DE60230807D1 - Behandlung von sarkom bei menschen mit adenovirus-vektor tnf-alpha - Google Patents

Behandlung von sarkom bei menschen mit adenovirus-vektor tnf-alpha

Info

Publication number
DE60230807D1
DE60230807D1 DE60230807T DE60230807T DE60230807D1 DE 60230807 D1 DE60230807 D1 DE 60230807D1 DE 60230807 T DE60230807 T DE 60230807T DE 60230807 T DE60230807 T DE 60230807T DE 60230807 D1 DE60230807 D1 DE 60230807D1
Authority
DE
Germany
Prior art keywords
human
dose
tnf
sarcoma
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60230807T
Other languages
English (en)
Inventor
Henrik S Rasmussen
Karen W Chu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genvec Inc
Original Assignee
Genvec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21693977&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60230807(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genvec Inc filed Critical Genvec Inc
Application granted granted Critical
Publication of DE60230807D1 publication Critical patent/DE60230807D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
DE60230807T 2001-11-02 2002-11-01 Behandlung von sarkom bei menschen mit adenovirus-vektor tnf-alpha Expired - Lifetime DE60230807D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/001,017 US20030086903A1 (en) 2001-11-02 2001-11-02 Therapeutic regimen for treating cancer
US10/151,633 US7214368B2 (en) 2001-11-02 2002-05-17 Therapeutic regimen for treating cancer comprising the administration of adenoviral vectors comprising a TNF-α transgene
PCT/US2002/035042 WO2003039458A2 (en) 2001-11-02 2002-11-01 TREATMENT OF HUMAN CANCER WITH ADENOVIRAL VECTOR EXPRESSING TNF-α

Publications (1)

Publication Number Publication Date
DE60230807D1 true DE60230807D1 (de) 2009-02-26

Family

ID=21693977

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60230807T Expired - Lifetime DE60230807D1 (de) 2001-11-02 2002-11-01 Behandlung von sarkom bei menschen mit adenovirus-vektor tnf-alpha

Country Status (7)

Country Link
US (5) US20030086903A1 (de)
EP (1) EP1455840B1 (de)
JP (1) JP2005536447A (de)
AT (1) ATE419875T1 (de)
CA (1) CA2465361A1 (de)
DE (1) DE60230807D1 (de)
WO (1) WO2003039458A2 (de)

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AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
US8034791B2 (en) * 2001-04-06 2011-10-11 The University Of Chicago Activation of Egr-1 promoter by DNA damaging chemotherapeutics
JP4173446B2 (ja) 2001-10-19 2008-10-29 ヴァスキュラー バイオジェニックス リミテッド 血管形成の標的化されたダウンレギュレーションおよび抗ガン治療のためのポリヌクレオチド構築物および薬学的組成物および方法
US20030086903A1 (en) * 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
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US20050027196A1 (en) * 2003-07-30 2005-02-03 Fitzgerald Loretta A. System for processing patient radiation treatment data
ATE458500T1 (de) 2003-11-14 2010-03-15 Genvec Inc Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc).
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US8586090B2 (en) * 2004-10-05 2013-11-19 Albert Einstein College Of Medicine Of Yeshiva University Melanin nanoshells for protection against radiation and electronic pulses
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WO2007149938A2 (en) * 2006-06-21 2007-12-27 The Salk Institute Biological Studies Methods for promoting hair growth
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WO2009118721A1 (en) * 2008-03-28 2009-10-01 Real Imaging Ltd. Method apparatus and system for analyzing thermal images
US8663210B2 (en) 2009-05-13 2014-03-04 Novian Health, Inc. Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy
WO2011054811A1 (en) 2009-11-03 2011-05-12 Santaris Pharma A/S Rna antagonists targeting hsp27 combination therapy
WO2011057248A2 (en) 2009-11-09 2011-05-12 Genvec, Inc. Simian adenovirus and methods of use
WO2011074564A1 (ja) * 2009-12-15 2011-06-23 タカラバイオ株式会社 アデノウイルスベクターの製造方法
EP3191131A4 (de) 2014-08-21 2018-09-05 The General Hospital Corporation Tumornekrosefaktor-superfamilie und tnf-like-ligand-muteine sowie verfahren zur herstellung und verwendung davon

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Also Published As

Publication number Publication date
CA2465361A1 (en) 2003-05-15
JP2005536447A (ja) 2005-12-02
ATE419875T1 (de) 2009-01-15
EP1455840A2 (de) 2004-09-15
WO2003039458A3 (en) 2003-11-20
EP1455840B1 (de) 2009-01-07
US7214368B2 (en) 2007-05-08
EP1455840A4 (de) 2004-12-15
WO2003039458A2 (en) 2003-05-15
US20100305199A1 (en) 2010-12-02
US20030086904A1 (en) 2003-05-08
US20030086903A1 (en) 2003-05-08
US20120203052A1 (en) 2012-08-09
US20070166284A1 (en) 2007-07-19

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