DE68924661D1 - System zur Verabreichung von einem, eine Übung simulierenden Medikaments im geschlossenen Kreislauf. - Google Patents
System zur Verabreichung von einem, eine Übung simulierenden Medikaments im geschlossenen Kreislauf.Info
- Publication number
- DE68924661D1 DE68924661D1 DE68924661T DE68924661T DE68924661D1 DE 68924661 D1 DE68924661 D1 DE 68924661D1 DE 68924661 T DE68924661 T DE 68924661T DE 68924661 T DE68924661 T DE 68924661T DE 68924661 D1 DE68924661 D1 DE 68924661D1
- Authority
- DE
- Germany
- Prior art keywords
- exercise
- responses
- adaptive
- cad
- acute
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 4
- 230000001154 acute effect Effects 0.000 abstract 3
- 230000008649 adaptation response Effects 0.000 abstract 3
- 230000004044 response Effects 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000003044 adaptive effect Effects 0.000 abstract 1
- 150000003943 catecholamines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
- C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/13—Infusion monitoring
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15787588A | 1988-02-19 | 1988-02-19 | |
US07/308,683 US5108363A (en) | 1988-02-19 | 1989-02-09 | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68924661D1 true DE68924661D1 (de) | 1995-12-07 |
DE68924661T2 DE68924661T2 (de) | 1996-03-21 |
Family
ID=26854551
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68928422T Expired - Fee Related DE68928422T2 (de) | 1988-02-19 | 1989-02-17 | Die Diagnose, die Bewertung und die Behandlung von einer Krankheit der Kranzarterie durch die Übungssimulierung unter Verwendung von einer geschlossenen Kreislauf Arzneimittellieferung eines übungssimulierenden Beta-Agonisten |
DE68924661T Expired - Fee Related DE68924661T2 (de) | 1988-02-19 | 1989-02-17 | System zur Verabreichung von einem, eine Übung simulierenden Medikaments im geschlossenen Kreislauf. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68928422T Expired - Fee Related DE68928422T2 (de) | 1988-02-19 | 1989-02-17 | Die Diagnose, die Bewertung und die Behandlung von einer Krankheit der Kranzarterie durch die Übungssimulierung unter Verwendung von einer geschlossenen Kreislauf Arzneimittellieferung eines übungssimulierenden Beta-Agonisten |
Country Status (13)
Country | Link |
---|---|
US (4) | US5108363A (de) |
EP (2) | EP0329464B1 (de) |
JP (2) | JP2806543B2 (de) |
AT (2) | ATE159710T1 (de) |
AU (1) | AU634152B2 (de) |
DE (2) | DE68928422T2 (de) |
DK (1) | DK73589A (de) |
ES (2) | ES2081299T3 (de) |
FI (1) | FI890776A (de) |
GR (2) | GR3018764T3 (de) |
IE (2) | IE71651B1 (de) |
NO (1) | NO890704L (de) |
NZ (1) | NZ239270A (de) |
Families Citing this family (125)
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JPS6144385A (ja) * | 1984-08-07 | 1986-03-04 | Tokyu Constr Co Ltd | 構造物内の放射線吸収体の探査方法 |
IL82997A0 (en) * | 1986-07-11 | 1987-12-20 | Tanabe Seiyaku Co | Method for epimerizing an optically active benzyl alcohol derivative |
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PT95542B (pt) * | 1989-10-10 | 1999-09-30 | Glaxo Group Ltd | Processo para a prparacao de derivados de fenetanolamina |
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WO1993009779A1 (en) * | 1991-11-13 | 1993-05-27 | Gensia, Inc. | Methods for increasing the sensitivity and decreasing the side effects of pharmacological stress testing for coronary artery disease |
IL104365A0 (en) * | 1992-01-31 | 1993-05-13 | Gensia Pharma | Method and apparatus for closed loop drug delivery |
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-
1989
- 1989-02-09 US US07/308,683 patent/US5108363A/en not_active Expired - Fee Related
- 1989-02-15 NZ NZ239270A patent/NZ239270A/xx unknown
- 1989-02-17 ES ES89301553T patent/ES2081299T3/es not_active Expired - Lifetime
- 1989-02-17 IE IE52689A patent/IE71651B1/en not_active IP Right Cessation
- 1989-02-17 AU AU30088/89A patent/AU634152B2/en not_active Ceased
- 1989-02-17 DE DE68928422T patent/DE68928422T2/de not_active Expired - Fee Related
- 1989-02-17 DE DE68924661T patent/DE68924661T2/de not_active Expired - Fee Related
- 1989-02-17 AT AT95101920T patent/ATE159710T1/de not_active IP Right Cessation
- 1989-02-17 EP EP89301553A patent/EP0329464B1/de not_active Expired - Lifetime
- 1989-02-17 IE IE960742A patent/IE80716B1/en not_active IP Right Cessation
- 1989-02-17 AT AT89301553T patent/ATE129644T1/de not_active IP Right Cessation
- 1989-02-17 DK DK073589A patent/DK73589A/da not_active Application Discontinuation
- 1989-02-17 ES ES95101920T patent/ES2111973T3/es not_active Expired - Lifetime
- 1989-02-17 FI FI890776A patent/FI890776A/fi not_active Application Discontinuation
- 1989-02-17 EP EP95101920A patent/EP0658538B1/de not_active Expired - Lifetime
- 1989-02-20 JP JP1042887A patent/JP2806543B2/ja not_active Expired - Lifetime
- 1989-02-20 NO NO89890704A patent/NO890704L/no unknown
-
1990
- 1990-12-11 US US07/625,362 patent/US5286252A/en not_active Expired - Fee Related
-
1993
- 1993-12-07 US US08/163,839 patent/US5460605A/en not_active Expired - Fee Related
- 1993-12-15 US US08/169,536 patent/US5395970A/en not_active Expired - Fee Related
-
1996
- 1996-01-24 GR GR960400162T patent/GR3018764T3/el unknown
-
1998
- 1998-01-14 GR GR980400065T patent/GR3025892T3/el unknown
- 1998-02-19 JP JP10037422A patent/JPH10276991A/ja active Pending
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EP0658538A1 (de) | 1995-06-21 |
US5286252A (en) | 1994-02-15 |
EP0329464A3 (de) | 1991-07-17 |
DK73589D0 (da) | 1989-02-17 |
EP0329464B1 (de) | 1995-11-02 |
GR3018764T3 (en) | 1996-04-30 |
DE68924661T2 (de) | 1996-03-21 |
DK73589A (da) | 1989-08-20 |
AU634152B2 (en) | 1993-02-18 |
EP0658538B1 (de) | 1997-10-29 |
DE68928422D1 (de) | 1997-12-04 |
DE68928422T2 (de) | 1998-02-26 |
JP2806543B2 (ja) | 1998-09-30 |
AU3008889A (en) | 1989-08-24 |
IE890526L (en) | 1989-08-19 |
US5395970A (en) | 1995-03-07 |
FI890776A0 (fi) | 1989-02-17 |
FI890776A (fi) | 1989-08-20 |
NZ239270A (en) | 1993-10-26 |
US5460605A (en) | 1995-10-24 |
US5108363A (en) | 1992-04-28 |
IE960742L (en) | 1989-08-19 |
ES2081299T3 (es) | 1996-03-01 |
IE80716B1 (en) | 1998-12-30 |
NO890704D0 (no) | 1989-02-20 |
NO890704L (no) | 1989-08-21 |
ATE129644T1 (de) | 1995-11-15 |
IE71651B1 (en) | 1997-02-26 |
JPH0217048A (ja) | 1990-01-22 |
JPH10276991A (ja) | 1998-10-20 |
ES2111973T3 (es) | 1998-03-16 |
EP0329464A2 (de) | 1989-08-23 |
GR3025892T3 (en) | 1998-04-30 |
ATE159710T1 (de) | 1997-11-15 |
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