DE602006019979D1 - Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen - Google Patents

Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen

Info

Publication number
DE602006019979D1
DE602006019979D1 DE602006019979T DE602006019979T DE602006019979D1 DE 602006019979 D1 DE602006019979 D1 DE 602006019979D1 DE 602006019979 T DE602006019979 T DE 602006019979T DE 602006019979 T DE602006019979 T DE 602006019979T DE 602006019979 D1 DE602006019979 D1 DE 602006019979D1
Authority
DE
Germany
Prior art keywords
montelucated
production
intermediate product
related compounds
new intermediate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006019979T
Other languages
English (en)
Inventor
Arjanne Overeem
Lambertus Thijs
Petr Benovsky
Jakub Castulik
Jie Zhu
Petr Bartos
Radomir Skoumal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthon BV
Original Assignee
Synthon BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon BV filed Critical Synthon BV
Publication of DE602006019979D1 publication Critical patent/DE602006019979D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18Halogen atoms or nitro radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/72Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/75Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
DE602006019979T 2005-11-18 2006-11-20 Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen Active DE602006019979D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73775205P 2005-11-18 2005-11-18
US79442906P 2006-04-24 2006-04-24
US82438206P 2006-09-01 2006-09-01
PCT/EP2006/011134 WO2007057228A1 (en) 2005-11-18 2006-11-20 A new intermediate for making montelukast and related compounds

Publications (1)

Publication Number Publication Date
DE602006019979D1 true DE602006019979D1 (de) 2011-03-17

Family

ID=37685804

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006019979T Active DE602006019979D1 (de) 2005-11-18 2006-11-20 Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen

Country Status (12)

Country Link
US (5) US7476748B2 (de)
EP (3) EP1948610A2 (de)
JP (1) JP2009515922A (de)
AR (3) AR056815A1 (de)
AT (1) ATE497493T1 (de)
AU (3) AU2006314726A1 (de)
CA (3) CA2629834A1 (de)
DE (1) DE602006019979D1 (de)
IL (1) IL185129A0 (de)
NO (1) NO20074188L (de)
PT (1) PT1954679E (de)
WO (3) WO2007057228A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1831171A4 (de) * 2004-11-19 2010-09-15 Matrix Lab Ltd Verfahren zur herstellung von neuem armorphen montelukast-natrium
KR100899585B1 (ko) 2005-07-05 2009-05-27 테바 파마슈티컬 인더스트리즈 리미티드 몬테루카스트의 정제
AR056815A1 (es) * 2005-11-18 2007-10-24 Synthon Bv PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST
EP2014650A1 (de) * 2007-07-13 2009-01-14 Lonza Ag Verfahren und Zwischenprodukt zur Herstellung eines Zwischenprodukts bei der Herstellung von Montelukast
ES2320077B1 (es) * 2007-07-31 2010-02-26 Moehs Iberica, S.L. Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo.
WO2009130056A1 (en) * 2008-04-25 2009-10-29 Synthon B.V. Process for making montelukast intermediates
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
SG185389A1 (en) 2010-05-03 2012-12-28 Teikoku Pharma Usa Inc Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
TWI450275B (zh) * 2010-05-19 2014-08-21 Wistron Corp 可提升寫入保護之記憶體系統及相關方法
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
EP2502910A1 (de) 2011-03-15 2012-09-26 Laboratorios Lesvi, S.L. Camphersulfonsalz eines Montelukastschlüssels Zwischenprodukt
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها

Family Cites Families (26)

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Publication number Priority date Publication date Assignee Title
EP0233228A1 (de) * 1985-08-06 1987-08-26 Boehringer Mannheim Italia S.P.A. Pharmazeutisch wirkzame 2-thiomethyl substituierte 1,4-dihydropyridine
CA2038178A1 (en) 1990-04-05 1991-10-06 Carl C. Greco Niobium alkoxyalkoxides and process for formation
US5428033A (en) * 1990-10-12 1995-06-27 Merck Frosst Canada, Inc. Saturated hydroxyalkylquinoline acids as leukotriene antagonists
DE69129257T2 (de) 1990-10-12 1998-11-05 Merck Frosst Canada Inc Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten
US5565473A (en) 1990-10-12 1996-10-15 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5856322A (en) 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5266568A (en) * 1990-10-12 1993-11-30 Merck Frosst Canada, Inc. Hydroxyalkylquinoline ether acids as leukotriene antagonists
IE920499A1 (en) * 1991-02-21 1992-08-26 Merck Frosst Canada Inc Quinoline-containing ketoacids as leukotriene antagonists
US5270324A (en) 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
TW416948B (en) 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5523477A (en) 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5869673A (en) 1997-02-28 1999-02-09 Merck & Co., Inc. Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde
CN1420113A (zh) 2001-11-16 2003-05-28 北京上地新世纪生物医药研究所 孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh) * 2001-12-26 2004-10-20 北京上地新世纪生物医药研究所 一种孟鲁司特钠的制备方法及其制备中间体
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
US20040265375A1 (en) 2003-04-16 2004-12-30 Platteeuw Johannes J. Orally disintegrating tablets
ES2371549T3 (es) * 2003-10-10 2012-01-05 Synthon B.V. Montelukast en estado sólido.
JP2007518826A (ja) * 2004-01-30 2007-07-12 テバ ファーマシューティカル インダストリーズ リミティド モンテルカスト遊離酸多形体
US7189853B2 (en) * 2004-04-15 2007-03-13 Dr. Reddy's Laboratories Limited Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
US7829716B2 (en) 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
EP1812394B1 (de) * 2004-07-19 2011-03-02 Matrix Laboratories Ltd Verfahren zur herstellung von montelukast und salzen davon
ITMI20050247A1 (it) * 2005-02-18 2006-08-19 Chemi Spa Processo per la preparazione di montelukast
AR056815A1 (es) * 2005-11-18 2007-10-24 Synthon Bv PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST

Also Published As

Publication number Publication date
WO2007057225A3 (en) 2007-07-26
AU2006314728A1 (en) 2007-05-24
PT1954679E (pt) 2011-05-05
US7601741B2 (en) 2009-10-13
US7786138B2 (en) 2010-08-31
ATE497493T1 (de) 2011-02-15
AR057909A1 (es) 2007-12-26
US20100099879A1 (en) 2010-04-22
US7476748B2 (en) 2009-01-13
CA2598093A1 (en) 2007-05-24
AR056815A1 (es) 2007-10-24
AR057908A1 (es) 2007-12-26
AU2006314726A1 (en) 2007-05-24
WO2007057228A1 (en) 2007-05-24
IL185129A0 (en) 2007-12-03
CA2629840A1 (en) 2007-05-24
US20090093636A1 (en) 2009-04-09
JP2009515922A (ja) 2009-04-16
CA2629834A1 (en) 2007-05-24
US20070135643A1 (en) 2007-06-14
EP1954679A1 (de) 2008-08-13
EP1948610A2 (de) 2008-07-30
US20070135642A1 (en) 2007-06-14
WO2007057225A2 (en) 2007-05-24
EP1960362A1 (de) 2008-08-27
US20070135480A1 (en) 2007-06-14
WO2007057227A1 (en) 2007-05-24
NO20074188L (no) 2008-08-13
EP1954679B1 (de) 2011-02-02
AU2006314729A1 (en) 2007-05-24

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