DE602004023207D1 - Benzimidazol-derivate als mek-hemmer - Google Patents
Benzimidazol-derivate als mek-hemmerInfo
- Publication number
- DE602004023207D1 DE602004023207D1 DE602004023207T DE602004023207T DE602004023207D1 DE 602004023207 D1 DE602004023207 D1 DE 602004023207D1 DE 602004023207 T DE602004023207 T DE 602004023207T DE 602004023207 T DE602004023207 T DE 602004023207T DE 602004023207 D1 DE602004023207 D1 DE 602004023207D1
- Authority
- DE
- Germany
- Prior art keywords
- benzimidazole derivatives
- mek inhibitors
- derivatives
- mek
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49001203P | 2003-07-24 | 2003-07-24 | |
| PCT/IB2004/002355 WO2005009975A2 (en) | 2003-07-24 | 2004-07-12 | Benzimidazole derivatives as mek inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004023207D1 true DE602004023207D1 (de) | 2009-10-29 |
Family
ID=34102957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004023207T Active DE602004023207D1 (de) | 2003-07-24 | 2004-07-12 | Benzimidazol-derivate als mek-hemmer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7160915B2 (de) |
| EP (1) | EP1651214B1 (de) |
| JP (1) | JP4896717B2 (de) |
| AT (1) | ATE442847T1 (de) |
| BR (1) | BRPI0412851A (de) |
| CA (1) | CA2532067C (de) |
| DE (1) | DE602004023207D1 (de) |
| ES (1) | ES2331246T3 (de) |
| MX (1) | MXPA06000921A (de) |
| WO (1) | WO2005009975A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| PL233177B1 (pl) | 2002-03-13 | 2019-09-30 | Array Biopharma Inc | (2-hydroksyetoksy)amid kwasu 6-(4-bromo-2-chlorofenyloamino)- 7-fluoro-3-metylo-3H-benzimidazolo-5-karboksylowego, zawierająca ten związek kompozycja farmaceutyczna oraz ich zastosowanie |
| US7632866B2 (en) | 2002-10-21 | 2009-12-15 | Ramot At Tel Aviv University | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators |
| US8183385B2 (en) | 2005-06-23 | 2012-05-22 | Array Biopharma Inc. | SNAR process for preparing benzimidazole compounds |
| TWI391380B (zh) | 2005-06-23 | 2013-04-01 | Array Biopharma Inc | 製備苯并咪唑化合物之方法 |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| WO2007025090A2 (en) * | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase |
| PT1934174E (pt) | 2005-10-07 | 2011-07-14 | Exelixis Inc | Azetidinas como inibidores de mek para o tratamento de doenças proliferativas |
| GB0601962D0 (en) | 2006-01-31 | 2006-03-15 | Ucb Sa | Therapeutic agents |
| CN101605540A (zh) | 2006-12-14 | 2009-12-16 | 埃克塞利希斯股份有限公司 | 使用mek抑制剂的方法 |
| JO2985B1 (ar) | 2006-12-20 | 2016-09-05 | Takeda Pharmaceuticals Co | مثبطات كينازmapk/erk |
| GB0714384D0 (en) | 2007-07-23 | 2007-09-05 | Ucb Pharma Sa | theraputic agents |
| AU2008288556A1 (en) * | 2007-08-16 | 2009-02-19 | F. Hoffmann-La Roche Ag | Substituted hydantoins |
| WO2009037705A2 (en) * | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation |
| CN101868443A (zh) | 2007-09-20 | 2010-10-20 | 特拉维夫大学拉莫特有限公司 | N-苯基邻氨基苯甲酸衍生物及其用途 |
| EP2227469B9 (de) | 2007-11-12 | 2014-09-10 | Takeda Pharmaceutical Company Limited | Inhibitoren von mapk/erk-kinase |
| US8063085B2 (en) | 2007-12-20 | 2011-11-22 | Hoffmann-La Roche Inc. | Substituted hydantoins |
| EP2240494B1 (de) | 2008-01-21 | 2016-03-30 | UCB Biopharma SPRL | Thienopyridin-derivate als mek-hemmer |
| GB0811304D0 (en) | 2008-06-19 | 2008-07-30 | Ucb Pharma Sa | Therapeutic agents |
| ES2426096T3 (es) * | 2008-07-01 | 2013-10-21 | Genentech, Inc. | Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización |
| ES2399384T3 (es) | 2008-11-10 | 2013-04-01 | Bayer Schering Pharma Ag | Sulfonamido fenoxibenzamidas sustituidas |
| JP5651125B2 (ja) | 2008-12-10 | 2015-01-07 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｅｋ阻害剤に対する耐性を付与するｍｅｋ突然変異 |
| WO2010143733A1 (en) | 2009-06-09 | 2010-12-16 | Takeda Pharmaceutical Company Limited | Novel fused cyclic compound and use thereof |
| CN102656142A (zh) | 2009-10-21 | 2012-09-05 | 拜耳制药股份公司 | 取代的苯磺酰胺 |
| CA2777430A1 (en) | 2009-10-21 | 2011-04-28 | Bayer Pharma Aktiengesellschaft | Substituted benzosulphonamides |
| EP2491014A1 (de) | 2009-10-21 | 2012-08-29 | Bayer Pharma Aktiengesellschaft | Substituierte halophenoxybenzamidderivate |
| MX360932B (es) | 2010-02-25 | 2018-11-21 | Dana Farber Cancer Inst Inc | Mutaciones del protooncogen de serina/treonina-proteina cinasa b-raf (braf) que confieren resistencia a los inhibidores del protooncogen de serina/treonina-proteina cinasa b-raf. |
| EA030276B1 (ru) | 2010-03-09 | 2018-07-31 | Дана-Фарбер Кэнсер Инститьют, Инк. | Способы идентификации страдающих раком пациентов и лечения рака у пациентов, у которых имеется или развивается резистентность к первой терапии рака |
| JP2013542214A (ja) | 2010-10-29 | 2013-11-21 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 置換フェノキシピリジン類 |
| CN103204822B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噁唑化合物及其制备方法和用途 |
| WO2013169858A1 (en) | 2012-05-08 | 2013-11-14 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| US20150267258A1 (en) | 2012-05-31 | 2015-09-24 | Bayer Pharma Aktiengesellschaft | Biomarkers for determining effective response of treatments of hepatocellular carcinoma (hcc) patients |
| PL2909188T3 (pl) | 2012-10-12 | 2018-08-31 | Exelixis, Inc. | Nowy sposób wytwarzania związków do stosowania w leczeniu raka |
| PT3702351T (pt) * | 2012-10-19 | 2024-01-17 | Array Biopharma Inc | Formulação contendo um inibidor de mek |
| CN111518031B (zh) * | 2020-05-29 | 2023-01-17 | 中国药科大学 | 一种含有异羟肟酸的化合物及其制备方法、应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5155110A (en) * | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
| US5525625A (en) * | 1995-01-24 | 1996-06-11 | Warner-Lambert Company | 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders |
| US6251943B1 (en) | 1997-02-28 | 2001-06-26 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a MEK inhibitor |
| AU757046B2 (en) | 1997-07-01 | 2003-01-30 | Warner-Lambert Company | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors |
| US6310060B1 (en) * | 1998-06-24 | 2001-10-30 | Warner-Lambert Company | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors |
| IL125425A (en) | 1998-07-20 | 2008-12-29 | Israel State | ADPGPPase CONTROL OF STARCH SYNTHESIS IN TOMATOES |
| KR100609800B1 (ko) | 1998-12-16 | 2006-08-09 | 워너-램버트 캄파니 엘엘씨 | Ｍｅｋ 저해제를 사용한 관절염 치료 방법 |
| SK9832001A3 (en) * | 1999-01-13 | 2003-02-04 | Warner Lambert Co | Benzoheterocycles and their use as MEK inhibitors |
| JP2000204079A (ja) * | 1999-01-13 | 2000-07-25 | Warner Lambert Co | ジアリ―ルアミン |
| KR20020012315A (ko) | 1999-07-16 | 2002-02-15 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | Ｍｅｋ 저해제를 사용한 만성 통증의 치료 방법 |
| WO2001005390A2 (en) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
| ES2360205T3 (es) | 2001-03-02 | 2011-06-01 | Agennix Ag | Sistema de ensayo de tres híbridos. |
| PL233177B1 (pl) * | 2002-03-13 | 2019-09-30 | Array Biopharma Inc | (2-hydroksyetoksy)amid kwasu 6-(4-bromo-2-chlorofenyloamino)- 7-fluoro-3-metylo-3H-benzimidazolo-5-karboksylowego, zawierająca ten związek kompozycja farmaceutyczna oraz ich zastosowanie |
| KR20040098013A (ko) | 2002-03-13 | 2004-11-18 | 어레이 바이오파마 인크. | Ｍｅｋ 억제제로서의 ｎ3 알킬화된 벤즈이미다졸 유도체 |
| US7235537B2 (en) | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
-
2004
- 2004-07-12 DE DE602004023207T patent/DE602004023207D1/de active Active
- 2004-07-12 EP EP04744015A patent/EP1651214B1/de not_active Not-in-force
- 2004-07-12 ES ES04744015T patent/ES2331246T3/es active Active
- 2004-07-12 WO PCT/IB2004/002355 patent/WO2005009975A2/en active Application Filing
- 2004-07-12 MX MXPA06000921A patent/MXPA06000921A/es unknown
- 2004-07-12 AT AT04744015T patent/ATE442847T1/de not_active IP Right Cessation
- 2004-07-12 JP JP2006520928A patent/JP4896717B2/ja not_active Expired - Fee Related
- 2004-07-12 CA CA2532067A patent/CA2532067C/en not_active Expired - Fee Related
- 2004-07-12 BR BRPI0412851-6A patent/BRPI0412851A/pt not_active IP Right Cessation
- 2004-07-22 US US10/897,464 patent/US7160915B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE442847T1 (de) | 2009-10-15 |
| BRPI0412851A (pt) | 2006-10-03 |
| US20050026970A1 (en) | 2005-02-03 |
| MXPA06000921A (es) | 2006-03-30 |
| EP1651214B1 (de) | 2009-09-16 |
| CA2532067C (en) | 2010-12-21 |
| CA2532067A1 (en) | 2005-02-03 |
| JP2006528621A (ja) | 2006-12-21 |
| JP4896717B2 (ja) | 2012-03-14 |
| ES2331246T3 (es) | 2009-12-28 |
| EP1651214A2 (de) | 2006-05-03 |
| WO2005009975A2 (en) | 2005-02-03 |
| WO2005009975A3 (en) | 2005-04-07 |
| US7160915B2 (en) | 2007-01-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |