DE68906940T2 - Antihyperlipidemische und antiatherosclerotische Verbindungen und Zusammensetzungen. - Google Patents
Antihyperlipidemische und antiatherosclerotische Verbindungen und Zusammensetzungen.Info
- Publication number
- DE68906940T2 DE68906940T2 DE89105547T DE68906940T DE68906940T2 DE 68906940 T2 DE68906940 T2 DE 68906940T2 DE 89105547 T DE89105547 T DE 89105547T DE 68906940 T DE68906940 T DE 68906940T DE 68906940 T2 DE68906940 T2 DE 68906940T2
- Authority
- DE
- Germany
- Prior art keywords
- antihyperlipidemic
- compositions
- compounds
- antiatherosclerotic
- antiatherosclerotic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/176,080 US4868210A (en) | 1988-03-30 | 1988-03-30 | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68906940D1 DE68906940D1 (de) | 1993-07-15 |
DE68906940T2 true DE68906940T2 (de) | 1993-10-28 |
Family
ID=22642893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE89105547T Expired - Lifetime DE68906940T2 (de) | 1988-03-30 | 1989-03-29 | Antihyperlipidemische und antiatherosclerotische Verbindungen und Zusammensetzungen. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4868210A (de) |
EP (1) | EP0335375B1 (de) |
JP (1) | JPH0688957B2 (de) |
AT (1) | ATE90340T1 (de) |
DE (1) | DE68906940T2 (de) |
ES (1) | ES2055754T3 (de) |
HK (1) | HK148295A (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5030653A (en) * | 1988-03-30 | 1991-07-09 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
US4948806A (en) * | 1988-03-30 | 1990-08-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
US5155127A (en) * | 1989-02-09 | 1992-10-13 | Warner-Lambert Company | N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
JPH0395153A (ja) * | 1989-06-15 | 1991-04-19 | Mitsubishi Kasei Corp | ジフェニル尿素誘導体 |
AU629376B2 (en) * | 1989-08-04 | 1992-10-01 | Mitsubishi Chemical Corporation | 1-phenylalkyl-3-phenylurea derivatives |
JPH05310678A (ja) * | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | 1−フェニルアルキル−3−フェニル尿素誘導体 |
DE69105786T2 (de) * | 1990-03-12 | 1995-04-27 | Yamanouchi Pharma Co Ltd | Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen. |
US5177104A (en) * | 1990-04-03 | 1993-01-05 | E. R. Squibb & Sons, Inc. | 6-α-hydroxy derivatives of mevinic acids |
ATE124408T1 (de) * | 1990-10-16 | 1995-07-15 | Takeda Chemical Industries Ltd | Heterozyklische aminderivate, deren herstellung und deren verwendung. |
JPH0694464B2 (ja) * | 1991-01-23 | 1994-11-24 | 協和醗酵工業株式会社 | 三環式化合物およびその中間体 |
IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Double-transformed urea and theories, their preparation and pharmaceutical preparations containing them |
FR2673629B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives du benzopyrane leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
TW209868B (de) * | 1991-04-04 | 1993-07-21 | Yoshitomi Pharmaceutical | |
US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
JPH07503737A (ja) * | 1992-05-28 | 1995-04-20 | フアイザー・インコーポレイテツド | アシル補酵素a:コレステロールアシルトランスフェラーゼ(acat)の阻害剤としての新規なn−アリールおよびn−ヘテロアリール尿素誘導体 |
JPH08500590A (ja) * | 1992-08-19 | 1996-01-23 | メレルダウファ−マス−ティカルズ インコーポレイテッド | 抗血管形成オリゴマー類 |
US5679703A (en) * | 1992-09-16 | 1997-10-21 | Kyowa Hakko Kogyo, Co., Ltd. | Tricyclic compounds having ACAT inhibiting activity |
CA2106103A1 (en) * | 1992-09-16 | 1994-03-17 | Masashi Yanase | Tricyclic compounds |
AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
EP0742208A1 (de) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamid-Derivate |
AU3172397A (en) * | 1996-06-05 | 1998-01-05 | Novartis Ag | Anti-neurodegeneratively effective xanthene derivatives |
FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2003508512A (ja) | 1999-09-08 | 2003-03-04 | ギルフォード ファーマシュウティカルズ インコーポレイテッド | 非ペプチド性サイクロフィリン結合化合物とその用途 |
AU781563B2 (en) * | 2000-02-02 | 2005-06-02 | Warner-Lambert Company | Dual inhibitors of cholesterol ester and wax ester synthesis for sebaceous gland disorders |
ATE485266T1 (de) * | 2000-08-10 | 2010-11-15 | Mitsubishi Tanabe Pharma Corp | 3-substituierte harnstoffderivate und deren medizinische verwendung |
CA2435829A1 (en) | 2001-01-25 | 2002-08-01 | Guilford Pharmaceuticals Inc. | Trisubstituted carbocyclic cyclophilin binding compounds and their use |
EP1506166B1 (de) | 2002-05-17 | 2011-11-16 | Janssen Pharmaceutica NV | Harnstoffderivate von aminotetralin als modulatoren des vanilloid-rezeptors vr1 |
US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
GB2393958A (en) | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2055608A (en) * | 1934-11-03 | 1936-09-29 | Du Pont | Ar. tetrahydro-naphthyl thioureas |
DE1810191C3 (de) * | 1967-12-15 | 1973-10-18 | L'oreal, Paris | Färbemittel für Keratinfasern und menschliche Haare, darin enthaltene Phenylharnstoffe bzw. Phenylthioharnstoffe und Verfahren zum Färben menschlicher Haare |
US3636104A (en) * | 1968-10-29 | 1972-01-18 | Olin Mathieson | Process for preparing n n'-diarylthioureas |
US3734961A (en) * | 1969-06-25 | 1973-05-22 | Exxon Co | Herbicidal fluorinated phenyl ureas and thioureas |
WO1981002156A1 (en) * | 1980-01-25 | 1981-08-06 | Reanal Finomvegyszergyar | Process for the preparation of n-aryl-n'-(mono-or disubstiuted)-urea derivatives |
US4387105A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
US4473579A (en) * | 1982-01-26 | 1984-09-25 | American Cyanamid Company | Antiatherosclerotic tetrasubstituted ureas and thioureas |
US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
JPS58222063A (ja) * | 1982-06-17 | 1983-12-23 | Nippon Tokushu Noyaku Seizo Kk | ベンジルウレア誘導体、その製法及び農園芸用殺菌剤 |
IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
-
1988
- 1988-03-30 US US07/176,080 patent/US4868210A/en not_active Expired - Lifetime
-
1989
- 1989-03-29 DE DE89105547T patent/DE68906940T2/de not_active Expired - Lifetime
- 1989-03-29 EP EP89105547A patent/EP0335375B1/de not_active Expired - Lifetime
- 1989-03-29 ES ES89105547T patent/ES2055754T3/es not_active Expired - Lifetime
- 1989-03-29 JP JP1075245A patent/JPH0688957B2/ja not_active Expired - Fee Related
- 1989-03-29 AT AT89105547T patent/ATE90340T1/de not_active IP Right Cessation
-
1995
- 1995-09-14 HK HK148295A patent/HK148295A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK148295A (en) | 1995-09-22 |
EP0335375B1 (de) | 1993-06-09 |
JPH0688957B2 (ja) | 1994-11-09 |
ES2055754T3 (es) | 1994-09-01 |
DE68906940D1 (de) | 1993-07-15 |
JPH026457A (ja) | 1990-01-10 |
EP0335375A3 (de) | 1991-04-17 |
EP0335375A2 (de) | 1989-10-04 |
ATE90340T1 (de) | 1993-06-15 |
US4868210A (en) | 1989-09-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |