DE60236522D1 - G-csf konjugate - Google Patents
G-csf konjugateInfo
- Publication number
- DE60236522D1 DE60236522D1 DE60236522T DE60236522T DE60236522D1 DE 60236522 D1 DE60236522 D1 DE 60236522D1 DE 60236522 T DE60236522 T DE 60236522T DE 60236522 T DE60236522 T DE 60236522T DE 60236522 D1 DE60236522 D1 DE 60236522D1
- Authority
- DE
- Germany
- Prior art keywords
- csf
- conjugates
- lysine residue
- polypeptide
- conjugated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/904,196 US6555660B2 (en) | 2000-01-10 | 2001-07-11 | G-CSF conjugates |
DKPA200200447 | 2002-03-22 | ||
DKPA200200708 | 2002-05-08 | ||
PCT/DK2002/000482 WO2003006501A2 (en) | 2001-07-11 | 2002-07-10 | G-csf conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60236522D1 true DE60236522D1 (de) | 2010-07-08 |
Family
ID=27222576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60236522T Expired - Lifetime DE60236522D1 (de) | 2001-07-11 | 2002-07-10 | G-csf konjugate |
Country Status (16)
Country | Link |
---|---|
US (4) | US7550565B2 (de) |
EP (1) | EP1425304B9 (de) |
JP (1) | JP4444652B2 (de) |
KR (1) | KR100961859B1 (de) |
AT (1) | ATE468862T1 (de) |
AU (1) | AU2002325819B2 (de) |
BR (1) | BR0211071A (de) |
CA (1) | CA2452582C (de) |
DE (1) | DE60236522D1 (de) |
HU (1) | HUP0400466A3 (de) |
IL (1) | IL159524A0 (de) |
MX (1) | MXPA04000231A (de) |
NO (1) | NO20040093L (de) |
NZ (1) | NZ530545A (de) |
PL (1) | PL371781A1 (de) |
WO (1) | WO2003006501A2 (de) |
Families Citing this family (50)
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US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
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US20060228331A1 (en) * | 2003-10-10 | 2006-10-12 | Novo Nordisk A/S | IL-21 Derivatives and variants |
WO2005035565A1 (en) * | 2003-10-10 | 2005-04-21 | Novo Nordisk A/S | Il-21 derivatives |
US7220407B2 (en) | 2003-10-27 | 2007-05-22 | Amgen Inc. | G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
NZ547554A (en) * | 2003-12-03 | 2009-09-25 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
EP1586334A1 (de) * | 2004-04-15 | 2005-10-19 | TRASTEC scpa | G-CSF Konjugate mit PEG |
EP1814573B1 (de) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf) |
CA2586365A1 (en) | 2004-11-05 | 2006-05-26 | Northwestern University | Use of scf and g-csf in the treatment of cerebral ischemia and neurological disorders |
JP2006137678A (ja) * | 2004-11-10 | 2006-06-01 | Shionogi & Co Ltd | インターロイキン−2組成物 |
NZ556436A (en) | 2005-01-10 | 2010-11-26 | Biogenerix Ag | Glycopegylated granulocyte colony stimulating factor |
US9187546B2 (en) | 2005-04-08 | 2015-11-17 | Novo Nordisk A/S | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
BRPI0611221A2 (pt) * | 2005-06-01 | 2010-08-24 | Maxygen Holdings Ltd | polipeptÍdeos de g-csf peguilados e mÉtodos de produÇço dos mesmos |
KR100694994B1 (ko) | 2005-06-13 | 2007-03-14 | 씨제이 주식회사 | 사람 과립구 콜로니 형성인자 동종체 |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007049941A1 (en) * | 2005-10-27 | 2007-05-03 | Peptron Co., Ltd | Bioactive substance carrier for in vivo stable delivery tehreof, conjugate containing the same, and method of in vivo stable delivery of the bioactive substance |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
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EP2049149B1 (de) * | 2006-07-31 | 2015-04-15 | Novo Nordisk A/S | Pegylierte verlängerte insuline |
ITMI20061624A1 (it) * | 2006-08-11 | 2008-02-12 | Bioker Srl | Mono-coniugati sito-specifici di g-csf |
JP2010505874A (ja) | 2006-10-03 | 2010-02-25 | ノヴォ ノルディスク アー/エス | ポリペプチドコンジュゲートの精製方法 |
KR20150064246A (ko) | 2007-04-03 | 2015-06-10 | 바이오제너릭스 게엠베하 | 글리코페길화 g―csf를 이용하는 치료 방법 |
JP5876649B2 (ja) | 2007-06-12 | 2016-03-02 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | ヌクレオチド糖の改良製造法 |
CN103497246B (zh) | 2008-02-27 | 2016-08-10 | 诺沃—诺迪斯克有限公司 | 缀合的因子viii分子 |
JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
CN102215876A (zh) * | 2008-09-19 | 2011-10-12 | 马克西根公司 | 通过施用多peg化的粒细胞集落刺激因子(g-csf)变体来治疗辐射诱发的嗜中性细胞减少症的方法 |
CN102625811B (zh) | 2008-10-10 | 2016-09-21 | 安姆根有限公司 | Fgf21突变体及其用途 |
EP2427207B1 (de) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Fgf21-mutanten und ihre verwendungen |
EA021425B1 (ru) | 2009-05-05 | 2015-06-30 | Амген Инк. | Мутанты fgf21 и их применение |
MX2011013903A (es) * | 2009-06-17 | 2012-05-08 | Amgen Inc | Polipeptidos quimericos y usos de los mismos. |
US8450086B2 (en) | 2009-11-17 | 2013-05-28 | Centocor Ortho Biotech Inc. | Bacterial membrane protein secretion |
MX2012006397A (es) | 2009-12-02 | 2012-11-30 | Amgen Inc | PROTEINAS DE ENLACE QUE ENLAZAN A FGFR1C HUMANO, ß-KLOTHO HUMANA Y TANTO FGFR1C HUMANO COMO ß-KLOTHO HUMANA. |
UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
CN102906108B (zh) | 2010-03-04 | 2016-01-20 | 菲尼克斯公司 | 用于无变性制备可溶性重组干扰素蛋白的方法 |
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US9517264B2 (en) | 2010-04-15 | 2016-12-13 | Amgen Inc. | Human FGF receptor and β-Klotho binding proteins |
US9320777B2 (en) * | 2011-05-13 | 2016-04-26 | Bolder Biotechnology, Inc. | Methods and use of growth hormone supergene family protein analogs for treatment of radiation exposure |
KR101623906B1 (ko) * | 2014-07-23 | 2016-05-24 | 주식회사 이큐스앤자루 | 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
WO2016013725A1 (ko) * | 2014-07-23 | 2016-01-28 | 주식회사 이큐스앤자루 | 과립구 콜로니 자극인자 변이 단백질 또는 이의 트랜스페린 융합 단백질을 유효성분으로 포함하는 약학적 조성물 |
SG11201700629TA (en) * | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
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US11229683B2 (en) | 2015-09-18 | 2022-01-25 | Bolder Biotechnology, Inc. | Hematopoietic growth factor proteins and analogs thereof and angiotensin converting enzyme inhibitors for treatment of radiation exposure |
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SG11201903882VA (en) | 2016-11-08 | 2019-05-30 | Delinia Inc | Il-2 variants for the treatment of autoimmune diseases |
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-
2002
- 2002-07-10 AU AU2002325819A patent/AU2002325819B2/en not_active Ceased
- 2002-07-10 AT AT02760160T patent/ATE468862T1/de not_active IP Right Cessation
- 2002-07-10 DE DE60236522T patent/DE60236522D1/de not_active Expired - Lifetime
- 2002-07-10 EP EP02760160A patent/EP1425304B9/de not_active Revoked
- 2002-07-10 WO PCT/DK2002/000482 patent/WO2003006501A2/en active Search and Examination
- 2002-07-10 CA CA2452582A patent/CA2452582C/en not_active Expired - Fee Related
- 2002-07-10 NZ NZ530545A patent/NZ530545A/en not_active IP Right Cessation
- 2002-07-10 HU HU0400466A patent/HUP0400466A3/hu active IP Right Revival
- 2002-07-10 MX MXPA04000231A patent/MXPA04000231A/es active IP Right Grant
- 2002-07-10 JP JP2003512271A patent/JP4444652B2/ja not_active Expired - Fee Related
- 2002-07-10 PL PL02371781A patent/PL371781A1/xx not_active Application Discontinuation
- 2002-07-10 BR BR0211071-7A patent/BR0211071A/pt not_active Application Discontinuation
- 2002-07-10 IL IL15952402A patent/IL159524A0/xx unknown
- 2002-07-10 KR KR1020047000431A patent/KR100961859B1/ko not_active IP Right Cessation
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2004
- 2004-01-09 NO NO20040093A patent/NO20040093L/no not_active Application Discontinuation
-
2006
- 2006-08-10 US US11/463,861 patent/US7550565B2/en not_active Expired - Fee Related
- 2006-08-10 US US11/463,863 patent/US7550566B2/en not_active Expired - Fee Related
- 2006-08-10 US US11/463,867 patent/US7696153B2/en not_active Expired - Fee Related
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2010
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Also Published As
Publication number | Publication date |
---|---|
WO2003006501A3 (en) | 2004-03-25 |
US20060286069A1 (en) | 2006-12-21 |
EP1425304B9 (de) | 2010-09-08 |
US20110020266A1 (en) | 2011-01-27 |
US20060286068A1 (en) | 2006-12-21 |
EP1425304B1 (de) | 2010-05-26 |
US7696153B2 (en) | 2010-04-13 |
CA2452582C (en) | 2013-01-22 |
US7550565B2 (en) | 2009-06-23 |
US20070010660A1 (en) | 2007-01-11 |
KR100961859B1 (ko) | 2010-06-09 |
NO20040093L (no) | 2004-03-09 |
IL159524A0 (en) | 2004-06-01 |
JP2005506317A (ja) | 2005-03-03 |
JP4444652B2 (ja) | 2010-03-31 |
KR20040084884A (ko) | 2004-10-06 |
HUP0400466A2 (hu) | 2005-01-28 |
NZ530545A (en) | 2006-10-27 |
WO2003006501A2 (en) | 2003-01-23 |
AU2002325819B2 (en) | 2008-06-19 |
BR0211071A (pt) | 2004-12-21 |
EP1425304A2 (de) | 2004-06-09 |
US7550566B2 (en) | 2009-06-23 |
ATE468862T1 (de) | 2010-06-15 |
PL371781A1 (en) | 2005-06-27 |
CA2452582A1 (en) | 2003-01-23 |
HUP0400466A3 (en) | 2006-01-30 |
MXPA04000231A (es) | 2004-05-04 |
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