DE60306572D1 - Vorrichtung und Verfahren zum Bewegen von Flüssikgeitstropfen mit Hilfe von elektrostatischer Kraft - Google Patents

Vorrichtung und Verfahren zum Bewegen von Flüssikgeitstropfen mit Hilfe von elektrostatischer Kraft

Info

Publication number
DE60306572D1
DE60306572D1 DE60306572T DE60306572T DE60306572D1 DE 60306572 D1 DE60306572 D1 DE 60306572D1 DE 60306572 T DE60306572 T DE 60306572T DE 60306572 T DE60306572 T DE 60306572T DE 60306572 D1 DE60306572 D1 DE 60306572D1
Authority
DE
Germany
Prior art keywords
liquid
electrostatic force
moving
drop
liquid drop
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60306572T
Other languages
English (en)
Other versions
DE60306572T2 (de
Inventor
Scott A Elrod
Eric Peeters
Francisco E Torres
David K Biegelsen
John L Dunec
Alan G Bell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palo Alto Research Center Inc
Original Assignee
Palo Alto Research Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palo Alto Research Center Inc filed Critical Palo Alto Research Center Inc
Publication of DE60306572D1 publication Critical patent/DE60306572D1/de
Application granted granted Critical
Publication of DE60306572T2 publication Critical patent/DE60306572T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/14—Mixing drops, droplets or bodies of liquid which flow together or contact each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B26/00—Optical devices or arrangements for the control of light using movable or deformable optical elements
    • G02B26/004—Optical devices or arrangements for the control of light using movable or deformable optical elements based on a displacement or a deformation of a fluid
    • G02B26/005—Optical devices or arrangements for the control of light using movable or deformable optical elements based on a displacement or a deformation of a fluid based on electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/0036—Nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
DE60306572T 2002-04-01 2003-04-01 Vorrichtung und Verfahren zum Bewegen von Flüssigkeitstropfen mit Hilfe von elektrostatischer Kraft Expired - Lifetime DE60306572T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/115,336 US7147763B2 (en) 2002-04-01 2002-04-01 Apparatus and method for using electrostatic force to cause fluid movement
US115336 2002-04-01

Publications (2)

Publication Number Publication Date
DE60306572D1 true DE60306572D1 (de) 2006-08-17
DE60306572T2 DE60306572T2 (de) 2006-11-09

Family

ID=28453897

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60306572T Expired - Lifetime DE60306572T2 (de) 2002-04-01 2003-04-01 Vorrichtung und Verfahren zum Bewegen von Flüssigkeitstropfen mit Hilfe von elektrostatischer Kraft

Country Status (4)

Country Link
US (1) US7147763B2 (de)
EP (1) EP1354630B1 (de)
JP (1) JP2004000935A (de)
DE (1) DE60306572T2 (de)

Families Citing this family (196)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754492B2 (en) * 2002-04-01 2010-07-13 Palo Alto Research Center Incorporated Thermal sensing device
US7141210B2 (en) * 2002-04-01 2006-11-28 Palo Alto Research Center Incorporated Apparatus and method for a nanocalorimeter for detecting chemical reactions
US7473031B2 (en) * 2002-04-01 2009-01-06 Palo Alto Research Center, Incorporated Resistive thermal sensing
US7833800B2 (en) * 2002-04-01 2010-11-16 Palo Alto Research Center Incorporated Thermal sensing with bridge circuitry
US7473030B2 (en) * 2002-04-01 2009-01-06 Palo Alto Research Center Incorporated Thermal sensing
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
US6989234B2 (en) * 2002-09-24 2006-01-24 Duke University Method and apparatus for non-contact electrostatic actuation of droplets
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
US7547380B2 (en) * 2003-01-13 2009-06-16 North Carolina State University Droplet transportation devices and methods having a fluid surface
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
AU2004229440B2 (en) 2003-04-10 2010-08-12 President And Fellows Of Harvard College Formation and control of fluidic species
JP4810636B2 (ja) * 2003-05-22 2011-11-09 サムスン エルシーディ ネザーランド アールアンドディ センター ビー ヴィ 表示装置
KR101222564B1 (ko) * 2003-06-30 2013-01-16 라우스테크 피티와이 엘티디 공간 선택적 증착에 의한 마이크로 및 나노 스케일의 제조물 및 제조 방법
AU2003903295A0 (en) * 2003-06-30 2003-07-10 Raustech Pty Ltd Substrate for combinatorial chemistry
EP1658133A1 (de) * 2003-08-27 2006-05-24 President And Fellows Of Harvard College Elektronische steuerung von fluidspezies
US7419835B2 (en) * 2003-11-21 2008-09-02 Palo Alto Research Center Incorporated Screening for ligand binding at specific target sites
US7416897B2 (en) * 2003-11-21 2008-08-26 Palo Alto Research Center Incorporated Method for high-throughput screening assay sample preparation and analysis
US7745161B2 (en) * 2003-12-19 2010-06-29 Palo Alto Research Center Incorporated Amplification of enzymatic reactions for use with an enthalpy array
US7413706B2 (en) * 2003-12-19 2008-08-19 Palo Alto Research Center Incorporated Replaceable parylene membranes for nanocalorimeter
ITPD20030312A1 (it) 2003-12-30 2005-06-30 Geox Spa Suola traspirante ed impermeabile per calzature
JP4256270B2 (ja) * 2004-01-19 2009-04-22 国立大学法人 筑波大学 送液装置及びその駆動方法
FR2866493B1 (fr) * 2004-02-16 2010-08-20 Commissariat Energie Atomique Dispositif de controle du deplacement d'une goutte entre deux ou plusieurs substrats solides
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US8974652B2 (en) * 2004-05-28 2015-03-10 Board Of Regents, The University Of Texas System Programmable fluidic processors
US20080135411A1 (en) * 2004-06-16 2008-06-12 Whitehead Lorne A Microfluidic Transport By Electrostatic Deformation of Fluidic Interfaces
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
ITBO20040420A1 (it) 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
FR2872715B1 (fr) * 2004-07-08 2006-11-17 Commissariat Energie Atomique Microreacteur goutte
DE602005024418D1 (de) 2004-08-26 2010-12-09 Life Technologies Corp Elektrobenetzende abgabevorrichtungen und dazugehörige verfahren
US7507433B2 (en) * 2004-09-03 2009-03-24 Boston Scientific Scimed, Inc. Method of coating a medical device using an electrowetting process
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006044966A1 (en) * 2004-10-18 2006-04-27 Stratos Biosystems, Llc Single-sided apparatus for manipulating droplets by electrowetting-on-dielectric techniques
JP4185904B2 (ja) * 2004-10-27 2008-11-26 株式会社日立ハイテクノロジーズ 液体搬送基板、分析システム、分析方法
US8685216B2 (en) * 2004-12-21 2014-04-01 Palo Alto Research Center Incorporated Apparatus and method for improved electrostatic drop merging and mixing
TWI262309B (en) * 2004-12-31 2006-09-21 Ind Tech Res Inst Droplet controlling apparatus, manufacturing method, controlling method and digital flow inspection apparatus
US7914735B2 (en) * 2005-01-18 2011-03-29 Palo Alto Research Center Incorporated Use of physical barriers to minimize evaporative heat losses
JP5897780B2 (ja) 2005-01-28 2016-03-30 デューク ユニバーシティ プリント回路基板上の液滴操作装置及び方法
US7454988B2 (en) * 2005-02-10 2008-11-25 Applera Corporation Method for fluid sampling using electrically controlled droplets
JP4632300B2 (ja) * 2005-02-14 2011-02-16 国立大学法人 筑波大学 送液装置
CA2606750C (en) * 2005-05-11 2015-11-24 Nanolytics, Inc. Method and device for conducting biochemical or chemical reactions at multiple temperatures
JP4616079B2 (ja) * 2005-05-30 2011-01-19 株式会社日立ハイテクノロジーズ 試料分析装置
ITBO20050481A1 (it) * 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US20070023292A1 (en) * 2005-07-26 2007-02-01 The Regents Of The University Of California Small object moving on printed circuit board
US20070031639A1 (en) * 2005-08-03 2007-02-08 General Electric Company Articles having low wettability and methods for making
US20070059213A1 (en) * 2005-09-15 2007-03-15 Lucent Technologies Inc. Heat-induced transitions on a structured surface
US8734003B2 (en) * 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US8721161B2 (en) * 2005-09-15 2014-05-13 Alcatel Lucent Fluid oscillations on structured surfaces
CN101097264B (zh) * 2006-06-26 2010-10-13 叶哲良 可调焦距的透镜
US7605984B2 (en) * 2005-09-21 2009-10-20 National Tsing Hua University Lens with adjustable focal length
ITBO20050646A1 (it) * 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
TWI303312B (en) * 2005-12-21 2008-11-21 Ind Tech Res Inst Matrix electrodes controlling device and digital fluid detection platform thereof
US7816146B2 (en) * 2005-12-27 2010-10-19 Palo Alto Research Center Incorporated Passive electronic devices
US7784173B2 (en) * 2005-12-27 2010-08-31 Palo Alto Research Center Incorporated Producing layered structures using printing
US8637138B2 (en) 2005-12-27 2014-01-28 Palo Alto Research Center Incorporated Layered structures on thin substrates
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US8261598B2 (en) 2006-03-09 2012-09-11 Agency For Science, Technology And Research Apparatus for performing a reaction in a droplet and method of using the same
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
WO2007114794A1 (en) * 2006-03-31 2007-10-11 Nam Trung Nguyen Active control for droplet-based microfluidics
US20070231542A1 (en) * 2006-04-03 2007-10-04 General Electric Company Articles having low wettability and high light transmission
US20140193807A1 (en) 2006-04-18 2014-07-10 Advanced Liquid Logic, Inc. Bead manipulation techniques
US8613889B2 (en) * 2006-04-13 2013-12-24 Advanced Liquid Logic, Inc. Droplet-based washing
US8492168B2 (en) * 2006-04-18 2013-07-23 Advanced Liquid Logic Inc. Droplet-based affinity assays
US8637317B2 (en) * 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US7763471B2 (en) * 2006-04-18 2010-07-27 Advanced Liquid Logic, Inc. Method of electrowetting droplet operations for protein crystallization
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
WO2007123908A2 (en) * 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
US8809068B2 (en) * 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US8470606B2 (en) * 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7439014B2 (en) * 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US7851184B2 (en) * 2006-04-18 2010-12-14 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification method and apparatus
US7815871B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet microactuator system
WO2009140671A2 (en) 2008-05-16 2009-11-19 Advanced Liquid Logic, Inc. Droplet actuator devices and methods for manipulating beads
US8980198B2 (en) 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US10078078B2 (en) 2006-04-18 2018-09-18 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US7816121B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet actuation system and method
WO2009111769A2 (en) 2008-03-07 2009-09-11 Advanced Liquid Logic, Inc. Reagent and sample preparation and loading on a fluidic device
US7822510B2 (en) * 2006-05-09 2010-10-26 Advanced Liquid Logic, Inc. Systems, methods, and products for graphically illustrating and controlling a droplet actuator
US7939021B2 (en) * 2007-05-09 2011-05-10 Advanced Liquid Logic, Inc. Droplet actuator analyzer with cartridge
US8041463B2 (en) * 2006-05-09 2011-10-18 Advanced Liquid Logic, Inc. Modular droplet actuator drive
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP2530168B1 (de) 2006-05-11 2015-09-16 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
WO2008057499A2 (en) * 2006-11-07 2008-05-15 Walter Charles Hernandez A surface to move a fluid via fringe electric fields
FR2909293B1 (fr) * 2006-12-05 2011-04-22 Commissariat Energie Atomique Micro-dispositif de traitement d'echantillons liquides
US20080145631A1 (en) * 2006-12-19 2008-06-19 General Electric Company Articles having antifouling surfaces and methods for making
US8685344B2 (en) * 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US9046514B2 (en) 2007-02-09 2015-06-02 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
EP2109774B1 (de) 2007-02-15 2018-07-04 Advanced Liquid Logic, Inc. Kapazitätserkennung in einem tröpfchenaktuator
US8440392B2 (en) 2007-03-22 2013-05-14 Advanced Liquid Logic Inc. Method of conducting a droplet based enzymatic assay
DE102007018056A1 (de) * 2007-04-17 2008-10-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Tropfenmanipulation
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US7632008B2 (en) * 2007-06-08 2009-12-15 Palo Alto Research Center Incorporated Ranking fragment types with calorimetry
TWI322032B (en) * 2007-06-20 2010-03-21 Nat Univ Chung Cheng Microfluid mixer
US8951732B2 (en) 2007-06-22 2015-02-10 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
US20100181195A1 (en) * 2007-07-03 2010-07-22 Nxp B.V. Microfluidic chip for and a method of handling fluidic droplets
US8268246B2 (en) 2007-08-09 2012-09-18 Advanced Liquid Logic Inc PCB droplet actuator fabrication
WO2009032863A2 (en) * 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
WO2009052321A2 (en) * 2007-10-18 2009-04-23 Advanced Liquid Logic, Inc. Droplet actuators, systems and methods
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
WO2009061017A1 (en) * 2007-11-09 2009-05-14 Electronics And Telecommunications Research Institute Bio lab-on-a-chip and method of fabricating and operating the same
KR20100100974A (ko) * 2007-12-23 2010-09-15 어드밴스드 리퀴드 로직, 아이엔씨. 액적 작업들을 수행하는 액적 작동기 구성부 및 방법
CA2639954C (en) * 2008-02-11 2017-08-15 Aaron R. Wheeler Droplet-based cell culture and cell assays using digital microfluidics
US8617899B2 (en) * 2008-02-14 2013-12-31 Palo Alto Research Center Incorporated Enhanced drop mixing using magnetic actuation
JP2011514528A (ja) * 2008-03-04 2011-05-06 ウオーターズ・テクノロジーズ・コーポレイシヨン デジタルマイクロ流体デバイスとのインターフェース
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
US7805090B2 (en) * 2008-05-30 2010-09-28 Xerox Corporation Fuser assemblies, xerographic apparatuses and methods of fusing toner on media in xerographic apparatuses
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US8187864B2 (en) * 2008-10-01 2012-05-29 The Governing Council Of The University Of Toronto Exchangeable sheets pre-loaded with reagent depots for digital microfluidics
US8053239B2 (en) 2008-10-08 2011-11-08 The Governing Council Of The University Of Toronto Digital microfluidic method for protein extraction by precipitation from heterogeneous mixtures
WO2010040227A1 (en) 2008-10-10 2010-04-15 The Governing Council Of The University Of Toronto Hybrid digital and channel microfluidic devices and methods of use thereof
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
US8877512B2 (en) * 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US9126198B2 (en) * 2009-02-20 2015-09-08 Japan Science And Technology Agency Transportation of micrometer-sized object and extraction of mechanical work by constant electric field
US9851365B2 (en) 2009-02-26 2017-12-26 The Governing Council Of The University Of Toronto Digital microfluidic liquid-liquid extraction device and method of use thereof
US8202736B2 (en) * 2009-02-26 2012-06-19 The Governing Council Of The University Of Toronto Method of hormone extraction using digital microfluidics
WO2010104606A1 (en) * 2009-03-13 2010-09-16 Sun Chemical Corporation Colored fluids for electrowetting, electrofluidic, and electrophoretic technologies
PT2408562T (pt) 2009-03-17 2018-06-06 Menarini Silicon Biosystems Spa Dispositivo microfluídico para isolamento de células
EP3415235A1 (de) 2009-03-23 2018-12-19 Raindance Technologies Inc. Manipulation von mikrofluidiktröpfchen
US8130072B2 (en) * 2009-05-14 2012-03-06 Palo Alto Research Center Incorporated Vanadium oxide thermal microprobes
US8393785B2 (en) * 2009-05-14 2013-03-12 Palo Alto Research Center Incorporated Nanocalorimeter based on thermal probes
US8628648B2 (en) * 2009-07-07 2014-01-14 The University Of Akron Apparatus and method for manipulating micro component
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) * 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US9091649B2 (en) 2009-11-06 2015-07-28 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel; electrophoresis and molecular analysis
EP2516669B1 (de) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzymassays auf einem tropfenaktuator
EP2517025B1 (de) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Verfahren zur reduzierung des austauschs von molekülen zwischen tröpfchen
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
WO2011126892A2 (en) 2010-03-30 2011-10-13 Advanced Liquid Logic, Inc. Droplet operations platform
EP2567213B1 (de) 2010-05-05 2018-01-24 The Governing Council of the Universtiy of Toronto Verfahren zur verarbeitung getrockneter proben mithilfe einer digitalen mikrofluidischen vorrichtung
EP2588322B1 (de) 2010-06-30 2015-06-17 Advanced Liquid Logic, Inc. Tropfen-stellgliedbaugruppen und verfahren zur herstellung davon
WO2012045012A2 (en) 2010-09-30 2012-04-05 Raindance Technologies, Inc. Sandwich assays in droplets
CA2813090C (en) 2010-10-01 2019-11-12 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
CA2833897C (en) 2011-05-09 2020-05-19 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
EP2707724A4 (de) 2011-05-10 2015-01-21 Advanced Liquid Logic Inc Enzymkonzentration und assays dafür
WO2012167142A2 (en) 2011-06-02 2012-12-06 Raindance Technolgies, Inc. Enzyme quantification
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
BR112014000257A2 (pt) 2011-07-06 2017-03-01 Advanced Liquid Logic Inc armazenamento de reagente em um atuador de gota
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US9513253B2 (en) 2011-07-11 2016-12-06 Advanced Liquid Logic, Inc. Droplet actuators and techniques for droplet-based enzymatic assays
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013016413A2 (en) 2011-07-25 2013-01-31 Advanced Liquid Logic Inc Droplet actuator apparatus and system
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
WO2013078216A1 (en) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Glucose-6-phosphate dehydrogenase assays
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
US9223317B2 (en) 2012-06-14 2015-12-29 Advanced Liquid Logic, Inc. Droplet actuators that include molecular barrier coatings
IN2015DN00359A (de) 2012-06-27 2015-06-12 Advanced Liquid Logic Inc
WO2014062551A1 (en) 2012-10-15 2014-04-24 Advanced Liquid Logic, Inc. Digital microfluidics cartridge and system for operating a flow cell
US8810893B2 (en) 2013-01-15 2014-08-19 The University Of Kentucky Research Foundation Low voltage electrowetting device and method for making same
CN103143406B (zh) * 2013-03-10 2015-01-07 复旦大学 一种基于液滴单向输运的二维数字微流控芯片
TWI511790B (zh) * 2013-07-11 2015-12-11 Univ Nat Taiwan 具有電極陣列的微流道元件
US10082500B2 (en) 2013-08-22 2018-09-25 Franz Baudenbacher Device and method for detecting a target analyte
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
DE102014100871B4 (de) * 2014-01-27 2016-11-17 Karlsruher Institut für Technologie Digitale Mikrofluidikplattform
WO2015160905A1 (en) * 2014-04-16 2015-10-22 Abbott Laboratories Droplet actuator fabrication apparatus, systems, and related methods
WO2016073159A1 (en) * 2014-11-04 2016-05-12 Applied Materials, Inc. Sensors employing control systems determining locations of movable droplets within passageways, and related methods
US10464067B2 (en) 2015-06-05 2019-11-05 Miroculus Inc. Air-matrix digital microfluidics apparatuses and methods for limiting evaporation and surface fouling
CN208562324U (zh) 2015-06-05 2019-03-01 米罗库鲁斯公司 空气基质数字微流控(dmf)装置
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10379101B2 (en) * 2015-11-23 2019-08-13 Hai Kang Life Corporation Limited Apparatus for detection of biomolecules and its fabrication
CN109414663B (zh) * 2016-06-29 2022-05-17 数字生物系统公司 在数字微流体装置中创建高分辨率温度谱线
CA3034064A1 (en) 2016-08-22 2018-03-01 Miroculus Inc. Feedback system for parallel droplet control in a digital microfluidic device
JP2020515815A (ja) 2016-12-28 2020-05-28 ミロキュラス インコーポレイテッド デジタルマイクロ流体デバイスおよび方法
WO2018187476A1 (en) 2017-04-04 2018-10-11 Miroculus Inc. Digital microfluidic apparatuses and methods for manipulating and processing encapsulated droplets
US11278892B2 (en) 2017-04-21 2022-03-22 Hewlett-Packard Development Company, L.P. Chip to chip fluidic interconnect
WO2018194651A1 (en) 2017-04-21 2018-10-25 Hewlett-Packard Development Company, Coplanar fluidic interconnect
WO2018194648A1 (en) 2017-04-21 2018-10-25 Hewlett-Packard Development Company Coplanar microfluidic manipulation
WO2018194665A1 (en) * 2017-04-21 2018-10-25 Hewlett-Packard Development Company, L.P. Microfluidic chip
WO2018200640A1 (en) * 2017-04-25 2018-11-01 The University Of Akron Electrowetting coalescence device with porous layers
WO2019023133A1 (en) 2017-07-24 2019-01-31 Miroculus Inc. DIGITAL MICROFLUIDIC SYSTEMS AND METHODS WITH INTEGRATED PLASMA COLLECTION DEVICE
CA3073058A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. Digital microfluidics devices and methods of using them
JP6354114B1 (ja) * 2017-10-12 2018-07-11 秋田県 液滴移動装置及び液滴の移動方法
WO2020175083A1 (ja) * 2019-02-25 2020-09-03 国立研究開発法人産業技術総合研究所 開放空間型の液体操作装置
EP3953041A4 (de) 2019-04-08 2023-01-25 Miroculus Inc. Digitale mikrofluidikvorrichtungen mit mehreren patronen und verfahren zur verwendung
GB2584466B (en) * 2019-06-05 2024-01-03 Jaguar Land Rover Ltd Device for manipulating a substance
WO2021016614A1 (en) 2019-07-25 2021-01-28 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11835529B1 (en) 2019-10-24 2023-12-05 University Of Louisville Research Foundation, Inc. Plasma thermograms for diagnosis and treatment of acute myocardial infarction
US20220365014A1 (en) * 2019-10-24 2022-11-17 University Of Louisville Research Foundation, Inc. Microfabricated differential scanning calorimetry system and methods of use thereof
US11857961B2 (en) 2022-01-12 2024-01-02 Miroculus Inc. Sequencing by synthesis using mechanical compression

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0916396B1 (de) 1991-11-22 2005-04-13 Affymetrix, Inc. (a Delaware Corporation) Kombinatorische Strategien für die Polymersynthese
GB9306729D0 (en) * 1993-03-31 1993-05-26 British Tech Group Improvements in separators
US5486337A (en) 1994-02-18 1996-01-23 General Atomics Device for electrostatic manipulation of droplets
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
WO1999015876A1 (en) 1997-09-19 1999-04-01 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
EP0921391A1 (de) 1997-12-05 1999-06-09 Interuniversitair Micro-Elektronica Centrum Vzw Vorrichtung und Verfahren zur thermischen Messung
US6545334B2 (en) 1997-12-19 2003-04-08 Imec Vzw Device and a method for thermal sensing
FI980874A (fi) 1998-04-20 1999-10-21 Wallac Oy Menetelmä ja laite pienten nestemäärien kemiallisen analyysin suorittamiseksi
US6261431B1 (en) * 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6294063B1 (en) * 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6193413B1 (en) * 1999-06-17 2001-02-27 David S. Lieberman System and method for an improved calorimeter for determining thermodynamic properties of chemical and biological reactions
DE19947788A1 (de) * 1999-10-05 2001-04-12 Bayer Ag Verfahren und Vorrichtung zum Bewegen von Flüssigkeiten
US20040038227A1 (en) 2000-05-08 2004-02-26 Philippe Verwaerde Method and technology for high-throughput lead profiling
US20030186464A1 (en) 2002-01-29 2003-10-02 Michelle Arkin Surface plasmon resonance methods
US7141210B2 (en) 2002-04-01 2006-11-28 Palo Alto Research Center Incorporated Apparatus and method for a nanocalorimeter for detecting chemical reactions

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