DE602005021541D1 - Verfahren zum formen einer mikronadel - Google Patents

Verfahren zum formen einer mikronadel

Info

Publication number
DE602005021541D1
DE602005021541D1 DE602005021541T DE602005021541T DE602005021541D1 DE 602005021541 D1 DE602005021541 D1 DE 602005021541D1 DE 602005021541 T DE602005021541 T DE 602005021541T DE 602005021541 T DE602005021541 T DE 602005021541T DE 602005021541 D1 DE602005021541 D1 DE 602005021541D1
Authority
DE
Germany
Prior art keywords
mold
mold apparatus
molding
micronadel
closed position
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005021541T
Other languages
English (en)
Inventor
Dennis E Ferguson
Satinder K Nayar
Donald L Pochardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of DE602005021541D1 publication Critical patent/DE602005021541D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17Component parts, details or accessories; Auxiliary operations
    • B29C45/46Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17Component parts, details or accessories; Auxiliary operations
    • B29C45/46Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/568Applying vibrations to the mould parts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17Component parts, details or accessories; Auxiliary operations
    • B29C45/46Means for plasticising or homogenising the moulding material or forcing it into the mould
    • B29C45/56Means for plasticising or homogenising the moulding material or forcing it into the mould using mould parts movable during or after injection, e.g. injection-compression moulding
    • B29C45/561Injection-compression moulding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053Methods for producing microneedles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C2045/0094Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C2791/00Shaping characteristics in general
    • B29C2791/004Shaping under special conditions
    • B29C2791/008Using vibrations during moulding
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17Component parts, details or accessories; Auxiliary operations
    • B29C45/26Moulds
    • B29C45/2669Moulds with means for removing excess material, e.g. with overflow cavities
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17Component parts, details or accessories; Auxiliary operations
    • B29C45/26Moulds
    • B29C45/34Moulds having venting means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/753Medical equipment; Accessories therefor
    • B29L2031/7544Injection needles, syringes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29LINDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00Other particular articles
    • B29L2031/756Microarticles, nanoarticles
DE602005021541T 2004-12-07 2005-12-07 Verfahren zum formen einer mikronadel Active DE602005021541D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63431904P 2004-12-07 2004-12-07
PCT/US2005/044121 WO2006062974A2 (en) 2004-12-07 2005-12-07 Method of molding a microneedle

Publications (1)

Publication Number Publication Date
DE602005021541D1 true DE602005021541D1 (de) 2010-07-08

Family

ID=36168440

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005021541T Active DE602005021541D1 (de) 2004-12-07 2005-12-07 Verfahren zum formen einer mikronadel

Country Status (11)

Country Link
US (3) US8088321B2 (de)
EP (2) EP1824655B1 (de)
JP (1) JP2008522875A (de)
KR (1) KR20070098851A (de)
CN (2) CN101072668B (de)
AT (1) ATE468961T1 (de)
AU (1) AU2005314151B2 (de)
CA (1) CA2589733C (de)
DE (1) DE602005021541D1 (de)
IL (1) IL183556A (de)
WO (1) WO2006062974A2 (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
CA2589733C (en) * 2004-12-07 2014-02-11 3M Innovative Properties Company Method of molding a microneedle
WO2007112309A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
US9119945B2 (en) * 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
US8101114B2 (en) * 2006-05-01 2012-01-24 Georgia Tech Research Corporation Particle based molding
CN101678584A (zh) 2007-06-20 2010-03-24 3M创新有限公司 幅材超声波注模
CN101340784A (zh) * 2007-07-04 2009-01-07 深圳富泰宏精密工业有限公司 电子装置机壳及其制造方法
JP5584202B2 (ja) * 2008-05-21 2014-09-03 セラジェクト, インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
EP2355887B1 (de) 2008-11-18 2017-08-02 3M Innovative Properties Company Hohlmikronadelfeld
WO2010117602A2 (en) 2009-04-10 2010-10-14 3M Innovative Properties Company Methods of making hollow microneedle arrays and articles and uses therefrom
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
US20110172609A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Microneedle component assembly for drug delivery device
US20110172638A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including multi-functional cover
US20110172639A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Device and method for delivery of microneedle to desired depth within the skin
US20110172645A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Wearable drug delivery device including integrated pumping and activation elements
US20110172637A1 (en) * 2010-01-08 2011-07-14 Ratio, Inc. Drug delivery device including tissue support structure
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
EP2563451B1 (de) 2010-04-28 2017-11-01 Kimberly-Clark Worldwide, Inc. Medizinische vorrichtungen zur abgabe von sirna
CN102958555A (zh) 2010-04-28 2013-03-06 金伯利-克拉克环球有限公司 注射成型微针阵列和用于形成该微针阵列的方法
EP2563454A4 (de) * 2010-04-28 2014-01-22 Kimberly Clark Co Injektionsgeformtes mikronadel-array und verfahren zur formung des mikronadel-arrays
JP5860032B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド 関節リウマチ薬の送達のためのデバイス
WO2012061556A1 (en) 2010-11-03 2012-05-10 Flugen, Inc. Wearable drug delivery device having spring drive and sliding actuation mechanism
KR101851034B1 (ko) * 2010-12-02 2018-04-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 액정성 중합체 미세바늘
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EP2686152B1 (de) * 2011-03-15 2016-04-27 3M Innovative Properties Company Verfahren zum ultraschallunterstützten spritzgiessen präzisionsgeformter artikel
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
KR20220051429A (ko) 2011-10-27 2022-04-26 소렌토 쎄라퓨틱스, 인코포레이티드 고점도 생체활성 제제의 경피 전달 방법
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
ES2908653T3 (es) 2011-10-27 2022-05-03 Sorrento Therapeutics Inc Dispositivos implantables para la administración de agentes bioactivos
US10155332B2 (en) * 2011-12-09 2018-12-18 National Taiwan University Of Science And Technology In-mold vibratile injection compression molding method and molding apparatus thereof
CN103301092B (zh) 2012-03-06 2014-12-03 中国科学院理化技术研究所 聚合物微针阵列芯片及其制备方法和应用
WO2013166162A1 (en) 2012-05-01 2013-11-07 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US8663537B2 (en) 2012-05-18 2014-03-04 3M Innovative Properties Company Injection molding apparatus and method
WO2014105458A1 (en) 2012-12-27 2014-07-03 3M Innovative Properties Company Article with hollow microneedles and method of making
US9682222B2 (en) 2013-05-31 2017-06-20 3M Innovative Properties Company Microneedle injection apparatus comprising an inverted actuator
JP6494601B2 (ja) 2013-05-31 2019-04-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードル注射及び注入装置並びにその使用方法
SG11201509722PA (en) 2013-05-31 2015-12-30 3M Innovative Properties Co Microneedle injection apparatus comprising a dual cover
US10384047B2 (en) 2013-07-16 2019-08-20 3M Innovative Properties Company Hollow microneedle with bevel opening
US10232157B2 (en) 2013-07-16 2019-03-19 3M Innovative Properties Company Hollow microneedle with beveled tip
CN105407957A (zh) 2013-07-16 2016-03-16 3M创新有限公司 一种包括微针的制品
US10099043B2 (en) 2013-07-16 2018-10-16 3M Innovative Properties Company Hollow microneedle array article
US9933387B1 (en) 2014-09-07 2018-04-03 Biolinq, Inc. Miniaturized sub-nanoampere sensitivity low-noise potentiostat system
KR102021212B1 (ko) * 2014-10-17 2019-09-11 카오카부시키가이샤 미세 중공 돌기물의 제조 방법
WO2016118459A1 (en) 2015-01-21 2016-07-28 3M Innovative Properties Company Microneedle array and method of use
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
WO2017120322A1 (en) 2016-01-05 2017-07-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
JP2017131397A (ja) * 2016-01-27 2017-08-03 花王株式会社 微細中空突起具の製造方法
KR101747099B1 (ko) * 2016-02-11 2017-06-14 권영덕 생체적합성 고분자를 이용한 마이크로니들의 제조방법
JP6626403B2 (ja) * 2016-05-10 2019-12-25 富士フイルム株式会社 凹状パターンを有するモールドの作製方法、及びパターンシートの製造方法
US10092207B1 (en) 2016-05-15 2018-10-09 Biolinq, Inc. Tissue-penetrating electrochemical sensor featuring a co-electrodeposited thin film comprised of polymer and bio-recognition element
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
WO2018211421A1 (en) * 2017-05-19 2018-11-22 Sabic Global Technologies B.V. Methods and systems of producing polymer microneedle arrays via ultrasonic embossing, and resulting microneedle arrays
AU2019229738B2 (en) * 2018-03-05 2024-01-18 Bae Systems Plc Pre-defined recess
EP3778169B1 (de) * 2018-03-27 2021-12-29 FUJIFILM Corporation Verfahren zur herstellung einer form mit konkavem sockelmuster und verfahren zur herstellung einer musterfolie
US20210228119A1 (en) 2018-05-16 2021-07-29 Kindeva Drug Delivery L.P. Microneedle biosensor
USD875254S1 (en) 2018-06-08 2020-02-11 Biolinq, Inc. Intradermal biosensor
EP3698841A1 (de) * 2019-02-19 2020-08-26 L'oreal Injektionsvorrichtung
JP6618647B1 (ja) 2019-04-26 2019-12-11 三光化成株式会社 微細パターン転写用モールド及び微細パターン成形方法
DE102019122648B4 (de) * 2019-08-22 2021-04-29 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Herstellung von Mikrostrukturen
EP4048152B1 (de) 2020-07-29 2023-12-20 Biolinq Incorporated System zur kontinuierlichen analytüberwachung mit einer mikronadelanordnung
CN112454809A (zh) * 2020-09-27 2021-03-09 鹰潭荣嘉集团医疗器械实业有限公司 一种输液器注塑成型装置及方法
KR20220065661A (ko) * 2020-11-13 2022-05-20 주식회사 대웅테라퓨틱스 마이크로니들 어레이 및 이의 제조방법
US11389376B2 (en) 2020-12-21 2022-07-19 Mediccene Inc. Wearable intravenous fluid delivery system
USD988160S1 (en) 2021-03-16 2023-06-06 Biolinq Incorporated Wearable dermal sensor
CN116113454A (zh) 2021-05-08 2023-05-12 比奥林股份有限公司 基于微针阵列的连续分析物监测装置的故障检测
AU2022306407A1 (en) 2021-07-07 2024-02-22 The Regents Of The University Of California Wearable, non-intrusive microneedle sensor
US11877848B2 (en) 2021-11-08 2024-01-23 Satio, Inc. Dermal patch for collecting a physiological sample
USD1013544S1 (en) 2022-04-29 2024-02-06 Biolinq Incorporated Wearable sensor
USD996999S1 (en) 2021-11-16 2023-08-29 Biolinq Incorporated Wearable sensor
CN114260351B (zh) * 2021-12-23 2024-01-26 哈尔滨工业大学 一种大面积阵列微结构跨尺度模压成形装置和方法
USD1012744S1 (en) 2022-05-16 2024-01-30 Biolinq Incorporated Wearable sensor with illuminated display
TWI817854B (zh) * 2022-11-29 2023-10-01 淡江大學學校財團法人淡江大學 微針模具組及使用其製造微針貼片的方法

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US275400A (en) * 1883-04-10 Running-gear for vehicles
US3072122A (en) 1959-01-15 1963-01-08 Rosenthal Sol Roy Package for transcutaneous injection
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US3678150A (en) 1971-07-27 1972-07-18 American Cyanamid Co Process for improving the stability of ppd, qt and histoplasmin on tine applicators
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
JPS6058010B2 (ja) 1981-04-14 1985-12-18 三井化学株式会社 射出圧縮成形方法
US4515543A (en) 1983-09-02 1985-05-07 The Budd Co. In-mold coating part ejection system
US4793954A (en) 1987-08-17 1988-12-27 The B. F. Goodrich Company Shear processing thermoplastics in the presence of ultrasonic vibration
JPH01182016A (ja) 1988-01-16 1989-07-19 Etsuhisa Abe プラスチック射出成形方法
JPH01218813A (ja) 1988-02-29 1989-09-01 Komatsu Ltd プラスチックの成形方法
EP0429842B1 (de) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
JP3131620B2 (ja) 1990-11-12 2001-02-05 株式会社不二越 射出圧縮成形法
US5160823A (en) 1991-01-03 1992-11-03 Hutchinson Technology, Inc. Moving mask laser imaging
US5141677A (en) 1991-01-22 1992-08-25 Minnesota Mining And Manufacturing Company Method of hot stamping intraocular lens bodies
US5152917B1 (en) 1991-02-06 1998-01-13 Minnesota Mining & Mfg Structured abrasive article
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5342737A (en) 1992-04-27 1994-08-30 The United States Of America As Represented By The Secretary Of The Navy High aspect ratio metal microstructures and method for preparing the same
DE4222856C1 (de) 1992-07-11 1993-05-27 Buerkert Gmbh
US5376317A (en) 1992-12-08 1994-12-27 Galic Maus Ventures Precision surface-replicating thermoplastic injection molding method and apparatus, using a heating phase and a cooling phase in each molding cycle
SG64333A1 (en) 1993-09-13 1999-04-27 Minnesota Mining & Mfg Abrasive article method of manufacture of same method of using same for finishing and a production tool
JP2551742B2 (ja) 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
WO1996010630A1 (en) 1994-09-30 1996-04-11 Rutgers, The State University Direct introduction of foreign materials into cells
AU5740496A (en) 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5657516A (en) 1995-10-12 1997-08-19 Minnesota Mining And Manufacturing Company Dual structured fastener elements
CA2265906C (en) 1996-09-17 2003-11-11 Deka Products Limited Partnership System for delivery of drugs by transport
US6021559A (en) 1996-11-01 2000-02-08 3M Innovative Properties Company Methods of making a cube corner article master mold
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US6248281B1 (en) 1996-11-14 2001-06-19 Idemitsu Petrochemical Co., Ltd. Compression apparatus for molding, injection compression molding machine, and injection compression molding method using the compression device
US6605332B2 (en) 1997-07-29 2003-08-12 3M Innovative Properties Company Unitary polymer substrate having napped surface of frayed end microfibers
EP1037687B8 (de) 1997-12-11 2008-10-22 Alza Corporation Vorrichtung zur verbesserung des transdermalen flusses von medikamenten
AU739616B2 (en) 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
WO1999064580A1 (en) 1998-06-10 1999-12-16 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
CN1191872C (zh) 1999-01-28 2005-03-09 塞托·帕尔斯科技公司 运送大分子进入细胞的装置
US6713291B2 (en) 1999-01-28 2004-03-30 Alan D. King Electrodes coated with treating agent and uses thereof
AR022471A1 (es) 1999-02-02 2002-09-04 Ortho Mcneil Pharm Inc Metodo para la fabricacion de matrices transdermicas
US6306331B1 (en) * 1999-03-24 2001-10-23 International Business Machines Corporation Ultra mold for encapsulating very thin packages
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6361733B1 (en) 1999-09-22 2002-03-26 Delphi Technologies, Inc. Ultrasonic injection molding
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
US20020095134A1 (en) 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
WO2001033614A1 (en) 1999-11-02 2001-05-10 University Of Hawaii Method for fabricating arrays of micro-needles
DE60022540T2 (de) 1999-11-15 2006-06-14 Velcro Ind Befestigungselement für die haut
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US6595947B1 (en) 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
AU2001275138A1 (en) 2000-06-02 2001-12-17 The University Of Utah Research Foundation Active needle devices with integrated functionality
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
US7108681B2 (en) 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
EP2554196B1 (de) 2000-11-30 2018-10-17 Valeritas, Inc. Flüssigkeitsabgabe- und -messsysteme
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
AU2002312315A1 (en) 2001-06-08 2002-12-23 The Regents Of The University Of California Microfabricated surgical devices and methods of making the same
US6686299B2 (en) 2001-06-21 2004-02-03 Carlo D. Montemagno Nanosyringe array and method
BR0210628A (pt) 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
AU2002327675A1 (en) 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
EP1469903A2 (de) 2001-09-28 2004-10-27 BioValve Technologies, Inc. Mikronadel mit membran
CN100387318C (zh) * 2001-10-31 2008-05-14 中国科学院电工研究所 透过皮肤给药的微型针阵列片及其制造方法
US7195872B2 (en) 2001-11-09 2007-03-27 3D Biosurfaces, Inc. High surface area substrates for microarrays and methods to make same
US20030199810A1 (en) 2001-11-30 2003-10-23 Trautman Joseph Creagan Methods and apparatuses for forming microprojection arrays
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US20040060902A1 (en) 2002-02-05 2004-04-01 Evans John D. Microprotrusion array and methods of making a microprotrusion
US20030215816A1 (en) 2002-05-20 2003-11-20 Narayan Sundararajan Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups
US6899838B2 (en) 2002-07-12 2005-05-31 Becton, Dickinson And Company Method of forming a mold and molding a micro-device
BR0312671A (pt) 2002-07-19 2005-04-26 3M Innovative Properties Co Dispositivo de microagulhas, método para utilizar um dispositivo de microagulhas, e, método para aplicar um dispositivo de microagulhas
NL1021421C2 (nl) 2002-09-10 2004-03-11 Fountain Patents B V Inrichting en werkwijze voor het vervaardigen van producten uit een warm plastische massa.
JP2004114552A (ja) * 2002-09-27 2004-04-15 Mitsuboshi Belting Ltd 針状体の製造方法および針状体
DE10246942A1 (de) * 2002-10-08 2004-04-22 Battenfeld Gmbh Vorrichtung zum Erzeugen von Mikrostrukturen
KR100563330B1 (ko) * 2003-01-16 2006-03-22 포스트마이크로 주식회사 Liga공정을 이용한 폴리머 재질의 미세 바늘 어레이제조방법
DE10325260A1 (de) 2003-06-03 2004-12-30 Gauss, Ralph Kunststoffeinspritzeinheit durch Doppelnadel
AU2004251699A1 (en) 2003-06-04 2005-01-06 Georgia Tech Research Corporation Drilling microneedle device
TW200513280A (en) 2003-07-02 2005-04-16 Alza Corp Microprojection array immunization patch and method
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
AU2004285484A1 (en) 2003-10-24 2005-05-12 Alza Corporation Pretreatment method and system for enhancing transdermal drug delivery
AU2004292953A1 (en) 2003-11-21 2005-06-09 Alza Corporation Ultrasound assisted transdermal vaccine delivery method and system
WO2005082596A1 (en) * 2004-02-23 2005-09-09 3M Innovative Properties Company Method of molding for microneedle arrays
CA2589733C (en) * 2004-12-07 2014-02-11 3M Innovative Properties Company Method of molding a microneedle
EP1968777B1 (de) * 2005-12-23 2013-11-06 3M Innovative Properties Company Herstellung von mikronadelanordnungen

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AU2005314151B2 (en) 2011-09-08
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EP1824655B1 (de) 2010-05-26
EP2067599B1 (de) 2016-10-26
US8246893B2 (en) 2012-08-21
AU2005314151A1 (en) 2006-06-15
ATE468961T1 (de) 2010-06-15
US8088321B2 (en) 2012-01-03
KR20070098851A (ko) 2007-10-05
CA2589733A1 (en) 2006-06-15
CA2589733C (en) 2014-02-11
US20110163479A1 (en) 2011-07-07
CN102358015A (zh) 2012-02-22
IL183556A0 (en) 2007-09-20
US20080088066A1 (en) 2008-04-17
EP2067599A3 (de) 2010-01-27
US8821779B2 (en) 2014-09-02
CN101072668A (zh) 2007-11-14
WO2006062974A3 (en) 2006-09-28
JP2008522875A (ja) 2008-07-03
IL183556A (en) 2011-11-30
EP1824655A2 (de) 2007-08-29
WO2006062974A2 (en) 2006-06-15

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