DE68927995T2 - Osteogene faktoren - Google Patents

Osteogene faktoren

Info

Publication number
DE68927995T2
DE68927995T2 DE68927995T DE68927995T DE68927995T2 DE 68927995 T2 DE68927995 T2 DE 68927995T2 DE 68927995 T DE68927995 T DE 68927995T DE 68927995 T DE68927995 T DE 68927995T DE 68927995 T2 DE68927995 T2 DE 68927995T2
Authority
DE
Germany
Prior art keywords
eluting
acetonitrile
subunit
protein preparation
daltons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68927995T
Other languages
English (en)
Other versions
DE68927995D1 (de
Inventor
Thomas Parsons
Arup Van Sen
Lynn Grinna
Carol Hersh
Georgia Theofan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Genetic Engineering Inc
Original Assignee
International Genetic Engineering Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Genetic Engineering Inc filed Critical International Genetic Engineering Inc
Publication of DE68927995D1 publication Critical patent/DE68927995D1/de
Application granted granted Critical
Publication of DE68927995T2 publication Critical patent/DE68927995T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/84—Bones; tendons; teeth; cartilage
DE68927995T 1988-10-11 1989-10-06 Osteogene faktoren Expired - Fee Related DE68927995T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25603488A 1988-10-11 1988-10-11
US07/415,555 US5106626A (en) 1988-10-11 1989-10-04 Osteogenic factors
PCT/US1989/004458 WO1990003733A1 (en) 1988-10-11 1989-10-06 Osteogenic factors

Publications (2)

Publication Number Publication Date
DE68927995D1 DE68927995D1 (de) 1997-05-28
DE68927995T2 true DE68927995T2 (de) 1997-09-11

Family

ID=26945113

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68927995T Expired - Fee Related DE68927995T2 (de) 1988-10-11 1989-10-06 Osteogene faktoren

Country Status (10)

Country Link
US (1) US5106626A (de)
EP (1) EP0394418B1 (de)
JP (1) JP3209740B2 (de)
AT (1) ATE152126T1 (de)
AU (1) AU615810B2 (de)
CA (1) CA2000498C (de)
DE (1) DE68927995T2 (de)
DK (1) DK141390D0 (de)
NZ (1) NZ230974A (de)
WO (1) WO1990003733A1 (de)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5328695A (en) * 1983-03-22 1994-07-12 Massachusetts Institute Of Technology Muscle morphogenic protein and use thereof
US5366875A (en) * 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
US5459047A (en) 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
ATE142644T1 (de) 1988-04-08 1996-09-15 Stryker Corp Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
PT94241A (pt) * 1989-06-02 1991-02-08 Chiron Corp Processo para a preparacao de factor calcificacao ossea e de composicoes farmaceuticas que os contem
US5238843A (en) * 1989-10-27 1993-08-24 Genencor International, Inc. Method for cleaning a surface on which is bound a glycoside-containing substance
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
AU8941791A (en) * 1990-10-18 1992-05-20 Creative Biomolecules, Inc. Osteogenic protein
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US7056882B2 (en) * 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6399569B1 (en) * 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
ATE203166T1 (de) * 1991-03-11 2001-08-15 Curis Inc Protein-induzierende morphogenese
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
ZA923086B (en) * 1991-04-29 1993-10-28 South African Medical Research A delivery system for biologicaly active growth or morphogenetic factors and a method for preparing such delivery system
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
ES2127757T3 (es) * 1991-06-25 1999-05-01 Genetics Inst Composiciones bmp-9.
US6287816B1 (en) * 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
CA2075240A1 (en) * 1991-08-05 1993-02-06 Mitsubishi Chemical Corporation Chondromodulin-ii protein
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
JP3504263B2 (ja) * 1991-11-04 2004-03-08 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
MX9301535A (es) * 1992-03-18 1994-03-31 Osteosa Inc Material proteinaceo biologicamente activo aislado y purificado.
EP0672064A1 (de) * 1992-11-03 1995-09-20 Creative Biomolecules, Inc. Op 3 - induzierte morphogenese
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
JP3717930B2 (ja) * 1993-12-07 2005-11-16 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー Ｂｍｐ−１２、ｂｍｐ−１３およびそれらの腱誘導組成物
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) * 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US20020193338A1 (en) * 1994-02-18 2002-12-19 Goldstein Steven A. In vivo gene transfer methods for wound healing
US5962427A (en) * 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6074840A (en) 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
DE69528128T2 (de) 1994-06-10 2003-03-13 United States Surgical Corp Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung
US5976104A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby
US5797871A (en) * 1994-08-19 1998-08-25 Lifenet Research Foundation Ultrasonic cleaning of allograft bone
US5556379A (en) * 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
US5977034A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Composition for cleaning bones
EP0883410B1 (de) * 1996-02-29 2004-08-18 Bioactive Bone Substitute OY, AB Osteogene vorrichtungen und methode zur herstellung derselben
CA2249368A1 (en) 1996-03-22 1997-09-25 The General Hospital Corporation Administration of polypeptide growth factors following central nervous system ischemia or trauma
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
WO1999006563A1 (en) 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
ES2209820T3 (es) 1999-02-04 2004-07-01 Sdgi Holdings, Inc. Composiciones esponjosas osteogenicas altamente mineralizadas, y usos de las mismas.
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US6818428B1 (en) 1999-09-17 2004-11-16 Cedars Sinai Medical Center 3-phosphoadenosine-5-phosphosulfate (PAPS) synthetase proteins and methods for treating osteoarthritic disorders
PT1223990E (pt) 1999-10-15 2004-12-31 Fidia Advanced Biopolymers Srl Formulacoes de acido hialuronico para administracao de proteinas osteogenicas
GB0021303D0 (en) * 2000-08-30 2000-10-18 Medinnova Sf Use
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
NZ530045A (en) * 2001-06-01 2007-07-27 Wyeth Corp Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
EP1519744A4 (de) * 2002-05-17 2007-10-03 Wyeth Corp Injizierbare feste hyaluronsäureträger zur zuführung von osteogenen proteinen
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
JP5392981B2 (ja) * 2003-09-12 2014-01-22 ワイス・エルエルシー 骨形成蛋白の送達のための注入可能なリン酸カルシウム固体ロッドおよびペースト
US8328876B2 (en) 2003-12-31 2012-12-11 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
KR100775958B1 (ko) * 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
WO2006104306A1 (en) * 2005-03-30 2006-10-05 Jung Moon Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
WO2006125868A1 (en) * 2005-05-27 2006-11-30 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
WO2007053850A2 (en) 2005-11-01 2007-05-10 Osteotech, Inc. Bone matrix compositions and methods
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US9492278B2 (en) 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
US9011537B2 (en) 2009-02-12 2015-04-21 Warsaw Orthopedic, Inc. Delivery system cartridge
CA3048850A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
NZ210699A (en) * 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
DE3588058T3 (de) * 1984-07-16 2005-04-07 Celtrix Pharmaceuticals, Inc., Palo Alto Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
KR900700116A (ko) * 1988-04-06 1990-08-11 원본미기재 뼈-유도 단백질
ATE142644T1 (de) * 1988-04-08 1996-09-15 Stryker Corp Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen

Also Published As

Publication number Publication date
DK141390A (da) 1990-06-08
EP0394418B1 (de) 1997-04-23
EP0394418A4 (en) 1992-01-22
DE68927995D1 (de) 1997-05-28
CA2000498A1 (en) 1990-04-11
US5106626A (en) 1992-04-21
WO1990003733A1 (en) 1990-04-19
ATE152126T1 (de) 1997-05-15
AU615810B2 (en) 1991-10-10
EP0394418A1 (de) 1990-10-31
NZ230974A (en) 1993-03-26
DK141390D0 (da) 1990-06-08
CA2000498C (en) 2004-01-13
JP3209740B2 (ja) 2001-09-17
AU4488689A (en) 1990-05-01
JPH04505151A (ja) 1992-09-10

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