DE60218285D1 - Verfahren zur partikelherstellung - Google Patents

Verfahren zur partikelherstellung

Info

Publication number
DE60218285D1
DE60218285D1 DE60218285T DE60218285T DE60218285D1 DE 60218285 D1 DE60218285 D1 DE 60218285D1 DE 60218285 T DE60218285 T DE 60218285T DE 60218285 T DE60218285 T DE 60218285T DE 60218285 D1 DE60218285 D1 DE 60218285D1
Authority
DE
Germany
Prior art keywords
liquid
particles
temperature
substance
modulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60218285T
Other languages
English (en)
Other versions
DE60218285T2 (de
Inventor
Goran Eric Sundholm
Mustafa Demirbuker
Saeed Moshashaee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60218285D1 publication Critical patent/DE60218285D1/de
Publication of DE60218285T2 publication Critical patent/DE60218285T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0403—Solvent extraction of solutions which are liquid with a supercritical fluid
    • B01D11/0411—Solvent extraction of solutions which are liquid with a supercritical fluid the supercritical fluid acting as solvent for the solvent and as anti-solvent for the solute, e.g. formation of particles from solutions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
DE60218285T 2001-01-26 2002-01-22 Verfahren zur partikelherstellung Expired - Lifetime DE60218285T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0102075.9A GB0102075D0 (en) 2001-01-26 2001-01-26 Process
GB0102075 2001-01-26
PCT/GB2002/000261 WO2002058674A2 (en) 2001-01-26 2002-01-22 Process for preparing particles

Publications (2)

Publication Number Publication Date
DE60218285D1 true DE60218285D1 (de) 2007-04-05
DE60218285T2 DE60218285T2 (de) 2007-11-15

Family

ID=9907591

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60218285T Expired - Lifetime DE60218285T2 (de) 2001-01-26 2002-01-22 Verfahren zur partikelherstellung

Country Status (22)

Country Link
US (2) US7108867B2 (de)
EP (1) EP1357901B1 (de)
JP (1) JP4175892B2 (de)
KR (1) KR100853596B1 (de)
CN (1) CN1298312C (de)
AT (1) ATE354352T1 (de)
BR (1) BR0206439A (de)
CA (1) CA2433838A1 (de)
CY (1) CY1106550T1 (de)
DE (1) DE60218285T2 (de)
DK (1) DK1357901T3 (de)
ES (1) ES2281509T3 (de)
GB (1) GB0102075D0 (de)
HK (1) HK1063157A1 (de)
IL (2) IL156720A0 (de)
MX (1) MXPA03006537A (de)
NO (1) NO20033241L (de)
NZ (1) NZ526942A (de)
PT (1) PT1357901E (de)
SI (1) SI1357901T1 (de)
WO (1) WO2002058674A2 (de)
ZA (1) ZA200304953B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
GB0126716D0 (en) * 2001-11-07 2002-01-02 Advanced Phytonics Ltd Method for the production of particles
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US20040202681A1 (en) * 2002-12-19 2004-10-14 Baxter International, Inc. Process for preparing pharmaceutical formulations using supercritical fluids
JP5207432B2 (ja) * 2003-04-29 2013-06-12 エム・エス・ディー・オス・ベー・フェー アンチ溶媒凝固プロセス
AU2004237131B2 (en) 2003-05-08 2009-09-10 Nektar Therapeutics Particulate materials
US20050181059A1 (en) * 2003-09-30 2005-08-18 Spherics, Inc. Nanoparticulate therapeutic biologically active agents
US7220456B2 (en) 2004-03-31 2007-05-22 Eastman Kodak Company Process for the selective deposition of particulate material
US7223445B2 (en) 2004-03-31 2007-05-29 Eastman Kodak Company Process for the deposition of uniform layer of particulate material
WO2007009164A1 (en) 2005-07-15 2007-01-25 Eiffel Technologies Limited Method of particle formation
NL1031224C2 (nl) * 2006-02-23 2007-09-03 Friesland Brands Bv Het bereiden van gedroogde deeltjes met behulp van een superkritisch medium.
US20080187568A1 (en) * 2007-02-06 2008-08-07 Sawhney Amarpreet S Polymerization with precipitation of proteins for elution in physiological solution
CN104188907A (zh) 2007-02-11 2014-12-10 Map药物公司 治疗性施用dhe用于快速减轻偏头痛而使副作用分布最小化的方法
JP5307382B2 (ja) * 2007-11-14 2013-10-02 日機装株式会社 微粒子化方法
CA2706684C (en) * 2007-12-07 2016-01-12 Xspray Microparticles Ab Method and arrangement for the production of particles
MX350838B (es) 2011-02-11 2017-09-18 Grain Proc Corporation * Composicion de sal.
MX353067B (es) * 2012-03-22 2017-12-19 Novo Nordisk As Composiciones de peptidos de glp-1 y preparaciones de las mismas.
JP6668652B2 (ja) 2015-09-18 2020-03-18 日本精工株式会社 直動案内装置、直動案内装置用エンドキャップ

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE99546T1 (de) 1989-05-01 1994-01-15 Alkermes Inc Verfahren zur herstellung von kleinen partikeln von biologisch aktiven molekuelen.
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5346702A (en) 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
GB9313642D0 (en) 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
GB9413202D0 (en) * 1994-06-30 1994-08-24 Univ Bradford Method and apparatus for the formation of particles
EP0855906B1 (de) 1995-10-17 2008-02-20 Jagotec AG Verabreichung unlöslicher arzneistoffe
GB9703673D0 (en) 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
GB9804379D0 (en) 1998-03-02 1998-04-22 Bradford Particle Design Ltd Method of particle formation
JP2002511398A (ja) 1998-04-09 2002-04-16 エフ．ホフマン−ラ ロシュ アーゲー 圧縮ガス及び界面活性剤に溶解することによって（サブ）ミクロンレベルの大きさの粒子を製造する方法
SE9801287D0 (sv) * 1998-04-14 1998-04-14 Astra Ab Incorporation of active substances in carrier matrixes
GB9810559D0 (en) 1998-05-15 1998-07-15 Bradford Particle Design Ltd Method and apparatus for particle formation
SE9804001D0 (sv) 1998-11-23 1998-11-23 Astra Ab New process
GB9828204D0 (en) 1998-12-21 1999-02-17 Smithkline Beecham Plc Process
GB9915975D0 (en) 1999-07-07 1999-09-08 Bradford Particle Design Ltd Method for the formation of particles
GB9920558D0 (en) 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
WO2003053561A2 (en) * 2001-07-12 2003-07-03 Eastman Kodak Company A surfactant assisted nanomaterial generation process
US6998051B2 (en) * 2002-07-03 2006-02-14 Ferro Corporation Particles from supercritical fluid extraction of emulsion
JP2007516259A (ja) * 2003-12-09 2007-06-21 メッドクリスタルフォームズ、エルエルシー 活性剤との混合相共結晶の調製方法
US7754243B2 (en) * 2004-08-03 2010-07-13 Clemson University Research Foundation Aqueous suspension of nanoscale drug particles from supercritical fluid processing

Also Published As

Publication number Publication date
US20040058007A1 (en) 2004-03-25
PT1357901E (pt) 2007-05-31
IL156720A0 (en) 2004-01-04
CA2433838A1 (en) 2002-08-01
AU2002225193B2 (en) 2006-07-27
DE60218285T2 (de) 2007-11-15
JP2004521891A (ja) 2004-07-22
ES2281509T3 (es) 2007-10-01
CY1106550T1 (el) 2012-01-25
WO2002058674A2 (en) 2002-08-01
US7108867B2 (en) 2006-09-19
MXPA03006537A (es) 2003-09-22
NO20033241D0 (no) 2003-07-17
NO20033241L (no) 2003-07-17
HK1063157A1 (en) 2004-12-17
CN1487825A (zh) 2004-04-07
KR20030070921A (ko) 2003-09-02
DK1357901T3 (da) 2007-06-04
US7829123B2 (en) 2010-11-09
NZ526942A (en) 2005-04-29
JP4175892B2 (ja) 2008-11-05
EP1357901B1 (de) 2007-02-21
ATE354352T1 (de) 2007-03-15
GB0102075D0 (en) 2001-03-14
IL156720A (en) 2010-03-28
KR100853596B1 (ko) 2008-08-22
ZA200304953B (en) 2004-08-25
CN1298312C (zh) 2007-02-07
SI1357901T1 (sl) 2007-08-31
EP1357901A2 (de) 2003-11-05
US20070009604A1 (en) 2007-01-11
BR0206439A (pt) 2003-12-30
WO2002058674A3 (en) 2002-11-21

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Legal Events

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8364 No opposition during term of opposition