US7459540B1
(en)
|
1999-09-07 |
2008-12-02 |
Amgen Inc. |
Fibroblast growth factor-like polypeptides
|
US8981061B2
(en)
|
2001-03-20 |
2015-03-17 |
Novo Nordisk A/S |
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
|
US9453251B2
(en)
|
2002-10-08 |
2016-09-27 |
Pfenex Inc. |
Expression of mammalian proteins in Pseudomonas fluorescens
|
EP2412816B1
(de)
|
2004-07-26 |
2014-12-03 |
Pfenex Inc. |
Verfahren zur verbesserten Proteinexpression durch Strain-Engineering
|
EP1789442B1
(de)
*
|
2004-09-02 |
2009-09-30 |
Eli Lilly And Company |
Muteine des fibroblasten-wachstumsfaktors 21
|
GB0426146D0
(en)
|
2004-11-29 |
2004-12-29 |
Bioxell Spa |
Therapeutic peptides and method
|
KR100888022B1
(ko)
*
|
2006-12-21 |
2009-03-09 |
재단법인 목암생명공학연구소 |
면역글로불린 Fc와 인간 아포리포단백질(a)크링글절편의 융합단백질 LK8Fc
|
CN107501407B
(zh)
|
2007-03-30 |
2022-03-18 |
Ambrx公司 |
经修饰fgf-21多肽和其用途
|
US9580719B2
(en)
|
2007-04-27 |
2017-02-28 |
Pfenex, Inc. |
Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
|
JP5444553B2
(ja)
|
2007-04-27 |
2014-03-19 |
フェネックス インコーポレイテッド |
微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および/または質が改善されている特定の株を同定する方法
|
US20110034373A1
(en)
*
|
2007-08-03 |
2011-02-10 |
Eli Lilly And Company |
Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity
|
JOP20190083A1
(ar)
|
2008-06-04 |
2017-06-16 |
Amgen Inc |
بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
|
CN102625811B
(zh)
*
|
2008-10-10 |
2016-09-21 |
安姆根有限公司 |
Fgf21突变体及其用途
|
EP2389190B1
(de)
*
|
2009-01-23 |
2018-09-19 |
Novo Nordisk A/S |
Fgf21-derivate mit albuminbinder a-b-c-d-e- und deren verwendung
|
EP2427207B1
(de)
|
2009-05-05 |
2017-08-16 |
Amgen, Inc |
Fgf21-mutanten und ihre verwendungen
|
EA021425B1
(ru)
|
2009-05-05 |
2015-06-30 |
Амген Инк. |
Мутанты fgf21 и их применение
|
MX2011013903A
(es)
|
2009-06-17 |
2012-05-08 |
Amgen Inc |
Polipeptidos quimericos y usos de los mismos.
|
RU2573896C2
(ru)
*
|
2009-10-15 |
2016-01-27 |
Дженентек, Инк. |
Химерные факторы роста фибробластов с измененной рецепторной специфичностью
|
MX2012006397A
(es)
*
|
2009-12-02 |
2012-11-30 |
Amgen Inc |
PROTEINAS DE ENLACE QUE ENLAZAN A FGFR1C HUMANO, ß-KLOTHO HUMANA Y TANTO FGFR1C HUMANO COMO ß-KLOTHO HUMANA.
|
UA109888C2
(uk)
|
2009-12-07 |
2015-10-26 |
|
ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
|
EP2460527A1
(de)
*
|
2010-01-21 |
2012-06-06 |
Sanofi |
Pharmazeutische Zusammensetzung zur Behandlung eines metabolischen Syndroms
|
WO2011120013A2
(en)
|
2010-03-26 |
2011-09-29 |
Trustees Of Dartmouth College |
Vista regulatory t cell mediator protein, vista binding agents and use thereof
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
US9517264B2
(en)
|
2010-04-15 |
2016-12-13 |
Amgen Inc. |
Human FGF receptor and β-Klotho binding proteins
|
US20130116171A1
(en)
|
2010-04-16 |
2013-05-09 |
Salk Institute For Biological Studies |
Methods for treating metabolic disorders using fgf
|
JP2013533227A
(ja)
|
2010-06-08 |
2013-08-22 |
ノヴォ ノルディスク アー/エス |
Fgf21類似体および誘導体
|
CN103415300B
(zh)
*
|
2010-07-20 |
2018-02-23 |
诺沃—诺迪斯克有限公司 |
N‑末端修饰的fgf21化合物
|
SG190082A1
(en)
*
|
2010-11-05 |
2013-06-28 |
Covx Technologies Ireland Ltd |
Anti-diabetic compounds
|
US9023791B2
(en)
*
|
2010-11-19 |
2015-05-05 |
Novartis Ag |
Fibroblast growth factor 21 mutations
|
US8980266B2
(en)
|
2011-06-28 |
2015-03-17 |
Inhibrx, Llc |
Serpin fusion polypeptides and methods of use thereof
|
WO2013006486A2
(en)
|
2011-07-01 |
2013-01-10 |
Ngm Biopharmaceuticals, Inc. |
Compositions, uses and methods for treatment of metabolic disorders and diseases
|
EP2548570A1
(de)
|
2011-07-19 |
2013-01-23 |
Sanofi |
Pharmazeutische Zusammensetzung zur Behandlung eines metabolischen Syndroms
|
UY34346A
(es)
|
2011-09-26 |
2013-04-30 |
Novartis Ag |
Proteínas de fusión para tratar trastornos metabólicos
|
WO2013093720A2
(en)
|
2011-12-22 |
2013-06-27 |
Pfizer Inc. |
Anti-diabetic compounds
|
CN108103069B
(zh)
|
2012-02-15 |
2021-08-10 |
诺和诺德股份有限公司 |
结合并阻断髓样细胞表达的触发受体-1 (trem-1)的抗体
|
US9550830B2
(en)
|
2012-02-15 |
2017-01-24 |
Novo Nordisk A/S |
Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1)
|
PL2814842T3
(pl)
|
2012-02-15 |
2018-12-31 |
Novo Nordisk A/S |
Przeciwciała wiążące białko 1 rozpoznające peptydoglikan
|
WO2013131091A1
(en)
|
2012-03-02 |
2013-09-06 |
New York University |
Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders
|
US9657075B2
(en)
|
2012-06-07 |
2017-05-23 |
New York University |
Chimeric fibroblast growth factor 23 proteins and methods of use
|
US9464126B2
(en)
|
2012-06-07 |
2016-10-11 |
New York University |
Chimeric fibroblast growth factor 21 proteins and methods of use
|
US9474785B2
(en)
|
2012-06-07 |
2016-10-25 |
New York University |
Chimeric fibroblast growth factor 19 proteins and methods of use
|
TWI513705B
(zh)
*
|
2012-06-11 |
2015-12-21 |
Lilly Co Eli |
纖維母細胞生長因子21蛋白質
|
CA2871656A1
(en)
|
2012-06-11 |
2013-12-19 |
Eli Lilly And Company |
Fibroblast growth factor 21 variants
|
AU2013277051B2
(en)
*
|
2012-06-22 |
2018-06-07 |
King's College London |
Novel VISTA-Ig constructs and the use of VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
US9890215B2
(en)
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
CN109793893B
(zh)
|
2012-09-07 |
2023-05-26 |
达特茅斯大学理事会 |
用于诊断和治疗癌症的vista调节剂
|
CA2892152A1
(en)
|
2012-11-28 |
2014-06-05 |
Ngm Biopharmaceuticals, Inc. |
Compositions and methods for treatment of metabolic disorders and diseases
|
US9290557B2
(en)
|
2012-11-28 |
2016-03-22 |
Ngm Biopharmaceuticals, Inc. |
Compositions comprising variants and fusions of FGF19 polypeptides
|
ES2915851T3
(es)
|
2012-12-27 |
2022-06-27 |
Ngm Biopharmaceuticals Inc |
Péptidos quiméricos de FGF19 para usar en el tratamiento de trastornos de ácidos biliares
|
US9273107B2
(en)
|
2012-12-27 |
2016-03-01 |
Ngm Biopharmaceuticals, Inc. |
Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
|
WO2014130659A1
(en)
|
2013-02-22 |
2014-08-28 |
New York University |
Chimeric fibroblast growth factor 23 proteins and methods of use
|
US20160235810A1
(en)
|
2013-10-18 |
2016-08-18 |
Novartis Ag |
Methods of treating diabetes and related disorders
|
MX2016005101A
(es)
|
2013-10-21 |
2017-01-09 |
Salk Inst For Biological Studi |
Factor de crecimiento de fibroblastos (fgf) 1 mutado y procedimientos de uso.
|
NZ718962A
(en)
|
2013-10-28 |
2019-12-20 |
Ngm Biopharmaceuticals Inc |
Cancer models and associated methods
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
CA2935378C
(en)
|
2013-12-24 |
2023-04-18 |
Janssen Pharmaceutica Nv |
Anti-vista antibodies and fragments
|
RS60593B1
(sr)
|
2014-01-24 |
2020-08-31 |
Ngm Biopharmaceuticals Inc |
Antitela koja vezuju domen 2 beta-kloto i postupci za njihovu upotrebu
|
US10398758B2
(en)
|
2014-05-28 |
2019-09-03 |
Ngm Biopharmaceuticals, Inc. |
Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
|
MX2016016310A
(es)
|
2014-06-11 |
2017-10-20 |
A Green Kathy |
Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral.
|
CA2951153A1
(en)
|
2014-06-16 |
2015-12-23 |
Ngm Biopharmaceuticals, Inc. |
Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
|
KR20170020383A
(ko)
*
|
2014-06-24 |
2017-02-22 |
노보 노르디스크 에이/에스 |
Mic-1 융합 단백질 및 그것의 사용
|
TN2017000008A1
(en)
|
2014-07-17 |
2018-07-04 |
Novo Nordisk As |
Site directed mutagenesis of trem-1 antibodies for decreasing viscosity.
|
CN107108711B
(zh)
|
2014-10-23 |
2021-11-23 |
恩格姆生物制药公司 |
包含肽变异体的药物组合物及其使用方法
|
PT3412302T
(pt)
|
2014-10-24 |
2021-06-09 |
Bristol Myers Squibb Co |
Polipéptidos de fgf-21 modificados e utilizações dos mesmos
|
WO2016073855A1
(en)
|
2014-11-07 |
2016-05-12 |
Ngm Biopharmaceuticals, Inc. |
Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
|
JP2018505911A
(ja)
|
2014-12-05 |
2018-03-01 |
イミュネクスト,インコーポレーテッド |
推定上のvista受容体としてのvsig8の同定と、vista/vsig8調節剤を産生するためのその使用
|
PT3236991T
(pt)
|
2014-12-23 |
2019-09-06 |
Novo Nordisk As |
Derivados de fgf21 e usos dos mesmos
|
KR20160088656A
(ko)
*
|
2015-01-16 |
2016-07-26 |
주식회사유한양행 |
지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
|
CN107922497B
(zh)
|
2015-06-24 |
2022-04-12 |
詹森药业有限公司 |
抗vista抗体和片段
|
WO2017019957A2
(en)
|
2015-07-29 |
2017-02-02 |
Ngm Biopharmaceuticals, Inc. |
Binding proteins and methods of use thereof
|
JP2018535964A
(ja)
|
2015-10-30 |
2018-12-06 |
ソーク インスティテュート フォー バイオロジカル スタディーズ |
線維芽細胞増殖因子(fgf)1アナログによるステロイド誘導性高血糖の処置
|
ES2871036T3
(es)
|
2015-11-09 |
2021-10-28 |
Ngm Biopharmaceuticals Inc |
Método para el tratamiento de trastornos relacionados con ácidos biliares
|
TWI756204B
(zh)
|
2016-02-12 |
2022-03-01 |
比利時商楊森製藥公司 |
抗vista抗體及片段、其用途及鑑定其之方法
|
SG11201808633RA
(en)
|
2016-04-15 |
2018-10-30 |
Immunext Inc |
Anti-human vista antibodies and use thereof
|
EP3502143A4
(de)
|
2016-08-19 |
2020-07-15 |
Ampsource Biopharma Shanghai Inc. |
Linker-peptid zur konstruktion von fusionsprotein
|
CN106279437B
(zh)
|
2016-08-19 |
2017-10-31 |
安源医药科技(上海)有限公司 |
高糖基化人凝血因子viii融合蛋白及其制备方法与用途
|
CN107759694B
(zh)
|
2016-08-19 |
2023-01-13 |
安源医药科技(上海)有限公司 |
双特异性抗体及其制备方法与用途
|
AU2017315459B2
(en)
|
2016-08-26 |
2023-06-29 |
Ngm Biopharmaceuticals, Inc. |
Methods of treating fibroblast growth factor 19-mediated cancers and tumors
|
WO2018166461A1
(en)
*
|
2017-03-14 |
2018-09-20 |
Sunshine Lake Pharma Co., Ltd. |
Dual-target fusion proteins comprising the fc portion of an immunoglobulin
|
WO2018174668A2
(ko)
|
2017-03-23 |
2018-09-27 |
한미약품 주식회사 |
인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
|
TWI710377B
(zh)
|
2017-05-23 |
2020-11-21 |
丹麥商諾佛 儂迪克股份有限公司 |
Mic-1化合物及其用途
|
BR112020004136A2
(pt)
|
2017-09-08 |
2020-09-08 |
Bristol-Myers Squibb Company |
fator de crescimento de fibroblastos modificado 21 (fgf-21) para uso nos métodos de tratamento de esteato-hepatite não alcoólica (nash)
|
CN111727055A
(zh)
*
|
2018-02-06 |
2020-09-29 |
温哥华生物技术有限公司 |
GHR-106单克隆抗体作为GnRH拮抗剂的用途
|
CN116098989A
(zh)
|
2018-02-08 |
2023-05-12 |
广东东阳光药业有限公司 |
Fgf21变体、融合蛋白及其应用
|
JOP20200240A1
(ar)
|
2018-04-02 |
2020-09-27 |
Bristol Myers Squibb Co |
أجسام مضادة ضد- trem-1 واستخداماتها
|
BR112020026512A2
(pt)
|
2018-07-03 |
2021-04-06 |
Bristol-Myers Squibb Company |
Formulações de fgf-21
|
CN111195349B
(zh)
*
|
2018-11-16 |
2023-02-24 |
鲁南制药集团股份有限公司 |
一种代谢调节融合蛋白的冻干粉制剂
|
CN114853908A
(zh)
|
2019-05-16 |
2022-08-05 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的融合蛋白
|
US11542309B2
(en)
|
2019-07-31 |
2023-01-03 |
Salk Institute For Biological Studies |
Fibroblast growth factor 1 (FGF1) mutant proteins that selectively activate FGFR1B to reduce blood glucose
|
TW202140074A
(zh)
|
2020-01-08 |
2021-11-01 |
美商必治妥美雅史谷比公司 |
Fgf-21結合物調配物
|
CN113728013B
(zh)
|
2020-01-11 |
2022-06-14 |
北京质肽生物医药科技有限公司 |
Glp-1和fgf21的融合蛋白的缀合物
|
WO2022032187A1
(en)
|
2020-08-07 |
2022-02-10 |
Bristol-Myers Squibb Company |
Fgf21 combined with ccr2/5 antagonists for the treatment of fibrosis
|
WO2022115597A1
(en)
|
2020-11-25 |
2022-06-02 |
Bristol-Myers Squibb Company |
Methods of treating liver diseases
|