DE60239612D1 - Monodisperse mischungen und verfahren zur behandlung von diabetes - Google Patents
Monodisperse mischungen und verfahren zur behandlung von diabetesInfo
- Publication number
- DE60239612D1 DE60239612D1 DE60239612T DE60239612T DE60239612D1 DE 60239612 D1 DE60239612 D1 DE 60239612D1 DE 60239612 T DE60239612 T DE 60239612T DE 60239612 T DE60239612 T DE 60239612T DE 60239612 D1 DE60239612 D1 DE 60239612D1
- Authority
- DE
- Germany
- Prior art keywords
- patient
- diabetes mellitus
- treatment
- diabetes
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26919801P | 2001-02-15 | 2001-02-15 | |
US34771302P | 2002-01-11 | 2002-01-11 | |
PCT/US2002/004440 WO2002065985A2 (en) | 2001-02-15 | 2002-02-14 | Methods of treating diabetes mellitus |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60239612D1 true DE60239612D1 (de) | 2011-05-12 |
Family
ID=26953561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60239612T Expired - Lifetime DE60239612D1 (de) | 2001-02-15 | 2002-02-14 | Monodisperse mischungen und verfahren zur behandlung von diabetes |
Country Status (17)
Country | Link |
---|---|
US (3) | US7060675B2 (de) |
EP (1) | EP1409006B1 (de) |
JP (1) | JP4113778B2 (de) |
KR (1) | KR100896945B1 (de) |
AT (1) | ATE503490T1 (de) |
AU (1) | AU2002244020B2 (de) |
BR (1) | BRPI0207700B8 (de) |
CA (1) | CA2437940C (de) |
CY (1) | CY1112034T1 (de) |
DE (1) | DE60239612D1 (de) |
DK (1) | DK1409006T3 (de) |
MX (1) | MXPA03007374A (de) |
NO (1) | NO327586B1 (de) |
NZ (1) | NZ527392A (de) |
PT (1) | PT1409006E (de) |
WO (1) | WO2002065985A2 (de) |
ZA (1) | ZA200306332B (de) |
Families Citing this family (71)
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US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
EP1270012A1 (de) * | 2001-06-21 | 2003-01-02 | Pfizer Products Inc. | Verwendung pulmonär verabreichten Insulins zur Behandlung von Diabetes |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US20030198666A1 (en) * | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
US7601688B2 (en) * | 2002-06-13 | 2009-10-13 | Biocon Limited | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
US20040091544A1 (en) * | 2002-11-08 | 2004-05-13 | Ruff Michael D. | Coated dibasic calcium phosphate |
AU2003297583B2 (en) * | 2002-11-26 | 2010-01-14 | Biocon, Ltd | Modified naturetic compounds, conjugates, and uses thereof |
ES2465496T3 (es) * | 2003-01-06 | 2014-06-05 | Emisphere Technologies, Inc. | Terapia de insulina oral nocturna |
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EP1605895A4 (de) * | 2003-03-06 | 2011-08-24 | Emisphere Tech Inc | Orale insulintherapien und protokoll |
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EP1660047B1 (de) * | 2003-08-13 | 2013-11-27 | Biocon Limited | Mikroteilchenförmige fettsäure-salz-festdosis-formulierungen für therapeutische mittel |
US20050203001A1 (en) * | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
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ATE522518T1 (de) | 2006-05-31 | 2011-09-15 | Takeda San Diego Inc | Indazol- und isoindolderivate als glucokinaseaktivierende stoffe |
KR20140109509A (ko) | 2006-07-11 | 2014-09-15 | 큐피에스 엘엘씨 | 펩타이드의 지속 방출 전달을 위한 의약 조성물 |
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TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
WO2013086927A1 (zh) * | 2011-12-15 | 2013-06-20 | 上海恒瑞医药有限公司 | 人胰岛素类似物及其酰化衍生物 |
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TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
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-
2002
- 2002-02-13 US US10/075,097 patent/US7060675B2/en not_active Expired - Lifetime
- 2002-02-14 MX MXPA03007374A patent/MXPA03007374A/es active IP Right Grant
- 2002-02-14 WO PCT/US2002/004440 patent/WO2002065985A2/en active Search and Examination
- 2002-02-14 KR KR1020037010645A patent/KR100896945B1/ko active IP Right Grant
- 2002-02-14 DE DE60239612T patent/DE60239612D1/de not_active Expired - Lifetime
- 2002-02-14 EP EP02709541A patent/EP1409006B1/de not_active Expired - Lifetime
- 2002-02-14 NZ NZ527392A patent/NZ527392A/en not_active IP Right Cessation
- 2002-02-14 JP JP2002565546A patent/JP4113778B2/ja not_active Expired - Lifetime
- 2002-02-14 AT AT02709541T patent/ATE503490T1/de active
- 2002-02-14 DK DK02709541.3T patent/DK1409006T3/da active
- 2002-02-14 PT PT02709541T patent/PT1409006E/pt unknown
- 2002-02-14 AU AU2002244020A patent/AU2002244020B2/en not_active Expired
- 2002-02-14 BR BRPI0207700A patent/BRPI0207700B8/pt not_active IP Right Cessation
- 2002-02-14 CA CA2437940A patent/CA2437940C/en not_active Expired - Lifetime
-
2003
- 2003-08-14 NO NO20033617A patent/NO327586B1/no not_active IP Right Cessation
- 2003-08-14 ZA ZA2003/06332A patent/ZA200306332B/en unknown
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2005
- 2005-12-21 US US11/314,309 patent/US7423014B2/en not_active Expired - Fee Related
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2006
- 2006-06-15 US US11/424,295 patent/US7381702B2/en not_active Expired - Fee Related
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Publication number | Publication date |
---|---|
CY1112034T1 (el) | 2015-11-04 |
ATE503490T1 (de) | 2011-04-15 |
KR20040043113A (ko) | 2004-05-22 |
MXPA03007374A (es) | 2003-12-04 |
NO327586B1 (no) | 2009-08-24 |
JP2004527487A (ja) | 2004-09-09 |
US7423014B2 (en) | 2008-09-09 |
EP1409006A4 (de) | 2005-01-19 |
DK1409006T3 (da) | 2011-06-14 |
AU2002244020B2 (en) | 2007-08-16 |
US20060100137A1 (en) | 2006-05-11 |
NO20033617D0 (no) | 2003-08-14 |
US7060675B2 (en) | 2006-06-13 |
JP4113778B2 (ja) | 2008-07-09 |
WO2002065985A2 (en) | 2002-08-29 |
PT1409006E (pt) | 2011-07-01 |
US20060293219A1 (en) | 2006-12-28 |
BRPI0207700B8 (pt) | 2021-05-25 |
US20030050228A1 (en) | 2003-03-13 |
US7381702B2 (en) | 2008-06-03 |
KR100896945B1 (ko) | 2009-05-14 |
WO2002065985A3 (en) | 2004-02-19 |
NO20033617L (no) | 2003-10-15 |
ZA200306332B (en) | 2005-07-27 |
CA2437940C (en) | 2012-07-10 |
EP1409006B1 (de) | 2011-03-30 |
BRPI0207700B1 (pt) | 2016-06-07 |
BR0207700A (pt) | 2005-07-19 |
NZ527392A (en) | 2008-01-31 |
EP1409006A2 (de) | 2004-04-21 |
CA2437940A1 (en) | 2002-08-29 |
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