DE68904905T2 - Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen. - Google Patents

Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.

Info

Publication number
DE68904905T2
DE68904905T2 DE8989903166T DE68904905T DE68904905T2 DE 68904905 T2 DE68904905 T2 DE 68904905T2 DE 8989903166 T DE8989903166 T DE 8989903166T DE 68904905 T DE68904905 T DE 68904905T DE 68904905 T2 DE68904905 T2 DE 68904905T2
Authority
DE
Germany
Prior art keywords
pct
preparation
ligand
radiopharmaceutical
date sep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8989903166T
Other languages
English (en)
Other versions
DE68904905D1 (de
Inventor
Roberto Pasqualini
Luciano Magon
Andre Bardy
Adriano Duatti
Andrea Marchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8803044A external-priority patent/FR2628428B1/fr
Priority claimed from FR8815414A external-priority patent/FR2639638B1/fr
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Publication of DE68904905D1 publication Critical patent/DE68904905D1/de
Application granted granted Critical
Publication of DE68904905T2 publication Critical patent/DE68904905T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
DE8989903166T 1988-03-09 1989-03-08 Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen. Expired - Fee Related DE68904905T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8803044A FR2628428B1 (fr) 1988-03-09 1988-03-09 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
FR8815414A FR2639638B1 (fr) 1988-11-25 1988-11-25 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
PCT/FR1989/000094 WO1989008657A2 (fr) 1988-03-09 1989-03-08 Preparation de complexes nitruro utilisables comme produits radiopharmaceutiques

Publications (2)

Publication Number Publication Date
DE68904905D1 DE68904905D1 (de) 1993-03-25
DE68904905T2 true DE68904905T2 (de) 1993-07-22

Family

ID=26226545

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989903166T Expired - Fee Related DE68904905T2 (de) 1988-03-09 1989-03-08 Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.

Country Status (9)

Country Link
US (1) US5300278A (de)
EP (1) EP0403524B1 (de)
JP (1) JPH07110869B2 (de)
AT (1) ATE85619T1 (de)
AU (1) AU619538B2 (de)
CA (1) CA1340899C (de)
DE (1) DE68904905T2 (de)
RU (1) RU2026300C1 (de)
WO (1) WO1989008657A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
ES2114209T3 (es) * 1993-07-19 1998-05-16 Resolution Pharm Inc Queladores de radionuclidos de tipo hidrazino que tienen una configuracion n3s.
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
FR2736834B1 (fr) * 1995-07-17 1997-08-29 Cis Bio Int Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide
US5879659A (en) * 1996-03-13 1999-03-09 Dupont Pharmaceuticals Company Ternary radiopharmaceutical complexes
KR100554563B1 (ko) 1996-12-18 2006-03-03 니혼 메디피직스 가부시키가이샤 방사성 전이 금속 질화물 헤테로-착물
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
EP1263771B1 (de) 2000-03-16 2006-06-14 The Regents Of The University Of California Chemoselektive anknüpfung durch verwendung eines phosphins
US7256259B2 (en) * 2000-05-12 2007-08-14 Wisconsin Alumni Research Foundation Methods for ligation of molecules to surfaces
US6972320B2 (en) * 2000-05-12 2005-12-06 Wisconsin Alumni Research Foundation Ligation method and reagents to form an amide bond
NZ523663A (en) * 2000-07-28 2004-06-25 Nihon Mediphysics Co Ltd Radiopharmaceutical for diagnostic imaging containing a technetium-99M nitride heterocomplex
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
US6974884B2 (en) * 2002-06-07 2005-12-13 Wisconsin Alumni Research Foundation Chemical synthesis of reagents for peptide coupling
CA2604907A1 (en) * 2005-04-15 2006-10-26 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
ES2369027T3 (es) 2006-01-20 2011-11-24 Nihon Medi-Physics Co., Ltd. Compuesto intermedio de un complejo de nitruro de tecnecio para la formación de imágenes radiodiagnósticas.
MX2009001877A (es) 2006-08-21 2009-03-02 Synta Pharmaceuticals Corp Compuestos para el tratamiento de trastornos proliferativos.
AU2007290490B2 (en) * 2006-08-31 2011-09-08 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387087A (en) * 1980-04-18 1983-06-07 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4374821A (en) * 1982-06-28 1983-02-22 E. R. Squibb & Sons, Inc. Myocardial imaging agent and method
JPS59146971A (ja) * 1983-02-04 1984-08-23 株式会社　満尾総合研究所 複合体の製造法と製造装置
EP0166746B1 (de) * 1983-12-29 1991-04-24 The Commonwealth Of Australia Herstellung von mit 99m tc markierten radioarzneimitteln
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5002754A (en) * 1988-06-15 1991-03-26 University Of Cincinnati Technetium (III/II) imaging agents
US4917879A (en) * 1989-05-19 1990-04-17 University Of Cincinnati 99MTC(III) myocardial imaging agents that are effective in humans

Also Published As

Publication number Publication date
DE68904905D1 (de) 1993-03-25
JPH03504964A (ja) 1991-10-31
WO1989008657A2 (fr) 1989-09-21
AU619538B2 (en) 1992-01-30
AU3351889A (en) 1989-10-05
EP0403524A1 (de) 1990-12-27
RU2026300C1 (ru) 1995-01-09
ATE85619T1 (de) 1993-02-15
WO1989008657A3 (fr) 1989-10-19
CA1340899C (en) 2000-02-15
US5300278A (en) 1994-04-05
JPH07110869B2 (ja) 1995-11-29
EP0403524B1 (de) 1993-02-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee