DE68924783T2 - Wässrige additivsysteme, verfahren und polymerteilchen. - Google Patents
Wässrige additivsysteme, verfahren und polymerteilchen.Info
- Publication number
- DE68924783T2 DE68924783T2 DE68924783T DE68924783T DE68924783T2 DE 68924783 T2 DE68924783 T2 DE 68924783T2 DE 68924783 T DE68924783 T DE 68924783T DE 68924783 T DE68924783 T DE 68924783T DE 68924783 T2 DE68924783 T2 DE 68924783T2
- Authority
- DE
- Germany
- Prior art keywords
- methods
- polymer particles
- additive systems
- aqueous additive
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25229888A | 1988-09-30 | 1988-09-30 | |
PCT/US1989/004267 WO1990003401A1 (en) | 1988-09-30 | 1989-09-29 | Targeting substance-diagnostic/therapeutic agent conjugates having schiff base linkages |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68924783D1 DE68924783D1 (de) | 1995-12-14 |
DE68924783T2 true DE68924783T2 (de) | 1996-03-28 |
Family
ID=22955432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68924783T Expired - Fee Related DE68924783T2 (de) | 1988-09-30 | 1989-09-29 | Wässrige additivsysteme, verfahren und polymerteilchen. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5633351A (de) |
EP (1) | EP0434765B1 (de) |
JP (1) | JPH04504248A (de) |
DE (1) | DE68924783T2 (de) |
WO (1) | WO1990003401A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU641361B2 (en) * | 1988-05-02 | 1993-09-23 | Zynaxis Technologies, Incorporated | Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles |
US5420105A (en) * | 1988-09-23 | 1995-05-30 | Gustavson; Linda M. | Polymeric carriers for non-covalent drug conjugation |
GB9024176D0 (en) * | 1990-11-07 | 1990-12-19 | Medical Res Council | Photolabile compounds,their synthesis and use as fluorophores |
CA2048078A1 (en) * | 1990-11-15 | 1992-05-16 | Wolfgang A. Wrasidlo | Chemical modification of antibodies for creation of immunoconjugates |
US5505931A (en) * | 1993-03-04 | 1996-04-09 | The Dow Chemical Company | Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents |
AU693433B2 (en) * | 1992-12-21 | 1998-07-02 | Promega Corporation | Prevention and treatment of sepsis |
US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
US6460271B2 (en) | 1995-04-19 | 2002-10-08 | Csp Technologies, Inc. | Insert having interconnecting channel morphology for aldehyde absorption |
USRE40941E1 (en) * | 1995-04-19 | 2009-10-20 | Csp Technologies, Inc. | Monolithic polymer composition having a releasing material |
US6221446B1 (en) | 1995-04-19 | 2001-04-24 | Capitol Specialty Plastics, Inc | Modified polymers having controlled transmission rates |
US6194079B1 (en) | 1995-04-19 | 2001-02-27 | Capitol Specialty Plastics, Inc. | Monolithic polymer composition having an absorbing material |
US6316520B1 (en) | 1995-04-19 | 2001-11-13 | Capitol Specialty Plastics, Inc. | Monolithic polymer composition having a releasing material |
US6174952B1 (en) | 1995-04-19 | 2001-01-16 | Capitol Specialty Plastics, Inc. | Monolithic polymer composition having a water absorption material |
US6177183B1 (en) * | 1995-04-19 | 2001-01-23 | Capitol Specialty Plastics, Inc. | Monolithic composition having an activation material |
EP0871490B1 (de) * | 1995-12-22 | 2003-03-19 | Bristol-Myers Squibb Company | Verzweigte hydrazongruppen enthaltende kuppler |
ES2232862T3 (es) * | 1996-10-21 | 2005-06-01 | Quadrant Drug Delivery Limited | Sustitutos de plaquetas y procedimientos de conjugacion apropiados para su preparacion. |
US6465532B1 (en) | 1997-03-05 | 2002-10-15 | Csp Tecnologies, Inc. | Co-continuous interconnecting channel morphology polymer having controlled gas transmission rate through the polymer |
US6953675B2 (en) | 1997-11-06 | 2005-10-11 | Immunomedics, Inc. | Landscaped antibodies and antibody fragments for clinical use |
IL139585A0 (en) * | 1998-06-26 | 2002-02-10 | Pfizer Prod Inc | Improved process for preparing schiff base adducts of amines with 0-hydroxy aldehydes and compositions of matter based thereon |
WO2000038735A1 (en) | 1998-12-24 | 2000-07-06 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical preparation |
US6881718B1 (en) * | 1999-10-22 | 2005-04-19 | The United States Of America As Represented By The Department Of Health And Human Services | Disulfide conjugated cell toxins and methods of making and using them |
US7186813B1 (en) | 2000-01-11 | 2007-03-06 | Nanogen Recognomics Gmbh | Biomolecules having multiple attachment moieties for binding to a substrate surface |
EP2295407B1 (de) * | 2000-03-22 | 2014-11-05 | Solulink, Inc. | Hydrazin- und Carbonyl-basierte bifunktionelle Vernetzungsmittel |
US6696002B1 (en) | 2000-03-29 | 2004-02-24 | Capitol Security Plastics, Inc. | Co-continuous interconnecting channel morphology polymer having modified surface properties |
US7129229B2 (en) | 2000-08-11 | 2006-10-31 | Nanogen Recognomics Gmbh | Hydrazide building blocks and hydrazide modified biomolecules |
RU2385879C2 (ru) * | 2004-01-21 | 2010-04-10 | Ново Нордиск Хелс Кеа Аг | Способ конъюгации пептидов, опосредованной трансглутаминазой |
ES2387195T3 (es) * | 2005-05-27 | 2012-09-17 | Royer Biomedical, Inc. | Matrices de polímero y métodos de fabricación y uso de las mismas |
AU2006286486A1 (en) | 2005-08-30 | 2007-03-08 | Novo Nordisk Health Care Ag | Liquid formulations of pegylated growth hormone |
AU2007271150A1 (en) | 2006-07-07 | 2008-01-10 | Novo Nordisk Health Care Ag | New protein conjugates and methods for their preparation |
GB0618524D0 (en) | 2006-09-20 | 2006-11-01 | Isis Innovation | Multimeric particles |
EP2947096B1 (de) | 2009-08-05 | 2018-11-28 | Philogen S.p.A. | Abzielung auf die neovaskulatur des knochenmarks |
TWI506269B (zh) * | 2012-10-23 | 2015-11-01 | Univ Ishou | 螢光醣類衍生物之用途 |
US20140227208A1 (en) * | 2013-02-08 | 2014-08-14 | The Procter & Gamble Company | Cosmetic compositions containing substituted azole and methods for alleviating mechanically-induced skin inflammation |
US10309959B2 (en) | 2014-12-03 | 2019-06-04 | Life Technologies Corporation | Charged reactive oligomers |
EP3227264B1 (de) * | 2014-12-03 | 2020-10-21 | Life Technologies Corporation | Hydrazinyl- und aminooxyverbindungen und verfahren zur verwendung davon |
US20230277682A1 (en) * | 2022-01-14 | 2023-09-07 | Regeneron Pharmaceuticals, Inc. | Verrucarin a derivatives and antibody drug conjugates thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2247163A1 (de) * | 1972-09-26 | 1974-03-28 | Merck Patent Gmbh | Traegermatrix zur fixierung biologisch wirksamer stoffe und verfahren zu ihrer herstellung |
IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
SE441042B (sv) * | 1976-09-08 | 1985-09-02 | Pharmacia Diagnostics Ab | Sett att pavisa rheumatoida faktorer |
US4314987A (en) * | 1979-04-04 | 1982-02-09 | Rheumatology Diagnostics Laboratory | Method for diagnosing rheumatological diseases |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
US4950738A (en) * | 1984-09-13 | 1990-08-21 | Cytogen Corporation | Amine derivatives of anthracycline antibiotics |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4443426A (en) * | 1982-06-14 | 1984-04-17 | Yale University | Blood agent |
US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
AU583854B2 (en) * | 1984-09-13 | 1989-05-11 | Cytogen Corporation | Antibody therapeutic agent conjugates |
EP0188256B1 (de) * | 1985-01-14 | 1991-08-21 | NeoRx | Metall-Radionuklid markiertes Protein für Diagnose und Therapie |
DE3688103T2 (de) * | 1985-05-17 | 1993-07-15 | Neorx Corp | Radiohalogenierte kleine molekuele fuer das markieren von proteinen. |
US4868106A (en) * | 1985-10-17 | 1989-09-19 | Konishiroku Photo Industry Co., Ltd. | Analytical element and method for determining a component in a test sample |
CA1330378C (en) * | 1986-05-08 | 1994-06-21 | Daniel J. Coughlin | Amine derivatives of folic acid analogs |
US4801688A (en) * | 1986-05-27 | 1989-01-31 | Eli Lilly And Company | Hydrazone immunoglobulin conjugates |
AU616161B2 (en) * | 1986-10-09 | 1991-10-24 | Neorx Corporation | Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
US4735792A (en) * | 1987-04-28 | 1988-04-05 | The United States Of America As Represented By The United States Department Of Energy | Radioiodinated maleimides and use as agents for radiolabeling antibodies |
FI102355B1 (fi) * | 1988-02-11 | 1998-11-30 | Bristol Myers Squibb Co | Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi |
US4925648A (en) * | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
-
1989
- 1989-09-29 EP EP89911718A patent/EP0434765B1/de not_active Expired - Lifetime
- 1989-09-29 WO PCT/US1989/004267 patent/WO1990003401A1/en active IP Right Grant
- 1989-09-29 JP JP1510891A patent/JPH04504248A/ja active Pending
- 1989-09-29 DE DE68924783T patent/DE68924783T2/de not_active Expired - Fee Related
-
1994
- 1994-11-01 US US08/332,045 patent/US5633351A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE68924783D1 (de) | 1995-12-14 |
EP0434765B1 (de) | 1995-11-08 |
JPH04504248A (ja) | 1992-07-30 |
EP0434765A1 (de) | 1991-07-03 |
WO1990003401A1 (en) | 1990-04-05 |
US5633351A (en) | 1997-05-27 |
EP0434765A4 (en) | 1992-06-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |