DE60229958D1 - Polymerstabilisierte proteinasen - Google Patents
Polymerstabilisierte proteinasenInfo
- Publication number
- DE60229958D1 DE60229958D1 DE60229958T DE60229958T DE60229958D1 DE 60229958 D1 DE60229958 D1 DE 60229958D1 DE 60229958 T DE60229958 T DE 60229958T DE 60229958 T DE60229958 T DE 60229958T DE 60229958 D1 DE60229958 D1 DE 60229958D1
- Authority
- DE
- Germany
- Prior art keywords
- proteinases
- polymer
- stabilized
- admixture
- stabilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89407101A | 2001-06-28 | 2001-06-28 | |
US10312802A | 2002-03-22 | 2002-03-22 | |
PCT/US2002/020417 WO2003002716A2 (en) | 2001-06-28 | 2002-06-28 | Polymer stabilized proteinases |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60229958D1 true DE60229958D1 (de) | 2009-01-02 |
Family
ID=26800115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60229958T Expired - Lifetime DE60229958D1 (de) | 2001-06-28 | 2002-06-28 | Polymerstabilisierte proteinasen |
Country Status (8)
Country | Link |
---|---|
US (1) | US7229810B2 (de) |
EP (1) | EP1421175B1 (de) |
AT (1) | ATE414711T1 (de) |
AU (1) | AU2002345938A1 (de) |
CA (1) | CA2450985A1 (de) |
DE (1) | DE60229958D1 (de) |
DK (1) | DK1421175T3 (de) |
WO (1) | WO2003002716A2 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020065397A1 (en) * | 2000-10-12 | 2002-05-30 | Joseph Roberts | Protecting therapeutic compositions from host-mediated inactivation |
WO2003064605A2 (en) | 2002-01-28 | 2003-08-07 | Ambion, Inc. | Crude biological derivatives competent for nucleic acid detection |
US8129330B2 (en) | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
CN1820024B (zh) * | 2003-05-12 | 2011-06-22 | 阿费麦克斯公司 | 新的聚(乙二醇)修饰的化合物及其用途 |
NZ563042A (en) | 2003-05-12 | 2008-09-26 | Affymax Inc | Novel spacer moiety for poly(ethylene glycol)-modified peptide-based compounds |
PL1625156T3 (pl) * | 2003-05-12 | 2013-03-29 | Affymax Inc | Peptydy wiążące się do receptora erytropoetyny |
WO2006062685A2 (en) * | 2004-11-11 | 2006-06-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
EP1814910A4 (de) * | 2004-11-11 | 2009-04-29 | Affymax Inc | Neue am erythropoietinrezeptor bindende peptide |
AU2006212024A1 (en) * | 2005-02-11 | 2006-08-17 | Dynal Biotech Asa | Method for isolating nucleic acids comprising the use of ethylene glycol multimers |
US7919461B2 (en) | 2005-06-03 | 2011-04-05 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US8324159B2 (en) * | 2005-06-03 | 2012-12-04 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US20070212865A1 (en) * | 2006-03-08 | 2007-09-13 | Craig Amrine | Method for planarizing vias formed in a substrate |
US7964350B1 (en) | 2007-05-18 | 2011-06-21 | Applied Biosystems, Llc | Sample preparation for in situ nucleic acid analysis |
US8211637B2 (en) | 2008-12-19 | 2012-07-03 | Life Technologies Corporation | Proteinase K inhibitors, methods and compositions therefor |
CN112135837A (zh) * | 2018-03-14 | 2020-12-25 | 勇·巴 | 聚乙二醇化抗冻蛋白及其制备和使用方法 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
JPS5599189A (en) | 1979-01-22 | 1980-07-28 | Mihama Hisaharu | Modified uricase free from antigenicity and its preparation |
JPS5816685A (ja) | 1981-07-22 | 1983-01-31 | Takeda Chem Ind Ltd | 固定化酵素,その製造法および製剤 |
JPS57118789A (en) | 1981-01-13 | 1982-07-23 | Eisai Co Ltd | Modified streptokinase and its preparation |
US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4844897A (en) | 1985-09-13 | 1989-07-04 | Hiroshi Maeda | Anti-tumor protease preparations |
JPS6255079A (ja) | 1986-04-23 | 1987-03-10 | Mihama Hisaharu | 修飾ウリカ−ゼ |
US5278062A (en) | 1987-04-03 | 1994-01-11 | Amgen | Proteolytic enzymes |
US5006333A (en) | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
US5246849A (en) | 1988-04-12 | 1993-09-21 | Enzon, Inc. | Thermally stable serine proteases |
JP2958019B2 (ja) | 1988-05-06 | 1999-10-06 | 住友製薬株式会社 | ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法 |
US4962020A (en) | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
US5498523A (en) | 1988-07-12 | 1996-03-12 | President And Fellows Of Harvard College | DNA sequencing with pyrophosphatase |
JPH02219571A (ja) * | 1989-02-20 | 1990-09-03 | Kanebo Ltd | 修飾プロテアーゼ及びその製造法 |
US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
DE69230873T3 (de) | 1991-09-24 | 2006-04-06 | Keygene N.V. | Selektive Restriktionsfragmentenamplifikation: generelles Verfahren für DNS-Fingerprinting |
ZA933926B (en) | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
US5321095A (en) * | 1993-02-02 | 1994-06-14 | Enzon, Inc. | Azlactone activated polyalkylene oxides |
US5482996A (en) * | 1993-12-08 | 1996-01-09 | University Of Pittsburgh | Protein-containing polymers and a method of synthesis of protein-containing polymers in organic solvents |
US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
CA2206852A1 (en) | 1994-12-07 | 1996-06-13 | Novo Nordisk A/S | Polypeptide with reduced allergenicity |
US5837517A (en) | 1995-05-05 | 1998-11-17 | Novo Nordisk A/S | Protease variants and compositions |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
JP2001503269A (ja) | 1996-11-04 | 2001-03-13 | ノボ ノルディスク アクティーゼルスカブ | ズブチラーゼ変異体及び、組成物 |
US6416756B1 (en) * | 1997-01-10 | 2002-07-09 | Novozymes A/S | Modified protease having 5 to 13 covalently coupled polymeric molecules for skin care |
EP1017794A1 (de) * | 1997-02-06 | 2000-07-12 | Novo Nordisk A/S | Polypeptid-polymer-konjugate mit hinzugefügten oder entfernten bindungsgruppen |
ES2296336T3 (es) | 1997-06-25 | 2008-04-16 | Novozymes A/S | Polipeptido modificado. |
US5847110A (en) * | 1997-08-15 | 1998-12-08 | Biomedical Frontiers, Inc. | Method of reducing a schiff base |
US6495136B1 (en) * | 1998-03-26 | 2002-12-17 | The Procter & Gamble Company | Proteases having modified amino acid sequences conjugated to addition moieties |
AU770911B2 (en) * | 1998-07-17 | 2004-03-04 | Novozymes A/S | A polypeptide-polymer conjugate with improved wash performance |
WO2000007629A2 (en) | 1998-08-06 | 2000-02-17 | Mountain View Pharmaceuticals, Inc. | Peg-urate oxidase conjugates and use thereof |
US6783965B1 (en) | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
-
2002
- 2002-06-28 EP EP02744682A patent/EP1421175B1/de not_active Expired - Lifetime
- 2002-06-28 AT AT02744682T patent/ATE414711T1/de active
- 2002-06-28 DK DK02744682T patent/DK1421175T3/da active
- 2002-06-28 AU AU2002345938A patent/AU2002345938A1/en not_active Abandoned
- 2002-06-28 WO PCT/US2002/020417 patent/WO2003002716A2/en not_active Application Discontinuation
- 2002-06-28 US US10/183,607 patent/US7229810B2/en not_active Expired - Fee Related
- 2002-06-28 DE DE60229958T patent/DE60229958D1/de not_active Expired - Lifetime
- 2002-06-28 CA CA002450985A patent/CA2450985A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2003002716A2 (en) | 2003-01-09 |
WO2003002716A3 (en) | 2003-10-16 |
US20030012777A1 (en) | 2003-01-16 |
EP1421175A2 (de) | 2004-05-26 |
AU2002345938A1 (en) | 2003-03-03 |
ATE414711T1 (de) | 2008-12-15 |
CA2450985A1 (en) | 2003-01-09 |
US7229810B2 (en) | 2007-06-12 |
EP1421175A4 (de) | 2004-12-08 |
EP1421175B1 (de) | 2008-11-19 |
DK1421175T3 (da) | 2009-03-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |