DE60316779D1 - Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen - Google Patents
Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzenInfo
- Publication number
- DE60316779D1 DE60316779D1 DE60316779T DE60316779T DE60316779D1 DE 60316779 D1 DE60316779 D1 DE 60316779D1 DE 60316779 T DE60316779 T DE 60316779T DE 60316779 T DE60316779 T DE 60316779T DE 60316779 D1 DE60316779 D1 DE 60316779D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- thiadiazolylpiperazine
- pain
- bzw
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36017202P | 2002-03-01 | 2002-03-01 | |
US360172P | 2002-03-01 | ||
US41108402P | 2002-09-17 | 2002-09-17 | |
US411084P | 2002-09-17 | ||
PCT/US2003/006107 WO2003074520A1 (en) | 2002-03-01 | 2003-02-28 | Thiadiazolylpiperazine derivatives useful for treating or preventing pain |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60316779D1 true DE60316779D1 (de) | 2007-11-22 |
DE60316779T2 DE60316779T2 (de) | 2008-07-17 |
Family
ID=27791632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60316779T Expired - Lifetime DE60316779T2 (de) | 2002-03-01 | 2003-02-28 | Thiadiazolylpiperazin derivate geeignet für die behandlung bzw. prävention von schmerzen |
Country Status (11)
Country | Link |
---|---|
US (2) | US6974818B2 (de) |
EP (1) | EP1487829B1 (de) |
JP (1) | JP4663984B2 (de) |
AT (1) | ATE375341T1 (de) |
AU (1) | AU2003225617A1 (de) |
CY (1) | CY1107850T1 (de) |
DE (1) | DE60316779T2 (de) |
DK (1) | DK1487829T3 (de) |
ES (1) | ES2295609T3 (de) |
PT (1) | PT1487829E (de) |
WO (1) | WO2003074520A1 (de) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7867516B2 (en) | 2001-01-29 | 2011-01-11 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
US8119854B2 (en) * | 2002-12-10 | 2012-02-21 | Pietro P. Sanna | Role of proteoglycans in drug dependence |
US20040142958A1 (en) * | 2002-12-13 | 2004-07-22 | Neurogen Corporation | Combination therapy for the treatment of pain |
PL376949A1 (pl) * | 2002-12-20 | 2006-01-09 | Dynogen Pharmaceuticals, Inc. | Sposoby leczenia niebolesnych zaburzeń pęcherza moczowego przy użyciu modulatorów podjednostki Ó2Ű kanału wapniowego |
US7582635B2 (en) | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
US7524515B2 (en) | 2003-01-10 | 2009-04-28 | Mutual Pharmaceuticals, Inc. | Pharmaceutical safety dosage forms |
CN1791399A (zh) * | 2003-03-21 | 2006-06-21 | 戴诺根医药品公司 | 用α2δ亚基钙通道调节剂和平滑肌调节剂一起治疗下泌尿道病症的方法 |
US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
US7129235B2 (en) | 2003-07-11 | 2006-10-31 | Abbott Laboratories | Amides useful for treating pain |
US20050009841A1 (en) * | 2003-07-11 | 2005-01-13 | Zheng Guo Zhu | Novel amides useful for treating pain |
PL1867644T3 (pl) * | 2003-07-24 | 2009-10-30 | Euro Celtique Sa | Związki heteroarylo-tetrahydropiperydylowe przydatne w leczeniu lub zapobieganiu bólu |
ES2327684T3 (es) * | 2003-07-24 | 2009-11-02 | Euro-Celtique S.A. | Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor. |
JP5148110B2 (ja) * | 2003-08-01 | 2013-02-20 | ユーロ−セルティーク エス.エイ. | 疼痛の治療に有用な治療薬 |
ATE399782T1 (de) * | 2003-09-22 | 2008-07-15 | Euro Celtique Sa | Zur behandlung von schmerzen geeignete phenylcarbonsäureamidverbindungen |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
EP1732549A4 (de) * | 2004-03-18 | 2009-11-11 | Brigham & Womens Hospital | Verfahren zur behandlung von synucleinopathien |
US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
US20050272722A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
EP1744751A4 (de) * | 2004-03-18 | 2010-03-10 | Brigham & Womens Hospital | Verfahren zur behandlung von synucleinopathien |
US20050272068A1 (en) * | 2004-03-18 | 2005-12-08 | The Brigham And Women's Hospital, Inc. | UCH-L1 expression and cancer therapy |
JPWO2006028161A1 (ja) * | 2004-09-09 | 2008-05-08 | 財団法人乙卯研究所 | セロトニン5−ht3受容体作動薬 |
TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
US20060194821A1 (en) * | 2005-02-18 | 2006-08-31 | The Brigham And Women's Hospital, Inc. | Compounds inhibiting the aggregation of superoxide dismutase-1 |
KR101158568B1 (ko) * | 2005-09-19 | 2012-07-02 | 뉴로내슨트, 아이엔씨. | 신경발생을 자극 및 신경 퇴화를 억제하는 방법 및 조성물 |
AU2013211455B2 (en) * | 2005-09-19 | 2017-12-07 | Neuronascent, Inc. | Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration |
DE102005062986A1 (de) | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Propiolsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
CA2685266C (en) | 2007-04-27 | 2014-01-28 | Purdue Pharma L.P. | Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal |
JP2011503075A (ja) * | 2007-11-09 | 2011-01-27 | ノバルティス アーゲー | エポチロンまたはエポチロン誘導体誘発下痢を処置するためのコルチコステロイド |
US8232402B2 (en) * | 2008-03-12 | 2012-07-31 | Link Medicine Corporation | Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications |
US20110060005A1 (en) * | 2008-11-13 | 2011-03-10 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
US20100331363A1 (en) * | 2008-11-13 | 2010-12-30 | Link Medicine Corporation | Treatment of mitochondrial disorders using a farnesyl transferase inhibitor |
CA2743717A1 (en) * | 2008-11-13 | 2010-05-20 | Link Medicine Corporation | Azaquinolinone derivatives and uses thereof |
US8921373B2 (en) | 2010-06-22 | 2014-12-30 | Shionogi & Co., Ltd. | Compounds having TRPV1 antagonistic activity and uses thereof |
WO2012158844A1 (en) | 2011-05-17 | 2012-11-22 | Shionogi & Co., Ltd. | Heterocyclic compounds |
EP2723732B1 (de) | 2011-06-22 | 2017-01-18 | Purdue Pharma LP | Trpv1-antagonisten mit dihydroxy-substituent und ihre verwendung |
BR112014006356B1 (pt) | 2011-09-19 | 2022-01-18 | Orexo Ab | Comprimido sublingual, processo para a preparação do mesmo e seu uso |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5316759A (en) * | 1986-03-17 | 1994-05-31 | Robert J. Schaap | Agonist-antagonist combination to reduce the use of nicotine and other drugs |
US5198459A (en) * | 1987-07-11 | 1993-03-30 | Sandoz Ltd. | Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents |
DE3822792C2 (de) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
US5075341A (en) * | 1989-12-01 | 1991-12-24 | The Mclean Hospital Corporation | Treatment for cocaine abuse |
IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
US6204284B1 (en) * | 1991-12-20 | 2001-03-20 | American Cyanamid Company | Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies |
US5232934A (en) * | 1992-07-17 | 1993-08-03 | Warner-Lambert Co. | Method for the treatment of psychomotor stimulant addiction |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
US5556837A (en) * | 1994-08-01 | 1996-09-17 | Regeneron Pharmaceuticals Inc. | Methods for treating addictive disorders |
US5762925A (en) * | 1994-11-03 | 1998-06-09 | Sagen; Jacqueline | Preventing opiate tolerance by cellular implantation |
DE69819345T2 (de) | 1997-08-20 | 2004-07-15 | The Regents Of The University Of California, Oakland | Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendung |
EP0943683A1 (de) | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Menschliches Vanilloid Rezeptorhomolog Vanilrep1 |
TR200101649T2 (tr) * | 1998-12-14 | 2001-10-22 | Fujisawa Pharmaceutical Co., Ltd. | Piperazin türevleri. |
PT1161424E (pt) * | 1999-03-03 | 2004-08-31 | Wyeth Corp | Novos derivados de diazole como agentes serotonergicos |
GB9907097D0 (en) | 1999-03-26 | 1999-05-19 | Novartis Ag | Organic compounds |
US6109269A (en) * | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
EP1301484A2 (de) | 2000-07-20 | 2003-04-16 | Neurogen Corporation | Capsaicin-rezeptor-liganden |
AU2001280229B2 (en) | 2000-08-21 | 2006-12-07 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
KR100453078B1 (ko) * | 2000-08-21 | 2004-10-15 | 주식회사 태평양 | 신규 티오우레아 화합물 및 이를 함유하는 약제학적 조성물 |
MY138086A (en) | 2001-09-13 | 2009-04-30 | Smithkline Beecham Plc | Novel urea derivative as vanilloid receptor-1 antagonist |
KR20040085151A (ko) | 2002-01-17 | 2004-10-07 | 뉴로젠 코포레이션 | 캡사이신 조절자로서의 치환된 퀴나졸린-4-일 아민 유사체 |
ATE416168T1 (de) | 2002-02-15 | 2008-12-15 | Glaxo Group Ltd | Modulatoren des vanilloidrezeptors |
US20030158188A1 (en) * | 2002-02-20 | 2003-08-21 | Chih-Hung Lee | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US7074805B2 (en) * | 2002-02-20 | 2006-07-11 | Abbott Laboratories | Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
US6974818B2 (en) * | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
-
2003
- 2003-02-27 US US10/374,863 patent/US6974818B2/en not_active Expired - Lifetime
- 2003-02-28 EP EP03743718A patent/EP1487829B1/de not_active Expired - Lifetime
- 2003-02-28 AT AT03743718T patent/ATE375341T1/de active
- 2003-02-28 JP JP2003572988A patent/JP4663984B2/ja not_active Expired - Fee Related
- 2003-02-28 PT PT03743718T patent/PT1487829E/pt unknown
- 2003-02-28 DE DE60316779T patent/DE60316779T2/de not_active Expired - Lifetime
- 2003-02-28 WO PCT/US2003/006107 patent/WO2003074520A1/en active IP Right Grant
- 2003-02-28 ES ES03743718T patent/ES2295609T3/es not_active Expired - Lifetime
- 2003-02-28 AU AU2003225617A patent/AU2003225617A1/en not_active Abandoned
- 2003-02-28 DK DK03743718T patent/DK1487829T3/da active
-
2005
- 2005-10-07 US US11/246,498 patent/US7342017B2/en not_active Expired - Lifetime
-
2008
- 2008-01-08 CY CY20081100025T patent/CY1107850T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1487829E (pt) | 2007-12-24 |
US6974818B2 (en) | 2005-12-13 |
CY1107850T1 (el) | 2013-06-19 |
DE60316779T2 (de) | 2008-07-17 |
JP4663984B2 (ja) | 2011-04-06 |
ES2295609T3 (es) | 2008-04-16 |
DK1487829T3 (da) | 2008-02-11 |
JP2005525365A (ja) | 2005-08-25 |
US20040006091A1 (en) | 2004-01-08 |
AU2003225617A1 (en) | 2003-09-16 |
US7342017B2 (en) | 2008-03-11 |
WO2003074520A1 (en) | 2003-09-12 |
ATE375341T1 (de) | 2007-10-15 |
US20060074090A1 (en) | 2006-04-06 |
EP1487829B1 (de) | 2007-10-10 |
EP1487829A1 (de) | 2004-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |