DE602005026786D1 - Verfahren zur herstellung von oxycodonhydrochlorid mit weniger als 25 ppm 14-hydroxycodeinon - Google Patents

Verfahren zur herstellung von oxycodonhydrochlorid mit weniger als 25 ppm 14-hydroxycodeinon

Info

Publication number
DE602005026786D1
DE602005026786D1 DE602005026786T DE602005026786T DE602005026786D1 DE 602005026786 D1 DE602005026786 D1 DE 602005026786D1 DE 602005026786 T DE602005026786 T DE 602005026786T DE 602005026786 T DE602005026786 T DE 602005026786T DE 602005026786 D1 DE602005026786 D1 DE 602005026786D1
Authority
DE
Germany
Prior art keywords
hydroxycodeinone
ppm
preparing
less
oxycodon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005026786T
Other languages
English (en)
Inventor
Robert Chapman
Lonn S Rider
Qi Hong
Donald Kyle
Robert Kupper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35124996&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005026786(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of DE602005026786D1 publication Critical patent/DE602005026786D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
DE602005026786T 2004-03-30 2005-03-30 Verfahren zur herstellung von oxycodonhydrochlorid mit weniger als 25 ppm 14-hydroxycodeinon Active DE602005026786D1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US55749204P 2004-03-30 2004-03-30
US60153404P 2004-08-13 2004-08-13
US62007204P 2004-10-18 2004-10-18
US64862505P 2005-01-31 2005-01-31
US65177805P 2005-02-10 2005-02-10
PCT/US2005/010666 WO2005097801A1 (en) 2004-03-30 2005-03-30 Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

Publications (1)

Publication Number Publication Date
DE602005026786D1 true DE602005026786D1 (de) 2011-04-21

Family

ID=35124996

Family Applications (2)

Application Number Title Priority Date Filing Date
DE202005021371U Expired - Lifetime DE202005021371U1 (de) 2004-03-30 2005-03-30 Oxycodonhydrochlorid mit weniger als 25 ppm 14-Hydroxycodeinon
DE602005026786T Active DE602005026786D1 (de) 2004-03-30 2005-03-30 Verfahren zur herstellung von oxycodonhydrochlorid mit weniger als 25 ppm 14-hydroxycodeinon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE202005021371U Expired - Lifetime DE202005021371U1 (de) 2004-03-30 2005-03-30 Oxycodonhydrochlorid mit weniger als 25 ppm 14-Hydroxycodeinon

Country Status (39)

Country Link
US (35) US7129248B2 (de)
EP (7) EP2314589B1 (de)
JP (8) JP4912294B2 (de)
KR (12) KR20100069719A (de)
CN (5) CN101812065B (de)
AP (1) AP2232A (de)
AR (1) AR049012A1 (de)
AT (2) ATE501150T1 (de)
AU (2) AU2005230826C1 (de)
BR (1) BRPI0508758B8 (de)
CA (3) CA2557845C (de)
CR (2) CR8593A (de)
CY (5) CY1111487T1 (de)
DE (2) DE202005021371U1 (de)
DK (6) DK1730151T4 (de)
EA (1) EA013208B1 (de)
EC (1) ECSP066953A (de)
ES (6) ES2665287T3 (de)
FI (1) FI7843U1 (de)
HK (3) HK1098745A1 (de)
HR (5) HRP20110425T4 (de)
HU (3) HUE036451T2 (de)
IL (8) IL178038A (de)
LT (2) LT2316837T (de)
MA (1) MA28492B1 (de)
ME (4) ME02411B (de)
MX (2) MX363228B (de)
MY (3) MY172063A (de)
NO (1) NO337669B1 (de)
NZ (3) NZ602862A (de)
PE (1) PE20050880A1 (de)
PL (5) PL2319846T3 (de)
PT (5) PT2305683E (de)
RS (5) RS54941B1 (de)
SG (3) SG170736A1 (de)
SI (5) SI2305683T1 (de)
TW (3) TW201509943A (de)
WO (1) WO2005097801A1 (de)
ZA (1) ZA200607181B (de)

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AR049012A1 (es) 2006-06-21
EP1730151A1 (de) 2006-12-13
KR20200000499A (ko) 2020-01-02
EP2316837B1 (de) 2018-01-10
EA200601520A1 (ru) 2007-02-27
HRP20160223T1 (hr) 2016-03-25
IL213891A0 (en) 2011-07-31
ZA200607181B (en) 2007-11-28
BRPI0508758A (pt) 2007-08-28
EP2314589A1 (de) 2011-04-27
JP5378486B2 (ja) 2013-12-25
PL1730151T5 (pl) 2023-09-18
US20060173029A1 (en) 2006-08-03
PT2319846T (pt) 2016-08-12
NO337669B1 (no) 2016-05-30
US9777011B2 (en) 2017-10-03
CA2913355A1 (en) 2005-10-20
NZ602862A (en) 2014-01-31
US11236098B2 (en) 2022-02-01
US20200062772A1 (en) 2020-02-27
KR20120106784A (ko) 2012-09-26
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US20150265598A1 (en) 2015-09-24
ES2585576T3 (es) 2016-10-06

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