DE60217377D1 - Durch thrombin spaltbare chimäre proteine - Google Patents

Durch thrombin spaltbare chimäre proteine

Info

Publication number
DE60217377D1
DE60217377D1 DE60217377T DE60217377T DE60217377D1 DE 60217377 D1 DE60217377 D1 DE 60217377D1 DE 60217377 T DE60217377 T DE 60217377T DE 60217377 T DE60217377 T DE 60217377T DE 60217377 D1 DE60217377 D1 DE 60217377D1
Authority
DE
Germany
Prior art keywords
thrombin
chimäre
spaltbare
proteine
durch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60217377T
Other languages
English (en)
Other versions
DE60217377T2 (de
Inventor
Bonniec Bernard Le
Pierre-Emmanuel Marque
Virginie Louvain
Claire Calmel
Elsa Bianchini
Martine Aiach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut National de la Sante et de la Recherche Medicale INSERM
Application granted granted Critical
Publication of DE60217377D1 publication Critical patent/DE60217377D1/de
Publication of DE60217377T2 publication Critical patent/DE60217377T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
DE60217377T 2001-10-19 2002-10-18 Thrombin-spaltbare chimäre proteine Expired - Lifetime DE60217377T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0113492 2001-10-19
FR0113492A FR2831170B1 (fr) 2001-10-19 2001-10-19 Proteines c modifiees activables directement par la thrombine
PCT/EP2002/012191 WO2003035861A2 (en) 2001-10-19 2002-10-18 Thrombin-cleavable chimeric proteins

Publications (2)

Publication Number Publication Date
DE60217377D1 true DE60217377D1 (en) 2007-02-15
DE60217377T2 DE60217377T2 (de) 2007-10-18

Family

ID=8868473

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60217377T Expired - Lifetime DE60217377T2 (de) 2001-10-19 2002-10-18 Thrombin-spaltbare chimäre proteine

Country Status (10)

Country Link
US (1) US7589178B2 (de)
EP (1) EP1436389B1 (de)
JP (1) JP4355924B2 (de)
AT (1) ATE350470T1 (de)
AU (1) AU2002357479B2 (de)
CA (1) CA2463772C (de)
DE (1) DE60217377T2 (de)
ES (1) ES2279010T3 (de)
FR (1) FR2831170B1 (de)
WO (1) WO2003035861A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
RU2006100035A (ru) * 2003-06-11 2006-08-27 Шеринг Акциенгезельшафт (De) Новые модифицированные кориновые молекулы, имеющие замещенные активирующие последовательности, и их применение
WO2004113385A1 (en) * 2003-06-20 2004-12-29 Maxygen Holdings Ltd. Protein c propeptide variants
WO2006018204A1 (en) * 2004-08-17 2006-02-23 Zlb Behring Gmbh Modified vitamin k dependent polypeptides
EP1871785B1 (de) * 2005-04-20 2010-05-05 Viromed Co., Ltd Zusammensetzungen und verfahren zur trennung von fusionsproteinen
EP1728798A1 (de) 2005-06-01 2006-12-06 ZLB Behring GmbH Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
WO2007015782A1 (en) * 2005-07-29 2007-02-08 Ecole Polytechnique Federale De Lausanne Molecular variant fibrinogen fusion proteins
MX336958B (es) 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (de) 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
EP2199387A1 (de) 2008-12-19 2010-06-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Serinproteasederivate und deren Verwendung zur Vorbeugung und/oder Behandlung von Blutgerinnungsstörungen
CA2747065A1 (en) 2008-12-19 2010-06-24 Inserm (Institut National De La Sante Et De La Recherche Medicale) Serine protease derivatives and uses in the prevention or the treatment of blood coagulation disorders
EP3560962A1 (de) 2010-07-09 2019-10-30 Bioverativ Therapeutics Inc. Verarbeitbare einkettige moleküle und daraus hergestellte polypeptide
LT2717898T (lt) 2011-06-10 2019-03-25 Bioverativ Therapeutics Inc. Pro-koagulianto junginiai ir jų gavimo būdai
US8900822B2 (en) 2011-11-21 2014-12-02 Ethicon, Inc. Fibrinogen assay
US20130309753A1 (en) * 2012-05-16 2013-11-21 Saint Louis University Recombinant auto-activating protease precursors
EP2863940A4 (de) 2012-06-08 2016-08-10 Biogen Ma Inc Chimäre gerinnungsfaktoren
JP2015521589A (ja) 2012-06-08 2015-07-30 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． プロコアグラント化合物
CA2879785C (en) 2012-07-25 2019-06-18 Catalyst Biosciences, Inc. Modified factor x polypeptides and uses thereof
MX2015008813A (es) 2013-01-31 2016-03-31 Pfizer Composiciones y metodos para contrarrestar la inhibicion del factor xa.
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
US9789209B2 (en) 2013-03-14 2017-10-17 The Regents Of The University Of California, Berke Activatable membrane-interacting peptides and methods of use
SG10201913874TA (en) 2013-03-15 2020-03-30 Biogen Ma Inc Factor ix polypeptide formulations
ES2657291T3 (es) 2013-04-22 2018-03-02 Csl Ltd. Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro
AU2014326257B2 (en) 2013-09-24 2017-08-10 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins
WO2015070014A1 (en) 2013-11-08 2015-05-14 Biogen Idec Ma Inc. Procoagulant fusion compound

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
US5851983A (en) * 1987-12-28 1998-12-22 Teijin Limited Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
US6232456B1 (en) * 1997-10-06 2001-05-15 Abbott Laboratories Serine protease reagents and methods useful for detecting and treating diseases of the prostate
FR2841904B1 (fr) 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine

Also Published As

Publication number Publication date
DE60217377T2 (de) 2007-10-18
CA2463772C (en) 2014-07-29
AU2002357479B2 (en) 2008-03-06
US7589178B2 (en) 2009-09-15
JP2005506086A (ja) 2005-03-03
ATE350470T1 (de) 2007-01-15
EP1436389B1 (de) 2007-01-03
WO2003035861A2 (en) 2003-05-01
FR2831170B1 (fr) 2004-03-19
ES2279010T3 (es) 2007-08-16
WO2003035861A3 (en) 2003-09-18
JP4355924B2 (ja) 2009-11-04
CA2463772A1 (en) 2003-05-01
US20050202527A1 (en) 2005-09-15
EP1436389A2 (de) 2004-07-14
FR2831170A1 (fr) 2003-04-25

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