DE60333646D1 - Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren - Google Patents
Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophorenInfo
- Publication number
- DE60333646D1 DE60333646D1 DE60333646T DE60333646T DE60333646D1 DE 60333646 D1 DE60333646 D1 DE 60333646D1 DE 60333646 T DE60333646 T DE 60333646T DE 60333646 T DE60333646 T DE 60333646T DE 60333646 D1 DE60333646 D1 DE 60333646D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- target polynucleotide
- multichromophores
- inch
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/107—Modifications characterised by incorporating a peptide nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/125—Specific component of sample, medium or buffer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/107—Alteration in the property of hybridised versus free label oligonucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39052402P | 2002-06-20 | 2002-06-20 | |
US40626602P | 2002-08-26 | 2002-08-26 | |
PCT/US2003/019678 WO2004001379A2 (en) | 2002-06-20 | 2003-06-20 | Methods and compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60333646D1 true DE60333646D1 (de) | 2010-09-16 |
Family
ID=30003161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60333646T Expired - Lifetime DE60333646D1 (de) | 2002-06-20 | 2003-06-20 | Verfahren und zusammensetzungen zum nachweis und zur analyse von polynukleotiden unter verwendung von licht einfangenden multichromophoren |
Country Status (12)
Country | Link |
---|---|
US (2) | US7214489B2 (de) |
EP (2) | EP1534857B1 (de) |
JP (1) | JP4528115B2 (de) |
KR (1) | KR20050010956A (de) |
CN (2) | CN102766695A (de) |
AT (1) | ATE476521T1 (de) |
AU (1) | AU2003243722A1 (de) |
CA (1) | CA2489922C (de) |
DE (1) | DE60333646D1 (de) |
EA (1) | EA007652B1 (de) |
IL (1) | IL165877A0 (de) |
WO (1) | WO2004001379A2 (de) |
Families Citing this family (56)
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---|---|---|---|---|
GB9425138D0 (en) | 1994-12-12 | 1995-02-08 | Dynal As | Isolation of nucleic acid |
CA2473376A1 (en) | 2002-01-16 | 2003-07-31 | Dynal Biotech Asa | Method for isolating nucleic acids and protein from a single sample |
US7144950B2 (en) | 2003-09-17 | 2006-12-05 | The Regents Of The University Of California | Conformationally flexible cationic conjugated polymers |
US10001475B2 (en) | 2002-06-20 | 2018-06-19 | The Regents Of The University Of California | Light harvesting multichromophore compositions and methods of using the same |
CN102766695A (zh) | 2002-06-20 | 2012-11-07 | 加州大学评议会 | 利用获取光的多发色团检测和分析多核苷酸的方法和组合物 |
US9371559B2 (en) | 2002-06-20 | 2016-06-21 | The Regents Of The University Of California | Compositions for detection and analysis of polynucleotides using light harvesting multichromophores |
EP2316971A1 (de) | 2002-08-26 | 2011-05-04 | The Regents of the University of California | Verfahren und Zusammensetzungen zum Nachweis und zur Analyse von Polynuckleotiden unter Benutzung von lichtsammelnden Multichromophoren. |
GB0229287D0 (en) * | 2002-12-16 | 2003-01-22 | Dna Res Innovations Ltd | Polyfunctional reagents |
CN1771335A (zh) | 2003-02-13 | 2006-05-10 | 加州大学评议会 | 使用集光多生色团检测和分析多核苷酸-结合蛋白相互作用的方法和组合物 |
DE112004001737B4 (de) | 2003-09-17 | 2016-08-11 | The Regents Of The University Of California | Verfahren umfassend lösliche, konjugierte Polymere zur Ausbildung benachbarter Schichten auf einem Substrat oder zum Hinzufügen einer Polymerschicht zu einem Substrat, mehrschichtige elektronische Vorrichtung und Verwendung in elektronischen Bauteilen |
JP5909314B2 (ja) | 2004-09-03 | 2016-04-26 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 可溶性共役ポリマーを使用する方法及びデバイス |
WO2006029231A1 (en) | 2004-09-03 | 2006-03-16 | The Regents Of The University Of California | Soluble conjugated polymers |
US7897684B2 (en) | 2005-01-10 | 2011-03-01 | The Regents Of The University Of California | Conjugated polymers suitable for strand-specific polynucleotide detection in homogeneous and solid state assays |
US7811755B2 (en) | 2005-01-10 | 2010-10-12 | The Regents Of The University Of California | Methods and articles for strand-specific polynucleotide detection with cationic multichromophores |
US7666594B2 (en) | 2005-01-31 | 2010-02-23 | The Regents Of The University Of California | Methods for assaying a sample for an aggregant |
WO2006094101A1 (en) | 2005-03-01 | 2006-09-08 | The Regents Of The University Of California | Multilayer polymer light-emitting diodes for solid state lighting applications |
JP4933458B2 (ja) * | 2005-03-03 | 2012-05-16 | ナショナル リサーチ カウンシル オブ カナダ | シグナル増幅による核酸の検出および分析のための方法および組成物 |
US8057989B2 (en) * | 2006-02-10 | 2011-11-15 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
US8309304B2 (en) | 2006-02-10 | 2012-11-13 | The University Of Hong Kong | Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes |
EP2164988B1 (de) | 2006-10-06 | 2016-02-17 | Sirigen Inc. | Fluoreszierende materialien und entsprechende verfahren zur verstärkung ausgerichteter biomarker-signale |
ITTO20060883A1 (it) * | 2006-12-14 | 2008-06-15 | Consiglio Naz Delle Ricerche Infm | Procedimento e microdispositivo a trasduzione ottica per l'identificazione e/o quantificazione di un analita in un campione biologico |
KR20080060744A (ko) * | 2006-12-27 | 2008-07-02 | 한국조폐공사 | 피엔에이 함유 잉크 및 이의 확인방법 |
US8765369B2 (en) * | 2007-07-13 | 2014-07-01 | National Research Council Of Canada | Ultrasensitive detection of target using target-ready particles |
US20090137925A1 (en) * | 2007-11-23 | 2009-05-28 | Divya Cantor | Impedance Spectroscopy Cervix Scanning Apparatus and Method |
US20090230362A1 (en) * | 2008-01-25 | 2009-09-17 | Bazan Guillermo C | Conjugated oligoelectrolyte electron transporting layers |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
SG177355A1 (en) | 2009-06-26 | 2012-02-28 | Sirigen Inc | Signal amplified biological detection with conjugated polymers |
US8575303B2 (en) | 2010-01-19 | 2013-11-05 | Sirigen Group Limited | Reagents for directed biomarker signal amplification |
WO2015050869A1 (en) | 2013-10-02 | 2015-04-09 | Becton Dickinson And Company | Polymersome encapsulation of hydrophobic fluorescent polymers |
EP3253889A4 (de) | 2015-02-02 | 2018-09-26 | Two Pore Guys, Inc. | Nanoporendetektion von zielpolynukleotiden aus einer probe |
JP2018509621A (ja) * | 2015-03-12 | 2018-04-05 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 紫外線吸収性ポリマー色素およびそれを使用する方法 |
WO2016191004A1 (en) | 2015-05-26 | 2016-12-01 | Becton, Dickinson And Company | Methods and systems for high resolution fluorescence microscopy of polymeric dye-labeled samples using polarized light |
ES2911298T3 (es) | 2015-12-16 | 2022-05-18 | Becton Dickinson Co | Colorantes poliméricos en tándem fluorescentes fotoestables que incluyen complejos de metales luminiscentes |
WO2017172608A1 (en) | 2016-03-28 | 2017-10-05 | Aat Bioquest, Inc. | Polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection |
BR112018071026B1 (pt) | 2016-04-15 | 2023-04-11 | Beckman Coulter, Inc | Polímero fluorescente solúvel em água e método para detectar um analito de uma amostra |
US10545137B2 (en) | 2016-04-22 | 2020-01-28 | Becton, Dickinson And Company | Multiplex polymeric dye devices and methods for using the same |
CN109562379A (zh) | 2016-06-20 | 2019-04-02 | 拜克门寇尔特公司 | 用于染料共轭试剂的干燥过程 |
CN109661439A (zh) | 2016-07-07 | 2019-04-19 | 贝克顿·迪金森公司 | 发荧光的水溶剂化共轭聚合物 |
WO2018009861A1 (en) | 2016-07-08 | 2018-01-11 | Biolegend | Substituted polyfluorene compounds |
WO2018013389A1 (en) | 2016-07-11 | 2018-01-18 | Becton, Dickinson And Company | Blue-excitable water-solvated polymeric dyes |
CN106770088B (zh) * | 2016-11-24 | 2019-06-11 | 北京科技大学 | 用于dna检测的荧光复合纳米粒子的制备及检测方法 |
CA3039672A1 (en) | 2016-12-12 | 2018-06-21 | Becton, Dickinson And Company | Water-soluble polymeric dyes |
US11320437B2 (en) | 2017-02-08 | 2022-05-03 | Becton, Dickinson And Company | Dried dye reagent devices and methods for making and using the same |
CN106857504B (zh) * | 2017-02-10 | 2020-03-10 | 中国科学院化学研究所 | 一种抑制和/或破坏生物膜的方法 |
CN111148987B (zh) | 2017-06-16 | 2023-04-14 | 杜克大学 | 用于改善标记检测、计算、分析物感应和可调随机数生成的谐振器网络 |
EP3658648B1 (de) | 2017-07-28 | 2021-10-27 | BioLegend, Inc. | Konjugierte polymere und verfahren zur verwendung |
EP3732254A4 (de) | 2017-12-26 | 2021-12-22 | Becton, Dickinson and Company | Tiefe uv-erregbare wassersolvatisierte polymerfarbstoffe |
CN111850103B (zh) * | 2020-08-20 | 2022-12-02 | 清华大学深圳国际研究生院 | 一种基于阳离子共轭聚合物和核酸酶辅助循环扩增的检测目的核酸的方法 |
CA3198558A1 (en) | 2020-11-13 | 2022-05-19 | Rajesh VENKATESH | Additives for reducing non-specific interactions between fluorescent polymer conjugates and cells in a biological sample |
AU2022216619A1 (en) | 2021-02-05 | 2023-09-07 | Beckman Coulter, Inc. | Compositions and methods for preventing non-specific interactions between polymer dyes-antibody conjugates |
WO2022235705A1 (en) | 2021-05-04 | 2022-11-10 | Beckman Coulter, Inc. | Uv-absorbing polymers, compositions and uses thereof |
WO2023086103A1 (en) | 2021-11-12 | 2023-05-19 | Beckman Coulter, Inc. | Novel formulation for drying of polymer dye conjugated antibodies |
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IL160519A0 (en) | 2001-08-23 | 2004-07-25 | Qtl Biosystems Llc | Bio-sensing platforms for detection and quantitation of biological molecules |
CN102766695A (zh) * | 2002-06-20 | 2012-11-07 | 加州大学评议会 | 利用获取光的多发色团检测和分析多核苷酸的方法和组合物 |
EP2316971A1 (de) * | 2002-08-26 | 2011-05-04 | The Regents of the University of California | Verfahren und Zusammensetzungen zum Nachweis und zur Analyse von Polynuckleotiden unter Benutzung von lichtsammelnden Multichromophoren. |
US7811755B2 (en) * | 2005-01-10 | 2010-10-12 | The Regents Of The University Of California | Methods and articles for strand-specific polynucleotide detection with cationic multichromophores |
JP2016031772A (ja) | 2014-07-30 | 2016-03-07 | 株式会社日立ハイテクファインシステムズ | 熱アシスト磁気ヘッド素子の検査方法及びその装置 |
-
2003
- 2003-06-20 CN CN2012102827293A patent/CN102766695A/zh active Pending
- 2003-06-20 WO PCT/US2003/019678 patent/WO2004001379A2/en active Application Filing
- 2003-06-20 AT AT03761235T patent/ATE476521T1/de not_active IP Right Cessation
- 2003-06-20 US US10/600,286 patent/US7214489B2/en active Active
- 2003-06-20 JP JP2004516105A patent/JP4528115B2/ja not_active Expired - Lifetime
- 2003-06-20 EP EP03761235A patent/EP1534857B1/de not_active Expired - Lifetime
- 2003-06-20 EP EP10008095A patent/EP2278027A3/de not_active Ceased
- 2003-06-20 CA CA2489922A patent/CA2489922C/en not_active Expired - Lifetime
- 2003-06-20 CN CN038198363A patent/CN1675377B/zh not_active Expired - Lifetime
- 2003-06-20 DE DE60333646T patent/DE60333646D1/de not_active Expired - Lifetime
- 2003-06-20 AU AU2003243722A patent/AU2003243722A1/en not_active Abandoned
- 2003-06-20 KR KR10-2004-7020729A patent/KR20050010956A/ko not_active Application Discontinuation
- 2003-06-20 EA EA200500041A patent/EA007652B1/ru unknown
-
2004
- 2004-12-20 IL IL16587704A patent/IL165877A0/xx unknown
-
2007
- 2007-05-08 US US11/746,055 patent/US8101416B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US7214489B2 (en) | 2007-05-08 |
AU2003243722A1 (en) | 2004-01-06 |
KR20050010956A (ko) | 2005-01-28 |
CN1675377B (zh) | 2012-10-03 |
WO2004001379A3 (en) | 2004-06-03 |
JP4528115B2 (ja) | 2010-08-18 |
JP2005530182A (ja) | 2005-10-06 |
EP1534857A4 (de) | 2007-10-31 |
EP1534857B1 (de) | 2010-08-04 |
WO2004001379A2 (en) | 2003-12-31 |
CA2489922C (en) | 2016-08-16 |
US20040219556A1 (en) | 2004-11-04 |
US20080280369A1 (en) | 2008-11-13 |
EA007652B1 (ru) | 2006-12-29 |
EP2278027A2 (de) | 2011-01-26 |
ATE476521T1 (de) | 2010-08-15 |
EP2278027A3 (de) | 2011-02-16 |
IL165877A0 (en) | 2006-01-15 |
CN102766695A (zh) | 2012-11-07 |
US8101416B2 (en) | 2012-01-24 |
CN1675377A (zh) | 2005-09-28 |
CA2489922A1 (en) | 2003-12-31 |
EP1534857A2 (de) | 2005-06-01 |
EA200500041A1 (ru) | 2005-08-25 |
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