DE68918860D1 - Photoempfindliche mittel. - Google Patents

Photoempfindliche mittel.

Info

Publication number
DE68918860D1
DE68918860D1 DE68918860T DE68918860T DE68918860D1 DE 68918860 D1 DE68918860 D1 DE 68918860D1 DE 68918860 T DE68918860 T DE 68918860T DE 68918860 T DE68918860 T DE 68918860T DE 68918860 D1 DE68918860 D1 DE 68918860D1
Authority
DE
Germany
Prior art keywords
compounds
tissue
pyropheophorbide
photodynamic therapy
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918860T
Other languages
English (en)
Other versions
DE68918860T2 (de
Inventor
Ravindra Pandey
Thomas Dougherty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc filed Critical Health Research Inc
Application granted granted Critical
Publication of DE68918860D1 publication Critical patent/DE68918860D1/de
Publication of DE68918860T2 publication Critical patent/DE68918860T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0474Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
DE68918860T 1988-07-20 1989-07-19 Photoempfindliche mittel. Expired - Fee Related DE68918860T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/221,804 US5002962A (en) 1988-07-20 1988-07-20 Photosensitizing agents
PCT/US1989/003115 WO1990000895A1 (en) 1988-07-20 1989-07-19 New photosensitizing agents

Publications (2)

Publication Number Publication Date
DE68918860D1 true DE68918860D1 (de) 1994-11-17
DE68918860T2 DE68918860T2 (de) 1995-02-16

Family

ID=22829459

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918860T Expired - Fee Related DE68918860T2 (de) 1988-07-20 1989-07-19 Photoempfindliche mittel.

Country Status (7)

Country Link
US (3) US5002962A (de)
EP (1) EP0425566B1 (de)
JP (1) JPH04500955A (de)
AT (1) ATE112680T1 (de)
AU (1) AU641362B2 (de)
DE (1) DE68918860T2 (de)
WO (1) WO1990000895A1 (de)

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US5219878A (en) * 1990-10-05 1993-06-15 Queen's University Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents
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US6100392A (en) * 1992-08-14 2000-08-08 The Trustees Of The University Of Pennsylavania Electron-deficient porphyrins and processes and intermediates for preparing same
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Also Published As

Publication number Publication date
US5002962A (en) 1991-03-26
JPH04500955A (ja) 1992-02-20
EP0425566A4 (en) 1992-03-11
EP0425566B1 (de) 1994-10-12
AU3971489A (en) 1990-02-19
AU641362B2 (en) 1993-09-23
DE68918860T2 (de) 1995-02-16
US5459159A (en) 1995-10-17
US5314905A (en) 1994-05-24
ATE112680T1 (de) 1994-10-15
WO1990000895A1 (en) 1990-02-08
EP0425566A1 (de) 1991-05-08

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee