DE60224401D1 - Hepatitis c virus polymerase inhibitoren mit heterobicylischer struktur - Google Patents
Hepatitis c virus polymerase inhibitoren mit heterobicylischer strukturInfo
- Publication number
- DE60224401D1 DE60224401D1 DE60224401T DE60224401T DE60224401D1 DE 60224401 D1 DE60224401 D1 DE 60224401D1 DE 60224401 T DE60224401 T DE 60224401T DE 60224401 T DE60224401 T DE 60224401T DE 60224401 D1 DE60224401 D1 DE 60224401D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- het
- heterobicylic
- hepatitis
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30767401P | 2001-07-25 | 2001-07-25 | |
US307674P | 2001-07-25 | ||
US33806101P | 2001-12-07 | 2001-12-07 | |
US338061P | 2001-12-07 | ||
PCT/CA2002/001128 WO2003010141A2 (en) | 2001-07-25 | 2002-07-18 | Hepatitis c virus polymerase inhibitors with a heterobicyclic structure |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60224401D1 true DE60224401D1 (de) | 2008-02-14 |
DE60224401T2 DE60224401T2 (de) | 2009-01-02 |
Family
ID=26975871
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60224401T Expired - Lifetime DE60224401T2 (de) | 2001-07-25 | 2002-07-18 | Hepatitis c virus polymerase inhibitoren mit heterobicylischer struktur |
DE60224400T Expired - Lifetime DE60224400T2 (de) | 2001-07-25 | 2002-07-18 | Hepatitis c virus polymerase inhibitoren mit heterobicylischer struktur |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60224400T Expired - Lifetime DE60224400T2 (de) | 2001-07-25 | 2002-07-18 | Hepatitis c virus polymerase inhibitoren mit heterobicylischer struktur |
Country Status (34)
Country | Link |
---|---|
US (5) | US7141574B2 (de) |
EP (5) | EP2335700A1 (de) |
JP (4) | JP4398725B2 (de) |
KR (3) | KR100949446B1 (de) |
CN (3) | CN100443469C (de) |
AR (2) | AR037495A1 (de) |
AT (2) | ATE382348T1 (de) |
AU (2) | AU2002355150B2 (de) |
BR (2) | BR0211360A (de) |
CA (2) | CA2450033C (de) |
CO (2) | CO5650161A2 (de) |
CY (2) | CY1107354T1 (de) |
DE (2) | DE60224401T2 (de) |
DK (2) | DK1414441T3 (de) |
EA (2) | EA007722B1 (de) |
ES (2) | ES2299591T3 (de) |
HK (2) | HK1069991A1 (de) |
HR (3) | HRP20040073B1 (de) |
HU (2) | HUP0402065A3 (de) |
IL (4) | IL159649A0 (de) |
ME (2) | MEP59608A (de) |
MX (2) | MXPA04000731A (de) |
MY (1) | MY151080A (de) |
NO (2) | NO327055B1 (de) |
NZ (2) | NZ531267A (de) |
PE (1) | PE20030305A1 (de) |
PL (2) | PL368357A1 (de) |
PT (2) | PT1414797E (de) |
RS (3) | RS20090517A (de) |
SG (1) | SG176999A1 (de) |
SI (2) | SI1414797T1 (de) |
UA (1) | UA84256C2 (de) |
UY (1) | UY27397A1 (de) |
WO (2) | WO2003010141A2 (de) |
Families Citing this family (204)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005505508A (ja) * | 2001-06-13 | 2005-02-24 | ジーンソフト ファーマシューティカルズ インコーポレイテッド | 抗感染活性を有するベンゾチオフェン化合物 |
EP2335700A1 (de) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur |
US7294457B2 (en) * | 2001-08-07 | 2007-11-13 | Boehringer Ingelheim (Canada) Ltd. | Direct binding assay for identifying inhibitors of HCV polymerase |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US20050075279A1 (en) | 2002-10-25 | 2005-04-07 | Boehringer Ingelheim International Gmbh | Macrocyclic peptides active against the hepatitis C virus |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7098231B2 (en) * | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
GB0307891D0 (en) * | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
ES2320771T3 (es) | 2003-04-16 | 2009-05-28 | Bristol-Myers Squibb Company | Inhibidores peptidicos de isoquinolina macrociclicos del virus de la hepatitis c. |
JP2006528685A (ja) | 2003-05-06 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | 新規化合物 |
TW200517381A (en) | 2003-08-01 | 2005-06-01 | Genelabs Tech Inc | Bicyclic heteroaryl derivatives |
WO2005014543A1 (ja) * | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
GB0321003D0 (en) | 2003-09-09 | 2003-10-08 | Angeletti P Ist Richerche Bio | Compounds, compositions and uses |
US7112601B2 (en) | 2003-09-11 | 2006-09-26 | Bristol-Myers Squibb Company | Cycloalkyl heterocycles for treating hepatitis C virus |
JP5054382B2 (ja) * | 2003-10-07 | 2012-10-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | インドール抗ウイルス組成物および方法 |
GB0323845D0 (en) * | 2003-10-10 | 2003-11-12 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
US20050119318A1 (en) * | 2003-10-31 | 2005-06-02 | Hudyma Thomas W. | Inhibitors of HCV replication |
CA2549606C (en) | 2003-12-22 | 2015-10-06 | K.U. Leuven Research & Development | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
EP1730167B1 (de) | 2004-01-21 | 2011-01-12 | Boehringer Ingelheim International GmbH | Makrocyclische peptide mit wirkung gegen das hepatitis-c-virus |
CN1922174A (zh) | 2004-02-20 | 2007-02-28 | 贝林格尔·英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
PL1719773T3 (pl) | 2004-02-24 | 2009-08-31 | Japan Tobacco Inc | Skondensowane związki heterotetracykliczne i ich zastosowanie jako inhibitora polimerazy HCV |
BRPI0508505A (pt) | 2004-03-08 | 2007-07-31 | Boehringer Ingelheim Pharma | processo para acoplamento cruzado de indóis |
US7126009B2 (en) * | 2004-03-16 | 2006-10-24 | Boehringer Ingelheim International, Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
GB0413087D0 (en) | 2004-06-11 | 2004-07-14 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
US7772271B2 (en) * | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US8013006B2 (en) * | 2004-07-14 | 2011-09-06 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
WO2007084413A2 (en) * | 2004-07-14 | 2007-07-26 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
PE20060569A1 (es) * | 2004-07-16 | 2006-06-22 | Boehringer Ingelheim Int | Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc |
WO2006019832A1 (en) * | 2004-07-22 | 2006-02-23 | Ptc Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
BRPI0513811A (pt) | 2004-07-27 | 2008-07-15 | Gilead Sciences Inc | imidazo [4,5-d] pirimidinas, seus usos e processos de preparação |
US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
MX2007008587A (es) * | 2005-01-14 | 2007-09-07 | Genelabs Tech Inc | Derivados de indol para tratamiento de infecciones virales. |
EP2530082A1 (de) * | 2005-02-11 | 2012-12-05 | Boehringer Ingelheim International GmbH | Verfahren zur Herstellung 2,3-disubstituierter Indole |
WO2006094292A2 (en) | 2005-03-02 | 2006-09-08 | Fibrogen, Inc. | Thienopyridine compounds, and methods of use thereof |
KR20070116682A (ko) | 2005-05-04 | 2007-12-10 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스성 화합물 |
ES2415742T3 (es) | 2005-05-13 | 2013-07-26 | Vertex Pharmaceuticals (Canada) Incorporated | Compuestos y procedimientos para el tratamiento o prevención de infecciones por flavivirus |
BRPI0612124A2 (pt) * | 2005-06-24 | 2010-10-19 | Genelabs Tech Inc | derivados de heteroarila para o tratamento de viroses |
JP5015154B2 (ja) | 2005-08-12 | 2012-08-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼインヒビター |
AU2006283297B2 (en) * | 2005-08-24 | 2012-07-26 | Pfizer Inc. | Methods for the preparation of HCV polymerase inhibitors |
JP2009523732A (ja) * | 2006-01-13 | 2009-06-25 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎の治療方法 |
CN103382216B (zh) | 2006-01-27 | 2016-04-20 | 菲布罗根有限公司 | 使低氧诱导因子(hif)稳定的氰基异喹啉化合物 |
US7816348B2 (en) * | 2006-02-03 | 2010-10-19 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
MX2008010355A (es) * | 2006-02-09 | 2008-10-31 | Schering Corp | Combinaciones que comprenden inhibidores de proteasa del virus de la hepatitis c e inhibidores de polimerasa del virus de la hepatitis c, y metodos de tratamiento relacionados con los mismos. |
WO2007106317A2 (en) * | 2006-03-03 | 2007-09-20 | Schering Corporation | Pharmaceutical combinations of hcv-protease and -ires inhibitors |
WO2007115315A2 (en) | 2006-04-04 | 2007-10-11 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as hif modulators |
EP1886685A1 (de) | 2006-08-11 | 2008-02-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methoden, Verwendungen und Zusammensetzungen zur Modulation der Replikation von HCV durch Aktivierung oder Hemmung des Farnesoid X Rezeptors |
RU2009109355A (ru) | 2006-08-17 | 2010-09-27 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Ингибиторы вырусной полимеразы |
MX2009002921A (es) | 2006-09-15 | 2009-04-01 | Schering Corp | Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico. |
AP2009004812A0 (en) | 2006-10-10 | 2009-04-30 | Medivir Ab | HCV nucleoside inhibitor |
EP2463389A1 (de) | 2006-10-20 | 2012-06-13 | Innogenetics N.V. | Methodik zur Analyse von Sequenzvariationen innerhalb des HCV-NS5B-Genombereichs |
EP2104674B8 (de) | 2006-11-15 | 2013-10-02 | Vertex Pharmaceuticals (Canada) Incorporated | Thiophenanaloga zur behandlung oder prävention von flavivirus-infektionen |
WO2008082488A1 (en) | 2006-12-22 | 2008-07-10 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
KR20090094154A (ko) | 2006-12-22 | 2009-09-03 | 쉐링 코포레이션 | Hcv 및 관련 바이러스 감염을 치료 또는 예방하기 위한 4,5-환 환상 인돌 유도체 |
US8268803B2 (en) | 2006-12-22 | 2012-09-18 | Merck Sharp & Dohme Corp. | 5, 6-ring annulated indole derivatives and use thereof |
AU2008216382A1 (en) * | 2007-02-12 | 2008-08-21 | Array Biopharma, Inc. | Novel inhibitors hepatitis C virus replication |
US7998951B2 (en) * | 2007-03-05 | 2011-08-16 | Bristol-Myers Squibb Company | HCV NS5B inhibitors |
CN101679437B (zh) | 2007-03-13 | 2013-04-17 | 百时美施贵宝公司 | 环丙基稠合的吲哚并苯并氮杂*hcv ns5b抑制剂 |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
US8258116B2 (en) | 2007-05-04 | 2012-09-04 | Vertex Pharmaceuticals Incorporated | Combination therapy for the treatment of HCV infection |
WO2009018657A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
CA2693495A1 (en) * | 2007-08-03 | 2009-02-12 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
JP5272008B2 (ja) | 2007-08-29 | 2013-08-28 | メルク・シャープ・アンド・ドーム・コーポレーション | 置換インドール誘導体およびその使用の方法 |
KR20100065167A (ko) | 2007-08-29 | 2010-06-15 | 쉐링 코포레이션 | 바이러스 감염 치료용 2,3-치환된 아자인돌 유도체 |
RU2010111550A (ru) | 2007-08-29 | 2011-10-10 | Шеринг Корпорейшн (US) | 2,3-замещенные индольные производные для лечения вирусных инфекций |
MX2010005292A (es) * | 2007-11-15 | 2010-07-05 | Boehringer Ingelheim Int | Inhibidores de la replicacion del virus de la inmunodeficiencia humana. |
CA2705586A1 (en) | 2007-11-16 | 2009-05-22 | Schering Corporation | 3-heterocyclic substituted indole derivatives and methods of use thereof |
EP2222672B1 (de) * | 2007-11-16 | 2013-12-18 | Merck Sharp & Dohme Corp. | 3-aminosulfonylsubstituierte indolderivate und verfahren zu deren anwendung |
EP2220084B1 (de) | 2007-11-16 | 2014-02-19 | Gilead Sciences, Inc. | Inhibitoren der replikation des human immunodeficiency virus |
EP2224942A4 (de) | 2007-12-05 | 2012-01-25 | Enanta Pharm Inc | Fluorierte tripeptid-hcv-serinprotease-hemmer |
CN101903351B (zh) | 2007-12-19 | 2014-09-10 | 贝林格尔.英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
DK2238142T3 (da) | 2007-12-24 | 2012-10-08 | Janssen R & D Ireland | Makrocykliske indoler som hepatitis C-virusinhibitorer |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
EP2303893B1 (de) | 2008-06-13 | 2016-12-07 | Merck Sharp & Dohme Corp. | Tricyclische indolderivate |
BRPI0916216A2 (pt) | 2008-07-15 | 2018-03-13 | Novartis Ag | composto orgânicos |
WO2010018233A1 (en) | 2008-08-14 | 2010-02-18 | Tibotec Pharmaceuticals | Macrocyclic indole derivatives useful as hepatitis c virus inhibitors |
UA103496C2 (uk) * | 2008-09-17 | 2013-10-25 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Комбінація інгібітора протеази ns3 hcv з інтерфероном і рибавірином |
EP2370422B1 (de) | 2008-11-14 | 2019-06-05 | Fibrogen, Inc. | Thiochromenderivate als hip-hydroxylasehemmer |
WO2010065681A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
EP2373172B1 (de) | 2008-12-03 | 2013-07-17 | Presidio Pharmaceuticals, Inc. | Hcv-ns5a-hemmer |
AU2009329867B2 (en) | 2008-12-23 | 2015-01-29 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
ES2567047T3 (es) * | 2008-12-23 | 2016-04-19 | Abbvie Inc. | Derivados de pirimidina anti-virales |
EA019295B1 (ru) * | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Соединения пуриновых нуклеозидов и способ их получения |
US8546405B2 (en) * | 2008-12-23 | 2013-10-01 | Abbott Laboratories | Anti-viral compounds |
NZ617066A (en) | 2008-12-23 | 2015-02-27 | Gilead Pharmasset Llc | Nucleoside analogs |
KR20110116136A (ko) | 2009-01-07 | 2011-10-25 | 싸이넥시스, 인크. | Hcv 및 hiv 감염의 치료에 사용하기 위한 사이클로스포린 유도체 |
AU2010203416C1 (en) | 2009-01-09 | 2013-07-25 | Inhibitex, Inc. | Phosphoramidate derivatives of guanosine nucleoside compounds for treatment of viral infections |
WO2010091413A1 (en) * | 2009-02-09 | 2010-08-12 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8314135B2 (en) * | 2009-02-09 | 2012-11-20 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole antivirals |
US8188132B2 (en) * | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8242156B2 (en) * | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8101643B2 (en) * | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
CN102427729B (zh) * | 2009-03-27 | 2014-09-03 | 默沙东公司 | 丙型肝炎病毒复制的抑制剂 |
KR20110131312A (ko) | 2009-03-27 | 2011-12-06 | 프레시디오 파마슈티칼스, 인코포레이티드 | 융합된 고리 c형 간염 억제제 |
US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
AU2010232729A1 (en) | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
WO2010117935A1 (en) * | 2009-04-06 | 2010-10-14 | Schering Corporation | Compounds and methods for antiviral treatment |
SG175144A1 (en) * | 2009-04-15 | 2011-11-28 | Abbott Lab | Anti-viral compounds |
CA2761650C (en) | 2009-05-13 | 2015-05-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic compounds as hepatitis c virus inhibitors |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
RS53856B1 (en) * | 2009-06-11 | 2015-08-31 | Abbvie Bahamas Ltd. | HETEROCYCLIC COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS |
US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8927709B2 (en) * | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
EP2475256A4 (de) * | 2009-09-11 | 2013-06-05 | Enanta Pharm Inc | Hemmer des hepatitis-c-virus |
US8703938B2 (en) * | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8759332B2 (en) * | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8822700B2 (en) * | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
NZ598465A (en) | 2009-10-30 | 2013-10-25 | Boehringer Ingelheim Int | Dosage regimens for hcv combination therapy comprising bi201335, interferon alpha and ribavirin |
AU2010317996A1 (en) | 2009-11-14 | 2012-05-10 | F. Hoffmann-La Roche Ag | Biomarkers for predicting rapid response to HCV treatment |
CA2781614A1 (en) | 2009-11-25 | 2011-06-09 | Vertex Pharmaceuticals Incorporated | 5-alkynyl-thiophene-2-carboxylic acid derivatives and their use for the treatment or prevention of flavivirus infections |
KR20120085877A (ko) | 2009-12-02 | 2012-08-01 | 에프. 호프만-라 로슈 아게 | Hcv 치료에 대한 지속된 반응을 예측하기 위한 생체마커 |
EP2512480A4 (de) * | 2009-12-14 | 2013-05-15 | Enanta Pharm Inc | Hemmer des hepatitis-c-virus |
KR20120130173A (ko) | 2009-12-24 | 2012-11-29 | 버텍스 파마슈티칼스 인코포레이티드 | 플라비바이러스 감염을 치료 또는 예방하기 위한 유사체들 |
CN102843909A (zh) | 2010-01-25 | 2012-12-26 | 埃南塔制药公司 | 丙型肝炎病毒抑制剂 |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
CN101775003B (zh) * | 2010-02-04 | 2013-12-04 | 银杏树药业(苏州)有限公司 | 苯并噻吩类衍生物及其制备方法和应用 |
US8623814B2 (en) * | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
US8178531B2 (en) * | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
JP2013521279A (ja) * | 2010-03-04 | 2013-06-10 | エナンタ ファーマシューティカルズ インコーポレイテッド | Hcv複製の阻害剤としての医薬併用剤 |
WO2011119858A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
TW201141857A (en) | 2010-03-24 | 2011-12-01 | Vertex Pharma | Analogues for the treatment or prevention of flavivirus infections |
JP2013522375A (ja) | 2010-03-24 | 2013-06-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | フラビウイルス感染を処置または予防するためのアナログ |
WO2011119870A1 (en) | 2010-03-24 | 2011-09-29 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
EP2552933A1 (de) | 2010-03-31 | 2013-02-06 | Gilead Pharmasset LLC | Purin-nukleosid-phosphoramidat |
AU2011235044A1 (en) | 2010-03-31 | 2012-11-22 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorus containing actives |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
WO2011127350A1 (en) | 2010-04-09 | 2011-10-13 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
AR082453A1 (es) | 2010-04-21 | 2012-12-12 | Novartis Ag | Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos |
CA2800509A1 (en) | 2010-05-24 | 2011-12-01 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
WO2011153396A1 (en) | 2010-06-04 | 2011-12-08 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
WO2011159826A2 (en) | 2010-06-15 | 2011-12-22 | Vertex Pharmaceuticals Incorporated | Hcv ns5b protease mutants |
EP2585448A1 (de) | 2010-06-28 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Verbindungen und verfahren zur behandlung oder vorbeugung von flavivirus-infektionen |
MX2012014918A (es) | 2010-06-28 | 2013-04-08 | Vertex Pharma | Compuestos y metodos para tratamiento o prevencion de infecciones por flavivirus. |
WO2012006070A1 (en) | 2010-06-28 | 2012-01-12 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
US8697704B2 (en) | 2010-08-12 | 2014-04-15 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2012020036A1 (en) | 2010-08-13 | 2012-02-16 | F. Hoffmann-La Roche Ag | Hepatitis c virus inhibitors |
WO2012024363A2 (en) | 2010-08-17 | 2012-02-23 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flaviviridae viral infections |
GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
AU2011305695B2 (en) | 2010-09-21 | 2016-05-19 | Enanta Pharmaceuticals, Inc. | Macrocyclic proline derived HCV serine protease inhibitors |
US8871737B2 (en) * | 2010-09-22 | 2014-10-28 | Alios Biopharma, Inc. | Substituted nucleotide analogs |
EA201300422A1 (ru) | 2010-09-30 | 2013-09-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Твердофазные формы активного ингибитора hcv |
MX2013003060A (es) * | 2010-09-30 | 2013-05-30 | Boehringer Ingelheim Int | Terapia de combinacion para tratar infeccion por hcv. |
CA2815537A1 (en) | 2010-10-26 | 2012-05-03 | Presidio Pharmaceuticals, Inc. | Inhibitors of hepatitis c virus |
WO2012075140A1 (en) | 2010-11-30 | 2012-06-07 | Pharmasset, Inc. | Compounds |
US9351989B2 (en) | 2010-12-29 | 2016-05-31 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
WO2012107589A1 (en) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of hcv infections |
WO2012123298A1 (en) | 2011-03-11 | 2012-09-20 | F. Hoffmann-La Roche Ag | Antiviral compounds |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2012158861A2 (en) | 2011-05-18 | 2012-11-22 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 5-azaspiro[2.4]heptane-6-carboxylic acid and its derivatives |
US20120328565A1 (en) | 2011-06-24 | 2012-12-27 | Brinkman John A | Antiviral compounds |
WO2013016499A1 (en) | 2011-07-26 | 2013-01-31 | Vertex Pharmaceuticals Incorporated | Methods for preparation of thiophene compounds |
AR087346A1 (es) | 2011-07-26 | 2014-03-19 | Vertex Pharma | Formulaciones de compuestos de tiofeno |
CA2840242C (en) | 2011-09-16 | 2019-03-26 | Gilead Sciences, Inc. | Methods for treating hcv |
US9180193B2 (en) | 2011-10-10 | 2015-11-10 | Hoffmann-La Roche Inc. | Antiviral compounds |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
US9364484B2 (en) | 2011-12-06 | 2016-06-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating viral diseases |
CA2855574A1 (en) | 2011-12-16 | 2013-06-20 | F. Hoffmann-La Roche Ag | Inhibitors of hcv ns5a |
SI2794629T1 (sl) | 2011-12-20 | 2017-10-30 | Riboscience Llc | 2'4'-difluoro-2'-metil substituirani nukleozidni derivati k0t zaviralci replikacije hcv-rna |
JP6118336B2 (ja) | 2011-12-20 | 2017-04-19 | リボサイエンス・エルエルシー | Hcvのrna複製の阻害剤としての4’−アジド、3’−フルオロ置換されたヌクレオシド誘導体 |
WO2013096680A1 (en) | 2011-12-22 | 2013-06-27 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
CN104185624B (zh) | 2012-02-24 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 抗病毒化合物 |
EP2828277A1 (de) | 2012-03-21 | 2015-01-28 | Vertex Pharmaceuticals Incorporated | Feste formen eines thiophosphoramidat-nucleotid-prodrugs |
WO2013142157A1 (en) | 2012-03-22 | 2013-09-26 | Alios Biopharma, Inc. | Pharmaceutical combinations comprising a thionucleotide analog |
WO2013147749A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient subgenotype populations |
WO2013147750A1 (en) | 2012-03-27 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
US20130261134A1 (en) | 2012-03-30 | 2013-10-03 | Boehringer Ingelheim International Gmbh | Mesylate salt forms of a potent hcv inhibitor |
US9064551B2 (en) | 2012-05-15 | 2015-06-23 | Micron Technology, Inc. | Apparatuses and methods for coupling load current to a common source |
US8976594B2 (en) | 2012-05-15 | 2015-03-10 | Micron Technology, Inc. | Memory read apparatus and methods |
US20140010783A1 (en) | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
US9064577B2 (en) | 2012-12-06 | 2015-06-23 | Micron Technology, Inc. | Apparatuses and methods to control body potential in memory operations |
EP2948440B1 (de) | 2013-01-23 | 2017-04-12 | F. Hoffmann-La Roche AG | Antivirale triazolderivate |
TWI685487B (zh) | 2013-01-24 | 2020-02-21 | 美商費比羅根公司 | {[1-氰基-5-(4-氯苯氧基)-4-羥基-異喹啉-3-羰基]-胺基}-乙酸之晶形 |
CN105748499B (zh) | 2013-01-31 | 2018-12-28 | 吉利德制药有限责任公司 | 两个抗病毒化合物的联用制剂 |
WO2014134251A1 (en) | 2013-02-28 | 2014-09-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions |
EP2964637B1 (de) | 2013-03-05 | 2017-04-12 | F. Hoffmann-La Roche AG | Antivirale verbindungen |
WO2014138374A1 (en) | 2013-03-08 | 2014-09-12 | Boehringer Ingelheim International Gmbh | Oral combination therapy for treating hcv infection in specific patient sub-population |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
RU2534613C2 (ru) | 2013-03-22 | 2014-11-27 | Александр Васильевич Иващенко | Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения |
MA38678A1 (fr) | 2013-05-16 | 2017-07-31 | Riboscience Llc | Dérivés nucléosidiques 4'-azido, 3'désoxy-3'-fluoro substitués |
UA123533C2 (uk) | 2013-05-16 | 2021-04-21 | Рібосаєнс Ллс | 4'-фтор-2'-метилзаміщені нуклеозидні похідні |
US20180200280A1 (en) | 2013-05-16 | 2018-07-19 | Riboscience Llc | 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication |
MX2016002185A (es) | 2013-08-27 | 2016-06-06 | Gilead Pharmasset Llc | Formulacion combinada de dos compuestos antivirales. |
GB2518639B (en) | 2013-09-26 | 2016-03-09 | Dyson Technology Ltd | A hand held appliance |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
SG10201913587WA (en) | 2016-02-05 | 2020-02-27 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
SI3552017T1 (sl) | 2016-12-09 | 2022-09-30 | Denali Therapeutics Inc. | Spojine uporabne kot zaviralci RIPK1 |
GB201701087D0 (en) | 2017-01-23 | 2017-03-08 | Univ Leuven Kath | Novel prodrugs of mizoribine |
US10176880B1 (en) | 2017-07-01 | 2019-01-08 | Intel Corporation | Selective body reset operation for three dimensional (3D) NAND memory |
EP3684374A4 (de) | 2017-09-21 | 2021-06-16 | Riboscience LLC | 4'-fluor-2'-methyl-substituierte nukleosidderivate als hemmer der hcv-rna-replikation |
KR102318294B1 (ko) * | 2021-07-15 | 2021-10-26 | 이용화 | 친환경 교면방수제 조성물 및 이를 이용한 방수공법 |
TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Pparg反向激動劑及其用途 |
Family Cites Families (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1094903A (en) | 1964-03-26 | 1967-12-13 | Smith Kline French Lab | Improvements in or relating to nitrofuran derivatives |
FR1604809A (en) | 1965-11-26 | 1972-04-17 | Thiazolyl benzimidazoles - animal feed additives | |
GB1186504A (en) | 1966-10-15 | 1970-04-02 | Fisons Pest Control Ltd | Substituted Heterocyclic Compounds |
NL6917115A (de) | 1968-11-22 | 1970-05-26 | ||
US3565912A (en) | 1969-01-27 | 1971-02-23 | Upjohn Co | 5-lower-alkanoyl-2,3-bis(p-methoxyphenyl)indoles |
DE2346316C2 (de) | 1973-09-14 | 1985-02-14 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von 2-Furylbenzimidazolen |
GB1509527A (en) | 1974-06-05 | 1978-05-04 | Ici Ltd | 1-(aryl-or heteroaryl)oxy-3-(substituted-amino)propan-2-ol derivatives processes for their manufacture and pharmaceutical compositions containing them |
FR2291749A1 (fr) | 1974-11-20 | 1976-06-18 | Delalande Sa | Nouveaux benzimidazoles acetiques, leur procede de preparation et leur application en therapeutique |
US4003908A (en) | 1976-03-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Derivatives of imidazo(4,5-b)pyridines |
CH632628B (de) | 1976-07-26 | Ciba Geigy Ag | Verfahren zur herstellung von benzofuranyl-benzimidazolen und deren verwendung als optische aufheller. | |
DE2641060A1 (de) | 1976-09-11 | 1978-03-16 | Hoechst Ag | Beta-lactamverbindungen und verfahren zu ihrer herstellung |
US4264325A (en) | 1977-02-22 | 1981-04-28 | Ciba-Geigy Corporation | Phenyl-benzimidazolyl-furanes for optical brightening of organic materials |
DE2720111A1 (de) | 1977-05-05 | 1978-11-16 | Agfa Gevaert Ag | Korrosionsschutzmittel fuer zweibad-stabilisatorbaeder |
DE2964427D1 (en) | 1978-10-04 | 1983-02-03 | Ciba Geigy Ag | Process for the preparation of furanyl-benzazoles |
ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
DE2852531A1 (de) | 1978-12-05 | 1980-06-19 | Bayer Ag | Benzofuranyl-benzimidazole |
DE2853765A1 (de) | 1978-12-13 | 1980-06-26 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuranen |
DE2904829A1 (de) | 1979-02-08 | 1980-08-14 | Bayer Ag | Verfahren zur herstellung von benzimidazolylbenzofuran |
US4384121A (en) | 1979-11-01 | 1983-05-17 | Ciba-Geigy Corporation | Cationic fluorescent whitening agents |
GR75101B (de) | 1980-10-23 | 1984-07-13 | Pfizer | |
GB8707798D0 (en) | 1987-04-01 | 1987-05-07 | Ici Plc | Recovery of metals |
ZA825413B (en) | 1981-08-26 | 1983-06-29 | Pfizer | Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them |
GB2118552A (en) | 1982-04-15 | 1983-11-02 | Pfizer Ltd | Thromboxane synthetase inhibitors |
US4613990A (en) * | 1984-06-25 | 1986-09-23 | At&T Bell Laboratories | Radiotelephone transmission power control |
LU85544A1 (fr) | 1984-09-19 | 1986-04-03 | Cird | Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique |
DE3522230A1 (de) | 1985-06-21 | 1987-01-02 | Thomae Gmbh Dr K | Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
GB8609175D0 (en) | 1986-04-15 | 1986-05-21 | Ici America Inc | Heterocyclic carboxamides |
GB8707051D0 (en) | 1986-04-15 | 1987-04-29 | Ici America Inc | Heterocyclic carboxamides |
US4859684A (en) | 1986-09-15 | 1989-08-22 | Janssen Pharmaceutica N.V. | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders |
CA1322005C (en) | 1987-11-25 | 1993-09-07 | Robert N. Young | Benzoheterazoles |
JP2700475B2 (ja) | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
JPH03157646A (ja) | 1989-11-15 | 1991-07-05 | Konica Corp | ハロゲン化銀写真感光材料 |
JPH03219232A (ja) | 1990-01-24 | 1991-09-26 | Konica Corp | 分光増感されたハロゲン化銀写真感光材料 |
JP2909645B2 (ja) | 1990-05-28 | 1999-06-23 | コニカ株式会社 | ハロゲン化銀カラー写真感光材料 |
US5527819A (en) | 1991-09-06 | 1996-06-18 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
GB9122590D0 (en) | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
JPH05165163A (ja) | 1991-12-11 | 1993-06-29 | Konica Corp | 色素画像形成方法 |
US5216003A (en) | 1992-01-02 | 1993-06-01 | G. D. Searle & Co. | Diacid-containing benzimidazole compounds for treatment of neurotoxic injury |
GB9203798D0 (en) * | 1992-02-21 | 1992-04-08 | Fujisawa Pharmaceutical Co | Quinolylbenzofuran derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
DE4237617A1 (de) | 1992-11-06 | 1994-05-11 | Bayer Ag | Verwendung von substituierten Benzimidazolen |
PT672031E (pt) | 1992-12-02 | 2003-06-30 | Pfizer | Dieteres de catecol como inibidores selectivos de pde iv |
JP3213426B2 (ja) * | 1993-02-19 | 2001-10-02 | エーザイ株式会社 | 6,7−ジヒドロ−5H−シクロペンタ〔d〕ピリミジン誘導体 |
DE4309969A1 (de) | 1993-03-26 | 1994-09-29 | Bayer Ag | Substituierte heteroanellierte Imidazole |
US6169107B1 (en) * | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
JP3156444B2 (ja) | 1993-06-02 | 2001-04-16 | 松下電器産業株式会社 | 短波長レーザ光源およびその製造方法 |
EP0669323B2 (de) | 1994-02-24 | 2004-04-07 | Haarmann & Reimer Gmbh | Kosmetische und dermatologische zubereitungen, enthaltend phenylen-1,4-bisbenzimidiazolesulfonsäuren |
CA2124169A1 (en) | 1994-05-24 | 1995-11-25 | Richard Mcculloch Keenan | Chemical compounds |
DE69530081T2 (de) | 1994-05-27 | 2003-12-24 | Black James Foundation | Gastrin- und cck-antagonisten |
US5817689A (en) | 1994-11-29 | 1998-10-06 | Dainippon Pharmaceutical Co., Ltd. | Indole derivatives having a 2-phenyl-ethanolamino-substituted lower alkyl group at the 2-or 3-position thereof |
EP0717143A1 (de) | 1994-12-16 | 1996-06-19 | Lignozym GmbH | Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung |
DE19507913C2 (de) | 1995-03-07 | 1998-04-16 | Agfa Gevaert Ag | Farbfotografisches Silberhalogenidmaterial |
US6069156A (en) | 1995-04-10 | 2000-05-30 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives as cGMP-PDE inhibitors |
CN1187812A (zh) * | 1995-04-10 | 1998-07-15 | 藤泽药品工业株式会社 | 作为环状乌苷3',5'-一磷酸盐磷酸二酯酶抑制剂的吲哚衍生物 |
US6444694B1 (en) | 1995-06-06 | 2002-09-03 | Wyeth | Styryl benzimidazole derivatives |
WO1997006141A1 (fr) | 1995-08-04 | 1997-02-20 | Otsuka Kagaku Kabushiki Kaisha | Derives des esters de l'acide indole-2-carboxylique, et bactericides destines a l'agriculture et a l'horticulture contenant ceux-ci comme ingredients actifs |
US5950124A (en) * | 1995-09-06 | 1999-09-07 | Telxon Corporation | Cellular communication system with dynamically modified data transmission parameters |
DE69617731T2 (de) * | 1995-10-05 | 2002-08-08 | Kyoto Pharma Ind | Neue heterozyklische derivate und ihre medizinische anwendung |
JPH09124632A (ja) | 1995-10-31 | 1997-05-13 | Sankyo Co Ltd | ベンゾヘテロ環誘導体 |
CA2241186C (en) | 1995-12-28 | 2006-02-14 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
US5850592A (en) * | 1996-01-11 | 1998-12-15 | Gte Internetworking Incorporated | Method for self-organizing mobile wireless station network |
JP2803626B2 (ja) * | 1996-04-05 | 1998-09-24 | 日本電気株式会社 | 移動無線端末の送信電力制御方式 |
GB9610811D0 (en) | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
EP0934307B1 (de) | 1996-06-19 | 2011-04-27 | Aventis Pharma Limited | Substituierte azabicyclische verbindungen und ihre verwendung als inhibitoren des tnf und der cyclischen amp phosphodiestrase |
AUPO118896A0 (en) | 1996-07-23 | 1996-08-15 | Fujisawa Pharmaceutical Co., Ltd. | New use |
SK23399A3 (en) | 1996-08-28 | 2000-08-14 | Pfizer | 6,5-hetero-bicyclic derivatives, use thereof and pharmaceutical composition on their base |
JPH10114654A (ja) | 1996-10-09 | 1998-05-06 | Fujisawa Pharmaceut Co Ltd | 新規用途 |
EP0949259B1 (de) * | 1996-12-26 | 2001-06-20 | Nikken Chemicals Company, Limited | N-hydroxyharnstoffderivate und sie enthaltende medizinische zubereitungen |
AU6229298A (en) | 1997-02-20 | 1998-09-09 | Shionogi & Co., Ltd. | Indole dicarboxylic acid derivatives |
US6089156A (en) * | 1997-03-21 | 2000-07-18 | Heidelberger Druckmaschinen Aktiengesellschaft | Turning device for a printing press |
US5932743A (en) * | 1997-08-21 | 1999-08-03 | American Home Products Corporation | Methods for the solid phase synthesis of substituted indole compounds |
DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
JP2001526028A (ja) | 1997-12-11 | 2001-12-18 | スミスクライン・ビーチャム・コーポレイション | C型肝炎ウイルスns5b末端切断タンパク質およびその抗ウイルス化合物同定方法 |
US6104512A (en) * | 1998-01-23 | 2000-08-15 | Motorola, Inc. | Method for adjusting the power level of an infrared signal |
KR100291413B1 (ko) * | 1998-03-02 | 2001-07-12 | 김영환 | 이동통신단말기의송신전력제어장치 |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
ES2244204T3 (es) | 1998-07-27 | 2005-12-01 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Derivados de dicetoacidos como inhibidores de polimerasas. |
AU5227999A (en) | 1998-07-27 | 2000-02-21 | Abbott Laboratories | Substituted oxazolines as antiproliferative agents |
US6228868B1 (en) * | 1998-07-27 | 2001-05-08 | Abbott Laboratories | Oxazoline antiproliferative agents |
KR20010099623A (ko) | 1998-08-21 | 2001-11-09 | 비로파마 인코포레이티드 | 바이러스 감염 및 관련 질병을 치료 또는 예방하는화합물, 조성물 및 방법 |
BR9913406A (pt) | 1998-09-04 | 2002-01-29 | Viropharma Inc | Processo de tratamento de infecção causada por pelo menos um vìrus da famìlia flaviviridae e de doença associada com a citada infecção em um hospedeiro vivo possuindo a citada infecção |
CN1324212A (zh) | 1998-09-25 | 2001-11-28 | 维洛药品公司 | 治疗或预防病毒感染及有关疾病的方法 |
GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
US6531475B1 (en) | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
US6514982B1 (en) | 1998-11-12 | 2003-02-04 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
US6358992B1 (en) | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
WO2000039099A1 (fr) | 1998-12-24 | 2000-07-06 | Fujisawa Pharmaceutical Co., Ltd. | Derives de benzimidazole |
WO2000059902A2 (en) * | 1999-04-02 | 2000-10-12 | Du Pont Pharmaceuticals Company | Aryl sulfonyls as factor xa inhibitors |
DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
JP2001122855A (ja) | 1999-10-27 | 2001-05-08 | Japan Tobacco Inc | インドール化合物及びその医薬用途 |
US6346493B1 (en) * | 1999-10-27 | 2002-02-12 | Ferro Corporation | Decorative glass enamels |
NL1013456C2 (nl) * | 1999-11-02 | 2001-05-03 | Dsm Nv | Kristallijn melamine en de toepassing in aminoformaldehydeharsen. |
US6455525B1 (en) | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
MXPA02006338A (es) | 1999-12-24 | 2002-12-13 | Aventis Pharma Ltd | Azaindoles. |
US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
ID30204A (id) | 1999-12-27 | 2001-11-15 | Japan Tobacco Inc | Senyawa-senyawa cincin terfusi dan penggunaannya sebagai obat |
GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US6940392B2 (en) * | 2001-04-24 | 2005-09-06 | Savi Technology, Inc. | Method and apparatus for varying signals transmitted by a tag |
US6765484B2 (en) * | 2000-09-07 | 2004-07-20 | Savi Technology, Inc. | Method and apparatus for supplying commands to a tag |
GB0102109D0 (en) | 2001-01-26 | 2001-03-14 | Syngenta Ltd | Chemical process |
IL157280A0 (en) | 2001-03-08 | 2004-02-19 | Boehringer Ingelheim Ca Ltd | Assay for identifying inhibitors of the rna dependent rna polymerase (ns5b) of hcv |
EP1256628A3 (de) | 2001-05-10 | 2003-03-19 | Agouron Pharmaceuticals, Inc. | Hepatitis C Virus (HCV) NS5B RNA Polymerase und davon abgeleitete Mutanten |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
JP2003212846A (ja) * | 2001-06-26 | 2003-07-30 | Japan Tobacco Inc | 縮合環化合物及びc型肝炎治療剤 |
EP1411928A1 (de) | 2001-07-20 | 2004-04-28 | Boehringer Ingelheim (Canada) Ltd. | Virale polymerase inhibitoren |
EP2335700A1 (de) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur |
US7294457B2 (en) | 2001-08-07 | 2007-11-13 | Boehringer Ingelheim (Canada) Ltd. | Direct binding assay for identifying inhibitors of HCV polymerase |
WO2003018555A1 (en) | 2001-08-22 | 2003-03-06 | Ciba Speciality Chemicals Holding Inc. | Process for the preparation of indole derivatives |
WO2003026587A2 (en) | 2001-09-26 | 2003-04-03 | Bristol-Myers Squibb Company | Compounds useful for treating hepatitus c virus |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
US7286844B1 (en) * | 2003-01-31 | 2007-10-23 | Bbn Technologies Corp. | Systems and methods for three dimensional antenna selection and power control in an Ad-Hoc wireless network |
GB0307891D0 (en) | 2003-04-04 | 2003-05-14 | Angeletti P Ist Richerche Bio | Chemical compounds,compositions and uses |
TW200517381A (en) | 2003-08-01 | 2005-06-01 | Genelabs Tech Inc | Bicyclic heteroaryl derivatives |
WO2005014543A1 (ja) | 2003-08-06 | 2005-02-17 | Japan Tobacco Inc. | 縮合環化合物及びそのhcvポリメラーゼ阻害剤としての利用 |
US7136667B2 (en) * | 2003-10-28 | 2006-11-14 | Nokia Corporation | Method and radio terminal equipment arrangement for power control, radio terminal equipment and secondary terminal unit |
US7212122B2 (en) * | 2003-12-30 | 2007-05-01 | G2 Microsystems Pty. Ltd. | Methods and apparatus of meshing and hierarchy establishment for tracking devices |
CN1922174A (zh) * | 2004-02-20 | 2007-02-28 | 贝林格尔·英格海姆国际有限公司 | 病毒聚合酶抑制剂 |
BRPI0508505A (pt) | 2004-03-08 | 2007-07-31 | Boehringer Ingelheim Pharma | processo para acoplamento cruzado de indóis |
US7126009B2 (en) | 2004-03-16 | 2006-10-24 | Boehringer Ingelheim International, Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
US7348875B2 (en) * | 2004-05-04 | 2008-03-25 | Battelle Memorial Institute | Semi-passive radio frequency identification (RFID) tag with active beacon |
PE20060569A1 (es) | 2004-07-16 | 2006-06-22 | Boehringer Ingelheim Int | Compuestos de indol carbonilamino como inhibidores de la polimerasa ne5b del vhc |
US7319397B2 (en) * | 2004-08-26 | 2008-01-15 | Avante International Technology, Inc. | RFID device for object monitoring, locating, and tracking |
US7342497B2 (en) * | 2004-08-26 | 2008-03-11 | Avante International Technology, Inc | Object monitoring, locating, and tracking system employing RFID devices |
EP2530082A1 (de) | 2005-02-11 | 2012-12-05 | Boehringer Ingelheim International GmbH | Verfahren zur Herstellung 2,3-disubstituierter Indole |
-
2002
- 2002-02-18 EP EP10185316A patent/EP2335700A1/de not_active Withdrawn
- 2002-07-18 RS RSP-2009/0517A patent/RS20090517A/sr unknown
- 2002-07-18 KR KR1020047001061A patent/KR100949446B1/ko not_active IP Right Cessation
- 2002-07-18 CA CA002450033A patent/CA2450033C/en not_active Expired - Fee Related
- 2002-07-18 EP EP07117984A patent/EP1891951A1/de not_active Withdrawn
- 2002-07-18 NZ NZ531267A patent/NZ531267A/en not_active IP Right Cessation
- 2002-07-18 SI SI200230674T patent/SI1414797T1/sl unknown
- 2002-07-18 IL IL15964902A patent/IL159649A0/xx not_active IP Right Cessation
- 2002-07-18 WO PCT/CA2002/001128 patent/WO2003010141A2/en active Application Filing
- 2002-07-18 DE DE60224401T patent/DE60224401T2/de not_active Expired - Lifetime
- 2002-07-18 AT AT02750715T patent/ATE382348T1/de active
- 2002-07-18 US US10/198,384 patent/US7141574B2/en not_active Expired - Lifetime
- 2002-07-18 ES ES02752904T patent/ES2299591T3/es not_active Expired - Lifetime
- 2002-07-18 DK DK02750715T patent/DK1414441T3/da active
- 2002-07-18 BR BR0211360-0A patent/BR0211360A/pt not_active IP Right Cessation
- 2002-07-18 HU HU0402065A patent/HUP0402065A3/hu unknown
- 2002-07-18 IL IL15954502A patent/IL159545A0/xx unknown
- 2002-07-18 PT PT02752904T patent/PT1414797E/pt unknown
- 2002-07-18 ME MEP-596/08A patent/MEP59608A/xx unknown
- 2002-07-18 CN CNB028187970A patent/CN100443469C/zh not_active Expired - Fee Related
- 2002-07-18 NZ NZ531229A patent/NZ531229A/xx not_active IP Right Cessation
- 2002-07-18 RS YUP-70/04A patent/RS50843B/sr unknown
- 2002-07-18 UA UA2004021313A patent/UA84256C2/ru unknown
- 2002-07-18 AT AT02752904T patent/ATE382605T1/de active
- 2002-07-18 ME MEP-621/08A patent/MEP62108A/xx unknown
- 2002-07-18 SI SI200230673T patent/SI1414441T1/sl unknown
- 2002-07-18 EP EP02750715A patent/EP1414441B1/de not_active Expired - Lifetime
- 2002-07-18 MX MXPA04000731A patent/MXPA04000731A/es active IP Right Grant
- 2002-07-18 DE DE60224400T patent/DE60224400T2/de not_active Expired - Lifetime
- 2002-07-18 SG SG2006005433A patent/SG176999A1/en unknown
- 2002-07-18 EP EP07117946A patent/EP1891950A1/de not_active Withdrawn
- 2002-07-18 EP EP02752904A patent/EP1414797B9/de not_active Expired - Lifetime
- 2002-07-18 ES ES02750715T patent/ES2299588T3/es not_active Expired - Lifetime
- 2002-07-18 HU HU0401784A patent/HUP0401784A3/hu unknown
- 2002-07-18 AU AU2002355150A patent/AU2002355150B2/en not_active Ceased
- 2002-07-18 EA EA200400114A patent/EA007722B1/ru not_active IP Right Cessation
- 2002-07-18 CA CA2449180A patent/CA2449180C/en not_active Expired - Fee Related
- 2002-07-18 PL PL02368357A patent/PL368357A1/xx not_active Application Discontinuation
- 2002-07-18 KR KR1020097024619A patent/KR101031183B1/ko not_active IP Right Cessation
- 2002-07-18 BR BR0211477-1A patent/BR0211477A/pt not_active IP Right Cessation
- 2002-07-18 US US10/198,680 patent/US7157486B2/en not_active Expired - Lifetime
- 2002-07-18 CN CN2011103245986A patent/CN102424680A/zh active Pending
- 2002-07-18 CN CN028187903A patent/CN1558759B/zh not_active Expired - Fee Related
- 2002-07-18 MX MXPA04000729A patent/MXPA04000729A/es active IP Right Grant
- 2002-07-18 PT PT02750715T patent/PT1414441E/pt unknown
- 2002-07-18 RS YUP-69/04A patent/RS51083B/sr unknown
- 2002-07-18 JP JP2003515500A patent/JP4398725B2/ja not_active Expired - Fee Related
- 2002-07-18 EA EA200400113A patent/EA007715B1/ru not_active IP Right Cessation
- 2002-07-18 AU AU2002313410A patent/AU2002313410B2/en not_active Ceased
- 2002-07-18 PL PL02372125A patent/PL372125A1/xx unknown
- 2002-07-18 JP JP2003515499A patent/JP4398241B2/ja not_active Expired - Fee Related
- 2002-07-18 DK DK02752904T patent/DK1414797T3/da active
- 2002-07-18 KR KR1020047001069A patent/KR100950868B1/ko not_active IP Right Cessation
- 2002-07-18 WO PCT/CA2002/001127 patent/WO2003010140A2/en active Application Filing
- 2002-07-23 MY MYPI20022780 patent/MY151080A/en unknown
- 2002-07-25 PE PE2002000663A patent/PE20030305A1/es not_active Application Discontinuation
- 2002-07-25 UY UY27397A patent/UY27397A1/es not_active Application Discontinuation
- 2002-07-25 AR ARP020102801A patent/AR037495A1/es not_active Application Discontinuation
-
2003
- 2003-12-24 IL IL159545A patent/IL159545A/en not_active IP Right Cessation
-
2004
- 2004-01-21 NO NO20040282A patent/NO327055B1/no not_active IP Right Cessation
- 2004-01-23 CO CO04005122A patent/CO5650161A2/es not_active Application Discontinuation
- 2004-01-23 NO NO20040322A patent/NO333121B1/no not_active IP Right Cessation
- 2004-01-23 HR HR20040073A patent/HRP20040073B1/xx not_active IP Right Cessation
- 2004-01-23 HR HR20040072A patent/HRP20040072B1/xx not_active IP Right Cessation
- 2004-01-27 CO CO04005915A patent/CO5650162A2/es active IP Right Grant
-
2005
- 2005-04-01 HK HK05102727.1A patent/HK1069991A1/xx not_active IP Right Cessation
- 2005-07-27 HK HK05106432.8A patent/HK1073786A1/xx not_active IP Right Cessation
-
2006
- 2006-01-17 US US11/333,163 patent/US7576079B2/en not_active Expired - Lifetime
- 2006-08-15 US US11/464,651 patent/US7803944B2/en not_active Expired - Lifetime
-
2008
- 2008-03-21 CY CY20081100331T patent/CY1107354T1/el unknown
- 2008-03-21 CY CY20081100332T patent/CY1107355T1/el unknown
- 2008-11-26 US US12/323,961 patent/US7893084B2/en not_active Expired - Lifetime
-
2009
- 2009-03-02 JP JP2009048600A patent/JP2009120616A/ja not_active Withdrawn
- 2009-04-06 JP JP2009092397A patent/JP2009275037A/ja not_active Withdrawn
- 2009-08-21 AR ARP090103220A patent/AR073106A2/es unknown
- 2009-12-14 HR HR20090668A patent/HRP20090668A2/hr not_active Application Discontinuation
-
2012
- 2012-10-30 IL IL222761A patent/IL222761A0/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60224400D1 (de) | Hepatitis c virus polymerase inhibitoren mit heterobicylische struktur | |
EA200602170A1 (ru) | Производные пиперидина, композиции на их основе, способы их применения | |
IL159981A0 (en) | Direct binding assay for identifying inhibitors of hcv polymerase | |
EA200501065A1 (ru) | Ингибиторы вирусной полимеразы | |
CY1117299T1 (el) | Ανθρανιλαμιδια, μεθοδος για την παρασκευη αυτων και παραγοντες ελεγχου επιβλαβων εντομων που τα περιεχουν | |
EA200601457A1 (ru) | Ингибиторы вирусной полимеразы | |
DE602005027213D1 (de) | Neue imidazolidinderivate | |
DK1414302T3 (da) | 7-aminotriazolopyrimidiner til bekæmpelse af skadelige svampe | |
NO20034595L (no) | Kinolin- og kinazolinderivater med azolylgruppe | |
CY1109183T1 (el) | Συντηγμενες ετεροκυκλικες ενωσεις και χρηση αυτων ως αναστολεας hcv πολυμερασης | |
FI923264A0 (fi) | Nya herbicider. | |
CO5680413A2 (es) | Aminoacidos con afinidad por la proteina c2 delta | |
DK1706414T3 (da) | Fremgangsmåde til fluorcytidinderivater | |
DK0641770T3 (da) | Hidtil ukendte forbindelser med blodpladeaggegationsinhiberende aktivitet | |
NO20025053L (no) | Benzo[b]tiofen-derivat og fremgangsmÕte for fremstilling derav | |
EA200601110A1 (ru) | Производные спиропиперидина, предназначенные для борьбы с вредителями | |
UA85366C2 (en) | Viral polymerase inhibitors | |
ATE450519T1 (de) | 1,2,4-thiadiazolverbindungen und diese enthaltende zusammensetzung zur bekämpfung von arthropoden | |
DE60330038D1 (de) | Neue alpha-ketoamidderivate und deren verwendung | |
TH102901B (th) | ตัวยับยั้งพอลิเมอเรสจากไวรัส | |
TH102901A (th) | ตัวยับยั้งพอลิเมอเรสจากไวรัส | |
ECSP044959A (es) | Inhibidores de polimerasas víricas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |