DE602006019979D1 - Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen - Google Patents
Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungenInfo
- Publication number
- DE602006019979D1 DE602006019979D1 DE602006019979T DE602006019979T DE602006019979D1 DE 602006019979 D1 DE602006019979 D1 DE 602006019979D1 DE 602006019979 T DE602006019979 T DE 602006019979T DE 602006019979 T DE602006019979 T DE 602006019979T DE 602006019979 D1 DE602006019979 D1 DE 602006019979D1
- Authority
- DE
- Germany
- Prior art keywords
- montelucated
- production
- intermediate product
- related compounds
- new intermediate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/75—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing singly-bound oxygen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73775205P | 2005-11-18 | 2005-11-18 | |
US79442906P | 2006-04-24 | 2006-04-24 | |
US82438206P | 2006-09-01 | 2006-09-01 | |
PCT/EP2006/011134 WO2007057228A1 (en) | 2005-11-18 | 2006-11-20 | A new intermediate for making montelukast and related compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006019979D1 true DE602006019979D1 (de) | 2011-03-17 |
Family
ID=37685804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006019979T Active DE602006019979D1 (de) | 2005-11-18 | 2006-11-20 | Neues zwischenprodukt zur herstellung von montelukast und verwandten verbindungen |
Country Status (12)
Country | Link |
---|---|
US (5) | US7476748B2 (de) |
EP (3) | EP1948610A2 (de) |
JP (1) | JP2009515922A (de) |
AR (3) | AR057909A1 (de) |
AT (1) | ATE497493T1 (de) |
AU (3) | AU2006314728A1 (de) |
CA (3) | CA2598093A1 (de) |
DE (1) | DE602006019979D1 (de) |
IL (1) | IL185129A0 (de) |
NO (1) | NO20074188L (de) |
PT (1) | PT1954679E (de) |
WO (3) | WO2007057225A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1831171A4 (de) * | 2004-11-19 | 2010-09-15 | Matrix Lab Ltd | Verfahren zur herstellung von neuem armorphen montelukast-natrium |
EP1904448B1 (de) | 2005-07-05 | 2011-02-02 | Teva Pharmaceutical Industries, Ltd. | Reinigung von montelukast |
AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
EP2014650A1 (de) * | 2007-07-13 | 2009-01-14 | Lonza Ag | Verfahren und Zwischenprodukt zur Herstellung eines Zwischenprodukts bei der Herstellung von Montelukast |
ES2320077B1 (es) | 2007-07-31 | 2010-02-26 | Moehs Iberica, S.L. | Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo. |
WO2009130056A1 (en) * | 2008-04-25 | 2009-10-29 | Synthon B.V. | Process for making montelukast intermediates |
WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
EA027666B1 (ru) | 2010-05-03 | 2017-08-31 | ТЕИКОКУ ФАРМА ЮСЭй, ИНК. | Неводные лекарственные средства в форме проэмульсии на основе таксанов и способы их приготовления и использования |
TWI450275B (zh) * | 2010-05-19 | 2014-08-21 | Wistron Corp | 可提升寫入保護之記憶體系統及相關方法 |
US8471030B2 (en) | 2010-12-06 | 2013-06-25 | Orochem Technologies Inc. | Purification of montelukast using simulated moving bed |
EP2502910A1 (de) | 2011-03-15 | 2012-09-26 | Laboratorios Lesvi, S.L. | Camphersulfonsalz eines Montelukastschlüssels Zwischenprodukt |
JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
CA2038178A1 (en) | 1990-04-05 | 1991-10-06 | Carl C. Greco | Niobium alkoxyalkoxides and process for formation |
US5266568A (en) * | 1990-10-12 | 1993-11-30 | Merck Frosst Canada, Inc. | Hydroxyalkylquinoline ether acids as leukotriene antagonists |
US5565473A (en) | 1990-10-12 | 1996-10-15 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
HUT61980A (en) * | 1990-10-12 | 1993-03-29 | Merck Frosst Canada Inc | Process for producing saturated hydroxyalkylquinoline acids and pharmaceutical compositions comprising such compounds as active ingredient |
US5856322A (en) * | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
EP0480717B1 (de) | 1990-10-12 | 1998-04-15 | Merck Frosst Canada Inc. | Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten |
IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
US5270324A (en) * | 1992-04-10 | 1993-12-14 | Merck Frosst Canada, Inc. | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
TW448160B (en) | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
GB9423511D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
US5585115A (en) * | 1995-01-09 | 1996-12-17 | Edward H. Mendell Co., Inc. | Pharmaceutical excipient having improved compressability |
US5523477A (en) * | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
US5869673A (en) | 1997-02-28 | 1999-02-09 | Merck & Co., Inc. | Process for 3-(2-(7-chloro-2-quinolinyl)ethenyl) - benzaldehyde |
CN1420113A (zh) * | 2001-11-16 | 2003-05-28 | 北京上地新世纪生物医药研究所 | 孟鲁司特钠的制备方法及其制备中间体 |
CN1171873C (zh) * | 2001-12-26 | 2004-10-20 | 北京上地新世纪生物医药研究所 | 一种孟鲁司特钠的制备方法及其制备中间体 |
US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
ES2371549T3 (es) | 2003-10-10 | 2012-01-05 | Synthon B.V. | Montelukast en estado sólido. |
KR20060117356A (ko) * | 2004-01-30 | 2006-11-16 | 테바 파마슈티컬 인더스트리즈 리미티드 | 몬테루카스트 유리산 다형체 |
US7189853B2 (en) * | 2004-04-15 | 2007-03-13 | Dr. Reddy's Laboratories Limited | Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts |
US7829716B2 (en) * | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
WO2006008751A2 (en) * | 2004-07-19 | 2006-01-26 | Matrix Laboratories Ltd | Process for the preparation of montelukast and its salts |
ITMI20050247A1 (it) * | 2005-02-18 | 2006-08-19 | Chemi Spa | Processo per la preparazione di montelukast |
AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
-
2006
- 2006-11-17 AR ARP060105063A patent/AR057909A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105062A patent/AR057908A1/es not_active Application Discontinuation
- 2006-11-17 AR ARP060105061A patent/AR056815A1/es not_active Application Discontinuation
- 2006-11-20 WO PCT/EP2006/011127 patent/WO2007057225A2/en active Application Filing
- 2006-11-20 AU AU2006314728A patent/AU2006314728A1/en not_active Abandoned
- 2006-11-20 US US11/561,689 patent/US7476748B2/en not_active Expired - Fee Related
- 2006-11-20 WO PCT/EP2006/011133 patent/WO2007057227A1/en active Application Filing
- 2006-11-20 US US11/561,732 patent/US7786138B2/en not_active Expired - Fee Related
- 2006-11-20 AU AU2006314729A patent/AU2006314729A1/en not_active Abandoned
- 2006-11-20 CA CA002598093A patent/CA2598093A1/en not_active Abandoned
- 2006-11-20 PT PT06818694T patent/PT1954679E/pt unknown
- 2006-11-20 AU AU2006314726A patent/AU2006314726A1/en not_active Abandoned
- 2006-11-20 CA CA002629840A patent/CA2629840A1/en not_active Abandoned
- 2006-11-20 EP EP06818691A patent/EP1948610A2/de not_active Withdrawn
- 2006-11-20 DE DE602006019979T patent/DE602006019979D1/de active Active
- 2006-11-20 CA CA002629834A patent/CA2629834A1/en not_active Abandoned
- 2006-11-20 EP EP06818693A patent/EP1960362A1/de not_active Withdrawn
- 2006-11-20 JP JP2008540534A patent/JP2009515922A/ja not_active Withdrawn
- 2006-11-20 WO PCT/EP2006/011134 patent/WO2007057228A1/en active Application Filing
- 2006-11-20 US US11/561,724 patent/US7601741B2/en not_active Expired - Fee Related
- 2006-11-20 EP EP06818694A patent/EP1954679B1/de not_active Not-in-force
- 2006-11-20 AT AT06818694T patent/ATE497493T1/de not_active IP Right Cessation
-
2007
- 2007-08-08 IL IL185129A patent/IL185129A0/en unknown
- 2007-08-15 NO NO20074188A patent/NO20074188L/no not_active Application Discontinuation
-
2008
- 2008-12-12 US US12/334,124 patent/US20090093636A1/en not_active Abandoned
-
2009
- 2009-10-09 US US12/576,773 patent/US20100099879A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2598093A1 (en) | 2007-05-24 |
EP1948610A2 (de) | 2008-07-30 |
JP2009515922A (ja) | 2009-04-16 |
EP1960362A1 (de) | 2008-08-27 |
WO2007057227A1 (en) | 2007-05-24 |
IL185129A0 (en) | 2007-12-03 |
US20090093636A1 (en) | 2009-04-09 |
ATE497493T1 (de) | 2011-02-15 |
CA2629834A1 (en) | 2007-05-24 |
EP1954679A1 (de) | 2008-08-13 |
PT1954679E (pt) | 2011-05-05 |
US7601741B2 (en) | 2009-10-13 |
WO2007057225A3 (en) | 2007-07-26 |
CA2629840A1 (en) | 2007-05-24 |
AR057908A1 (es) | 2007-12-26 |
US20070135642A1 (en) | 2007-06-14 |
AR056815A1 (es) | 2007-10-24 |
AU2006314729A1 (en) | 2007-05-24 |
US20070135643A1 (en) | 2007-06-14 |
WO2007057225A2 (en) | 2007-05-24 |
AU2006314726A1 (en) | 2007-05-24 |
US20070135480A1 (en) | 2007-06-14 |
US7476748B2 (en) | 2009-01-13 |
US7786138B2 (en) | 2010-08-31 |
EP1954679B1 (de) | 2011-02-02 |
WO2007057228A1 (en) | 2007-05-24 |
AU2006314728A1 (en) | 2007-05-24 |
AR057909A1 (es) | 2007-12-26 |
US20100099879A1 (en) | 2010-04-22 |
NO20074188L (no) | 2008-08-13 |
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