DE60228592D1 - Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheiten - Google Patents

Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheiten

Info

Publication number
DE60228592D1
DE60228592D1 DE60228592T DE60228592T DE60228592D1 DE 60228592 D1 DE60228592 D1 DE 60228592D1 DE 60228592 T DE60228592 T DE 60228592T DE 60228592 T DE60228592 T DE 60228592T DE 60228592 D1 DE60228592 D1 DE 60228592D1
Authority
DE
Germany
Prior art keywords
expression profile
sample
patients
inflammatory diseases
gene expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228592T
Other languages
English (en)
Inventor
Hakon Hakonarson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Decode Genetics ehf
Original Assignee
Decode Genetics ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decode Genetics ehf filed Critical Decode Genetics ehf
Application granted granted Critical
Publication of DE60228592D1 publication Critical patent/DE60228592D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
DE60228592T 2001-09-06 2002-09-02 Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheiten Expired - Lifetime DE60228592D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/947,991 US7384736B2 (en) 2001-09-06 2001-09-06 Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
PCT/IB2002/003613 WO2003021261A2 (en) 2001-09-06 2002-09-02 Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease

Publications (1)

Publication Number Publication Date
DE60228592D1 true DE60228592D1 (de) 2008-10-09

Family

ID=25487094

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228592T Expired - Lifetime DE60228592D1 (de) 2001-09-06 2002-09-02 Verfahren zur erkennung von medikamentenempfindlichkeit in patienten mit entzündungskrankheiten

Country Status (9)

Country Link
US (3) US7384736B2 (de)
EP (1) EP1428023B1 (de)
JP (1) JP2005502345A (de)
AT (1) ATE406575T1 (de)
AU (1) AU2002328110B2 (de)
CA (1) CA2457476A1 (de)
DE (1) DE60228592D1 (de)
DK (1) DK1428023T3 (de)
WO (1) WO2003021261A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1233651A1 (de) * 2000-04-07 2002-08-21 Ibiden Co., Ltd. Keramisches heizelement
US7198895B2 (en) * 2000-11-14 2007-04-03 Mohanlal Ramon W In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals
US6893828B2 (en) * 2001-09-06 2005-05-17 Decode Genetics Ehf. Methods for producing ex vivo models for inflammatory disease and uses thereof
US7384736B2 (en) 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
KR20040064275A (ko) * 2001-11-09 2004-07-16 소스 프리시전 메디슨, 인코포레이티드 유전자 발현 프로파일을 이용한 질병의 동정, 모니터링,치료 및 생물학적 상태의 확인
ATE554790T1 (de) * 2001-12-07 2012-05-15 Univ Wyoming Verfahren und zusammensetzungen zur diagnose von asthma
US7774143B2 (en) * 2002-04-25 2010-08-10 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states
US7655397B2 (en) * 2002-04-25 2010-02-02 The United States Of America As Represented By The Department Of Health And Human Services Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers
AU2003291482A1 (en) * 2002-11-12 2004-06-03 Becton, Dickinson And Company Diagnosis of sepsis or sirs using biomarker profiles
AU2003900639A0 (en) * 2003-02-12 2003-02-27 G2 Therapies Ltd Novel method of treating inflammatory diseases
AU2003304165A1 (en) * 2003-05-30 2005-01-21 Reinhard Guthke Method for assessing the response behavior of an individual to antirheumatics
CA2527323A1 (en) * 2003-06-09 2004-12-16 Decode Genetics Ehf. Methods for predicting drug efficacy in patients afflicted with hypertension
EP1689427A1 (de) * 2003-11-25 2006-08-16 Novartis AG Biomarker für die wirksamkeit von calcitonin und parathormon-behanldung
DE602006005333D1 (de) * 2006-03-06 2009-04-09 Gen Electric Automatische Kalibrierung der Sensibilität einer Person gegenüber einem Arzneimittel
WO2008120659A1 (ja) * 2007-03-30 2008-10-09 Oji Paper Co., Ltd. 遺伝子発現情報を用いた植物の形質を判定もしくは予測する方法
AU2008298612A1 (en) 2007-09-14 2009-03-19 University Of South Florida Gene signature for the prediction of radiation therapy response
WO2009078793A1 (en) 2007-12-14 2009-06-25 Index Pharmaceuticals Ab Method for predicting the response to a therapy
US8577620B2 (en) * 2008-03-27 2013-11-05 Gus J. Slotman Methods for assessing drug efficacy and response of patient to therapy
EP2271770B1 (de) * 2008-03-31 2018-08-22 Genentech, Inc. Zusammensetzungen und verfahren zur behandlung und diagnose von asthma
AU2011343570B2 (en) 2010-12-16 2016-11-03 Genentech, Inc. Diagnosis and treatments relating to TH2 inhibition
WO2014066894A1 (en) * 2012-10-26 2014-05-01 Case Western Reserve University Biomarkers for nod2 and/or rip2 activity related application
CN105308460A (zh) * 2013-05-02 2016-02-03 天主教大学基金会 个性化药物
CL2015001420A1 (es) * 2015-05-26 2015-10-02 Univ Chile Método ex vivo y kit predictor de respuesta a tratamiento con glucocorticoides (gc) en pacientes portadores de enfermedades inflamatorias, basado en la cuantificación de la razón de cambio de los niveles de las isoformas del receptor de gc.
WO2019046233A1 (en) * 2017-08-30 2019-03-07 Bristol-Myers Squibb Company METHOD FOR MONITORING PHARMACODYNAMIC RESPONSES MEDIATED BY IN VIVO DELIVERY OF GLUCOCORTICOIDS
CN108830040B (zh) * 2018-06-07 2021-06-15 中南大学 一种基于细胞系和药物相似性网络的药物敏感性预测方法
WO2022098882A1 (en) * 2020-11-04 2022-05-12 Massachusetts Institute Of Technology Methods for identifying drivers of immune responses using molecular expression signatures of immunomodulating agents
US20220293264A1 (en) * 2021-03-12 2022-09-15 PulManage, Inc. Spirometry data systems, methods, and apparatuses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6801859B1 (en) 1998-12-23 2004-10-05 Rosetta Inpharmatics Llc Methods of characterizing drug activities using consensus profiles
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US7198895B2 (en) * 2000-11-14 2007-04-03 Mohanlal Ramon W In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals
WO2002059367A2 (en) * 2000-11-30 2002-08-01 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Diagnostic microarray for inflammatory bowel disease, crohn's disease and ulcerative colitis
WO2002048310A2 (en) * 2000-12-15 2002-06-20 Genetics Institute, Llc Methods and compositions for diagnosing and treating rheumatoid arthritis
EP1349546A2 (de) * 2000-12-20 2003-10-08 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Dissoziierte glucocorticoid-rezeptorantagonisten zur behandlung von nebenwirkungen von glucocorticoiden
US6893828B2 (en) * 2001-09-06 2005-05-17 Decode Genetics Ehf. Methods for producing ex vivo models for inflammatory disease and uses thereof
US7384736B2 (en) 2001-09-06 2008-06-10 Decode Genetics Ehf. Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US20040116462A1 (en) 2002-12-12 2004-06-17 Mitsunori Ono Indolizine compounds
CA2527323A1 (en) * 2003-06-09 2004-12-16 Decode Genetics Ehf. Methods for predicting drug efficacy in patients afflicted with hypertension

Also Published As

Publication number Publication date
AU2002328110B2 (en) 2007-01-25
WO2003021261A2 (en) 2003-03-13
WO2003021261A3 (en) 2003-11-20
US20070054309A1 (en) 2007-03-08
US7148008B2 (en) 2006-12-12
EP1428023B1 (de) 2008-08-27
DK1428023T3 (da) 2009-01-19
ATE406575T1 (de) 2008-09-15
JP2005502345A (ja) 2005-01-27
US7384736B2 (en) 2008-06-10
CA2457476A1 (en) 2003-03-13
US20030134776A1 (en) 2003-07-17
EP1428023A2 (de) 2004-06-16
US20030113831A1 (en) 2003-06-19

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