DE60234193D1 - Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungen - Google Patents
Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungenInfo
- Publication number
- DE60234193D1 DE60234193D1 DE60234193T DE60234193T DE60234193D1 DE 60234193 D1 DE60234193 D1 DE 60234193D1 DE 60234193 T DE60234193 T DE 60234193T DE 60234193 T DE60234193 T DE 60234193T DE 60234193 D1 DE60234193 D1 DE 60234193D1
- Authority
- DE
- Germany
- Prior art keywords
- geneva
- bindings
- disulphide
- constructed
- factor viii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29857801P | 2001-06-14 | 2001-06-14 | |
PCT/US2002/019017 WO2002103024A2 (en) | 2001-06-14 | 2002-06-14 | Stabilized proteins with engineered disulfide bonds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60234193D1 true DE60234193D1 (de) | 2009-12-10 |
Family
ID=23151124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60234193T Expired - Lifetime DE60234193D1 (de) | 2001-06-14 | 2002-06-14 | Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungen |
Country Status (8)
Country | Link |
---|---|
US (2) | US7205278B2 (de) |
EP (2) | EP2110385A1 (de) |
JP (2) | JP4361786B2 (de) |
AU (1) | AU2002310438B2 (de) |
CA (1) | CA2450732A1 (de) |
DE (1) | DE60234193D1 (de) |
ES (1) | ES2331909T3 (de) |
WO (1) | WO2002103024A2 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2450732A1 (en) * | 2001-06-14 | 2002-12-27 | John H. Griffin | Stabilized proteins with engineered disulfide bonds |
EP1502921A1 (de) * | 2003-07-29 | 2005-02-02 | ZLB Behring GmbH | Rekombinanter mutierter menschlicher Factor VIII (FVIII) mit verbesserter Stabilität |
US7855274B2 (en) * | 2003-12-03 | 2010-12-21 | University Of Rochester | Recombinant factor VIII having increased specific activity |
US20060019893A1 (en) * | 2004-07-02 | 2006-01-26 | Genentech, Inc. | Factor VIIa variants |
NO345800B1 (no) * | 2004-11-12 | 2021-08-09 | Bayer Healthcare Llc | Isolert konjugat omfattende full-lengde faktor VIII kovalent festet ved B-domenet til en eller flere biokompatible polymerer, farmasøytisk sammensetning og anvendelse for behandling av hemofili. |
US20110124565A1 (en) * | 2005-04-14 | 2011-05-26 | Hans-Peter Hauser | Modified Coagulation Factor VIII With Enhanced Stability and Its Derivatives |
GB0514779D0 (en) * | 2005-07-19 | 2005-08-24 | Celltech R&D Ltd | Biological products |
EP1816201A1 (de) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modifizierter Koagulationsfaktor VIIa mit verbesserter 'half-life'-Stabiltät |
US20100144620A1 (en) * | 2006-11-16 | 2010-06-10 | Crucell Holland B.V. | Complementation of factor xi deficeincy by factor v mutants |
EP2097096B1 (de) | 2006-12-22 | 2017-05-31 | CSL Behring GmbH | Veränderte koagulationsfaktoren mit verlängerter in vivo halbwertzeit |
MX2010004813A (es) * | 2007-11-01 | 2010-10-04 | Univ Rochester | Factor viii recombinante que tiene estabilidad incrementada. |
WO2009156137A1 (en) | 2008-06-24 | 2009-12-30 | Csl Behring Gmbh | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
AU2010207725B2 (en) * | 2009-01-22 | 2015-06-11 | Novo Nordisk Health Care Ag | Stable growth hormone compounds |
MX2012004677A (es) * | 2009-10-30 | 2012-07-25 | Agres Ltd | Proteinas en capsulantes de aceites modificados y sus usos. |
MX345736B (es) | 2010-01-22 | 2017-02-14 | Novo Nordisk Healthcare Ag | Hormonas de crecimiento con eficacia in vivo prolongada. |
EP2525833A2 (de) * | 2010-01-22 | 2012-11-28 | Novo Nordisk Health Care AG | Stabile wachstumshormonverbindungen |
WO2012007324A2 (en) * | 2010-07-15 | 2012-01-19 | Novo Nordisk A/S | Stabilized factor viii variants |
WO2012010516A1 (en) * | 2010-07-22 | 2012-01-26 | Novo Nordisk Health Care Ag | Growth hormone conjugates |
ES2651523T3 (es) | 2012-02-15 | 2018-01-26 | Csl Behring Gmbh | Variantes del Factor de von Willebrand que tienen afinidad de unión al Factor VIII mejorada |
US9238676B2 (en) | 2012-05-17 | 2016-01-19 | Ra Pharmaceuticals, Inc. | Peptide and peptidomimetic inhibitors |
AU2014237111B2 (en) * | 2013-03-15 | 2018-06-21 | Bayer Healthcare Llc | Recombinant factor VIII formulations |
US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
ES2657291T3 (es) | 2013-04-22 | 2018-03-02 | Csl Ltd. | Un complejo covalente de factor de von Willebrand y factor VIII asociado por un puente disulfuro |
JP2017500372A (ja) * | 2013-11-04 | 2017-01-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 出血または凝固性低下と関係する容態の治療療法または予防療法 |
JP6676551B2 (ja) | 2014-07-02 | 2020-04-08 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 改変フォンウィルブランド因子 |
JP2018510212A (ja) | 2015-03-06 | 2018-04-12 | ツェー・エス・エル・ベーリング・レコンビナント・ファシリティ・アクチエンゲゼルシャフト | 向上した半減期を有する改変したフォンヴィレブランド因子 |
EP3297656B1 (de) | 2015-05-22 | 2020-01-08 | CSL Behring Lengnau AG | Verkürzte von-willebrand-faktor-polypeptide zur behandlung von hämophilie |
SG11201708754XA (en) | 2015-05-22 | 2017-12-28 | Csl Behring Recombinant Facility Ag | Methods for preparing modified von willebrand factor |
CN104974228B (zh) * | 2015-06-15 | 2017-10-17 | 四川合泰新光生物科技有限公司 | 一种小分子多肽zy4及其应用 |
DK3400238T3 (da) | 2016-01-07 | 2021-07-26 | CSL Behring Lengnau AG | Muteret von willebrand faktor |
ES2909573T3 (es) | 2016-01-07 | 2022-05-09 | CSL Behring Lengnau AG | Factor de von Willebrand truncado mutado |
ES2869339T3 (es) | 2016-11-11 | 2021-10-25 | CSL Behring Lengnau AG | Polipéptidos del factor von Willebrand truncados para el tratamiento de la hemofilia |
SG10201912768YA (en) | 2016-11-11 | 2020-02-27 | CSL Behring Lengnau AG | Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder |
CN112368379A (zh) | 2018-04-19 | 2021-02-12 | 自由大学基金会 | 蛋白质大环化 |
WO2019210187A1 (en) * | 2018-04-26 | 2019-10-31 | The University Of North Carolina At Chapel Hill | Methods and compositions for treatment of hemophilia |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5214033A (en) | 1983-03-31 | 1993-05-25 | Scripps Clinic & Research Foundation | Factor VIII coagulant polypeptides |
US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
SE8501050D0 (sv) | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
EP0218712B1 (de) | 1985-04-12 | 1992-02-26 | Genetics Institute, Inc. | Neue prokoagulierungsproteine |
US5198349A (en) | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
US5250421A (en) | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
US5422260A (en) | 1986-05-29 | 1995-06-06 | Genetics Institute, Inc. -Legal Affairs | Human factor VIII:c muteins |
US4853871A (en) * | 1987-04-06 | 1989-08-01 | Genex Corporation | Computer-based method for designing stablized proteins |
US5449759A (en) * | 1987-05-16 | 1995-09-12 | Somatogen, Inc. | Hemoglobins with intersubunit desulfide bonds |
US5827821A (en) * | 1987-12-10 | 1998-10-27 | The Burnham Institute | Conformationally stabilized cell adhesion peptides |
US5009889A (en) | 1987-12-31 | 1991-04-23 | Oklahoma Medical Research Foundation | Treatment of dysfunctional vascular endothelium using activated protein C |
US4852871A (en) * | 1988-12-02 | 1989-08-01 | John Perko | Hand exercise device |
US5082767A (en) | 1989-02-27 | 1992-01-21 | Hatfield G Wesley | Codon pair utilization |
US5610137A (en) | 1990-12-20 | 1997-03-11 | The Uab Research Foundation | Transgenic, cross-linked hemoglobin |
US5661008A (en) | 1991-03-15 | 1997-08-26 | Kabi Pharmacia Ab | Recombinant human factor VIII derivatives |
US5114148A (en) * | 1991-07-09 | 1992-05-19 | Liu Ming Zen | Puzzle device |
US6174666B1 (en) | 1992-03-27 | 2001-01-16 | The United States Of America As Represented By The Department Of Health And Human Services | Method of eliminating inhibitory/instability regions from mRNA |
US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
US5364771A (en) | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
US5453937A (en) | 1993-04-28 | 1995-09-26 | Immunex Corporation | Method and system for protein modeling |
US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
DE4418635C2 (de) * | 1994-05-27 | 1997-07-24 | Immuno Ag | Pharmazeutische Zusammensetzung zur Vorbeugung und Behandlung von Blutgerinnungsstörungen |
US5681746A (en) | 1994-12-30 | 1997-10-28 | Chiron Viagene, Inc. | Retroviral delivery of full length factor VIII |
US5543149A (en) * | 1995-03-01 | 1996-08-06 | Rubin; Stan M. | Treatment for insect bites |
US5935568A (en) | 1995-05-18 | 1999-08-10 | National Jewish Medical & Research Center | Gene therapy for effector cell regulation |
US5910481A (en) * | 1995-11-13 | 1999-06-08 | Immuno Ag | Hybrid proteins with modified activity |
US20040092442A1 (en) * | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
US6114148C1 (en) | 1996-09-20 | 2012-05-01 | Gen Hospital Corp | High level expression of proteins |
US6262238B1 (en) * | 1997-01-14 | 2001-07-17 | Roche Diagnostic, Gmbh | Process for modifying the stability of antibodies |
EP0969862B1 (de) | 1997-02-07 | 2006-10-18 | Merck & Co., Inc. | Synthetische hiv gag gene |
US6358703B1 (en) | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
CA2450732A1 (en) * | 2001-06-14 | 2002-12-27 | John H. Griffin | Stabilized proteins with engineered disulfide bonds |
-
2002
- 2002-06-14 CA CA002450732A patent/CA2450732A1/en not_active Abandoned
- 2002-06-14 ES ES02737516T patent/ES2331909T3/es not_active Expired - Lifetime
- 2002-06-14 JP JP2003505346A patent/JP4361786B2/ja not_active Expired - Fee Related
- 2002-06-14 US US10/172,712 patent/US7205278B2/en not_active Expired - Fee Related
- 2002-06-14 AU AU2002310438A patent/AU2002310438B2/en not_active Ceased
- 2002-06-14 EP EP09159506A patent/EP2110385A1/de not_active Withdrawn
- 2002-06-14 EP EP02737516A patent/EP1421539B1/de not_active Expired - Fee Related
- 2002-06-14 DE DE60234193T patent/DE60234193D1/de not_active Expired - Lifetime
- 2002-06-14 WO PCT/US2002/019017 patent/WO2002103024A2/en active Application Filing
-
2007
- 2007-01-25 US US11/627,197 patent/US7928199B2/en not_active Expired - Fee Related
-
2008
- 2008-05-12 JP JP2008124202A patent/JP2008271975A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2110385A8 (de) | 2010-06-02 |
JP4361786B2 (ja) | 2009-11-11 |
EP1421539A4 (de) | 2005-11-09 |
JP2005500831A (ja) | 2005-01-13 |
EP2110385A1 (de) | 2009-10-21 |
US7928199B2 (en) | 2011-04-19 |
US20030125232A1 (en) | 2003-07-03 |
WO2002103024A3 (en) | 2004-03-18 |
AU2002310438B2 (en) | 2008-05-01 |
ES2331909T3 (es) | 2010-01-20 |
EP1421539B1 (de) | 2009-10-28 |
EP1421539A2 (de) | 2004-05-26 |
JP2008271975A (ja) | 2008-11-13 |
US20070276128A1 (en) | 2007-11-29 |
CA2450732A1 (en) | 2002-12-27 |
WO2002103024A2 (en) | 2002-12-27 |
US7205278B2 (en) | 2007-04-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |