Lifeline Scientific, Inc. Ex vivo methods for validating substance testing with human organs and/or tissues
US8771930B2 (en) * 2007-05-18 2014-07-08 Lifeline Scientific, Inc. Ex vivo methods for testing toxicity of substances using donated human organs or tissues
EP2183353B1 (de) 2007-08-22 2015-04-29 ProBioGen AG Kultursystem und verfahren zum testen von immunogenität und immunfunktion in vitro
ES2639183T3 (es) 2007-09-19 2017-10-25 The Charles Stark Draper Laboratory, Inc. Estructuras microfluídicas con sección transversal circular
US20110033887A1 (en) * 2007-09-24 2011-02-10 Fang Nicholas X Three-Dimensional Microfabricated Bioreactors with Embedded Capillary Network
US20090234332A1 (en) * 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
KR102481683B1 (ko) 2008-07-16 2022-12-28 칠드런'즈 메디컬 센터 코포레이션 마이크로채널을 갖는 기관 모방 장치 및 그 사용 및 제조 방법
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
WO2011119637A1 (en) 2010-03-22 2011-09-29 Stemina Biomarker Discovery, Inc. Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics
EP2404672A1 (de) * 2010-07-06 2012-01-11 Universiteit Twente Multiwell-System mit hohem Durchsatz zum Kultivieren von in-vitro oder in-vivo 3D-Gewebekonstrukten, Verfahren zum Herstellen des Multiwell-Systems und Verfahren zur Herstellung von 3D-Gewebekonstrukten aus Zellen, die das Multiwell-System verwenden
US9725689B2 (en) 2010-10-08 2017-08-08 Terumo Bct, Inc. Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
WO2012071578A2 (en) * 2010-11-24 2012-05-31 Bc Genesis Llc Pharmacology bioassays for drug discovery, toxicity evaluation and in vitro cancer research using a 3d nano-cellulose scaffold and living tissue
DK2681306T3 (en) 2011-02-28 2019-04-23 Harvard College CELL CULTURE SYSTEM
EP3425391A1 (de) * 2011-11-04 2019-01-09 inRegen Arzneimittelscreening- und -potenztests
US20130143230A1 (en) * 2011-12-02 2013-06-06 The Trustees Of The Stevens Institute Of Technology Microfluidic-based cell-culturing platform and method
EP2788119A1 (de) 2011-12-05 2014-10-15 Research Triangle Institute Modell für den menschlichen atemweg mit mehreren fluidischen pfaden
US20140308688A1 (en) 2011-12-08 2014-10-16 Research Triangle Institute Human emulated response with microfluidic enhanced systems
US9725687B2 (en) 2011-12-09 2017-08-08 President And Fellows Of Harvard College Integrated human organ-on-chip microphysiological systems
US9861663B2 (en) * 2012-02-23 2018-01-09 Technion Research & Development Foundation Ltd. Ex-vivo vascularized implant composition comprising poly-l-lactic acid, polylactic-co-glycolic-acid and olfactory bulb cells
CN104428672B (zh) * 2012-04-26 2017-08-29 蒂斯由斯股份有限公司 测定和/或监测三维细胞培养物系统的条件的方法和进行所述方法的光学传感器设备
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
EP3019587A2 (de) * 2013-07-12 2016-05-18 CN Bio Innovations Limited Leberinfektion
CN104278008B (zh) 2013-07-12 2020-08-21 北京宏冠再生医学科技有限公司 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途
EP3024582A4 (de) 2013-07-22 2017-03-08 President and Fellows of Harvard College Anordnung mikrofluidischer kartuschen
US10041045B2 (en) 2013-09-20 2018-08-07 Hackensack University Medical Center Microfluidic three-dimensional osteocyte network reconstructed with microbeads as scaffold
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
CA2934662C (en) 2013-12-20 2024-02-20 President And Fellows Of Harvard College Low shear microfluidic devices and methods of use and manufacturing thereof
EP3108846B1 (de) * 2014-02-19 2021-06-23 J. Morita Manufacturing Corporation Element für medizinisches instrument
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
GB2546424A (en) 2014-07-14 2017-07-19 Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
US20170307595A1 (en) * 2014-10-22 2017-10-26 The General Hospital Corporation Methods and devices to study metabolism
EP3223831B1 (de) * 2014-11-25 2020-06-24 President and Fellows of Harvard College Verfahren zur erzeugung von podozyten aus pluripotenten stammzellen und dadurch hergestellte zellen
JP6517031B2 (ja) * 2015-02-05 2019-05-22 キヤノンメディカルシステムズ株式会社 医用画像処理装置および磁気共鳴イメージング装置
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
JP6841609B2 (ja) 2015-07-10 2021-03-10 3スキャン インコーポレイテッド 組織学的染色の空間的多重化
WO2017019542A1 (en) 2015-07-24 2017-02-02 President And Fellows Of Harvard College Radial microfluidic devices and methods of use
CN108884436B (zh) 2015-08-13 2021-11-05 北昊干细胞与再生医学研究院有限公司 诱导的扩展的多潜能干细胞、制备及使用方法
CN115708731A (zh) 2015-08-14 2023-02-24 通用医疗公司 用于使用在活组织中提供连通的仿生结构的系统和方法
BR112018003614A2 (pt) 2015-08-26 2018-09-25 EMULATE, Inc. conjunto distribuidor de perfusão
CN108934168B (zh) 2015-11-30 2022-05-03 北昊干细胞与再生医学研究院有限公司 用于将非多能细胞重编程为多能干细胞的改进方法
EP3181700A1 (de) * 2015-12-18 2017-06-21 Safeguard Biosystems Holdings Ltd. Dreidimensionales polymer netzwerk mit darin befindlichen kanälen
WO2017184222A1 (en) * 2016-04-22 2017-10-26 Curators Of The University Of Missouri Chemical library diversity enhancement through in vitro library pre-metabolism
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US20200277567A1 (en) 2017-05-31 2020-09-03 BeiHao Stem Cell and Regenerative Medicine Research Institute Co., Ltd Methods for chemically induced lineage reprogramming
KR102062465B1 (ko) 2017-09-25 2020-01-03 아주대학교산학협력단 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법
WO2019059702A2 (ko) * 2017-09-25 2019-03-28 아주대학교산학협력단 나노섬유 기반 장기간 초대 간세포 3차원 배양시스템 및 배양방법
WO2019191299A1 (en) 2018-03-27 2019-10-03 San Diego State University In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
CN117752862A (zh) * 2018-05-25 2024-03-26 通用医疗公司 复杂可植入维生装置的增材制造
WO2020051159A1 (en) * 2018-09-05 2020-03-12 Zymtronix Catalytic Systems, Inc. Immobilized enzymes and microsomes on magnetic scaffolds
EP3927417A4 (de) * 2019-02-19 2022-11-16 Iontox LLC Verfahren zur vorhersage der toxizität bei wiederholter dosis mittels einer integrierten organplattform
US10945034B2 (en) 2019-07-11 2021-03-09 International Business Machines Corporation Video fractal cross correlated action bubble transition
CA3155890A1 (en) * 2019-10-16 2021-04-22 Wisconsin Alumni Research Foundation MECHANICALLY STABLE HIGH CELL DENSITY HONEYCOMB RETINAL SCAFFOLD DESIGN FOR PHOTORECEPTOR CELL TRANSPLANTATION AND RETINAL PIGMENT HELIUM EPIT THERAPY
CN115698262A (zh) 2020-03-30 2023-02-03 阿卜杜拉国王科技大学 用于控制细胞身份的组合物和方法
WO2023018634A1 (en) * 2021-08-12 2023-02-16 Merck Sharp & Dohme Llc Dosage regimen for administration of belzutifan
WO2023056408A1 (en) * 2021-09-30 2023-04-06 University Of Southern California Human hepatocyte culture medium and conditioned medium of in vitro cultured human hepatocytes and uses thereof
WO2023076285A1 (en) * 2021-10-25 2023-05-04 Satellite Biosciences, Inc. Engineered tissue constructs for the treatment of hyperammonemia

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907687A (en) 1968-12-07 1975-09-23 Baxter Laboratories Inc Plate dialyzer
US3684097A (en) 1970-07-02 1972-08-15 Gen Electric Blood component exchange device
US3839204A (en) 1972-04-27 1974-10-01 Gen Electric Integral blood heat and component exchange device and two flow path membrane blood gas exchanger
FR2197565B1 (de) 1972-08-30 1975-03-07 Rhone Poulenc Ind
US3892533A (en) 1973-03-02 1975-07-01 Sci Med Oxygenator gas distribution header
NL7310808A (nl) 1973-08-06 1975-02-10 Josef Augustinus Elizabeth Spa Inrichting voor het uitwisselen van stoffen tussen twee zich aan weerszijden van een membraan bevindende
US4008047A (en) 1974-12-26 1977-02-15 North Star Research Institute Blood compatible polymers for blood oxygenation devices
DE2622684B2 (de) 1976-05-21 1979-03-15 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt Membranaustauscher
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4229290A (en) * 1978-03-14 1980-10-21 Raj Ghen M G Compact low surface area dialyzer method and apparatus
GB2072047B (en) 1979-08-21 1984-03-14 Lidorenko N S Gas-permeable membrane method of making it and blood oxygenator based on the use thereof
AU2336784A (en) 1982-12-07 1984-07-05 Bellhouse Brian John Transfer membrane apparatus
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
JPH0342927Y2 (de) 1987-02-09 1991-09-09
IT1202689B (it) 1987-03-25 1989-02-09 Franco Maria Montevecchi Procedimento e dispositivo per la circolazione extracorporea del sangue e per assistenza cardiovascolare
US5225161A (en) 1988-10-20 1993-07-06 Baxter International Inc. Integrated membrane blood oxygenator/heat exchanger
US5316724A (en) 1989-03-31 1994-05-31 Baxter International Inc. Multiple blood path membrane oxygenator
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5061620A (en) 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5222982A (en) 1991-02-11 1993-06-29 Ommaya Ayub K Spinal fluid driven artificial organ
US5263924A (en) 1991-09-25 1993-11-23 Baxter International Inc. Integrated low priming volume centrifugal pump and membrane oxygenator
CA2074671A1 (en) * 1991-11-04 1993-05-05 Thomas Bormann Device and method for separating plasma from a biological fluid
US5549674A (en) 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
DE4320198C1 (de) 1993-06-18 1994-07-14 Fresenius Ag Vorrichtung zum Gasaustausch, insbesondere zum Oxygenieren von Blut
US6200802B1 (en) 1993-10-08 2001-03-13 Arch Development Corporation Human peroxisome proliferator activated receptor gamma: compositions and methods
US5518680A (en) 1993-10-18 1996-05-21 Massachusetts Institute Of Technology Tissue regeneration matrices by solid free form fabrication techniques
US6176874B1 (en) * 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5626759A (en) 1994-08-01 1997-05-06 Regents Of The University Of Colorado Blood treatment device with moving membrane
DE4433376C1 (de) 1994-09-20 1996-04-04 Peter M Prof Dr Kunz Verfahren zum Entrosten von Oberflächen auf organischer Basis und Verfahren zur Herstellung des eingesetzten Mittels
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7008634B2 (en) 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
BE1009306A5 (fr) 1995-04-28 1997-02-04 Baxter Int Bioreacteur.
US5665596A (en) 1995-07-31 1997-09-09 Becton, Dickinson And Company Device for cell co-culture and method for its use in culturing cells
US6573063B2 (en) 1995-10-04 2003-06-03 Cytoscan Sciences, Llc Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US5885829A (en) 1996-05-28 1999-03-23 The Regents Of The University Of Michigan Engineering oral tissues
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
ATE260076T1 (de) 1996-09-05 2004-03-15 Childrens Medical Center Nierenprothese
WO1999049807A2 (en) 1997-01-16 1999-10-07 Yissum Research And Development Company Of The Hebrew University Of Jerusalem A device and method for performing a biological modification of a fluid
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6287558B1 (en) 1997-08-01 2001-09-11 Biohybrio Technologies Llc Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
CA2227827A1 (en) 1998-01-23 1999-07-23 Unknown In vitro artificial cornea and sclera
DE69903800T2 (de) * 1998-03-18 2003-10-02 Massachusetts Inst Technology Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
CA2330104A1 (en) 1998-04-09 1999-10-21 Charlotte-Mecklenberg Hospital Authority Creation of three-dimensional tissues
WO1999057306A2 (en) * 1998-05-01 1999-11-11 Queen's University At Kingston Method for diagnosing a vascular condition
US20020035459A1 (en) 1998-09-14 2002-03-21 George M. Grass Pharmacokinetic-based drug design tool and method
US6547994B1 (en) 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
IT1304503B1 (it) 1998-12-24 2001-03-19 In Te C S R L Uso di una membrana selettiva in un dispositivo biomedicale per iltrattamento extracorporeo di sangue e di altri liquidi organici.
US6479072B1 (en) 1999-02-11 2002-11-12 The General Hospital Corporation Microfabricated membranes and matrices
US20020090725A1 (en) 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
EP1187909B1 (de) * 1999-04-30 2005-02-02 Massachusetts General Hospital Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
US20030129736A1 (en) 1999-07-15 2003-07-10 Eduardo Mitrani Device and method for performing a biological modification of a fluid
IL147990A0 (en) 1999-08-05 2002-09-12 Mcl Llc Multipotent adult stem cells and methods for isolation
US6525242B1 (en) 1999-11-02 2003-02-25 The University Of Connecticut Propagation of human hepatocytes in non-human mammals
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
WO2001068135A2 (en) 2000-03-14 2001-09-20 The University Of Western Ontario Compositions and methods for affecting osteogenesis
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US6458275B1 (en) 2000-06-05 2002-10-01 Harvard Apparatus, Inc. Multi-well equilibrium dialysis system
AU2001294671A1 (en) 2000-09-25 2002-04-08 The Board Of Trustees Of The University Of Illinois Microfabrication of membranes for the growth of cells
US6607910B1 (en) * 2000-11-13 2003-08-19 Synthecon, Inc. Two chamber cell culture vessel
RU2286177C2 (ru) 2000-11-28 2006-10-27 Арт ов Ксен Лимитед Устройство для поддержания безопасного давления газа в заданных пределах и экономии использования газа во время процесса газообмена
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
NL1017570C2 (nl) 2001-03-12 2002-09-13 Stichting Hogeschool Van Utrec Bloedbehandelingsinrichting.
US20020173033A1 (en) * 2001-05-17 2002-11-21 Kyle Hammerick Device and method or three-dimensional spatial localization and functional interconnection of different types of cells
MXPA04004018A (es) * 2001-10-31 2004-07-23 Bristol Myers Squibb Co Metodos de separacion por exclusion para toxicidad de compuestos de prueba.
BR0214217A (pt) 2001-11-16 2004-09-21 Childrens Medical Center Aumento de função de órgão
US20030121594A1 (en) * 2001-12-28 2003-07-03 Brill Russell P. Method for manufacture of tubular multilayer structure from fiber-resin material
AU2003205241A1 (en) * 2002-01-22 2003-09-02 The Penn State Research Foundation Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems
DE10203237B4 (de) 2002-01-28 2006-08-17 Siemens Ag Verfahren zur Magnetresonanz-Bildgebung mit automatischer Anpassung des Messfeldes
AU2003265228A1 (en) 2002-03-12 2003-12-22 Surface Logix, Inc. Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound
WO2004006840A2 (en) * 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
WO2004026115A2 (en) 2002-09-23 2004-04-01 The General Hospital Corporation Theree-dimensional construct for the design and fabrication of physiological fluidic networks
US20040147016A1 (en) * 2002-09-30 2004-07-29 Rowley Jonathan A. Programmable scaffold and methods for making and using the same
US7264723B2 (en) 2002-11-01 2007-09-04 Sandia Corporation Dialysis on microchips using thin porous polymer membranes
EP1589814B1 (de) * 2003-01-16 2009-08-12 The General Hospital Corporation Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
EP1673167A2 (de) * 2003-09-15 2006-06-28 Tecan Trading AG Mikrofluidvorrichtungen und verfahren zur durchführung von auf zellen basierenden analysen
EP1773978B1 (de) * 2004-05-19 2014-04-02 Massachusetts Institute Of Technology Perfundierte dreidimensionale zellen-/gewebeerkrankungsmodelle
US20100240086A1 (en) * 2009-03-20 2010-09-23 Dmitry Kashanin Biochip assembly and assay method thereof

Also Published As

Publication number Publication date
EP1589814A2 (de) 2005-11-02
US20110008765A1 (en) 2011-01-13
WO2004065616A2 (en) 2004-08-05
EP1589814B1 (de) 2009-08-12
EP1589814A4 (de) 2007-04-25
WO2004065616A3 (en) 2004-11-18
US8173361B2 (en) 2012-05-08
US20060019326A1 (en) 2006-01-26
ATE439039T1 (de) 2009-08-15
US7670797B2 (en) 2010-03-02

Similar Documents

Publication Publication Date Title
DE602004022508D1 (de) Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
Ma et al. Design and fabrication of a liver-on-a-chip platform for convenient, highly efficient, and safe in situ perfusion culture of 3D hepatic spheroids
WO2003061585A3 (en) Drug candidate screening systems based on micropatterned hydrogels and microfluidic systems
JP2019213562A5 (de)
Wong et al. Microfluidic assay for the on-chip electrochemical measurement of cell monolayer permeability
EP2245453A4 (de) Zellkulturmatrixsystem für automatisierte tests sowie bedienungs- und herstellungsverfahren dafür
Abaci et al. Design and development of microbioreactors for long-term cell culture in controlled oxygen microenvironments
WO2008011259A3 (en) System and method for integrated workforce and quality management
DE602005002408D1 (de) Ionenleitende Polymerelektrolytmembran und Produktionsmethode für diesselbe
MY150146A (en) Techniques to manage wireless connections
GB2406473B (en) A method of determining the identity of an unknown neighbour cell,and apparatus therefor
ATE541222T1 (de) Relative positionierung
EP2119284A4 (de) Verfahren und anordnung für erweiterte zellenidentifikation und zellenpositionsbestimmung
WO2007094929A3 (en) Cell culture well-plates having inverted colloidal crystal scaffolds
ATE460664T1 (de) Gerinnungstestsystem
ES2316597T8 (es) Instrumentos analíticos, biosensores y métodos
SG170761A1 (en) Methods for cell expansion and uses of cells and conditioned media produced thereby for therapy
PT1261480E (pt) Membranas compositas reforcadas nao ondulantes com faces opostas diferentes metodos para producao e sua utilizacao em varias aplicacoes
ATE399997T1 (de) Elektrowetting-zelle und verfahren zu deren herstellung
DE60328001D1 (de) Elektrochemische nachweissystemen
ATE403151T1 (de) Trägerplatte zur durchführung funktioneller tests an biologischen zellen sowie verfahren zur beschichtung der trägerplatte
ATE383573T1 (de) Polymer-elektrolyt, halbzelle für elektrochemische messungen sowie deren verwendung
Babic et al. An easy-to-build and re-usable microfluidic system for live-cell imaging
Carvalho et al. Thyroid‐on‐a‐Chip: An Organoid Platform for In Vitro Assessment of Endocrine Disruption
ATE456042T1 (de) Elektrochemischer gas-sensor mit hydrophiler membranbeschichtung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition