DE60228997D1 - Zusammensetzungen und verfahren zur diagnose und behandlung eines tumors - Google Patents

Zusammensetzungen und verfahren zur diagnose und behandlung eines tumors

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Publication number
DE60228997D1
DE60228997D1 DE60228997T DE60228997T DE60228997D1 DE 60228997 D1 DE60228997 D1 DE 60228997D1 DE 60228997 T DE60228997 T DE 60228997T DE 60228997 T DE60228997 T DE 60228997T DE 60228997 D1 DE60228997 D1 DE 60228997D1
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Germany
Prior art keywords
polypeptides
present
methods
tumor
diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228997T
Other languages
English (en)
Inventor
Austin L Gurney
Mickey P Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
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Filing date
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21841414&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60228997(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/028,072 external-priority patent/US20030004311A1/en
Priority claimed from US10/119,480 external-priority patent/US20040087769A1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Priority claimed from PCT/US2002/033050 external-priority patent/WO2003053334A2/en
Application granted granted Critical
Publication of DE60228997D1 publication Critical patent/DE60228997D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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Families Citing this family (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300487B1 (en) * 1996-03-19 2001-10-09 Cell Therapuetics, Inc. Mammalian lysophosphatidic acid acyltransferase
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20060122373A1 (en) * 1997-04-04 2006-06-08 Millennium Pharmaceuticals, Inc. Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
US7198917B2 (en) 1997-11-21 2007-04-03 Genentech, Inc. Compounds, compositions and methods for the treatment of diseases characterized by A-33 related antigens
AU764441B2 (en) * 1998-02-09 2003-08-21 Genset S.A. cDNAs encoding secreted proteins
US20030175778A1 (en) * 1998-06-05 2003-09-18 Jian Ni Interferon Receptor HKAEF92
US20030211578A1 (en) * 1998-06-05 2003-11-13 Jian Ni Interferon receptor HKAEF92
US6699688B1 (en) * 1998-09-16 2004-03-02 The Research Foundation Of The State University Of New York Human platelet F11 receptor
EP1117773A4 (de) * 1998-09-30 2005-11-16 Millennium Pharm Inc Sekretierte Proteine und dafür kodierende Nukleinsäuren
US7393823B1 (en) 1999-01-20 2008-07-01 Oregon Health And Science University HER-2 binding antagonists
US7625859B1 (en) * 2000-02-16 2009-12-01 Oregon Health & Science University HER-2 binding antagonists
US7396810B1 (en) 2000-08-14 2008-07-08 Oregon Health Sciences University Compositions and methods for treating cancer by modulating HER-2 and EGF receptors
US7144996B1 (en) * 1999-03-05 2006-12-05 Genentech, Inc. Nucleic acid encoding human suppressor of fused
EP1171597A2 (de) * 1999-04-12 2002-01-16 Agensys, Inc. In prostatakarzinom exprimiertes prostata-begrenztes gen 30p3c8
US6468543B1 (en) 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
US6630142B2 (en) 1999-05-03 2003-10-07 Zymogenetics, Inc. Method of treating fibroproliferative disorders
AUPQ206399A0 (en) * 1999-08-06 1999-08-26 Imr Worldwide Pty Ltd. Network user measurement system and method
US6602501B1 (en) 1999-08-12 2003-08-05 Agensys, Inc. C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
US7842458B2 (en) * 1999-08-12 2010-11-30 Agensys, Inc. Nucleic acids and corresponding proteins entitled 58P1D12 useful in treatment and detection of cancer
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
ATE478952T1 (de) * 1999-10-28 2010-09-15 Agensys Inc 36p6d5: ausgeschiedenes tumorprotein
US6639041B2 (en) * 1999-12-03 2003-10-28 Dupont-Toray Co. Ltd. Spandex having low set at low temperatures
US20010044525A1 (en) * 2000-01-05 2001-11-22 Conklin Darrell C. Novel FGF Homolog zFGF12
US20060160181A1 (en) * 2000-02-15 2006-07-20 Amgen Inc. Fibroblast Growth Factor-23 molecules and uses thereof
WO2001083775A2 (en) * 2000-05-04 2001-11-08 Incyte Genomics, Inc. Proteases
US20040081961A1 (en) * 2001-05-04 2004-04-29 Delegeane Angelo M Proteases
US7329729B1 (en) * 2000-06-21 2008-02-12 Amgen Inc. Secreted epithelial colon stromal-1 molecules and uses thereof
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US8044259B2 (en) 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
EP1191097A1 (de) * 2000-09-21 2002-03-27 Leids Universitair Medisch Centrum Induktion von "exon-skipping" in eukaryotischen Zellen
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US7927597B2 (en) * 2001-04-10 2011-04-19 Agensys, Inc. Methods to inhibit cell growth
WO2002083921A2 (en) * 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
US7163691B2 (en) 2001-10-12 2007-01-16 Osteotech, Inc. Bone graft
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
JP2005506073A (ja) * 2001-10-19 2005-03-03 ザイモジェネティクス，インコーポレイティド 二量体化された成長因子及びそれを生成するための材料及び方法
US6935922B2 (en) 2002-02-04 2005-08-30 Kla-Tencor Technologies Corp. Methods and systems for generating a two-dimensional map of a characteristic at relative or absolute locations of measurement spots on a specimen during polishing
CA2475177A1 (en) * 2002-02-11 2003-08-21 Zymogenetics, Inc. Materials and methods for preparing dimeric growth factors
US6993539B2 (en) 2002-03-19 2006-01-31 Network Appliance, Inc. System and method for determining changes in two snapshots and for transmitting changes to destination snapshot
AU2003280992A1 (en) 2002-07-10 2004-02-02 Takeda Pharmaceutical Company Limited Novel proteins and use thereof
US7126148B2 (en) * 2002-07-17 2006-10-24 The Johns Hopkins University Neutron detection based on boron activated liquid scintillation
DE10232329A1 (de) * 2002-07-17 2004-02-05 Daimlerchrysler Ag Kraftwagenkarosserie mit einer Strebenanordnung
EP1585482A4 (de) * 2002-09-25 2009-09-09 Genentech Inc Neue zusammensetzungen und verfahren zur behandlung von psoriasis
US6890175B2 (en) * 2002-12-18 2005-05-10 Ultradent Products, Inc. Cooling system for hand-held curing light
JP2004267015A (ja) * 2003-03-05 2004-09-30 National Institute Of Advanced Industrial & Technology 核酸及び該核酸を用いた癌化検定方法
EP2248899B8 (de) * 2003-03-19 2015-07-15 Biogen MA Inc. NOGO Rezeptor bindendes Protein
CA2524255C (en) 2003-03-21 2014-02-11 Academisch Ziekenhuis Leiden Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
NZ544050A (en) * 2003-06-11 2009-03-31 Osteotech Inc Osteoimplants and methods for their manufacture
JP4054727B2 (ja) * 2003-07-14 2008-03-05 株式会社リコー 出力バッファ回路及び出力バッファ回路を使用したインタフェース回路
US20070178458A1 (en) * 2003-09-05 2007-08-02 O'brien Philippa Methods of diagnosis and prognosis of ovarian cancer II
EP1560025A3 (de) * 2003-10-03 2011-09-07 F. Hoffmann-La Roche AG Marker spezifisch für Diabetes
ZA200604365B (en) * 2003-11-20 2008-01-30 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
AU2004315198A1 (en) * 2004-01-29 2005-08-18 Genentech, Inc. Variants of the extracellular domain of BCMA and uses thereof
US20070248579A1 (en) * 2004-02-20 2007-10-25 Develogen Akteiengesellschaft Use of Secreted Protein Products for Preventing and Treating Pancreatic Diseases and/or Obesity and/or Metabolic Syndrome
DE102004010203B4 (de) * 2004-03-02 2007-05-10 Siemens Ag Verfahren, Vorrichtung und Computerprogramm zur Erstellung einer Projektierung für ein Bediengerät einer Automatisierungskomponente
WO2005089799A1 (ja) * 2004-03-24 2005-09-29 Oncotherapy Science, Inc. Fam3dに対する抗体のエフェクター機能による細胞障害方法
US20050214303A1 (en) * 2004-03-24 2005-09-29 Oncotherapy Science, Inc. Methods for damaging cells using effector functions of anti FAM3D antibodies
US7659915B2 (en) * 2004-04-02 2010-02-09 K-Nfb Reading Technology, Inc. Portable reading device with mode processing
NZ550110A (en) 2004-04-14 2009-09-25 Genentech Inc Compositions and methods comprising an EGFL7 antagonist for modulating vascular development
JP2007535959A (ja) * 2004-05-10 2007-12-13 エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー アルツハイマー病のためのｋｃｎｊ６の診断および治療使用
US20080038255A1 (en) * 2004-06-04 2008-02-14 Aplied Research Systems Ars Holding N.V. Splice Variant of Unc5h2
AU2005258335B2 (en) 2004-06-24 2011-03-17 Biogen Ma Inc. Treatment of conditions involving demyelination
WO2006005459A2 (en) * 2004-07-15 2006-01-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with thyrotropin-releasing hormone degrading ectoenzyme (trhde)
CN101044164A (zh) * 2004-07-20 2007-09-26 健泰科生物技术公司 血管生成素样4蛋白抑制剂，组合，以及其用途
KR20070061524A (ko) * 2004-07-20 2007-06-13 제넨테크, 인크. 안지오포이에틴-유사 4 단백질을 사용하는 조성물 및 방법
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
WO2006014013A1 (ja) * 2004-08-04 2006-02-09 Riken 骨・関節疾患感受性遺伝子およびその用途
JP2008509700A (ja) * 2004-08-16 2008-04-03 アジェンシス， インコーポレイテッド 癌の処置および検出において有用な５８ｐ１ｄ１２と称される核酸および対応するタンパク質
CA2583230A1 (en) * 2004-10-05 2006-04-20 Oregon Health And Science University Compositions and methods for treating disease
US7938307B2 (en) * 2004-10-18 2011-05-10 Tyco Healthcare Group Lp Support structures and methods of using the same
US20060155862A1 (en) * 2005-01-06 2006-07-13 Hari Kathi Data traffic load balancing based on application layer messages
CA2594733A1 (en) * 2005-01-14 2006-07-20 Osteotech, Inc. Expandable osteoimplant
US20080193446A1 (en) * 2005-01-27 2008-08-14 Phillips Heidi S Compositions and Methods for the Diagnosis and Treatment of Tumor
EP3925997A3 (de) 2005-04-22 2022-04-20 Mitsubishi Chemical Corporation Aus einer biomassenressource gewonnenes polyester und herstellungsverfahren dafür
WO2006115295A1 (en) * 2005-04-25 2006-11-02 University Of Yamanashi Compositions and methods for treating hemostasis disorders associated with clec-2 signal transduction
MX2008000253A (es) 2005-07-08 2008-04-02 Biogen Idec Inc Anticuerpos de sp35 y usos de los mismos.
WO2007021423A2 (en) * 2005-08-15 2007-02-22 Genentech, Inc. Gene disruptions, compositions and methods relating thereto
EP2287615A1 (de) * 2005-08-16 2011-02-23 Genentech, Inc. APO2L/TRAIL Apoptose Resistenz Prüfung mittels GALNAC-T14 Gewebeexpression
JP2007063225A (ja) 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
US7722889B2 (en) 2005-09-30 2010-05-25 Seattle Biomedical Research Institute Plasmodium liver stage antigens
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
EP1961065A4 (de) 2005-10-31 2009-11-11 Oncomed Pharm Inc Zusammensetzungen und verfahren zur diagnostizierung und behandlung von krebs
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US7293487B2 (en) * 2005-11-15 2007-11-13 3M Innovative Properties Company Cutting tool having variable and independent movement in an x-direction and a z-direction into and laterally along a work piece for making microstructures
US20070197532A1 (en) * 2005-11-18 2007-08-23 Cao Sheldon X Glucokinase activators
WO2007084487A2 (en) * 2006-01-13 2007-07-26 Wayne State University Pericytes for use as stem cells
EP2001875A2 (de) 2006-03-08 2008-12-17 Takeda San Diego, Inc. Glucokinase-aktivatoren
WO2007123391A1 (en) * 2006-04-20 2007-11-01 Academisch Ziekenhuis Leiden Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene.
EP1857548A1 (de) * 2006-05-19 2007-11-21 Academisch Ziekenhuis Leiden Mittel und Verfahren zur Induktion von Exon-skipping
US8008332B2 (en) 2006-05-31 2011-08-30 Takeda San Diego, Inc. Substituted indazoles as glucokinase activators
EP2049664B1 (de) 2006-08-11 2011-09-14 Prosensa Technologies B.V. Einzelsträngige Oligonukleotide, welche komplementär zu repetitiven Elementen sind, zur Behandlung von DNS-Wiederholungen-Instabilitäts-assoziierten Erkrankungen
EP3357932A1 (de) * 2006-09-29 2018-08-08 OncoMed Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur diagnose und behandlung von krebs
US7875747B2 (en) * 2006-10-10 2011-01-25 Afton Chemical Corporation Branched succinimide dispersant compounds and methods of making the compounds
JP2010507340A (ja) * 2006-10-20 2010-03-04 シュレイダー エレクトロニクス リミテッド Ｒｆデータリンクにおけるデータエラー検出及び修正方法
WO2008127352A2 (en) * 2006-11-14 2008-10-23 Genentech, Inc. Knockout mice for pr01105, pro1279 or pro1783 coding genes
EP2091947A2 (de) 2006-12-20 2009-08-26 Takeda San Diego, Inc. Glucokinaseaktivatoren
US7980000B2 (en) 2006-12-29 2011-07-19 Applied Materials, Inc. Vapor dryer having hydrophilic end effector
US8128926B2 (en) 2007-01-09 2012-03-06 Biogen Idec Ma Inc. Sp35 antibodies and uses thereof
EP2106439B1 (de) 2007-01-24 2014-11-12 The Regents of the University of Michigan Zusammensetzungen und verfahren zur behandlung und diagnostizierung von pankreaskrebs
EP1961849A1 (de) * 2007-02-22 2008-08-27 ALBIS Spa Vorverfestigte Spinnvliesbahn, Verbundvlies mit vorverfestigter Spinnvliesbahn, Verfahren und kontinuierliches System zur Herstellung dieses Verbundstoffes
GB0704396D0 (en) * 2007-03-07 2007-04-11 Royal Bank Of Scotland Plc The Cash dispensing methods and systems
US8173645B2 (en) 2007-03-21 2012-05-08 Takeda San Diego, Inc. Glucokinase activators
US20080240081A1 (en) * 2007-03-30 2008-10-02 Texas Instruments Incorporated Method, system and apparatus for providing rules-based restriction of incoming calls
US7705085B2 (en) * 2007-04-06 2010-04-27 3M Innovative Properties Company Fluoroelastomer composition for cold shrink articles
WO2009008725A2 (en) * 2007-07-12 2009-01-15 Prosensa Technologies B.V. Molecules for targeting compounds to various selected organs, tissues or tumor cells
JP5706157B2 (ja) * 2007-07-12 2015-04-22 プロセンサ テクノロジーズ ビー．ブイ．Ｐｒｏｓｅｎｓａ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． 化合物を種々の選択臓器又は組織に標的化するための分子
US8103302B2 (en) * 2007-09-11 2012-01-24 Telefonaktiebolaget Lm Ericsson (Publ) Power-aware link adaptation with variable bandwidth allocation
US8691222B2 (en) * 2007-10-02 2014-04-08 Genentech, Inc. NLRR-1 antagonists and uses thereof
US20110020786A1 (en) * 2007-10-08 2011-01-27 Baylor College Of Medicine Peptide dendrimers: affinity reagents for binding noroviruses
CA2701189C (en) * 2007-10-11 2017-05-16 Biogen Idec Ma Inc. Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell survival via administration of lingo-1 antagonists and trkb agonists
JP5600064B2 (ja) 2007-10-26 2014-10-01 アカデミシュ ジーケンハウス ライデン 筋障害を相殺するための手段と方法
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
EP2217697B1 (de) * 2007-11-08 2015-06-10 Biogen MA Inc. Verwendung von lingo-4-antagonisten bei der behandlung von leiden mit demyelinierung
AU2009210872A1 (en) * 2008-02-08 2009-08-13 Prosensa Holding Bv Methods and means for treating DNA repeat instability associated genetic disorders
EP2119783A1 (de) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Verfahren für effizientes Exon (44)-Skipping bei Duchenne-Muskeldystrophie und entsprechende Mittel
DK2982695T3 (da) * 2008-07-09 2019-05-13 Biogen Ma Inc Sammensætninger, der omfatter antistoffer mod lingo eller fragmenter deraf
US20100047166A1 (en) * 2008-08-20 2010-02-25 Kanner Steven B Antibodies and related molecules that bind to 58p1d12 proteins
WO2010026473A2 (en) * 2008-09-04 2010-03-11 Oxford Biotherapeutics Ltd. Pta072 protein
CA2738485A1 (en) 2008-09-26 2010-04-01 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
US8551789B2 (en) 2010-04-01 2013-10-08 OncoMed Pharmaceuticals Frizzled-binding agents and their use in screening for WNT inhibitors
JP2012506733A (ja) 2008-10-24 2012-03-22 ウォーソー・オーソペディック・インコーポレーテッド 骨形成を促進するための組成物および方法
JP2010225758A (ja) * 2009-03-23 2010-10-07 Fuji Xerox Co Ltd 有機半導体トランジスタ
CA2759899A1 (en) 2009-04-24 2010-10-28 Prosensa Technologies B.V. Oligonucleotide comprising an inosine for treating dmd
US8404811B2 (en) 2009-05-08 2013-03-26 Genentech, Inc. Humanized anti-EGFL7 antibodies and methods using same
WO2010132888A2 (en) * 2009-05-15 2010-11-18 Insight Genetics, Inc. Methods and compositions relating to fusions of alk for diagnosing and treating cancer
EP2470337B1 (de) 2009-08-28 2020-03-04 Solenis Technologies Cayman, L.P. Stabile haftstoffe aus säuredenaturiertem soja/harnstoff und herstellungsverfahren dafür
ES2567030T3 (es) 2009-09-03 2016-04-19 Cancer Research Technology Limited Inhibidores de CLEC14A
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
PT2488204E (pt) 2009-10-16 2016-06-09 Oncomed Pharm Inc Combinação terapêutica e utilização de anticorpos antagonistas de dll4 e agentes anti-hipertensivos
US20120322075A1 (en) 2009-10-26 2012-12-20 Externautics S.P.A. Lung Tumor Markers and Methods of Use Thereof
EP3345920A1 (de) 2009-10-26 2018-07-11 Externautics S.p.A. Brustkrebsmarker und verfahren zur verwendung davon
US20130022983A1 (en) 2009-10-26 2013-01-24 Externautics S.P.A. Colon and Rectal Tumor Markers and Methods of Use Thereof
US9134323B2 (en) 2009-12-01 2015-09-15 The Rockefeller University Antibody that specifically binds to an epitope in the tureet region of a human Kir channel
WO2011068840A1 (en) * 2009-12-01 2011-06-09 Oncomed Pharmaceuticals, Inc. Methods for treating cancers comprising k-ras mutations
GB0922085D0 (en) * 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
CA2785451C (en) 2009-12-24 2019-01-22 Prosensa Technologies B.V. Molecule for treating an inflammatory disorder
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
ES2537814T3 (es) * 2010-04-09 2015-06-12 Amgen Inc. Proteínas, ácidos nucleicos, y anticuerpos BTNL9 y usos de los mismos
US9139629B2 (en) 2010-06-05 2015-09-22 The Uab Research Foundation Methods for treatment of nephrotic syndrome and related conditions
US20110301103A1 (en) 2010-06-05 2011-12-08 Chugh Sumant S Methods of Treatment
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
CN102569428B (zh) * 2010-12-21 2015-06-03 上海华虹宏力半导体制造有限公司 纵向电压控制变容器及其制备方法
US8858941B2 (en) 2011-09-23 2014-10-14 Oncomed Pharmaceuticals, Inc. VEGF/DLL4 binding agents and uses thereof
WO2013059426A1 (en) * 2011-10-21 2013-04-25 The Regents Of The University Of California Human endogenous retrovirus peptides, antibodies to the peptides, and methods of use thereof
US9443007B2 (en) 2011-11-02 2016-09-13 Salesforce.Com, Inc. Tools and techniques for extracting knowledge from unstructured data retrieved from personal data sources
ITUD20110196A1 (it) * 2011-12-02 2013-06-03 Asoltech S R L Composizione a base di ubidecarenone
WO2013112053A1 (en) 2012-01-27 2013-08-01 Prosensa Technologies B.V. Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
JP2015518829A (ja) 2012-05-14 2015-07-06 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． 運動ニューロンに関する状態の処置のためのｌｉｎｇｏ−２アンタゴニスト
US20140035949A1 (en) * 2012-08-03 2014-02-06 Tempo Ai, Inc. Method and apparatus for enhancing a calendar view on a device
US9266959B2 (en) 2012-10-23 2016-02-23 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using frizzled-binding agents
JP6371294B2 (ja) 2012-10-31 2018-08-08 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｄｌｌ４アンタゴニストによる処置の方法およびモニタリング
US9359444B2 (en) 2013-02-04 2016-06-07 Oncomed Pharmaceuticals Inc. Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
JP6404313B2 (ja) 2013-03-15 2018-10-10 アムジエン・インコーポレーテツド ヘテロ二量体性二重特異性抗体
EP3733710A1 (de) 2013-09-25 2020-11-04 Amgen, Inc Heterodimeriche v-c-fc-v-c-antikörper
US10367649B2 (en) 2013-11-13 2019-07-30 Salesforce.Com, Inc. Smart scheduling and reporting for teams
AU2015323313B2 (en) 2014-09-25 2021-04-01 Amgen Inc. Protease-activatable bispecific proteins
MX2017005258A (es) 2014-10-31 2017-07-26 Oncomed Pharm Inc Terapia combinada para tratamiento de enfermedad.
MX2017009038A (es) 2015-01-08 2017-10-25 Biogen Ma Inc Antagonistas de proteina 1 de interacción con el receptor de nogo que contiene el dominio de inmunoglobulina y repeticiones ricas en leucina (lingo-1) y usos para el tratamiento de trastornos desmielinizantes.
US20190248905A1 (en) 2015-09-07 2019-08-15 Helmholtz Zentrum Muenchen-Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) Novel igfr-like receptor and uses thereof
JP6967003B2 (ja) 2015-09-23 2021-11-17 メレオ バイオファーマ ５ インコーポレイテッド がんの処置のための方法および組成物
US20180061660A1 (en) * 2016-08-26 2018-03-01 Infineon Technologies Ag Barrier Layer Formation Using Thermal Processing
US11667697B2 (en) 2016-10-19 2023-06-06 Vanderbilt University Human orthopoxvirus antibodies and methods of use therefor
CA3048224A1 (en) 2016-12-23 2018-06-28 Bluefin Biomedicine, Inc. Anti-sez6l2 antibodies and antibody drug conjugates
EP3346271A1 (de) * 2017-01-10 2018-07-11 Chang Gung Memorial Hospital, Linkou Verfahren und kits zur detektion von krebs
US11043305B1 (en) * 2018-02-02 2021-06-22 Immuneering Corporation Systems and methods for rapid gene set enrichment analysis
CN113286814A (zh) * 2018-10-31 2021-08-20 德里尼亚公司 多价调节性t细胞调节子
MX2021015045A (es) 2019-06-07 2022-03-17 Amgen Inc Construcciones de unión biespecíficas.
EP4161969A1 (de) 2020-06-04 2023-04-12 Amgen Inc. Bispezifische bindungskonstrukte
JP2023553384A (ja) 2020-12-03 2023-12-21 アムジエン・インコーポレーテツド 複数の結合ドメインを有する免疫グロブリン構築物

Family Cites Families (363)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US553637A (en) * 1896-01-28 bagnall
US2929866A (en) * 1953-10-30 1960-03-22 Westinghouse Electric Corp Television pickup tube
GB937358A (en) * 1961-11-13 1963-09-18 Marconi Wireless Telegraph Co Improvements in or relating to television scanning systems
JPS4844279B1 (de) * 1965-05-08 1973-12-24
US3515800A (en) * 1966-05-10 1970-06-02 Victor Company Of Japan Television camera for selectively picking up scenes in color or monochromatically
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US3783190A (en) * 1971-04-08 1974-01-01 Gte Sylvania Inc Aperture correction circuit for low light level television camera
JPS5110986B2 (de) * 1972-10-05 1976-04-08
GB1415827A (en) * 1973-03-31 1975-11-26 Schumacher Klimsch Co E Photomechanical reproduction
US4256833A (en) * 1979-01-08 1981-03-17 Majid Ali Enzyme immunoassay for allergic disorders
JPS57108866A (en) * 1980-12-26 1982-07-07 Fuji Xerox Co Ltd Dichromatic copying machine
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4433346A (en) * 1982-03-31 1984-02-21 Xerox Corporation Raster input scanner
US4491865A (en) * 1982-09-29 1985-01-01 Welch Allyn, Inc. Image sensor assembly
US4516153A (en) * 1983-03-30 1985-05-07 Rca Corporation Composite video signal processing apparatus providing amplitude equalization
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DE3429548A1 (de) * 1983-08-24 1985-05-15 Kabushiki Kaisha Toshiba, Kawasaki, Kanagawa Farbsteuereinheit fuer ein bilderzeugungsgeraet
KR850004274A (ko) * 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4608606A (en) * 1984-03-15 1986-08-26 Rca Corporation CCD floating-element output stages providing low reset noise with single sampling
US4658956A (en) * 1984-05-30 1987-04-21 El Planning System Ltd. Portable case for a small size audio-visual sensory apparatus
JPS612957A (ja) * 1984-06-18 1986-01-08 Toyota Motor Corp 無段変速機付き動力伝達装置の油圧制御装置
JPS6147919A (ja) * 1984-08-15 1986-03-08 Olympus Optical Co Ltd 内視鏡用撮像光学系
JPS6142513U (ja) * 1984-08-23 1986-03-19 富士写真光機株式会社 内視鏡
US4599116A (en) * 1984-11-08 1986-07-08 Parker Chemical Company Alkaline cleaning process
US4879224A (en) * 1985-01-10 1989-11-07 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides
AU584739B2 (en) * 1985-08-13 1989-06-01 British Technology Group Limited Optical fibres
JPH0522897Y2 (de) * 1985-08-16 1993-06-11
JP2679014B2 (ja) * 1986-03-19 1997-11-19 オリンパス光学工業株式会社 電子内視鏡装置
JPS6365840A (ja) * 1986-04-04 1988-03-24 オリンパス光学工業株式会社 内視鏡
US4735501A (en) * 1986-04-21 1988-04-05 Identechs Corporation Method and apparatus for fluid propelled borescopes
JPH0664243B2 (ja) * 1986-04-30 1994-08-22 オリンパス光学工業株式会社 内視鏡
DE3715417A1 (de) * 1986-05-13 1987-11-19 Olympus Optical Co Halbleiter-bilderzeugungsvorrichtung, sowie hiermit ausgestattetes endoskop
JPS635722A (ja) * 1986-06-25 1988-01-11 オリンパス光学工業株式会社 内視鏡
JP2812940B2 (ja) * 1986-09-01 1998-10-22 オリンパス光学工業株式会社 内視鏡
US4946778A (en) * 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5013652A (en) * 1986-10-14 1991-05-07 Genex Corporation Composite yeast vectors
US4733937A (en) * 1986-10-17 1988-03-29 Welch Allyn, Inc. Illuminating system for endoscope or borescope
US4758891A (en) * 1986-10-20 1988-07-19 North American Philips Consumer Electronics Corp. Method and apparatus for improving the rise and fall time of a video signal
US4895431A (en) * 1986-11-13 1990-01-23 Olympus Optical Co., Ltd. Method of processing endoscopic images
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US4727859A (en) * 1986-12-29 1988-03-01 Welch Allyn, Inc. Right angle detachable prism assembly for borescope
US4918521A (en) * 1987-01-20 1990-04-17 Olympus Optical Co., Ltd. Solid state imaging apparatus
JPS63316476A (ja) * 1987-06-18 1988-12-23 Seiko Instr & Electronics Ltd 半導体装置およびその製造方法
US4796607A (en) * 1987-07-28 1989-01-10 Welch Allyn, Inc. Endoscope steering section
US4794912A (en) * 1987-08-17 1989-01-03 Welch Allyn, Inc. Borescope or endoscope with fluid dynamic muscle
US4786609A (en) * 1987-10-05 1988-11-22 North American Philips Corporation, Signetics Division Method of fabricating field-effect transistor utilizing improved gate sidewall spacers
US5021888A (en) * 1987-12-18 1991-06-04 Kabushiki Kaisha Toshiba Miniaturized solid state imaging device
JP2594627B2 (ja) * 1988-02-26 1997-03-26 オリンパス光学工業株式会社 電子内視鏡装置
US5654270A (en) * 1988-06-28 1997-08-05 La Jolla Cancer Research Foundation Use of fibromodulin to prevent or reduce dermal scarring
US5583103A (en) * 1988-06-28 1996-12-10 La Jolla Cancer Research Foundation Inhibition of transforming growth factor beta activity
US4862253A (en) * 1988-07-20 1989-08-29 Welch Allyn, Inc. Apparatus for converting a video processor
US5089473A (en) * 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
US4909600A (en) * 1988-10-28 1990-03-20 Welch Allyn, Inc. Light chopper assembly
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5968778A (en) * 1989-01-12 1999-10-19 Jurgen Hoppe PDGF-AB, preparation process and pharmaceuticals containing them
JP2751320B2 (ja) * 1989-02-21 1998-05-18 日本電気株式会社 エミッタホロワ回路
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US4993405A (en) * 1989-05-15 1991-02-19 Olympus Optical Co., Ltd. Imaging apparatus
US5014515A (en) * 1989-05-30 1991-05-14 Welch Allyn, Inc. Hydraulic muscle pump
US4913369A (en) * 1989-06-02 1990-04-03 Welch Allyn, Inc. Reel for borescope insertion tube
JPH0323832A (ja) * 1989-06-22 1991-01-31 Toshiba Corp 電子内視鏡装置
US5194596A (en) * 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5395760A (en) * 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
US4941456A (en) * 1989-10-05 1990-07-17 Welch Allyn, Inc. Portable color imager borescope
US4941454A (en) * 1989-10-05 1990-07-17 Welch Allyn, Inc. Servo actuated steering mechanism for borescope or endoscope
FR2654258A1 (fr) * 1989-11-03 1991-05-10 Philips Nv Procede pour fabriquer un dispositif a transistor mis ayant une electrode de grille en forme de "t" inverse.
JP2579372B2 (ja) * 1989-12-04 1997-02-05 日本テキサス・インスツルメンツ株式会社 低消費電力撮像装置
US4971655A (en) * 1989-12-26 1990-11-20 Micron Technology, Inc. Protection of a refractory metal silicide during high-temperature processing using a dual-layer cap of silicon dioxide and silicon nitride
WO1991010727A1 (en) 1990-01-22 1991-07-25 La Jolla Cancer Research Foundation Inhibitors of cell regulatory factors
US5014600A (en) * 1990-02-06 1991-05-14 Welch Allyn, Inc. Bistep terminator for hydraulic or pneumatic muscle
US4998182A (en) * 1990-02-08 1991-03-05 Welch Allyn, Inc. Connector for optical sensor
US4981810A (en) * 1990-02-16 1991-01-01 Micron Technology, Inc. Process for creating field effect transistors having reduced-slope, staircase-profile sidewall spacers
US5536638A (en) * 1990-04-18 1996-07-16 N.V. Innogenetics S.A. Hybridization probes derived from the spacer region between the 16S and 23S rRNA genes for the detection of Neisseria gonorrhoeae
US5126283A (en) * 1990-05-21 1992-06-30 Motorola, Inc. Process for the selective encapsulation of an electrically conductive structure in a semiconductor device
US5019121A (en) * 1990-05-25 1991-05-28 Welch Allyn, Inc. Helical fluid-actuated torsional motor
US4989581A (en) * 1990-06-01 1991-02-05 Welch Allyn, Inc. Torsional strain relief for borescope
US5203319A (en) * 1990-06-18 1993-04-20 Welch Allyn, Inc. Fluid controlled biased bending neck
US5018506A (en) * 1990-06-18 1991-05-28 Welch Allyn, Inc. Fluid controlled biased bending neck
JPH0456341A (ja) * 1990-06-26 1992-02-24 Matsushita Electric Ind Co Ltd 半導体集積回路のレイアウト方法
US5306655A (en) * 1990-07-24 1994-04-26 Matsushita Electric Industrial Co., Ltd. Structure and method of manufacture for MOS field effect transistor having lightly doped drain and source diffusion regions
US5018436A (en) * 1990-07-31 1991-05-28 Welch Allyn, Inc. Folded bladder for fluid dynamic muscle
US5114636A (en) * 1990-07-31 1992-05-19 Welch Allyn, Inc. Process for reducing the internal cross section of elastomeric tubing
JP3216650B2 (ja) * 1990-08-27 2001-10-09 オリンパス光学工業株式会社 固体撮像装置
JPH0817235B2 (ja) * 1990-08-29 1996-02-21 株式会社東芝 オフセットゲート構造トランジスタおよびその製造方法
US5418566A (en) * 1990-09-10 1995-05-23 Kabushiki Kaisha Toshiba Compact imaging apparatus for electronic endoscope with improved optical characteristics
DE4037837A1 (de) * 1990-11-28 1992-06-04 Behringwerke Ag Zellfreie rezeptorbindungsteste, ihre herstellung und verwendung
WO1992010518A1 (en) 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
EP0490535B1 (de) * 1990-12-07 1996-08-21 AT&T Corp. Feldeffekttransistor mit inverser T-förmiger Silizid-Torelektrode
US5291151A (en) * 1991-01-19 1994-03-01 Canon Kabushiki Kaisha Sensor amplifier
US5994088A (en) * 1991-03-08 1999-11-30 Board Of Trustees Of The University Of Illinois Methods and reagents for preparing and using immunological agents specific for P-glycoprotein
JP3078085B2 (ja) * 1991-03-26 2000-08-21 オリンパス光学工業株式会社 画像処理装置および画像処理方法
JPH0595900A (ja) * 1991-04-11 1993-04-20 Olympus Optical Co Ltd 内視鏡画像処理装置
US5417210A (en) * 1992-05-27 1995-05-23 International Business Machines Corporation System and method for augmentation of endoscopic surgery
KR940006702B1 (ko) * 1991-06-14 1994-07-25 금성일렉트론 주식회사 모스패트의 제조방법
US5191879A (en) * 1991-07-24 1993-03-09 Welch Allyn, Inc. Variable focus camera for borescope or endoscope
US5314834A (en) * 1991-08-26 1994-05-24 Motorola, Inc. Field effect transistor having a gate dielectric with variable thickness
KR960000225B1 (ko) * 1991-08-26 1996-01-03 가부시키가이샤 한도오따이 에네루기 겐큐쇼 절연게이트형 반도체장치의 제작방법
US5445940A (en) * 1991-08-28 1995-08-29 Brigham & Women's Hospital Methods and compositions for detecting and treating a subset of human patients having an autoimmune disease
US5202758A (en) * 1991-09-16 1993-04-13 Welch Allyn, Inc. Fluorescent penetrant measurement borescope
US5565332A (en) * 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
JP3067347B2 (ja) * 1991-10-30 2000-07-17 株式会社島津製作所 ゲル状ビーズの選別装置
US5187759A (en) * 1991-11-07 1993-02-16 At&T Bell Laboratories High gain multi-mode optical amplifier
US5932211A (en) * 1991-11-12 1999-08-03 Women's And Children's Hospital Glycosylation variants of iduronate 2-sulfatase
US5817310A (en) * 1991-12-02 1998-10-06 Cor Therapeutics, Inc. Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
US5614943A (en) * 1991-12-19 1997-03-25 Olympus Optical Co., Ltd. Dissimilar endoscopes usable with a common control unit
US5278642A (en) * 1992-02-26 1994-01-11 Welch Allyn, Inc. Color imaging system
US5441883A (en) * 1992-03-03 1995-08-15 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University A3 adenosine receptor, DNA, and uses
GB2264948B (en) * 1992-03-13 1996-10-16 Merck & Co Inc Human adenosine receptors
US5569662A (en) * 1992-03-23 1996-10-29 Pfizer Inc. Quinuclidine derivatives as substance P antagonists
DE4211547C2 (de) * 1992-04-06 1994-08-11 Henke Sass Wolf Gmbh Schutzabdeckung für das distale Ende von Endoskopen
US5306951A (en) * 1992-05-14 1994-04-26 Micron Technology, Inc. Sidewall silicidation for improved reliability and conductivity
DE69330640T2 (de) * 1992-05-29 2002-07-04 Vivorx Inc Mikroverkapselung von zellen
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
JPH07509602A (ja) 1992-06-22 1995-10-26 マトリテク　インコーポレイテッド 新規な悪性細胞型内部核マトリックスマーカー
US5874082A (en) * 1992-07-09 1999-02-23 Chiron Corporation Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
US5275152A (en) * 1992-07-27 1994-01-04 Welch Allyn, Inc. Insertion tube terminator
CA2142007C (en) * 1992-08-11 2007-10-30 Robert Glen Urban Immunomodulatory peptides
US5480805A (en) * 1992-08-12 1996-01-02 Amoco Corporation Composition for modulating sterols in yeast
US5322807A (en) * 1992-08-19 1994-06-21 At&T Bell Laboratories Method of making thin film transistors including recrystallization and high pressure oxidation
JP3472587B2 (ja) * 1992-08-28 2003-12-02 アベンティス ファーマ株式会社 骨関連カルボキシペプチダーゼ様タンパク質およびその製造法
JPH06121678A (ja) * 1992-08-28 1994-05-06 Hoechst Japan Ltd 骨関連サルファターゼ様タンパク質およびその製造法
US5262352A (en) * 1992-08-31 1993-11-16 Motorola, Inc. Method for forming an interconnection structure for conductive layers
JP3537141B2 (ja) * 1992-10-30 2004-06-14 ザ ゼネラル ホスピタル コーポレーション 新種蛋白質分離のための相互作用を用いる補捉システム
KR970011744B1 (ko) * 1992-11-04 1997-07-15 마쯔시다덴기산교 가부시기가이샤 상보형 반도체장치 및 그 제조방법
KR950011983B1 (ko) * 1992-11-23 1995-10-13 삼성전자주식회사 반도체 장치의 제조방법
US5371026A (en) * 1992-11-30 1994-12-06 Motorola Inc. Method for fabricating paired MOS transistors having a current-gain differential
US5314070A (en) * 1992-12-16 1994-05-24 Welch Allyn, Inc. Case for flexible borescope and endoscope insertion tubes
JP3220538B2 (ja) * 1992-12-24 2001-10-22 オリンパス光学工業株式会社 立体視内視鏡及び立体視内視鏡装置
US5798224A (en) * 1992-12-29 1998-08-25 Doheny Eye Institute Nucleic acids encoding protocadherin
JPH06214354A (ja) * 1993-01-14 1994-08-05 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料及びその処理方法
US5293836A (en) * 1993-01-15 1994-03-15 Ziggity Systems, Inc. Water retaining trigger pin
US5386344A (en) * 1993-01-26 1995-01-31 International Business Machines Corporation Flex circuit card elastomeric cable connector assembly
US5633675A (en) * 1993-02-16 1997-05-27 Welch Allyn, Inc, Shadow probe
US5674182A (en) * 1993-02-26 1997-10-07 Olympus Optical Co., Ltd. Endoscope system including endoscope and protection cover
USD358471S (en) * 1993-03-11 1995-05-16 Welch Allyn, Inc. Combined control handle and viewing screen for an endoscope
US5334556A (en) * 1993-03-23 1994-08-02 Texas Instruments Incorporated Method for improving gate oxide integrity using low temperature oxidation during source/drain anneal
CA2159639A1 (en) * 1993-04-02 1994-10-13 Vincent J. Miles Method for selective inactivation of viral replication
US5536637A (en) * 1993-04-07 1996-07-16 Genetics Institute, Inc. Method of screening for cDNA encoding novel secreted mammalian proteins in yeast
US5323899A (en) * 1993-06-01 1994-06-28 Welch Allyn, Inc. Case for video probe
US5435296A (en) * 1993-06-11 1995-07-25 Welch Allyn, Inc. Endoscope having crimped and soldered cable terminator
US5382533A (en) * 1993-06-18 1995-01-17 Micron Semiconductor, Inc. Method of manufacturing small geometry MOS field-effect transistors having improved barrier layer to hot electron injection
GB9315011D0 (en) * 1993-07-20 1993-09-01 British Telecomm Dispersion compensation
US5439483A (en) * 1993-10-21 1995-08-08 Ventritex, Inc. Method of quantifying cardiac fibrillation using wavelet transform
US6983051B1 (en) * 1993-11-18 2006-01-03 Digimarc Corporation Methods for audio watermarking and decoding
US5439846A (en) * 1993-12-17 1995-08-08 Sgs-Thomson Microelectronics, Inc. Self-aligned method for forming contact with zero offset to gate
US5556767A (en) * 1993-12-22 1996-09-17 Human Genome Sciences, Inc. Polynucleotide encoding macrophage inflammatory protein γ
US5552329A (en) * 1994-01-05 1996-09-03 Lg Semicon Co., Ltd. Method of making metal oxide semiconductor transistors
US5519003A (en) * 1994-02-01 1996-05-21 Board Of Trustees Of The Leland Stanford Junior University WD-40-derived peptides and uses thereof
JP3423761B2 (ja) * 1994-03-02 2003-07-07 東北パイオニア株式会社 光波長変換装置
US5712111A (en) * 1994-04-15 1998-01-27 Merck & Co., Inc. DNA encoding bradykinin B1 receptor
TW387560U (en) * 1994-05-13 2000-04-11 Prec Optics Coroporation Viewing scope with image intensification
KR0141195B1 (ko) * 1994-06-08 1998-07-15 김광호 저저항 게이트전극을 갖는 반도체소자의 제조방법
US5622701A (en) * 1994-06-14 1997-04-22 Protein Design Labs, Inc. Cross-reacting monoclonal antibodies specific for E- and P-selectin
JPH0829701A (ja) * 1994-07-18 1996-02-02 Olympus Optical Co Ltd 立体視内視鏡システム
US5853975A (en) * 1994-08-23 1998-12-29 Millennium Pharmaceuticals, Inc. Methods for identifying compositions for the treatment of body weight disorders, including obesity
US6068867A (en) * 1994-11-02 2000-05-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem Protective coatings for food and agricultural products
US6221839B1 (en) * 1994-11-14 2001-04-24 Helsinki University Licensing Ltd. Oy FIt4 ligand and methods of use
US5888774A (en) * 1994-12-19 1999-03-30 Cangene Corporation Recombinant DNA molecules and expression vectors for erythropoietin
JPH08243078A (ja) * 1995-03-07 1996-09-24 Fuji Photo Optical Co Ltd 電子内視鏡の撮像素子組付け体
US5730129A (en) * 1995-04-03 1998-03-24 General Electric Company Imaging of interventional devices in a non-stationary subject
GB9506954D0 (en) * 1995-04-04 1995-05-24 Street Graham S B Method and apparatus for image enhancement
US6008325A (en) * 1995-04-19 1999-12-28 Orion Diagnostica Antibody to aminoterminal propeptide of type 1 procollagen
DE69631041T2 (de) * 1995-04-24 2004-09-02 Medical Research Council Promotor des utrophingens
WO1996039419A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. Colon specific genes and proteins
US5684126A (en) * 1995-06-06 1997-11-04 The Johns Hopkins University School Of Medicine Ebnerin: a secreted von Ebner's gland protein associated with taste buds
US5627848A (en) * 1995-09-05 1997-05-06 Imra America, Inc. Apparatus for producing femtosecond and picosecond pulses from modelocked fiber lasers cladding pumped with broad area diode laser arrays
US6060879A (en) * 1995-09-07 2000-05-09 Core Engineering Inc. Current magnitude sensing circuit
EP0853668B2 (de) * 1995-09-29 2013-03-06 Vegenics Pty Ltd Regulierte gene und ihre verwendungen
KR0169376B1 (ko) * 1995-10-10 1999-03-20 김광호 멀티미디어 대응 가능한 씨씨디 카메라 시스템
JPH09124697A (ja) * 1995-11-01 1997-05-13 Toagosei Co Ltd ペプチド及びモノクローナル抗体
KR970049406A (ko) * 1995-12-15 1997-07-29 김광호 그래픽 오버레이속도 향상기능을 갖는 화상처리장치
US6613544B1 (en) * 1995-12-22 2003-09-02 Amgen Inc. Osteoprotegerin
US6586570B1 (en) * 1996-01-11 2003-07-01 Corixa Corporation Compositions and methods for the treatment and diagnosis of breast cancer
US5867305A (en) * 1996-01-19 1999-02-02 Sdl, Inc. Optical amplifier with high energy levels systems providing high peak powers
US6300487B1 (en) * 1996-03-19 2001-10-09 Cell Therapuetics, Inc. Mammalian lysophosphatidic acid acyltransferase
WO1997034997A1 (en) * 1996-03-21 1997-09-25 Human Genome Sciences, Inc. Human endometrial specific steroid-binding factor i, ii and iii
US6004780A (en) * 1996-03-26 1999-12-21 Human Genome Sciences, Inc. Growth factor HTTER36
US5874254A (en) * 1996-03-29 1999-02-23 Director-General Of Agency Of Industrial Science And Technology FGF-5 analogous protein, and pharmaceutical composition containing the same
US5861248A (en) * 1996-03-29 1999-01-19 Urocor, Inc. Biomarkers for detection of prostate cancer
ES2242227T5 (es) * 1996-07-15 2011-12-09 Chugai Seiyaku Kabushiki Kaisha Nuevo factor de tipo vegf.
US5857963A (en) * 1996-07-17 1999-01-12 Welch Allyn, Inc. Tab imager assembly for use in an endoscope
US5734418A (en) * 1996-07-17 1998-03-31 Welch Allyn, Inc. Endoscope with tab imager package
US5754313A (en) * 1996-07-17 1998-05-19 Welch Allyn, Inc. Imager assembly
US6111090A (en) * 1996-08-16 2000-08-29 Schering Corporation Mammalian cell surface antigens; related reagents
DK0956339T3 (da) * 1996-08-23 2006-01-30 Licentia Oy Rekombinant vaskulær endotelcellevækstfaktor D (VEGF-D)
US6586210B1 (en) * 1996-08-23 2003-07-01 Human Genome Sciences, Inc. Polynucleotides encoding T1 receptor like ligand II
US6329197B2 (en) * 1996-10-09 2001-12-11 Synaptic Pharmaceutical Corporation DNA encoding galanin GALR3 receptors and uses thereof
NZ335382A (en) * 1996-10-25 2001-03-30 Searle & Co Multi-functional chimeric hematopoietic polypeptides of IL-3, GCSF, Flt3L, EPO, stem cell factor, cmpl link with or without linker group consisting of Alanine, Glycine and/or Serine for treating autoimmune and tumour related diseases
WO1999063088A2 (en) 1998-06-02 1999-12-09 Genentech, Inc. Membrane-bound proteins and nucleic acids encoding the same
US6632923B1 (en) * 1996-11-27 2003-10-14 Boston Heart Foundation, Inc. Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
US6084461A (en) * 1996-11-29 2000-07-04 Varian Medical Systems, Inc. Charge sensitive amplifier with high common mode signal rejection
AU5902398A (en) * 1996-12-31 1998-07-31 Human Genome Sciences, Inc. Cortistatin polypeptides
US5840532A (en) * 1997-01-21 1998-11-24 Board Of Regents, The University Of Texas System Neuronal bHLH-PAS domain proteins
EP0988385A2 (de) * 1997-01-21 2000-03-29 Human Genome Sciences Polypeptide, die tace und matrilysin ähneln.
US5965397A (en) * 1997-01-31 1999-10-12 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
US6130325A (en) * 1997-02-14 2000-10-10 Incyte Pharmaceuticals, Inc. Human P24 vesicle proteins
US5939271A (en) * 1997-02-19 1999-08-17 The Regents Of The University Of California Netrin receptor
JPH10295388A (ja) * 1997-02-28 1998-11-10 Japan Tobacco Inc 哺乳動物由来生理活性タンパク
CA2284131A1 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 70 human secreted proteins
WO1998042738A1 (en) * 1997-03-21 1998-10-01 Human Genome Sciences, Inc. 87 human secreted proteins
WO1999022243A1 (en) * 1997-10-24 1999-05-06 Human Genome Sciences, Inc. 148 human secreted proteins
US7053190B2 (en) * 1997-03-07 2006-05-30 Human Genome Sciences, Inc. Secreted protein HRGDF73
CA2283299A1 (en) 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
US20030065139A1 (en) * 1998-03-19 2003-04-03 Craig A. Rosen Secreted protein hmmbd35
US6420526B1 (en) * 1997-03-07 2002-07-16 Human Genome Sciences, Inc. 186 human secreted proteins
WO2000006698A1 (en) * 1998-07-30 2000-02-10 Human Genome Sciences, Inc. 98 human secreted proteins
US5856139A (en) * 1997-03-11 1999-01-05 Incyte Pharmaceuticals, Inc. Proline-rich acidic protein
US5989909A (en) * 1997-09-26 1999-11-23 Millennium Biotherapeutics, Inc. Huchordin and uses thereof
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US20030004311A1 (en) * 1997-06-18 2003-01-02 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000012708A2 (en) * 1998-09-01 2000-03-09 Genentech, Inc. Further pro polypeptides and sequences thereof
US5925521A (en) * 1997-03-31 1999-07-20 Incyte Pharmaceuticals, Inc. Human serine carboxypeptidase
US6088612A (en) * 1997-04-04 2000-07-11 Medtech Research Corporation Method and apparatus for reflective glare removal in digital photography useful in cervical cancer detection
US5877803A (en) * 1997-04-07 1999-03-02 Tritech Mircoelectronics International, Ltd. 3-D image detector
US20030162956A1 (en) * 1997-04-07 2003-08-28 Human Genome Sciences, Inc. Leukocyte regulatory factors 1 and 2
US20010039335A1 (en) * 1997-04-10 2001-11-08 Kenneth Jacobs Secreted proteins and polynucleotides encoding them
AU746956B2 (en) * 1997-05-06 2002-05-09 Zymogenetics Inc. Novel tumor antigens
KR100508338B1 (ko) * 1997-05-15 2005-08-17 츄가이 세이야꾸 가부시키가이샤 악액질 치료제
US5922567A (en) * 1997-06-03 1999-07-13 Incyte Pharmaceuticals, Inc. Two new human DNAJ-like proteins
US6525174B1 (en) * 1997-06-06 2003-02-25 Human Genome Sciences, Inc. Precerebellin-like protein
CA2294526A1 (en) 1997-06-13 1998-12-17 Human Genome Sciences, Inc. 86 human secreted proteins
DE19726796A1 (de) * 1997-06-24 1999-01-07 Basf Ag Propylenpolymerisate
US5818630A (en) * 1997-06-25 1998-10-06 Imra America, Inc. Single-mode amplifiers and compressors based on multi-mode fibers
WO1999002990A1 (en) * 1997-07-11 1999-01-21 Eli Lilly And Company Combinatorial process for preparing fused substituted pyrimidine libraries
RU2218402C2 (ru) * 1997-07-18 2003-12-10 Займодженетикс, Инк. Выделенный полипептид, имеющий гомологию относительно комплемент родственного белка адипоцитов (варианты), гибридный белок (варианты), экспрессирующий вектор, способ получения полипептида, поликлональное антитело, фрагмент выделенного полинуклеотида (варианты)
US6060284A (en) * 1997-07-25 2000-05-09 Schering Corporation DNA encoding interleukin-B30
EP1000146B1 (de) * 1997-08-01 2006-08-30 Serono Genetics Institute S.A. 5' ests für proteine, die nicht gewebespezifisch sind
US6380370B1 (en) * 1997-08-14 2002-04-30 Genome Therapeutics Corporation Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
AU9115898A (en) 1997-08-21 1999-03-08 Genetics Institute Inc. Secreted proteins
US5876963A (en) * 1997-08-27 1999-03-02 Mitchell; Peter Human nucleotide pyrophosphohydrolase
US6211904B1 (en) * 1997-09-11 2001-04-03 Edwin L. Adair Surgical devices incorporating reduced area imaging devices
ATE447583T1 (de) 1997-09-17 2009-11-15 Genentech Inc Polypeptide und dafür kodierende nukleinsäure
CA2273842A1 (en) * 1997-10-06 1999-04-15 Zymogenetics, Inc. A human 2-19 protein homologue, z219a
US20030176681A1 (en) * 1997-10-24 2003-09-18 Ping Feng 148 human secreted proteins
US5932445A (en) * 1997-11-07 1999-08-03 Incyte Pharmaceuticals, Inc. Signal peptide-containing proteins
US6548633B1 (en) * 1998-12-22 2003-04-15 Genset, S.A. Complementary DNA's encoding proteins with signal peptides
US6573068B1 (en) * 1997-11-13 2003-06-03 Genset, S. A. Claudin-50 protein
US6025194A (en) * 1997-11-19 2000-02-15 Geron Corporation Nucleic acid sequence of senescence asssociated gene
US5972684A (en) * 1997-11-25 1999-10-26 Incyte Pharmaceuticals, Inc. Carbonic anhydrase VIII
US6194556B1 (en) * 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
ATE305510T1 (de) * 1997-12-17 2005-10-15 Immunex Corp Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden
US6124095A (en) * 1997-12-22 2000-09-26 Incyte Pharmaceuticals, Inc. Human nucleotide pyrophosphohydrolase-2
WO1999033963A1 (en) * 1997-12-31 1999-07-08 Chiron Corporation Metastatic cancer regulated gene
US6191809B1 (en) * 1998-01-15 2001-02-20 Vista Medical Technologies, Inc. Method and apparatus for aligning stereo images
AU764441B2 (en) * 1998-02-09 2003-08-21 Genset S.A. cDNAs encoding secreted proteins
US6607879B1 (en) * 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
EP1056760A4 (de) * 1998-02-26 2003-03-05 Human Genome Sciences Inc 36 menschliche sekretierte proteine
US6034975A (en) * 1998-03-09 2000-03-07 Imra America, Inc. High power, passively modelocked fiber laser, and method of construction
EP1490386B1 (de) 1998-03-10 2008-08-13 Genentech, Inc. Neuartiges polypeptid und dessen kodierende nukleinsäuren
US6174687B1 (en) * 1999-02-26 2001-01-16 The Burnham Institute Methods of identifying lung homing molecules using membrane dipeptidase
US6245550B1 (en) * 1998-03-20 2001-06-12 Smithkline Beecham Corporation Cytokine family member EF-7
US5945308A (en) * 1998-04-03 1999-08-31 Incyte Pharmaceuticals, Inc. Human oxidized LDL receptor
DE69942607D1 (de) * 1998-04-14 2010-09-02 Chugai Pharmaceutical Co Ltd Neues cytokinartiges protein
DE19817948A1 (de) * 1998-04-17 1999-10-21 Metagen Gesellschaft Fuer Genomforschung Mbh Menschliche Nukleinsäuresequenzen aus Endometrium-Tumor
US6150502A (en) * 1998-04-29 2000-11-21 Genesis Research & Development Corporation Limited Polypeptides expressed in skin cells
US6573095B1 (en) * 1998-04-29 2003-06-03 Genesis Research & Development Corporation Limited Polynucleotides isolated from skin cells
US6800473B1 (en) * 1998-06-05 2004-10-05 Daiichi Fine Chemical Co., Ltd. Human cathepsin L2 protein, gene encoding said protein and use thereof
US20020182677A1 (en) 1998-08-03 2002-12-05 Zymogenetics, Inc. Pancreatic and ovarian polypeptide, zsig58
EP0978251B1 (de) * 1998-08-07 2005-01-26 Olympus Corporation Autoklavierbares Endoskop
US6168920B1 (en) * 1998-08-10 2001-01-02 Incyte Genomics, Inc. Extracellular adhesive proteins
AU5475199A (en) * 1998-08-10 2000-03-06 Genetics Institute Inc. Human chordin-related proteins and polynucleotides encoding them
US20030096951A1 (en) * 1998-08-14 2003-05-22 Kenneth Jacobs Secreted proteins and polynucleotides encoding them
JP2002537757A (ja) 1998-08-24 2002-11-12 アルファジーン・インコーポレイテッド 分泌タンパク質及びそれらをコードするポリヌクレオチド
AU5583799A (en) * 1998-08-25 2000-03-14 Human Genome Sciences, Inc. 49 human secreted proteins
US7071304B2 (en) * 1998-09-01 2006-07-04 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6142899A (en) 1998-09-10 2000-03-27 Incyte Pharmaceuticals, Inc. Human transferase proteins
US6808895B1 (en) * 1999-10-06 2004-10-26 Incyte Corporation DNA encoding oxidoreductase and polypeptide encoded thereby
US6174311B1 (en) * 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
JP2002530062A (ja) * 1998-10-28 2002-09-17 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド １２個のヒト分泌タンパク質
US6214582B1 (en) * 1998-11-16 2001-04-10 The Research Foundation Of State University Of Ny Y2H35 a strong IKK binding protein
WO2000031275A1 (fr) * 1998-11-19 2000-06-02 Azwell Inc. Phosphatase de recombinaison d'acide lysophosphatidique
US6275512B1 (en) * 1998-11-25 2001-08-14 Imra America, Inc. Mode-locked multimode fiber laser pulse source
WO2001053455A2 (en) 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
EP1143005A4 (de) * 1998-12-09 2002-11-06 Shionogi & Co Menschliche sekretorische phospholipase a
US6278042B1 (en) * 1998-12-16 2001-08-21 E.I. Du Pont De Nemours And Company Plant arsenic transporters
KR100468978B1 (ko) 1998-12-16 2005-02-02 제넨테크, 인크. 분비 및 막횡단 폴리펩티드, 및 이를 코딩하는 핵산
US6184514B1 (en) * 1998-12-18 2001-02-06 Eastman Kodak Company Plastic cover for image sensors
WO2000037025A2 (en) * 1998-12-21 2000-06-29 Ludwig Institute For Cancer Research Antibodies to truncated vegf-d and uses thereof
US6172361B1 (en) * 1998-12-29 2001-01-09 Cirrus Logic, Inc. Methods for mounting an imager to a support structure and circuitry and systems embodying the same
US6083152A (en) * 1999-01-11 2000-07-04 Welch Allyn, Inc. Endoscopic insertion tube
US20040132158A1 (en) * 1999-01-11 2004-07-08 Incyte Corporation Human peptidases
WO2000042201A2 (en) * 1999-01-11 2000-07-20 Incyte Pharmaceuticals, Inc. Human peptidases
EP1144614A4 (de) 1999-01-19 2003-08-06 Human Genome Sciences Inc Menschliche, ausgeschiedene proteine
WO2000043493A2 (en) * 1999-01-22 2000-07-27 Human Genome Sciences, Inc. Metalloproteinase adam 22
US6492505B1 (en) * 1999-02-01 2002-12-10 Incyte Genomics, Inc. Composition for detection of genes encoding membrane-associated proteins
TR200102745T2 (tr) 1999-03-26 2002-05-21 Smithkline Beecham Biologicals S.A. Yeni bileşikler
US6331427B1 (en) * 1999-03-26 2001-12-18 Millennium Pharmaceuticals, Inc. Protease homologs
AU3774500A (en) 1999-03-31 2000-10-16 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; "orfx"
EP1051037A3 (de) * 1999-05-04 2001-08-29 Everest-VIT, Inc. (a New Jersey Corporation) Inspektionssystem und -Verfahren
EP1179066A2 (de) * 1999-05-19 2002-02-13 Incyte Genomics, Inc. Extrazelluläre signalmoleküle
CA2373693A1 (en) * 1999-05-20 2000-11-30 Human Genome Sciences, Inc. Seven transmembrane receptor genes
US6186834B1 (en) * 1999-06-08 2001-02-13 Avaya Technology Corp. Enhanced communication connector assembly with crosstalk compensation
US20030082586A1 (en) * 1999-06-29 2003-05-01 Millennium Pharmaceuticals, Inc. Antibodies having diagnostic, preventive, therapeutic, and other uses
US6696279B1 (en) * 1999-07-01 2004-02-24 University Of Tennessee Research Foundation Purified and isolated Mat II β subunit nucleic acids and polypeptides and therapeutic and screening methods using same
EP1130094A3 (de) 1999-07-08 2001-11-21 Helix Research Institute Primer zur Synthese von vollständigen cDNA Klonen und ihre Verwendung
US6951738B2 (en) * 1999-07-16 2005-10-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
US20050048623A1 (en) * 1999-07-21 2005-03-03 Incyte Corporation Cell cycle and proliferation proteins
CA2379801A1 (en) * 1999-07-21 2001-02-01 Incyte Genomics, Inc. Receptors and associated proteins
EP1074617A3 (de) 1999-07-29 2004-04-21 Research Association for Biotechnology Primers für Synthese von ganzen-Länge cDNS und deren Anwendung
AU6181200A (en) * 1999-07-29 2001-02-19 Helix Research Institute Stomach cancer-associated gene
CA2311201A1 (en) * 1999-08-05 2001-02-05 Genset S.A. Ests and encoded human proteins
US6602501B1 (en) * 1999-08-12 2003-08-05 Agensys, Inc. C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof
AU6590500A (en) * 1999-08-16 2001-03-13 Universita' Degli Studi Di Siena Vegf-d and angiogenic use thereof
US7090847B1 (en) * 1999-09-09 2006-08-15 Schering Corporation Mammalian cytokines; related reagents and methods
JP2003511012A (ja) * 1999-09-24 2003-03-25 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ３２個のヒト分泌タンパク質
WO2001022920A2 (en) 1999-09-29 2001-04-05 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
AU7508100A (en) * 1999-10-04 2001-05-10 Jens Andersen Human seizure related proteins
WO2001025444A2 (en) * 1999-10-07 2001-04-12 Zymogenetics, Inc. Novel human phosphodiesterase zcytor13
US6992170B2 (en) * 1999-10-15 2006-01-31 Curagen Corporation Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin
AU1449001A (en) 1999-11-05 2001-06-06 Human Genome Sciences, Inc. 28 human secreted proteins
AUPQ434899A0 (en) * 1999-11-26 1999-12-23 University Of Queensland, The Novel polynucleotide and polypeptide
JP2004522404A (ja) 1999-12-01 2004-07-29 ジェネンテック・インコーポレーテッド 分泌及び膜貫通ポリペプチドとそれをコードしている核酸
EP1242443A4 (de) 1999-12-23 2005-06-22 Nuvelo Inc Neue nukleinsäuren und polypeptide
US6569662B1 (en) * 2000-01-21 2003-05-27 Hyseq, Inc. Nucleic acids and polypeptides
GB0001898D0 (en) * 2000-01-27 2000-03-22 Smithkline Beecham Plc Novel compounds
CA2398003A1 (en) * 2000-01-28 2001-08-02 Incyte Genomics, Inc. Phosphodiesterases
WO2001055319A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Endocrine related nucleic acids, proteins and antibodies
CA2393616A1 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001057190A2 (en) 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
AU2001235000A1 (en) 2000-02-11 2001-08-20 Incyte Genomics, Inc. Drug metabolizing enzymes
JP2003523190A (ja) 2000-02-14 2003-08-05 スミスクライン・ビーチャム・コーポレイション 新規化合物
US20060160181A1 (en) * 2000-02-15 2006-07-20 Amgen Inc. Fibroblast Growth Factor-23 molecules and uses thereof
WO2001066595A2 (en) * 2000-03-08 2001-09-13 Chiron Corporation Human fgf-23 gene and gene expression products
AU2001287275A1 (en) * 2000-03-24 2001-10-08 Millenium Pharmaceuticals, Inc. 33877 and 47179, novel human glycosyl transferase family members and uses thereof
US6800455B2 (en) * 2000-03-31 2004-10-05 Scios Inc. Secreted factors
EP1832599A3 (de) 2000-04-12 2007-11-21 Human Genome Sciences, Inc. Albuminfusionsproteine
US7264926B2 (en) * 2000-04-18 2007-09-04 Millennium Pharmaceuticals, Inc. Nucleoside Phosphatase
CA2407850A1 (en) * 2000-05-05 2001-11-15 Incyte Genomics, Inc. Cytoskeleton-associated proteins
US7422743B2 (en) * 2000-05-10 2008-09-09 Schering Corporation Mammalian receptor protein DCRS5;methods of treatment
WO2001090304A2 (en) 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
US6734005B2 (en) * 2000-05-22 2004-05-11 Pharmacia & Upjohn Company Matrix metalloproteinases
US7190705B2 (en) * 2000-05-23 2007-03-13 Imra America. Inc. Pulsed laser sources
US6429127B1 (en) * 2000-06-08 2002-08-06 Micron Technology, Inc. Methods for forming rough ruthenium-containing layers and structures/methods using same
US6590470B1 (en) * 2000-06-13 2003-07-08 Welch Allyn, Inc. Cable compensator circuit for CCD video probe
EP1176200A3 (de) * 2000-06-20 2005-01-12 Switch Biotech Aktiengesellschaft Verwendung von Polypeptiden oder diese kodierende Nukleinsäuren zur Diagnose oder Behandlung von Hauterkrankung oder Wundheilung sowie ihre Verwendung zur Indentifizierung von pharmakologisch aktiven Substanzen
AU2001273151A1 (en) 2000-06-30 2002-01-14 Incyte Genomics, Inc. Human extracellular matrix and cell adhesion polypeptides
ATE461213T1 (de) * 2000-07-19 2010-04-15 Advanced Res & Tech Inst Neuer fibroblastwachstumsfaktor (fgf23) und methoden zur verwendung
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US6492281B1 (en) * 2000-09-22 2002-12-10 Advanced Micro Devices, Inc. Method of fabricating conductor structures with metal comb bridging avoidance
US20030143686A1 (en) * 2000-09-29 2003-07-31 Incyte Genomics, Inc. Transferases
US6531297B2 (en) * 2000-10-20 2003-03-11 Applera Corporation Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
US20030130485A1 (en) * 2000-11-14 2003-07-10 Meyers Rachel E. Novel human genes and methods of use thereof
CA2429343A1 (en) 2000-11-17 2002-08-01 Hyseq, Inc. Nucleic acids and polypeptides
EP1397495A2 (de) 2000-12-21 2004-03-17 Millenium Pharmaceuticals, Inc. 22347, eine menschliche sulfatase und deren verwendungen
US20030148920A1 (en) 2000-12-27 2003-08-07 Steven Rosen Sulfatases and methods of use thereof
US7262797B2 (en) * 2001-02-22 2007-08-28 Ge Inspection Technologies Lp Method and system for storing calibration data within image files
EP1370651A4 (de) * 2001-02-23 2005-04-06 Human Genome Sciences Inc 70 humane sekretierte proteines
US6536637B1 (en) 2001-03-16 2003-03-25 Mclaughlin Marty E. Combination backpack and water container
WO2002079441A2 (en) * 2001-03-30 2002-10-10 Incyte Genomics, Inc. Secreted proteins
US7436435B2 (en) * 2001-10-01 2008-10-14 Minolta Co., Ltd. Image taking device having image-blur compensator
US6841087B2 (en) * 2002-04-19 2005-01-11 Korea Institute Of Science And Technology Refrigerant composition comprising difluoromethane, 1,1,1-trifluoroethane and 1,1,1,2-tetrafluoroethane
KR101076931B1 (ko) * 2002-10-30 2011-10-26 제넨테크, 인크. Ｉｌ―１７ 생성의 억제
WO2004068840A2 (en) * 2003-01-29 2004-08-12 Everest Vit, Inc. Remote video inspection system
WO2004071517A2 (en) * 2003-02-06 2004-08-26 Schering Corporation Uses of il-23 related reagents
SI1601694T1 (sl) * 2003-03-10 2010-01-29 Schering Corp Uporabe IL-23 antagonistov; sorodni reagenti
US20050050707A1 (en) * 2003-09-05 2005-03-10 Scott Joshua Lynn Tip tool
ZA200604365B (en) 2003-11-20 2008-01-30 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
US20050162643A1 (en) * 2004-01-22 2005-07-28 Thomas Karpen Automotive fuel tank inspection device
CA2556425A1 (en) * 2004-02-17 2005-09-01 Schering Corporation Methods of modulating il-23 activity; related reagents
US20050287593A1 (en) * 2004-05-03 2005-12-29 Schering Corporation Use of cytokine expression to predict skin inflammation; methods of treatment
US20060050983A1 (en) * 2004-09-08 2006-03-09 Everest Vit, Inc. Method and apparatus for enhancing the contrast and clarity of an image captured by a remote viewing device
EP2292758A3 (de) * 2004-12-20 2013-12-25 Merck Sharp & Dohme Corp. Verwendung von Säuger-Zytokin; verwandte Reagenzien

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US20030087346A1 (en) 2003-05-08
US20030087385A1 (en) 2003-05-08
US7521539B2 (en) 2009-04-21
US20030073216A1 (en) 2003-04-17
US20030082706A1 (en) 2003-05-01
US20030068797A1 (en) 2003-04-10
US20030138891A1 (en) 2003-07-24
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US7309763B2 (en) 2007-12-18
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US20030143674A1 (en) 2003-07-31
US20030199058A1 (en) 2003-10-23
US20040253666A1 (en) 2004-12-16
US7704496B2 (en) 2010-04-27
US20030166074A1 (en) 2003-09-04
US20030166085A1 (en) 2003-09-04
US20030017563A1 (en) 2003-01-23
US20030166084A1 (en) 2003-09-04
US20030190719A1 (en) 2003-10-09
US7408032B2 (en) 2008-08-05
US20030082711A1 (en) 2003-05-01
US20030134368A1 (en) 2003-07-17
US7342098B2 (en) 2008-03-11
US20030092113A1 (en) 2003-05-15
US20030207362A1 (en) 2003-11-06
US20030207365A1 (en) 2003-11-06
US7294703B2 (en) 2007-11-13
US7351793B2 (en) 2008-04-01
US7495082B2 (en) 2009-02-24
US20030082687A1 (en) 2003-05-01
US20030207423A1 (en) 2003-11-06
US20030194770A1 (en) 2003-10-16
US20030092103A1 (en) 2003-05-15
US20030157613A1 (en) 2003-08-21
US7291717B2 (en) 2007-11-06
US7189813B2 (en) 2007-03-13
US20030087365A1 (en) 2003-05-08
US20030082704A1 (en) 2003-05-01
US7425621B2 (en) 2008-09-16
US7718173B2 (en) 2010-05-18
US20030082700A1 (en) 2003-05-01
US7285628B2 (en) 2007-10-23
US20040033558A1 (en) 2004-02-19
US20030166090A1 (en) 2003-09-04
US20030190729A1 (en) 2003-10-09
US20030180873A1 (en) 2003-09-25
US7282559B2 (en) 2007-10-16
US20030092110A1 (en) 2003-05-15
US20030134375A1 (en) 2003-07-17
US20030077777A1 (en) 2003-04-24
US20030199061A1 (en) 2003-10-23
US20030207358A1 (en) 2003-11-06
US20030096386A1 (en) 2003-05-22
US20030166096A1 (en) 2003-09-04
US20030194774A1 (en) 2003-10-16
US20030087363A1 (en) 2003-05-08
US20030180864A1 (en) 2003-09-25
US7285626B2 (en) 2007-10-23
US20030175873A1 (en) 2003-09-18
US20030082763A1 (en) 2003-05-01
US20030203440A1 (en) 2003-10-30
US7304132B2 (en) 2007-12-04
US20030077718A1 (en) 2003-04-24
US7189806B2 (en) 2007-03-13
US7309768B2 (en) 2007-12-18
US7408042B2 (en) 2008-08-05
US20030082712A1 (en) 2003-05-01
US20030092108A1 (en) 2003-05-15
US20030049816A1 (en) 2003-03-13
US20030138885A1 (en) 2003-07-24
US20030207355A1 (en) 2003-11-06
US20030170788A1 (en) 2003-09-11
US20030077716A1 (en) 2003-04-24
US20030082760A1 (en) 2003-05-01
US20030077714A1 (en) 2003-04-24
US20030087355A1 (en) 2003-05-08
US20030194776A1 (en) 2003-10-16
US20030199026A1 (en) 2003-10-23
US20030092115A1 (en) 2003-05-15
US7355006B2 (en) 2008-04-08
US7307151B2 (en) 2007-12-11
US20030077720A1 (en) 2003-04-24
US20030077776A1 (en) 2003-04-24
US20030148425A1 (en) 2003-08-07
US7342104B2 (en) 2008-03-11
US20030134376A1 (en) 2003-07-17
US20050136515A1 (en) 2005-06-23
US20030207388A1 (en) 2003-11-06
US7417115B2 (en) 2008-08-26
US20030082696A1 (en) 2003-05-01
US20030207356A1 (en) 2003-11-06
US7335745B2 (en) 2008-02-26
US20030203430A1 (en) 2003-10-30
US20030082686A1 (en) 2003-05-01
US20030207381A1 (en) 2003-11-06
US7098003B2 (en) 2006-08-29
US20030207354A1 (en) 2003-11-06
US20030207379A1 (en) 2003-11-06
US7396907B2 (en) 2008-07-08
US20030203437A1 (en) 2003-10-30
US7390887B2 (en) 2008-06-24
US20030087350A1 (en) 2003-05-08
US20030166075A1 (en) 2003-09-04
US20030166080A1 (en) 2003-09-04
US20030199053A1 (en) 2003-10-23
US20030138892A1 (en) 2003-07-24
US20040203125A1 (en) 2004-10-14
US20080050758A1 (en) 2008-02-28
US7361732B2 (en) 2008-04-22
US20030199054A1 (en) 2003-10-23
US20030134384A1 (en) 2003-07-17
US20030207359A1 (en) 2003-11-06
US7314920B2 (en) 2008-01-01
US7087428B2 (en) 2006-08-08
US7361337B2 (en) 2008-04-22
US20030082695A1 (en) 2003-05-01
US20030082701A1 (en) 2003-05-01
US20030134357A1 (en) 2003-07-17
US20030207373A1 (en) 2003-11-06
US20090142786A1 (en) 2009-06-04
US7417123B2 (en) 2008-08-26
US20030138883A1 (en) 2003-07-24
US7375195B2 (en) 2008-05-20
US20030157619A1 (en) 2003-08-21
US20030166092A1 (en) 2003-09-04
US20030199064A1 (en) 2003-10-23
US20030166102A1 (en) 2003-09-04
US20030077723A1 (en) 2003-04-24
US20050019823A1 (en) 2005-01-27
US20030077726A1 (en) 2003-04-24
US20030134362A1 (en) 2003-07-17
US7700736B2 (en) 2010-04-20
US20030166081A1 (en) 2003-09-04
US7425609B2 (en) 2008-09-16
US20030175875A1 (en) 2003-09-18
US20030166101A1 (en) 2003-09-04
US20020137890A1 (en) 2002-09-26
US20090209732A1 (en) 2009-08-20
US20030170789A1 (en) 2003-09-11
US7323544B2 (en) 2008-01-29
US20030207361A1 (en) 2003-11-06
US20050187379A1 (en) 2005-08-25
US20030207364A1 (en) 2003-11-06
US20030157630A1 (en) 2003-08-21
US20030199062A1 (en) 2003-10-23
US20030207363A1 (en) 2003-11-06
US20030207366A1 (en) 2003-11-06
US20030207427A1 (en) 2003-11-06
US20030082710A1 (en) 2003-05-01
US7294705B2 (en) 2007-11-13
US20030208055A1 (en) 2003-11-06
US20030153034A1 (en) 2003-08-14
US20030087361A1 (en) 2003-05-08
US20030157612A1 (en) 2003-08-21
US20030077779A1 (en) 2003-04-24
US20030203439A1 (en) 2003-10-30
US7396916B2 (en) 2008-07-08
US20030129690A1 (en) 2003-07-10
US20030134361A1 (en) 2003-07-17
US20030194769A1 (en) 2003-10-16
US20030207385A1 (en) 2003-11-06
US7319136B2 (en) 2008-01-15
US7524497B2 (en) 2009-04-28
US20030082709A1 (en) 2003-05-01
US20030077783A1 (en) 2003-04-24
US20030022328A1 (en) 2003-01-30
US20030134382A1 (en) 2003-07-17
US20030190731A1 (en) 2003-10-09
US20030073211A1 (en) 2003-04-17
US20030077713A1 (en) 2003-04-24
US20030207376A1 (en) 2003-11-06
US20030082765A1 (en) 2003-05-01
US7193049B2 (en) 2007-03-20
US7294702B2 (en) 2007-11-13
US20030207384A1 (en) 2003-11-06
US7309764B2 (en) 2007-12-18
US20030054517A1 (en) 2003-03-20
US7635478B2 (en) 2009-12-22
US20030194791A1 (en) 2003-10-16
US7301007B2 (en) 2007-11-27
US20030194773A1 (en) 2003-10-16
US7247710B2 (en) 2007-07-24
US20030199052A1 (en) 2003-10-23
US7449554B2 (en) 2008-11-11
US20030203429A1 (en) 2003-10-30
US7285627B2 (en) 2007-10-23
US20060257971A1 (en) 2006-11-16
US20030077717A1 (en) 2003-04-24
US20030157621A1 (en) 2003-08-21
US20030087351A1 (en) 2003-05-08
US20030087367A1 (en) 2003-05-08
US20040077064A1 (en) 2004-04-22
US20030087353A1 (en) 2003-05-08
US20030207367A1 (en) 2003-11-06
US7335746B2 (en) 2008-02-26
US20030129689A1 (en) 2003-07-10

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