DE655458T1 - Neues Verfahren zur Herstellung von Finasteriden. - Google Patents

Neues Verfahren zur Herstellung von Finasteriden.

Info

Publication number
DE655458T1
DE655458T1 DE0655458T DE95200270T DE655458T1 DE 655458 T1 DE655458 T1 DE 655458T1 DE 0655458 T DE0655458 T DE 0655458T DE 95200270 T DE95200270 T DE 95200270T DE 655458 T1 DE655458 T1 DE 655458T1
Authority
DE
Germany
Prior art keywords
finasteride
magnesium halide
production
new process
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE0655458T
Other languages
English (en)
Other versions
DE29500270U1 (de
Inventor
Ulf H Dolling
James A Mccauley
Richard J Varsolona
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26681536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE655458(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE655458T1 publication Critical patent/DE655458T1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic System
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic System without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N5/00—Details of television systems
    • H04N5/74—Projection arrangements for image reproduction, e.g. using eidophor
    • H04N5/7416—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal
    • H04N5/7458—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal the modulator being an array of deformable mirrors, e.g. digital micromirror device [DMD]
DE0655458T 1992-11-19 1993-11-12 Neues Verfahren zur Herstellung von Finasteriden. Pending DE655458T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97853592A 1992-11-19 1992-11-19
US08/010,734 US5468860A (en) 1992-11-19 1993-01-29 New finasteride processes

Publications (1)

Publication Number Publication Date
DE655458T1 true DE655458T1 (de) 1995-11-30

Family

ID=26681536

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69323754T Expired - Fee Related DE69323754T2 (de) 1992-11-19 1993-11-12 Neues Verfahren zur Herstellung von Finasteriden
DE69317856T Expired - Lifetime DE69317856T2 (de) 1992-11-19 1993-11-12 Ein Verfahren zur Herstellung von Finasteride
DE0599376T Pending DE599376T1 (de) 1992-11-19 1993-11-12 Ein Verfahren zur Herstellung von Finasteride.
DE0655458T Pending DE655458T1 (de) 1992-11-19 1993-11-12 Neues Verfahren zur Herstellung von Finasteriden.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE69323754T Expired - Fee Related DE69323754T2 (de) 1992-11-19 1993-11-12 Neues Verfahren zur Herstellung von Finasteriden
DE69317856T Expired - Lifetime DE69317856T2 (de) 1992-11-19 1993-11-12 Ein Verfahren zur Herstellung von Finasteride
DE0599376T Pending DE599376T1 (de) 1992-11-19 1993-11-12 Ein Verfahren zur Herstellung von Finasteride.

Country Status (33)

Country Link
US (3) US5468860A (de)
EP (3) EP0823436A3 (de)
JP (2) JPH07110875B2 (de)
CN (1) CN1058018C (de)
AT (2) ATE177112T1 (de)
AU (1) AU658774B2 (de)
BG (2) BG62362B1 (de)
CA (1) CA2103107C (de)
CY (1) CY2135B1 (de)
CZ (3) CZ287842B6 (de)
DE (4) DE69323754T2 (de)
DK (2) DK0599376T4 (de)
DZ (1) DZ1733A1 (de)
ES (2) ES2072848T3 (de)
FI (4) FI107450B (de)
GR (4) GR940300045T1 (de)
HK (1) HK1008338A1 (de)
HR (2) HRP931410B1 (de)
HU (2) HU216195B (de)
IL (1) IL107574A (de)
IS (2) IS1692B (de)
LV (2) LV12212B (de)
MX (1) MX9307222A (de)
MY (2) MY110410A (de)
NO (3) NO305912B1 (de)
PH (1) PH31120A (de)
RO (2) RO115164B1 (de)
RU (1) RU2120445C1 (de)
SI (1) SI9300603B (de)
SK (2) SK286488B6 (de)
TW (1) TW257766B (de)
UA (1) UA41341C2 (de)
WO (1) WO1994011387A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
IT1270660B (it) * 1994-10-13 1997-05-07 Poli Ind Chimica Spa Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
US5670643A (en) * 1995-03-16 1997-09-23 Glaxo Wellcome Inc. Method for preparing finasteride
US5585383A (en) * 1995-05-03 1996-12-17 Merck & Co., Inc. Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
CA2231041A1 (en) * 1995-09-15 1997-03-20 Raman K. Bakshi 4-azasteroids for treatment of hyperandrogenic conditions
GB2338234B (en) * 1998-06-10 2000-05-03 Torcan Chemical Ltd Preparation of finasteride
ES2153789B1 (es) * 1999-07-05 2001-10-16 Raga Consultores S L Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
AU773067B2 (en) * 1999-11-01 2004-05-13 Torcan Chemical Ltd. Production of polymorphic forms I and II of finasteride by complexation with group I or II metal salts
PL361014A1 (en) * 2000-09-07 2004-09-20 Dr.Reddy's Laboratories Ltd. Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
AU2001269911B2 (en) * 2000-09-07 2006-09-21 Dr. Reddy's Laboratories Ltd. Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5-alpha-androst-1-en-3-one and a process for preparing it
CZ2003679A3 (cs) * 2000-09-07 2004-02-18 Dr. Reddy´S Laboratories Ltd. Nová polymorfní forma 17beta-(N-terc-butylkarbamoyl)-4-aza-5alfa-androst-1-en-3-on a způsob její přípravy
KR100415858B1 (ko) * 2001-09-22 2004-01-24 한미약품 주식회사 17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법
CN100428897C (zh) * 2002-08-16 2008-10-29 浙江寿峰堂生物工程有限公司 抗疲劳改善亚健康的保健食品及其制备方法
ES2206065B1 (es) * 2002-10-31 2005-08-16 Ragactives, S.L. Procedimiento para la obtencion de la forma polimorfica i de finasterida.
WO2004083230A1 (en) * 2003-03-19 2004-09-30 Hetero Drugs Limited Novel crystalline forms of finasteride
EP1651661B1 (de) * 2003-07-03 2008-08-27 Cipla Ltd. Verfahren zur herstellung von finasterid form i
US20050136015A1 (en) * 2003-12-17 2005-06-23 McKie Derrick B. Topical use of halosalicylic acid derivatives
US20070167477A1 (en) * 2006-01-13 2007-07-19 Mandava Venkata Naga Brahmeswa Processes to prepare finasteride polymorphs
US7531658B2 (en) * 2006-01-20 2009-05-12 Apotex Pharmachem Inc. Process for the preparation of 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones
US7927614B2 (en) 2006-02-03 2011-04-19 Jr Chem, Llc Anti-aging treatment using copper and zinc compositions
US7897800B2 (en) 2006-02-03 2011-03-01 Jr Chem, Llc Chemical compositions and methods of making them
US7687650B2 (en) 2006-02-03 2010-03-30 Jr Chem, Llc Chemical compositions and methods of making them
US7867522B2 (en) 2006-09-28 2011-01-11 Jr Chem, Llc Method of wound/burn healing using copper-zinc compositions
US20090076058A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched finasteride
US8273791B2 (en) 2008-01-04 2012-09-25 Jr Chem, Llc Compositions, kits and regimens for the treatment of skin, especially décolletage
EP2274609B1 (de) * 2008-05-05 2012-03-28 Abbott GmbH & Co. KG Verfahren zur beurteilung der löslichkeit eines kristallinen stoffes in einem polymer
US20160184354A1 (en) 2009-01-23 2016-06-30 Jr Chem, Llc Rosacea treatments and kits for performing them
US8952057B2 (en) 2011-01-11 2015-02-10 Jr Chem, Llc Compositions for anorectal use and methods for treating anorectal disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
DE3888378T2 (de) * 1987-04-03 1994-09-29 Merck & Co Inc Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
CA2044706C (en) * 1990-06-15 2003-02-25 Michael Midler Jr. Crystallization method to improve crystal structure and size
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5120847A (en) † 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5091534A (en) 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5061801A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes

Also Published As

Publication number Publication date
EP0655458A2 (de) 1995-05-31
ES2052476T5 (es) 2008-11-01
DK0655458T3 (da) 1999-09-27
LV12460B (en) 2000-09-20
JPH09235294A (ja) 1997-09-09
HRP20000295A2 (en) 2000-08-31
LV12212A (lv) 1999-01-20
GR940300045T1 (en) 1994-07-29
FI20040559A (fi) 2004-04-21
IS1692B (is) 1998-04-20
CN1090583A (zh) 1994-08-10
AU658774B2 (en) 1995-04-27
RU95112521A (ru) 1997-02-10
BG103170A (en) 1999-09-30
DZ1733A1 (fr) 2002-02-17
IS1671B (is) 1997-12-19
US5886184A (en) 1999-03-23
EP0823436A3 (de) 1998-11-25
FI952422A0 (fi) 1995-05-18
LV12212B (en) 1999-03-20
EP0599376B2 (de) 2008-04-16
FI114800B (fi) 2004-12-31
FI116941B (fi) 2006-04-13
BG64464B1 (bg) 2005-03-31
ES2072848T3 (es) 1999-05-01
EP0599376A3 (en) 1994-09-28
SK281765B6 (sk) 2001-07-10
NO951986D0 (no) 1995-05-19
LV12460A (lv) 2000-04-20
NO990468D0 (no) 1999-02-01
GR3029554T3 (en) 1999-06-30
CZ301160B6 (cs) 2009-11-18
CZ301191B6 (cs) 2009-12-02
EP0599376B1 (de) 1998-04-08
HU9303275D0 (en) 1994-03-28
ATE164850T1 (de) 1998-04-15
ES2052476T3 (es) 1998-06-16
SI9300603B (sl) 2004-06-30
US5652365A (en) 1997-07-29
FI20010290A (fi) 2001-02-15
WO1994011387A3 (en) 1994-09-29
EP0655458A3 (de) 1996-07-10
FI952422A (fi) 1995-05-18
DE599376T1 (de) 1994-12-08
NO990468L (no) 1995-05-19
ES2052476T1 (es) 1994-07-16
NO305912B1 (no) 1999-08-16
RO115165B1 (ro) 1999-11-30
CZ126895A3 (en) 1995-12-13
HK1008338A1 (en) 1999-05-07
DE69317856D1 (de) 1998-05-14
BG62362B1 (bg) 1999-09-30
MY110410A (en) 1998-05-30
SK65995A3 (en) 1995-10-11
EP0823436A2 (de) 1998-02-11
WO1994011387A2 (en) 1994-05-26
JPH07110875B2 (ja) 1995-11-29
TW257766B (de) 1995-09-21
HU210535A9 (en) 1995-04-28
FI107450B (fi) 2001-08-15
JPH06199889A (ja) 1994-07-19
EP0655458B1 (de) 1999-03-03
US5468860A (en) 1995-11-21
NO992580L (no) 1995-05-19
BG99637A (bg) 1996-04-30
AU5078793A (en) 1994-06-16
NO307609B1 (no) 2000-05-02
DK0599376T4 (da) 2008-07-28
NO951986L (no) 1995-05-19
NO307888B3 (no) 2000-06-13
SK286488B6 (sk) 2008-11-06
UA41341C2 (uk) 2001-09-17
CY2135B1 (en) 2002-05-21
MY110411A (en) 1998-05-30
IL107574A (en) 2000-07-16
FI20010289A (fi) 2001-02-15
DE69323754T2 (de) 1999-10-07
DE69323754D1 (de) 1999-04-08
RU2120445C1 (ru) 1998-10-20
EP0599376A2 (de) 1994-06-01
NO992580D0 (no) 1999-05-28
IS4094A (is) 1994-05-20
HUT66973A (en) 1995-01-30
HRP931410A2 (en) 1996-06-30
CN1058018C (zh) 2000-11-01
CA2103107A1 (en) 1994-05-20
JP2742409B2 (ja) 1998-04-22
HU216195B (hu) 1999-05-28
ATE177112T1 (de) 1999-03-15
GR950300043T1 (en) 1995-07-31
IS4286A (is) 1994-05-20
ES2072848T1 (es) 1995-08-01
GR3026577T3 (en) 1998-07-31
CZ287842B6 (en) 2001-02-14
MX9307222A (es) 1994-07-29
DE69317856T2 (de) 1998-11-05
HRP20000295B1 (en) 2002-08-31
HRP931410B1 (en) 2000-06-30
CA2103107C (en) 2010-09-28
NO307888B1 (no) 2000-06-13
IL107574A0 (en) 1994-02-27
RO115164B1 (ro) 1999-11-30
FI114215B (fi) 2004-09-15
SI9300603A (en) 1994-06-30
PH31120A (en) 1998-02-23

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