DE68909935T2 - Kontraststoffe für magnetische resonanzbildherstellung. - Google Patents
Kontraststoffe für magnetische resonanzbildherstellung.Info
- Publication number
- DE68909935T2 DE68909935T2 DE89904039T DE68909935T DE68909935T2 DE 68909935 T2 DE68909935 T2 DE 68909935T2 DE 89904039 T DE89904039 T DE 89904039T DE 68909935 T DE68909935 T DE 68909935T DE 68909935 T2 DE68909935 T2 DE 68909935T2
- Authority
- DE
- Germany
- Prior art keywords
- contrastics
- magnetic resonance
- resonance image
- image production
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
- A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888808305A GB8808305D0 (en) | 1988-04-08 | 1988-04-08 | Compositions |
PCT/EP1989/000376 WO1989009625A1 (en) | 1988-04-08 | 1989-04-06 | Contrast agents for magnetic resonance imaging |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68909935D1 DE68909935D1 (de) | 1993-11-18 |
DE68909935T2 true DE68909935T2 (de) | 1994-03-17 |
Family
ID=10634845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE89904039T Expired - Fee Related DE68909935T2 (de) | 1988-04-08 | 1989-04-06 | Kontraststoffe für magnetische resonanzbildherstellung. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5128121A (de) |
EP (1) | EP0414700B1 (de) |
JP (1) | JPH082802B2 (de) |
AU (1) | AU624132B2 (de) |
DE (1) | DE68909935T2 (de) |
DK (1) | DK239490D0 (de) |
GB (1) | GB8808305D0 (de) |
WO (1) | WO1989009625A1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX12394A (es) * | 1987-07-23 | 1993-12-01 | Ciba Geigy Ag | Procedimiento par la obtencion de carbamatos de polietilenglicol. |
GB8830215D0 (en) * | 1988-12-23 | 1989-02-22 | Hafslund Nycomed Innovation | Method |
US5393525A (en) * | 1989-07-21 | 1995-02-28 | Nycomed Imaging As | Contrast medium comprising superparamagnetic or ferromagnetic particles capable of increasing viscosity after administration |
US5190744A (en) * | 1990-03-09 | 1993-03-02 | Salutar | Methods for detecting blood perfusion variations by magnetic resonance imaging |
US5494655A (en) * | 1990-03-09 | 1996-02-27 | The Regents Of The University Of California | Methods for detecting blood perfusion variations by magnetic resonance imaging |
US5358702A (en) * | 1990-04-10 | 1994-10-25 | Unger Evan C | Methoxylated gel particle contrast media for improved diagnostic imaging |
GB9020075D0 (en) | 1990-09-14 | 1990-10-24 | Filler Aaron G | Contrast agents for magnetic resonance imaging of axonal transport |
ATE166233T1 (de) * | 1990-09-14 | 1998-06-15 | Syngenix Ltd | Verwendung von substanzen in partikelform |
US5948384A (en) * | 1990-09-14 | 1999-09-07 | Syngenix Limited | Particulate agents |
US6919067B2 (en) | 1991-09-13 | 2005-07-19 | Syngenix Limited | Compositions comprising a tissue glue and therapeutic agents |
US5282827A (en) * | 1991-11-08 | 1994-02-01 | Kensey Nash Corporation | Hemostatic puncture closure system and method of use |
US5676689A (en) * | 1991-11-08 | 1997-10-14 | Kensey Nash Corporation | Hemostatic puncture closure system including vessel location device and method of use |
CA2121681A1 (en) * | 1991-11-19 | 1993-05-27 | Evan C. Unger | Gel particle contrast media for improved diagnostic imaging |
DE4218321A1 (de) * | 1991-12-09 | 1993-06-17 | Siemens Ag | Diagnostikanlage |
WO1993025895A1 (en) * | 1992-06-15 | 1993-12-23 | Board Of Regents, The University Of Texas System | Clay enclosed transition and rare earth metal ions as contrast agents for the gastrointestinal tract |
US5323780A (en) * | 1992-08-07 | 1994-06-28 | University Of Florida Research Foundation, Inc. | Artifact-free imaging contrast agent |
US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
GB9314499D0 (en) * | 1993-07-12 | 1993-08-25 | Nycomed Imaging As | Method |
US5804561A (en) * | 1993-08-16 | 1998-09-08 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5840701A (en) * | 1993-08-16 | 1998-11-24 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5725839A (en) * | 1993-08-16 | 1998-03-10 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI |
US5824781A (en) * | 1993-08-16 | 1998-10-20 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5817632A (en) * | 1993-08-16 | 1998-10-06 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5741893A (en) * | 1993-08-16 | 1998-04-21 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
US5767089A (en) * | 1993-08-16 | 1998-06-16 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
TW381022B (en) | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
US5807831A (en) * | 1993-08-16 | 1998-09-15 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
EP0650738B1 (de) | 1993-10-28 | 2003-05-02 | Medrad, Inc. | System zur Administration von Flüssigkeiten bei mehreren Patienten |
EP1258262A3 (de) | 1993-10-28 | 2002-12-18 | Medrad, Inc. | System zur Kontrastmittelabgabe |
GB9416767D0 (en) * | 1994-08-18 | 1994-10-12 | Nycomed Innovation Ab | Compositions |
GB9416768D0 (en) * | 1994-08-18 | 1994-10-12 | Nycomed Innovation Ab | Compositions |
US5863519A (en) * | 1994-08-18 | 1999-01-26 | Nycomed Imaging As | Composition and method of MRI using both a positive and a negative contrast agent |
US5840026A (en) * | 1994-09-21 | 1998-11-24 | Medrad, Inc. | Patient specific dosing contrast delivery systems and methods |
GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
DK81095A (da) * | 1995-07-11 | 1997-01-12 | Henrik S Thomsen | Peroralt MR-kontraststof til lever og øvre tarmkanal |
US7169410B1 (en) * | 1998-05-19 | 2007-01-30 | Sdg, Inc. | Targeted liposomal drug delivery system |
WO2000009170A1 (en) * | 1998-08-10 | 2000-02-24 | Bracco Research S.A. | Combination of a positive mri contrast agent with a negative mri contrast agent |
EP0988864A1 (de) * | 1998-09-23 | 2000-03-29 | Luboldt, Wolfgang, Dr.med. Dipl.-Phys. | Kontrastmittel für die Magnetresonanztomographie |
US7871597B2 (en) | 1999-04-09 | 2011-01-18 | Amag Pharmaceuticals, Inc. | Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents |
DK1169062T3 (da) * | 1999-04-09 | 2010-01-25 | Amag Pharmaceuticals Inc | Varmestabile overtrukne kolloide jernoxider |
CZ2002343A3 (cs) * | 1999-07-29 | 2002-08-14 | Epix Medical, Inc. | Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností |
US20030120151A1 (en) * | 2001-01-10 | 2003-06-26 | Johns Hopkins University | Magnetic resonance imaging methods and compositions |
US8961541B2 (en) | 2007-12-03 | 2015-02-24 | Cardio Vascular Technologies Inc. | Vascular closure devices, systems, and methods of use |
US8992567B1 (en) | 2001-04-24 | 2015-03-31 | Cardiovascular Technologies Inc. | Compressible, deformable, or deflectable tissue closure devices and method of manufacture |
US20080109030A1 (en) | 2001-04-24 | 2008-05-08 | Houser Russell A | Arteriotomy closure devices and techniques |
US6934574B1 (en) * | 2001-06-21 | 2005-08-23 | Fonar Corporation | MRI scanner and method for modular patient handling |
TWI221406B (en) * | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
US6944492B1 (en) | 2001-10-01 | 2005-09-13 | Fonar Corporation | Patient bed support for an open MRI system |
US7109974B2 (en) * | 2002-03-05 | 2006-09-19 | Matsushita Electric Industrial Co., Ltd. | Remote control system including an on-screen display (OSD) |
EP1812101A4 (de) * | 2004-11-16 | 2014-04-23 | Medrad Inc | Modellierung von pharmazeutischer verbreitung |
EP2990073B1 (de) | 2004-11-24 | 2018-05-02 | Bayer Healthcare LLC | Vorrichtungen und systeme zur flüssigkeitsabgabe |
US8023172B2 (en) * | 2006-08-30 | 2011-09-20 | Silicon Quest Kabushiki-Kaisha | Mirror device |
JP2010514506A (ja) * | 2006-12-29 | 2010-05-06 | メドラッド インコーポレーテッド | 薬剤伝搬のモデリング |
EP3376504A1 (de) | 2006-12-29 | 2018-09-19 | Bayer Healthcare, LLC | Patientenbasierte parametergenerierungssysteme für medizinische injektionsverfahren |
US8195275B2 (en) * | 2007-05-23 | 2012-06-05 | Siemens Aktiengesellschaft | Vessel size imaging for antiangiogenic therapy |
EP2005970A1 (de) | 2007-06-22 | 2008-12-24 | Berlin Science Partners GmbH i.V. | Bildgebende Diagnostik durch Kombination von Kontrastmitteln |
US8428694B2 (en) * | 2007-07-17 | 2013-04-23 | Medrad, Inc. | Methods for determination of parameters for a procedure, for estimation of cardiopulmonary function and for fluid delivery |
WO2009012288A2 (en) * | 2007-07-17 | 2009-01-22 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging |
US8608484B2 (en) * | 2008-03-04 | 2013-12-17 | Medrad, Inc. | Dynamic anthropomorphic cardiovascular phantom |
US8315449B2 (en) * | 2008-06-24 | 2012-11-20 | Medrad, Inc. | Identification of regions of interest and extraction of time value curves in imaging procedures |
US9421330B2 (en) | 2008-11-03 | 2016-08-23 | Bayer Healthcare Llc | Mitigation of contrast-induced nephropathy |
CN104739461A (zh) | 2009-04-09 | 2015-07-01 | 心血管科技股份有限公司 | 组织封闭装置、输送装置和系统、用于其的套件和方法 |
EP2585116A4 (de) | 2010-06-24 | 2017-03-29 | Bayer Healthcare LLC | Modellierung einer pharmazeutikumsausbreitung und parametererstellung für injektionsprotokolle |
JP2014527881A (ja) | 2011-09-21 | 2014-10-23 | ベイヤー メディカル ケア インク. | 連続多流体ポンプ装置、駆動および作動システムならびに方法 |
FR2986332A1 (fr) * | 2012-01-30 | 2013-08-02 | Centre Nat Rech Scient | Nanoparticules a luminescence persistante pour l'imagerie optique en temps reel, l'imagerie multimodale optique-irm in vivo, et la theranostique |
CA2873351C (en) | 2012-05-14 | 2022-07-26 | Bayer Medical Care Inc. | Systems and methods for determination of pharmaceutical fluid injection protocols based on x-ray tube voltage |
US9555379B2 (en) | 2013-03-13 | 2017-01-31 | Bayer Healthcare Llc | Fluid path set with turbulent mixing chamber, backflow compensator |
RU2714926C2 (ru) | 2015-01-09 | 2020-02-21 | БАЙЕР ХелсКер ЛЛСи | Многофлюидная система доставки с многоразовым расходным комплектом и ее конструкционные особенности |
WO2017152036A1 (en) | 2016-03-03 | 2017-09-08 | Bayer Healthcare Llc | System and method for improved fluid delivery in multi-fluid injector systems |
WO2019046260A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | METHOD FOR CONTROLLING DYNAMIC PRESSURE IN A FLUID INJECTOR SYSTEM |
US11478581B2 (en) | 2017-08-31 | 2022-10-25 | Bayer Healthcare Llc | Fluid injector system volume compensation system and method |
CA3067740A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | Method for drive member position and fluid injection system mechanical calibration |
WO2019046282A1 (en) | 2017-08-31 | 2019-03-07 | Bayer Healthcare Llc | SYSTEM AND METHOD FOR INJECTOR PRESSURE CALIBRATION |
US11141535B2 (en) | 2017-08-31 | 2021-10-12 | Bayer Healthcare Llc | Fluid path impedance assessment for improving fluid delivery performance |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3731377A (en) * | 1971-08-19 | 1973-05-08 | W Muckelroy | Method for handling beam-lead and odd-shaped semi-conductor devices |
JPS53130572A (en) * | 1977-04-05 | 1978-11-14 | Tdk Electronics Co Ltd | Highhgradient magnetic separator using amorphous magnetic alloy |
US4735796A (en) * | 1983-12-08 | 1988-04-05 | Gordon Robert T | Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease |
US4590922A (en) * | 1983-08-19 | 1986-05-27 | Gordon Robert T | Use of ferromagnetic, paramagnetic and diamagnetic particles in the treatment of infectious diseases |
GB8408127D0 (en) * | 1984-03-29 | 1984-05-10 | Nyegaard & Co As | Contrast agents |
GB8413772D0 (en) * | 1984-05-30 | 1984-07-04 | Nyegaard & Co As | Chemical compounds |
US4889120A (en) * | 1984-11-13 | 1989-12-26 | Gordon Robert T | Method for the connection of biological structures |
US4827945A (en) * | 1986-07-03 | 1989-05-09 | Advanced Magnetics, Incorporated | Biologically degradable superparamagnetic materials for use in clinical applications |
US4813399A (en) * | 1986-07-18 | 1989-03-21 | Gordon Robert T | Process for the treatment of neurological or neuromuscular diseases and development |
-
1988
- 1988-04-08 GB GB888808305A patent/GB8808305D0/en active Pending
-
1989
- 1989-04-06 EP EP89904039A patent/EP0414700B1/de not_active Expired - Lifetime
- 1989-04-06 WO PCT/EP1989/000376 patent/WO1989009625A1/en active IP Right Grant
- 1989-04-06 JP JP1503744A patent/JPH082802B2/ja not_active Expired - Fee Related
- 1989-04-06 AU AU33598/89A patent/AU624132B2/en not_active Ceased
- 1989-04-06 DE DE89904039T patent/DE68909935T2/de not_active Expired - Fee Related
- 1989-04-06 US US07/585,140 patent/US5128121A/en not_active Expired - Lifetime
-
1990
- 1990-10-04 DK DK239490A patent/DK239490D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK239490A (da) | 1990-10-04 |
JPH082802B2 (ja) | 1996-01-17 |
US5128121A (en) | 1992-07-07 |
AU624132B2 (en) | 1992-06-04 |
WO1989009625A1 (en) | 1989-10-19 |
AU3359889A (en) | 1989-11-03 |
DK239490D0 (da) | 1990-10-04 |
GB8808305D0 (en) | 1988-05-11 |
DE68909935D1 (de) | 1993-11-18 |
EP0414700B1 (de) | 1993-10-13 |
EP0414700A1 (de) | 1991-03-06 |
JPH03503612A (ja) | 1991-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |