DE60233434D1 - Ph-empfindliche polymere konjugate eines karzinostatischen anthracyclin-arzneimittels für die gezielte therapie - Google Patents
Ph-empfindliche polymere konjugate eines karzinostatischen anthracyclin-arzneimittels für die gezielte therapieInfo
- Publication number
- DE60233434D1 DE60233434D1 DE60233434T DE60233434T DE60233434D1 DE 60233434 D1 DE60233434 D1 DE 60233434D1 DE 60233434 T DE60233434 T DE 60233434T DE 60233434 T DE60233434 T DE 60233434T DE 60233434 D1 DE60233434 D1 DE 60233434D1
- Authority
- DE
- Germany
- Prior art keywords
- amino acids
- units
- amino
- oligopeptides
- methacryloylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ20014653A CZ293787B6 (cs) | 2001-12-20 | 2001-12-20 | pH senzitivní polymerní konjugáty antracyklinového kancerostatika pro cílenou terapii |
| PCT/CZ2002/000070 WO2003053473A2 (en) | 2001-12-20 | 2002-12-20 | Ph-sensitive polymeric conjugates of an anthracycline drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60233434D1 true DE60233434D1 (de) | 2009-10-01 |
Family
ID=5473644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60233434T Expired - Lifetime DE60233434D1 (de) | 2001-12-20 | 2002-12-20 | Ph-empfindliche polymere konjugate eines karzinostatischen anthracyclin-arzneimittels für die gezielte therapie |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7919076B2 (de) |
| EP (2) | EP1463529B9 (de) |
| JP (1) | JP4718117B2 (de) |
| KR (1) | KR20040076874A (de) |
| AT (1) | ATE439864T1 (de) |
| AU (1) | AU2002366715A1 (de) |
| CA (1) | CA2470976A1 (de) |
| CZ (1) | CZ293787B6 (de) |
| DE (1) | DE60233434D1 (de) |
| DK (1) | DK1463529T5 (de) |
| EA (1) | EA007353B1 (de) |
| ES (1) | ES2331303T3 (de) |
| HU (1) | HUP0500541A3 (de) |
| PL (1) | PL216518B1 (de) |
| PT (1) | PT1463529E (de) |
| SI (1) | SI1463529T1 (de) |
| SK (1) | SK2912004A3 (de) |
| WO (1) | WO2003053473A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ294996B6 (cs) * | 2003-07-16 | 2005-04-13 | Ústav Makromolekulární Chemie Av Čr | Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů |
| US8614228B2 (en) | 2004-08-11 | 2013-12-24 | Arqule, Inc. | Quinone prodrug compositions and methods of use |
| US7812051B2 (en) | 2004-08-11 | 2010-10-12 | Arqule, Inc. | Pharmaceutical compositions of β-lapachone and β-lapachone analogs with improved tumor targeting potential |
| CZ297827B6 (cs) * | 2005-09-05 | 2007-04-04 | Zentiva, A. S. | Zpusob prípravy polymerních konjugátu doxorubicinu s pH-rízeným uvolnováním léciva |
| CZ2006207A3 (cs) * | 2006-03-28 | 2008-01-16 | Zentiva, A. S. | Micelární nosiče léčiv s protinádorovou aktivitou |
| SG174055A1 (en) | 2006-08-09 | 2011-09-29 | Sumitomo Bakelite Co | Sugar chain-capturing substance and use thereof |
| CZ2006505A3 (cs) * | 2006-08-09 | 2008-04-09 | Zentiva, A. S. | Polymerní konjugáty doxorubicinu s pH-rízeným uvolnováním léciva a zpusob jejich prípravy |
| CZ298945B6 (cs) * | 2006-09-18 | 2008-03-19 | Zentiva, A. S. | Polymerní lécivo a zpusob jeho výroby |
| DK2152686T3 (en) | 2007-04-30 | 2015-01-12 | Arqule Inc | HYDROXYSULFONAT OF quinone compounds AND THEIR USES |
| CZ301288B6 (cs) * | 2008-10-23 | 2009-12-30 | Zentiva, A. S | Polymerní prípravek se synergickým úcinkem pri lécbe nádorových onemocnení |
| CZ302830B6 (cs) * | 2009-12-15 | 2011-11-30 | Ústav makromolekulární chemie AV CR, v.v.i. | Vysokomolekulární polymerní nosice léciv odvozené od dendrimeru a jejich konjugáty s lécivy pro lécbu zejména pevných nádoru |
| EP3069715A1 (de) | 2015-03-20 | 2016-09-21 | Salmon Pharma GmbH | Dosierungsformen von atomoxetin mit sofortiger freisetzung |
| EP3525808A4 (de) * | 2016-10-14 | 2020-06-24 | University of Utah Research Foundation | Antikörper-polymer-wirkstoffkonjugate |
| WO2021084087A1 (en) * | 2019-10-30 | 2021-05-06 | Cis Pharma Ag | Biocompatible polymeric drug carriers for delivering active agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
-
2001
- 2001-12-20 CZ CZ20014653A patent/CZ293787B6/cs not_active IP Right Cessation
-
2002
- 2002-12-20 CA CA002470976A patent/CA2470976A1/en not_active Abandoned
- 2002-12-20 JP JP2003554229A patent/JP4718117B2/ja not_active Expired - Lifetime
- 2002-12-20 AU AU2002366715A patent/AU2002366715A1/en not_active Abandoned
- 2002-12-20 SI SI200230855T patent/SI1463529T1/sl unknown
- 2002-12-20 WO PCT/CZ2002/000070 patent/WO2003053473A2/en active Application Filing
- 2002-12-20 PL PL370719A patent/PL216518B1/pl not_active IP Right Cessation
- 2002-12-20 KR KR10-2004-7009872A patent/KR20040076874A/ko not_active Application Discontinuation
- 2002-12-20 PT PT02805243T patent/PT1463529E/pt unknown
- 2002-12-20 DE DE60233434T patent/DE60233434D1/de not_active Expired - Lifetime
- 2002-12-20 SK SK291-2004A patent/SK2912004A3/sk not_active Application Discontinuation
- 2002-12-20 AT AT02805243T patent/ATE439864T1/de active
- 2002-12-20 EP EP02805243A patent/EP1463529B9/de not_active Expired - Lifetime
- 2002-12-20 US US10/499,422 patent/US7919076B2/en active Active
- 2002-12-20 DK DK02805243.9T patent/DK1463529T5/da active
- 2002-12-20 EA EA200400802A patent/EA007353B1/ru not_active IP Right Cessation
- 2002-12-20 EP EP06025316A patent/EP1782833A3/de not_active Withdrawn
- 2002-12-20 HU HU0500541A patent/HUP0500541A3/hu unknown
- 2002-12-20 ES ES02805243T patent/ES2331303T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| PL370719A1 (en) | 2005-05-30 |
| CA2470976A1 (en) | 2003-07-03 |
| ATE439864T1 (de) | 2009-09-15 |
| HUP0500541A3 (en) | 2011-08-29 |
| WO2003053473A3 (en) | 2004-04-29 |
| JP4718117B2 (ja) | 2011-07-06 |
| PL216518B1 (pl) | 2014-04-30 |
| EA007353B1 (ru) | 2006-10-27 |
| AU2002366715A1 (en) | 2003-07-09 |
| EP1463529A2 (de) | 2004-10-06 |
| ES2331303T9 (es) | 2011-08-18 |
| SI1463529T1 (sl) | 2010-01-29 |
| EP1463529B9 (de) | 2011-03-23 |
| EA200400802A1 (ru) | 2005-02-24 |
| HUP0500541A2 (hu) | 2005-09-28 |
| CZ20014653A3 (cs) | 2003-08-13 |
| ES2331303T3 (es) | 2009-12-29 |
| KR20040076874A (ko) | 2004-09-03 |
| PT1463529E (pt) | 2009-11-03 |
| CZ293787B6 (cs) | 2004-07-14 |
| US20060057099A1 (en) | 2006-03-16 |
| EP1782833A2 (de) | 2007-05-09 |
| DK1463529T5 (da) | 2011-06-27 |
| AU2002366715A8 (en) | 2003-07-09 |
| DK1463529T3 (da) | 2009-10-19 |
| JP2005519044A (ja) | 2005-06-30 |
| EP1463529B1 (de) | 2009-08-19 |
| WO2003053473A2 (en) | 2003-07-03 |
| US7919076B2 (en) | 2011-04-05 |
| EP1782833A3 (de) | 2008-03-19 |
| SK2912004A3 (en) | 2004-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |